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P77555 (ALLD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ureidoglycolate dehydrogenase
EC=1.1.1.154
Gene names
Name:allD
Synonyms:glxB8, ylbC
Ordered Locus Names:b0517, JW0505
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the anaerobic utilization of allantoin. Ref.1

Catalytic activity

(S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H.

Pathway

Nitrogen metabolism; (S)-allantoin degradation; oxalurate from (S)-ureidoglycolate: step 1/1.

Subcellular location

Cytoplasm Probable.

Induction

By glyoxylate and allantoin under anaerobic conditions.

Sequence similarities

Belongs to the LDH2/MDH2 oxidoreductase family.

Ontologies

Keywords
   Biological processPurine metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processallantoin assimilation pathway

Inferred from direct assay Ref.1. Source: EcoCyc

purine nucleobase metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionureidoglycolate dehydrogenase activity

Inferred from direct assay Ref.1PubMed 23284870. Source: EcoCyc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Ureidoglycolate dehydrogenase
PRO_0000083822

Secondary structure

1 ........................................................ 349
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P77555 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 93C3076A66141C4E

FASTA34937,967
        10         20         30         40         50         60 
MKISRETLHQ LIENKLCQAG LKREHAATVA EVLVYADARG IHSHGAVRVE YYAERISKGG 

        70         80         90        100        110        120 
TNREPEFRLE ETGPCSAILH ADNAAGQVAA KMGMEHAIKT AQQNGVAVVG ISRMGHSGAI 

       130        140        150        160        170        180 
SYFVQQAARA GFIGISMCQS DPMVVPFGGA EIYYGTNPLA FAAPGEGDEI LTFDMATTVQ 

       190        200        210        220        230        240 
AWGKVLDARS RNMSIPDTWA VDKNGVPTTD PFAVHALLPA AGPKGYGLMM MIDVLSGVLL 

       250        260        270        280        290        300 
GLPFGRQVSS MYDDLHAGRN LGQLHIVINP NFFSSSELFR QHLSQTMREL NAITPAPGFN 

       310        320        330        340 
QVYYPGQDQD IKQRKAAVEG IEIVDDIYQY LISDALYNTS YETKNPFAQ

« Hide

References

« Hide 'large scale' references
[1]"Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli."
Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J.
J. Bacteriol. 181:7479-7484(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: K12 / ECL1.
[2]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U89279 Genomic DNA. Translation: AAB93858.1.
U82664 Genomic DNA. Translation: AAB40269.1.
U00096 Genomic DNA. Translation: AAC73619.1.
AP009048 Genomic DNA. Translation: BAE76295.1.
PIRD64783.
RefSeqNP_415050.1. NC_000913.2.
YP_488807.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XRHX-ray2.25A/B/C/D/E/F/G/H2-349[»]
4H8AX-ray1.64A/B1-337[»]
ProteinModelPortalP77555.
SMRP77555. Positions 2-342.
ModBaseSearch...

Protein-protein interaction databases

IntActP77555. 5 interactions.
STRING511145.b0517.

Protocols and materials databases

DNASU948342.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73619; AAC73619; b0517.
BAE76295; BAE76295; BAE76295.
GeneID12932447.
948342.
KEGGecj:Y75_p0503.
eco:b0517.
PATRIC32116191. VBIEscCol129921_0537.

Organism-specific databases

EchoBASEEB3389.
EcoGeneEG13624. allD.

Phylogenomic databases

eggNOGCOG2055.
HOGENOMHOG000173270.
KOK00073.
OMAVINPAYF.
ProtClustDBPRK15025.

Enzyme and pathway databases

BioCycEcoCyc:G6286-MONOMER.
ECOL316407:JW0505-MONOMER.
MetaCyc:G6286-MONOMER.
UniPathwayUPA00395; UER00657.

Gene expression databases

GenevestigatorP77555.

Family and domain databases

InterProIPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]
PANTHERPTHR11091. PTHR11091. 1 hit.
PfamPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMSSF89733. MDH_LDH. 1 hit.
TIGRFAMsTIGR03175. AllD. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP77555.

Entry information

Entry nameALLD_ECOLI
AccessionPrimary (citable) accession number: P77555
Secondary accession number(s): Q2MBR1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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