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Protein

Ureidoglycolate dehydrogenase (NAD(+))

Gene

allD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the anaerobic utilization of allantoin.1 Publication

Catalytic activityi

(S)-ureidoglycolate + NAD+ = oxalurate + NADH.

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes oxalurate from (S)-ureidoglycolate.
Proteins known to be involved in this subpathway in this organism are:
  1. Ureidoglycolate dehydrogenase (NAD(+)) (allD)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxalurate from (S)-ureidoglycolate, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

  • ureidoglycolate dehydrogenase activity Source: EcoCyc

GO - Biological processi

  • allantoin assimilation pathway Source: EcoCyc
  • purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:G6286-MONOMER.
ECOL316407:JW0505-MONOMER.
MetaCyc:G6286-MONOMER.
BRENDAi1.1.1.350. 2026.
UniPathwayiUPA00395; UER00657.

Names & Taxonomyi

Protein namesi
Recommended name:
Ureidoglycolate dehydrogenase (NAD(+)) (EC:1.1.1.350)
Gene namesi
Name:allD
Synonyms:glxB8, ylbC
Ordered Locus Names:b0517, JW0505
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13624. allD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838221 – 349Ureidoglycolate dehydrogenase (NAD(+))Add BLAST349

Proteomic databases

PaxDbiP77555.
PRIDEiP77555.

Expressioni

Inductioni

By glyoxylate and allantoin under anaerobic conditions.

Interactioni

Protein-protein interaction databases

BioGridi4261441. 91 interactors.
IntActiP77555. 5 interactors.
STRINGi511145.b0517.

Structurei

Secondary structure

1349
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15
Helixi23 – 39Combined sources17
Helixi42 – 44Combined sources3
Helixi46 – 48Combined sources3
Helixi49 – 57Combined sources9
Beta strandi68 – 73Combined sources6
Beta strandi76 – 80Combined sources5
Helixi86 – 104Combined sources19
Beta strandi105 – 114Combined sources10
Helixi121 – 129Combined sources9
Beta strandi132 – 138Combined sources7
Beta strandi149 – 151Combined sources3
Beta strandi159 – 164Combined sources6
Beta strandi170 – 175Combined sources6
Beta strandi177 – 180Combined sources4
Helixi182 – 191Combined sources10
Beta strandi199 – 201Combined sources3
Turni211 – 213Combined sources3
Turni220 – 222Combined sources3
Helixi223 – 236Combined sources14
Helixi238 – 240Combined sources3
Helixi245 – 247Combined sources3
Turni251 – 253Combined sources3
Beta strandi261 – 268Combined sources8
Helixi270 – 272Combined sources3
Helixi276 – 291Combined sources16
Helixi307 – 319Combined sources13
Beta strandi321 – 323Combined sources3
Helixi325 – 331Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XRHX-ray2.25A/B/C/D/E/F/G/H2-349[»]
4H8AX-ray1.64A/B1-337[»]
ProteinModelPortaliP77555.
SMRiP77555.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77555.

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH2/MDH2 oxidoreductase family.Curated

Phylogenomic databases

eggNOGiENOG4105DG4. Bacteria.
COG2055. LUCA.
HOGENOMiHOG000173270.
InParanoidiP77555.
KOiK00073.
OMAiERIPPSW.
PhylomeDBiP77555.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
TIGRFAMsiTIGR03175. AllD. 1 hit.

Sequencei

Sequence statusi: Complete.

P77555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISRETLHQ LIENKLCQAG LKREHAATVA EVLVYADARG IHSHGAVRVE
60 70 80 90 100
YYAERISKGG TNREPEFRLE ETGPCSAILH ADNAAGQVAA KMGMEHAIKT
110 120 130 140 150
AQQNGVAVVG ISRMGHSGAI SYFVQQAARA GFIGISMCQS DPMVVPFGGA
160 170 180 190 200
EIYYGTNPLA FAAPGEGDEI LTFDMATTVQ AWGKVLDARS RNMSIPDTWA
210 220 230 240 250
VDKNGVPTTD PFAVHALLPA AGPKGYGLMM MIDVLSGVLL GLPFGRQVSS
260 270 280 290 300
MYDDLHAGRN LGQLHIVINP NFFSSSELFR QHLSQTMREL NAITPAPGFN
310 320 330 340
QVYYPGQDQD IKQRKAAVEG IEIVDDIYQY LISDALYNTS YETKNPFAQ
Length:349
Mass (Da):37,967
Last modified:February 1, 1997 - v1
Checksum:i93C3076A66141C4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA. Translation: AAB93858.1.
U82664 Genomic DNA. Translation: AAB40269.1.
U00096 Genomic DNA. Translation: AAC73619.1.
AP009048 Genomic DNA. Translation: BAE76295.1.
PIRiD64783.
RefSeqiNP_415050.1. NC_000913.3.
WP_000703900.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73619; AAC73619; b0517.
BAE76295; BAE76295; BAE76295.
GeneIDi948342.
KEGGiecj:JW0505.
eco:b0517.
PATRICi32116191. VBIEscCol129921_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA. Translation: AAB93858.1.
U82664 Genomic DNA. Translation: AAB40269.1.
U00096 Genomic DNA. Translation: AAC73619.1.
AP009048 Genomic DNA. Translation: BAE76295.1.
PIRiD64783.
RefSeqiNP_415050.1. NC_000913.3.
WP_000703900.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XRHX-ray2.25A/B/C/D/E/F/G/H2-349[»]
4H8AX-ray1.64A/B1-337[»]
ProteinModelPortaliP77555.
SMRiP77555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261441. 91 interactors.
IntActiP77555. 5 interactors.
STRINGi511145.b0517.

Proteomic databases

PaxDbiP77555.
PRIDEiP77555.

Protocols and materials databases

DNASUi948342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73619; AAC73619; b0517.
BAE76295; BAE76295; BAE76295.
GeneIDi948342.
KEGGiecj:JW0505.
eco:b0517.
PATRICi32116191. VBIEscCol129921_0537.

Organism-specific databases

EchoBASEiEB3389.
EcoGeneiEG13624. allD.

Phylogenomic databases

eggNOGiENOG4105DG4. Bacteria.
COG2055. LUCA.
HOGENOMiHOG000173270.
InParanoidiP77555.
KOiK00073.
OMAiERIPPSW.
PhylomeDBiP77555.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00657.
BioCyciEcoCyc:G6286-MONOMER.
ECOL316407:JW0505-MONOMER.
MetaCyc:G6286-MONOMER.
BRENDAi1.1.1.350. 2026.

Miscellaneous databases

EvolutionaryTraceiP77555.
PROiP77555.

Family and domain databases

InterProiIPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]
PANTHERiPTHR11091. PTHR11091. 1 hit.
PfamiPF02615. Ldh_2. 1 hit.
[Graphical view]
SUPFAMiSSF89733. SSF89733. 1 hit.
TIGRFAMsiTIGR03175. AllD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALLD_ECOLI
AccessioniPrimary (citable) accession number: P77555
Secondary accession number(s): Q2MBR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.