Reviewed, UniProtKB/Swiss-Prot P77561 (YDEP_ECOLI)

Names and origin

Protein names

Recommended name:
    Protein ydeP

Gene names

Name:	ydeP
Ordered Locus Names:	b1501, JW1495

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	759 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probably involved in acid resistance. Ref.4 Ref.5
Cofactor	Binds 1 4Fe-4S cluster Potential. Molybdenum (molybdopterin) By similarity.
Induction	By evgA. Ref.4 Ref.5
Sequence similarities	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding Molybdenum
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW formate dehydrogenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW molybdenum ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
mdtP	P32714	1	EBI-545210,EBI-1124272
mtlD	P09424	1	EBI-545210,EBI-554652

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 759	759	Protein ydeP		PRO_0000063227
Sites
	Metal binding	49	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	52	1	Iron-sulfur (4Fe-4S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P77561-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 4DE7C14068FB66DD	FASTA	759	83,495
	10 20 30 40 50 60 MKKKIESYQG AAGGWGAVKS VANAVRKQMD IRQDVIAMFD MNKPEGFDCP GCAWPDPKHS 70 80 90 100 110 120 ASFDICENGA KAIAWEVTDK QVNASFFAEN TVQSLLTWGD HELEAAGRLT QPLKYDAVSD 130 140 150 160 170 180 CYKPLSWQQA FDEIGARLQS YSDPNQVEFY TSGRTSNEAA FLYQLFAREY GSNNFPDCSN 190 200 210 220 230 240 MCHEPTSVGL AASIGVGKGT VLLEDFEKCD LVICIGHNPG TNHPRMLTSL RALVKRGAKM 250 260 270 280 290 300 IAINPLQERG LERFTAPQNP FEMLTNSETQ LASAYYNVRI GGDMALLKGM MRLLIERDDA 310 320 330 340 350 360 ASAAGRPSLL DDEFIQTHTV GFDELRRDVL NSEWKDIERI SGLSQTQIAE LADAYAAAER 370 380 390 400 410 420 TIICYGMGIT QHEHGTQNVQ QLVNLLLMKG NIGKPGAGIC PLRGHSNVQG DRTVGITEKP 430 440 450 460 470 480 SAEFLARLGE RYGFTPPHAP GHAAIASMQA ICTGQARALI CMGGNFALAM PDREASAVPL 490 500 510 520 530 540 TQLDLAVHVA TKLNRSHLLT ARHSYILPVL GRSEIDMQKN GAQAVTVEDS MSMIHASRGV 550 560 570 580 590 600 LKPAGVMLKS ECAVVAGIAQ AALPQSVVAW EYLVEDYDRI RNDIEAVLPE FADYNQRIRH 610 620 630 640 650 660 PGGFHLINAA AERRWMTPSG KANFITSKGL LEDPSSAFNS KLVMATVRSH DQYNTTIYGM 670 680 690 700 710 720 DDRYRGVFGQ RDVVFMSAKQ AKICRVKNGE RVNLIALTPD GKRSSRRMDR LKVVIYPMAD 730 740 750 RSLVTYFPES NHMLTLDNHD PLSGIPGYKS IPVELEPSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. , Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T. DNA Res. 3:363-377(1996) [PubMed: 9097039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Escherichia coli gene expression responsive to levels of the response regulator EvgA." Masuda N., Church G.M. J. Bacteriol. 184:6225-6234(2002) [PubMed: 12399493] [Abstract] Cited for: FUNCTION, INDUCTION. Strain: K12 / MG1655 / ATCC 47076.
[5]	"Regulatory network of acid resistance genes in Escherichia coli." Masuda N., Church G.M. Mol. Microbiol. 48:699-712(2003) [PubMed: 12694615] [Abstract] Cited for: FUNCTION, INDUCTION. Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00096 Genomic DNA. Translation: AAC74574.1. AP009048 Genomic DNA. Translation: BAA15174.1.
PIR	H64903.
RefSeq	AP_002123.1. NP_416018.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:28057N.
IntAct	P77561. 10 interactions.
Genome annotation databases
GeneID	946055.
GenomeReviews	Gene locus JW1495 in contig AP009048_GR. Gene locus b1501 in contig U00096_GR.
KEGG	ecj:JW1495. eco:b1501.
Organism-specific databases
EchoBASE	EB3559.
EcoGene	EG13798. ydeP.
CMR	Search...
Phylogenomic databases
HOGENOM	P77561.
OMA	P77561. DRTIICY.
Enzyme and pathway databases
BioCyc	EcoCyc:G6791-MON.
Family and domain databases
InterPro	IPR009010. Asp_de-COase-like_fold. IPR006656. Mopterin_OxRdtase. IPR010046. Mopterin_OxRdtse_a_bac. IPR006657. MPT_dinuc_bd. [Graphical view]
Gene3D	G3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
Pfam	PF00384. Molybdopterin. 2 hits. PF01568. Molydop_binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR01701. Fdhalpha-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YDEP_ECOLI

Accession

Primary (citable) accession number: P77561
Secondary accession number(s): P78160

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)