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P77555

- ALLD_ECOLI

UniProt

P77555 - ALLD_ECOLI

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Protein

Ureidoglycolate dehydrogenase (NAD(+))

Gene

allD

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the anaerobic utilization of allantoin.1 Publication

Catalytic activityi

(S)-ureidoglycolate + NAD+ = oxalurate + NADH.

Pathwayi

GO - Molecular functioni

  1. ureidoglycolate dehydrogenase activity Source: EcoCyc

GO - Biological processi

  1. allantoin assimilation pathway Source: EcoCyc
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:G6286-MONOMER.
ECOL316407:JW0505-MONOMER.
MetaCyc:G6286-MONOMER.
UniPathwayiUPA00395; UER00657.

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate dehydrogenase (NAD(+)) (EC:1.1.1.350)
Gene namesi
Name:allD
Synonyms:glxB8, ylbC
Ordered Locus Names:b0517, JW0505
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13624. allD.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Ureidoglycolate dehydrogenase (NAD(+))PRO_0000083822Add
BLAST

Expressioni

Inductioni

By glyoxylate and allantoin under anaerobic conditions.

Gene expression databases

GenevestigatoriP77555.

Interactioni

Protein-protein interaction databases

IntActiP77555. 5 interactions.
STRINGi511145.b0517.

Structurei

Secondary structure

1
349
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1915
Helixi23 – 3917
Helixi42 – 443
Helixi46 – 483
Helixi49 – 579
Beta strandi68 – 736
Beta strandi76 – 805
Helixi86 – 10419
Beta strandi105 – 11410
Helixi121 – 1299
Beta strandi132 – 1387
Beta strandi149 – 1513
Beta strandi159 – 1646
Beta strandi170 – 1756
Beta strandi177 – 1804
Helixi182 – 19110
Beta strandi199 – 2013
Turni211 – 2133
Turni220 – 2223
Helixi223 – 23614
Helixi238 – 2403
Helixi245 – 2473
Turni251 – 2533
Beta strandi261 – 2688
Helixi270 – 2723
Helixi276 – 29116
Helixi307 – 31913
Beta strandi321 – 3233
Helixi325 – 3317

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XRHX-ray2.25A/B/C/D/E/F/G/H2-349[»]
4H8AX-ray1.64A/B1-337[»]
ProteinModelPortaliP77555.
SMRiP77555. Positions 1-337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77555.

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family.Curated

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000173270.
InParanoidiP77555.
KOiK00073.
OMAiMMVDVLS.
OrthoDBiEOG6ZPSZJ.
PhylomeDBiP77555.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
TIGRFAMsiTIGR03175. AllD. 1 hit.

Sequencei

Sequence statusi: Complete.

P77555-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKISRETLHQ LIENKLCQAG LKREHAATVA EVLVYADARG IHSHGAVRVE
60 70 80 90 100
YYAERISKGG TNREPEFRLE ETGPCSAILH ADNAAGQVAA KMGMEHAIKT
110 120 130 140 150
AQQNGVAVVG ISRMGHSGAI SYFVQQAARA GFIGISMCQS DPMVVPFGGA
160 170 180 190 200
EIYYGTNPLA FAAPGEGDEI LTFDMATTVQ AWGKVLDARS RNMSIPDTWA
210 220 230 240 250
VDKNGVPTTD PFAVHALLPA AGPKGYGLMM MIDVLSGVLL GLPFGRQVSS
260 270 280 290 300
MYDDLHAGRN LGQLHIVINP NFFSSSELFR QHLSQTMREL NAITPAPGFN
310 320 330 340
QVYYPGQDQD IKQRKAAVEG IEIVDDIYQY LISDALYNTS YETKNPFAQ
Length:349
Mass (Da):37,967
Last modified:February 1, 1997 - v1
Checksum:i93C3076A66141C4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89279 Genomic DNA. Translation: AAB93858.1.
U82664 Genomic DNA. Translation: AAB40269.1.
U00096 Genomic DNA. Translation: AAC73619.1.
AP009048 Genomic DNA. Translation: BAE76295.1.
PIRiD64783.
RefSeqiNP_415050.1. NC_000913.3.
YP_488807.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73619; AAC73619; b0517.
BAE76295; BAE76295; BAE76295.
GeneIDi12932447.
948342.
KEGGiecj:Y75_p0503.
eco:b0517.
PATRICi32116191. VBIEscCol129921_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89279 Genomic DNA. Translation: AAB93858.1 .
U82664 Genomic DNA. Translation: AAB40269.1 .
U00096 Genomic DNA. Translation: AAC73619.1 .
AP009048 Genomic DNA. Translation: BAE76295.1 .
PIRi D64783.
RefSeqi NP_415050.1. NC_000913.3.
YP_488807.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XRH X-ray 2.25 A/B/C/D/E/F/G/H 2-349 [» ]
4H8A X-ray 1.64 A/B 1-337 [» ]
ProteinModelPortali P77555.
SMRi P77555. Positions 1-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P77555. 5 interactions.
STRINGi 511145.b0517.

Protocols and materials databases

DNASUi 948342.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73619 ; AAC73619 ; b0517 .
BAE76295 ; BAE76295 ; BAE76295 .
GeneIDi 12932447.
948342.
KEGGi ecj:Y75_p0503.
eco:b0517.
PATRICi 32116191. VBIEscCol129921_0537.

Organism-specific databases

EchoBASEi EB3389.
EcoGenei EG13624. allD.

Phylogenomic databases

eggNOGi COG2055.
HOGENOMi HOG000173270.
InParanoidi P77555.
KOi K00073.
OMAi MMVDVLS.
OrthoDBi EOG6ZPSZJ.
PhylomeDBi P77555.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00657 .
BioCyci EcoCyc:G6286-MONOMER.
ECOL316407:JW0505-MONOMER.
MetaCyc:G6286-MONOMER.

Miscellaneous databases

EvolutionaryTracei P77555.
PROi P77555.

Gene expression databases

Genevestigatori P77555.

Family and domain databases

InterProi IPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view ]
PANTHERi PTHR11091. PTHR11091. 1 hit.
Pfami PF02615. Ldh_2. 1 hit.
[Graphical view ]
SUPFAMi SSF89733. SSF89733. 1 hit.
TIGRFAMsi TIGR03175. AllD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli."
    Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J.
    J. Bacteriol. 181:7479-7484(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: K12 / ECL1.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiALLD_ECOLI
AccessioniPrimary (citable) accession number: P77555
Secondary accession number(s): Q2MBR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3