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Protein

Ureidoglycolate dehydrogenase (NAD(+))

Gene

allD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the anaerobic utilization of allantoin.1 Publication

Catalytic activityi

(S)-ureidoglycolate + NAD+ = oxalurate + NADH.

Pathwayi

GO - Molecular functioni

  1. ureidoglycolate dehydrogenase activity Source: EcoCyc

GO - Biological processi

  1. allantoin assimilation pathway Source: EcoCyc
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:G6286-MONOMER.
ECOL316407:JW0505-MONOMER.
MetaCyc:G6286-MONOMER.
BRENDAi1.1.1.350. 2026.
UniPathwayiUPA00395; UER00657.

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate dehydrogenase (NAD(+)) (EC:1.1.1.350)
Gene namesi
Name:allD
Synonyms:glxB8, ylbC
Ordered Locus Names:b0517, JW0505
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13624. allD.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Ureidoglycolate dehydrogenase (NAD(+))PRO_0000083822Add
BLAST

Expressioni

Inductioni

By glyoxylate and allantoin under anaerobic conditions.

Gene expression databases

GenevestigatoriP77555.

Interactioni

Protein-protein interaction databases

IntActiP77555. 5 interactions.
STRINGi511145.b0517.

Structurei

Secondary structure

1
349
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1915Combined sources
Helixi23 – 3917Combined sources
Helixi42 – 443Combined sources
Helixi46 – 483Combined sources
Helixi49 – 579Combined sources
Beta strandi68 – 736Combined sources
Beta strandi76 – 805Combined sources
Helixi86 – 10419Combined sources
Beta strandi105 – 11410Combined sources
Helixi121 – 1299Combined sources
Beta strandi132 – 1387Combined sources
Beta strandi149 – 1513Combined sources
Beta strandi159 – 1646Combined sources
Beta strandi170 – 1756Combined sources
Beta strandi177 – 1804Combined sources
Helixi182 – 19110Combined sources
Beta strandi199 – 2013Combined sources
Turni211 – 2133Combined sources
Turni220 – 2223Combined sources
Helixi223 – 23614Combined sources
Helixi238 – 2403Combined sources
Helixi245 – 2473Combined sources
Turni251 – 2533Combined sources
Beta strandi261 – 2688Combined sources
Helixi270 – 2723Combined sources
Helixi276 – 29116Combined sources
Helixi307 – 31913Combined sources
Beta strandi321 – 3233Combined sources
Helixi325 – 3317Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XRHX-ray2.25A/B/C/D/E/F/G/H2-349[»]
4H8AX-ray1.64A/B1-337[»]
ProteinModelPortaliP77555.
SMRiP77555. Positions 1-337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77555.

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family.Curated

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000173270.
InParanoidiP77555.
KOiK00073.
OMAiFGKHVSS.
OrthoDBiEOG6ZPSZJ.
PhylomeDBiP77555.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
TIGRFAMsiTIGR03175. AllD. 1 hit.

Sequencei

Sequence statusi: Complete.

P77555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISRETLHQ LIENKLCQAG LKREHAATVA EVLVYADARG IHSHGAVRVE
60 70 80 90 100
YYAERISKGG TNREPEFRLE ETGPCSAILH ADNAAGQVAA KMGMEHAIKT
110 120 130 140 150
AQQNGVAVVG ISRMGHSGAI SYFVQQAARA GFIGISMCQS DPMVVPFGGA
160 170 180 190 200
EIYYGTNPLA FAAPGEGDEI LTFDMATTVQ AWGKVLDARS RNMSIPDTWA
210 220 230 240 250
VDKNGVPTTD PFAVHALLPA AGPKGYGLMM MIDVLSGVLL GLPFGRQVSS
260 270 280 290 300
MYDDLHAGRN LGQLHIVINP NFFSSSELFR QHLSQTMREL NAITPAPGFN
310 320 330 340
QVYYPGQDQD IKQRKAAVEG IEIVDDIYQY LISDALYNTS YETKNPFAQ
Length:349
Mass (Da):37,967
Last modified:January 31, 1997 - v1
Checksum:i93C3076A66141C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA. Translation: AAB93858.1.
U82664 Genomic DNA. Translation: AAB40269.1.
U00096 Genomic DNA. Translation: AAC73619.1.
AP009048 Genomic DNA. Translation: BAE76295.1.
PIRiD64783.
RefSeqiNP_415050.1. NC_000913.3.
YP_488807.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73619; AAC73619; b0517.
BAE76295; BAE76295; BAE76295.
GeneIDi12932447.
948342.
KEGGiecj:Y75_p0503.
eco:b0517.
PATRICi32116191. VBIEscCol129921_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA. Translation: AAB93858.1.
U82664 Genomic DNA. Translation: AAB40269.1.
U00096 Genomic DNA. Translation: AAC73619.1.
AP009048 Genomic DNA. Translation: BAE76295.1.
PIRiD64783.
RefSeqiNP_415050.1. NC_000913.3.
YP_488807.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XRHX-ray2.25A/B/C/D/E/F/G/H2-349[»]
4H8AX-ray1.64A/B1-337[»]
ProteinModelPortaliP77555.
SMRiP77555. Positions 1-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP77555. 5 interactions.
STRINGi511145.b0517.

Protocols and materials databases

DNASUi948342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73619; AAC73619; b0517.
BAE76295; BAE76295; BAE76295.
GeneIDi12932447.
948342.
KEGGiecj:Y75_p0503.
eco:b0517.
PATRICi32116191. VBIEscCol129921_0537.

Organism-specific databases

EchoBASEiEB3389.
EcoGeneiEG13624. allD.

Phylogenomic databases

eggNOGiCOG2055.
HOGENOMiHOG000173270.
InParanoidiP77555.
KOiK00073.
OMAiFGKHVSS.
OrthoDBiEOG6ZPSZJ.
PhylomeDBiP77555.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00657.
BioCyciEcoCyc:G6286-MONOMER.
ECOL316407:JW0505-MONOMER.
MetaCyc:G6286-MONOMER.
BRENDAi1.1.1.350. 2026.

Miscellaneous databases

EvolutionaryTraceiP77555.
PROiP77555.

Gene expression databases

GenevestigatoriP77555.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
TIGRFAMsiTIGR03175. AllD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli."
    Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J.
    J. Bacteriol. 181:7479-7484(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: K12 / ECL1.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiALLD_ECOLI
AccessioniPrimary (citable) accession number: P77555
Secondary accession number(s): Q2MBR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: January 31, 1997
Last modified: March 31, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.