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P77555

- ALLD_ECOLI

UniProt

P77555 - ALLD_ECOLI

Protein

Ureidoglycolate dehydrogenase (NAD(+))

Gene

allD

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Involved in the anaerobic utilization of allantoin.1 Publication

    Catalytic activityi

    (S)-ureidoglycolate + NAD+ = oxalurate + NADH.

    Pathwayi

    GO - Molecular functioni

    1. ureidoglycolate dehydrogenase activity Source: EcoCyc

    GO - Biological processi

    1. allantoin assimilation pathway Source: EcoCyc
    2. purine nucleobase metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciEcoCyc:G6286-MONOMER.
    ECOL316407:JW0505-MONOMER.
    MetaCyc:G6286-MONOMER.
    UniPathwayiUPA00395; UER00657.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ureidoglycolate dehydrogenase (NAD(+)) (EC:1.1.1.350)
    Gene namesi
    Name:allD
    Synonyms:glxB8, ylbC
    Ordered Locus Names:b0517, JW0505
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13624. allD.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Ureidoglycolate dehydrogenase (NAD(+))PRO_0000083822Add
    BLAST

    Expressioni

    Inductioni

    By glyoxylate and allantoin under anaerobic conditions.

    Gene expression databases

    GenevestigatoriP77555.

    Interactioni

    Protein-protein interaction databases

    IntActiP77555. 5 interactions.
    STRINGi511145.b0517.

    Structurei

    Secondary structure

    1
    349
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1915
    Helixi23 – 3917
    Helixi42 – 443
    Helixi46 – 483
    Helixi49 – 579
    Beta strandi68 – 736
    Beta strandi76 – 805
    Helixi86 – 10419
    Beta strandi105 – 11410
    Helixi121 – 1299
    Beta strandi132 – 1387
    Beta strandi149 – 1513
    Beta strandi159 – 1646
    Beta strandi170 – 1756
    Beta strandi177 – 1804
    Helixi182 – 19110
    Beta strandi199 – 2013
    Turni211 – 2133
    Turni220 – 2223
    Helixi223 – 23614
    Helixi238 – 2403
    Helixi245 – 2473
    Turni251 – 2533
    Beta strandi261 – 2688
    Helixi270 – 2723
    Helixi276 – 29116
    Helixi307 – 31913
    Beta strandi321 – 3233
    Helixi325 – 3317

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XRHX-ray2.25A/B/C/D/E/F/G/H2-349[»]
    4H8AX-ray1.64A/B1-337[»]
    ProteinModelPortaliP77555.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP77555.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH2/MDH2 oxidoreductase family.Curated

    Phylogenomic databases

    eggNOGiCOG2055.
    HOGENOMiHOG000173270.
    KOiK00073.
    OMAiMMVDVLS.
    OrthoDBiEOG6ZPSZJ.
    PhylomeDBiP77555.

    Family and domain databases

    InterProiIPR003767. Malate/L-lactate_DH.
    IPR017590. Ureidoglycolate_dehydrogenase.
    [Graphical view]
    PANTHERiPTHR11091. PTHR11091. 1 hit.
    PfamiPF02615. Ldh_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF89733. SSF89733. 1 hit.
    TIGRFAMsiTIGR03175. AllD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P77555-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISRETLHQ LIENKLCQAG LKREHAATVA EVLVYADARG IHSHGAVRVE    50
    YYAERISKGG TNREPEFRLE ETGPCSAILH ADNAAGQVAA KMGMEHAIKT 100
    AQQNGVAVVG ISRMGHSGAI SYFVQQAARA GFIGISMCQS DPMVVPFGGA 150
    EIYYGTNPLA FAAPGEGDEI LTFDMATTVQ AWGKVLDARS RNMSIPDTWA 200
    VDKNGVPTTD PFAVHALLPA AGPKGYGLMM MIDVLSGVLL GLPFGRQVSS 250
    MYDDLHAGRN LGQLHIVINP NFFSSSELFR QHLSQTMREL NAITPAPGFN 300
    QVYYPGQDQD IKQRKAAVEG IEIVDDIYQY LISDALYNTS YETKNPFAQ 349
    Length:349
    Mass (Da):37,967
    Last modified:February 1, 1997 - v1
    Checksum:i93C3076A66141C4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89279 Genomic DNA. Translation: AAB93858.1.
    U82664 Genomic DNA. Translation: AAB40269.1.
    U00096 Genomic DNA. Translation: AAC73619.1.
    AP009048 Genomic DNA. Translation: BAE76295.1.
    PIRiD64783.
    RefSeqiNP_415050.1. NC_000913.3.
    YP_488807.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73619; AAC73619; b0517.
    BAE76295; BAE76295; BAE76295.
    GeneIDi12932447.
    948342.
    KEGGiecj:Y75_p0503.
    eco:b0517.
    PATRICi32116191. VBIEscCol129921_0537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89279 Genomic DNA. Translation: AAB93858.1 .
    U82664 Genomic DNA. Translation: AAB40269.1 .
    U00096 Genomic DNA. Translation: AAC73619.1 .
    AP009048 Genomic DNA. Translation: BAE76295.1 .
    PIRi D64783.
    RefSeqi NP_415050.1. NC_000913.3.
    YP_488807.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XRH X-ray 2.25 A/B/C/D/E/F/G/H 2-349 [» ]
    4H8A X-ray 1.64 A/B 1-337 [» ]
    ProteinModelPortali P77555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P77555. 5 interactions.
    STRINGi 511145.b0517.

    Protocols and materials databases

    DNASUi 948342.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73619 ; AAC73619 ; b0517 .
    BAE76295 ; BAE76295 ; BAE76295 .
    GeneIDi 12932447.
    948342.
    KEGGi ecj:Y75_p0503.
    eco:b0517.
    PATRICi 32116191. VBIEscCol129921_0537.

    Organism-specific databases

    EchoBASEi EB3389.
    EcoGenei EG13624. allD.

    Phylogenomic databases

    eggNOGi COG2055.
    HOGENOMi HOG000173270.
    KOi K00073.
    OMAi MMVDVLS.
    OrthoDBi EOG6ZPSZJ.
    PhylomeDBi P77555.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00657 .
    BioCyci EcoCyc:G6286-MONOMER.
    ECOL316407:JW0505-MONOMER.
    MetaCyc:G6286-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P77555.
    PROi P77555.

    Gene expression databases

    Genevestigatori P77555.

    Family and domain databases

    InterProi IPR003767. Malate/L-lactate_DH.
    IPR017590. Ureidoglycolate_dehydrogenase.
    [Graphical view ]
    PANTHERi PTHR11091. PTHR11091. 1 hit.
    Pfami PF02615. Ldh_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89733. SSF89733. 1 hit.
    TIGRFAMsi TIGR03175. AllD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli."
      Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J.
      J. Bacteriol. 181:7479-7484(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: K12 / ECL1.
    2. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiALLD_ECOLI
    AccessioniPrimary (citable) accession number: P77555
    Secondary accession number(s): Q2MBR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3