Ureidoglycolate dehydrogenase - Escherichia coli (strain K12)

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P77555 (ALLD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ureidoglycolate dehydrogenase
EC=1.1.1.154

Gene names

Name:	allD
Synonyms:	glxB8, ylbC
Ordered Locus Names:	b0517, JW0505

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the anaerobic utilization of allantoin. Ref.1
Catalytic activity	(S)-ureidoglycolate + NAD(P)⁺ = oxalureate + NAD(P)H.
Pathway	Nitrogen metabolism; (S)-allantoin degradation; oxalurate from (S)-ureidoglycolate: step 1/1.
Subcellular location	Cytoplasm Probable.
Induction	By glyoxylate and allantoin under anaerobic conditions.
Sequence similarities	Belongs to the LDH2/MDH2 oxidoreductase family.

Ontologies

Keywords
Biological process	Purine metabolism
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	allantoin assimilation pathway Inferred from direct assay Ref.1. Source: EcoCyc purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ureidoglycolate dehydrogenase activity Inferred from direct assay Ref.1. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 349

349

Ureidoglycolate dehydrogenase

PRO_0000083822

Secondary structure

349

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P77555 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 93C3076A66141C4E
Show »

FASTA

349

37,967

        10         20         30         40         50         60 
MKISRETLHQ LIENKLCQAG LKREHAATVA EVLVYADARG IHSHGAVRVE YYAERISKGG 

        70         80         90        100        110        120 
TNREPEFRLE ETGPCSAILH ADNAAGQVAA KMGMEHAIKT AQQNGVAVVG ISRMGHSGAI 

       130        140        150        160        170        180 
SYFVQQAARA GFIGISMCQS DPMVVPFGGA EIYYGTNPLA FAAPGEGDEI LTFDMATTVQ 

       190        200        210        220        230        240 
AWGKVLDARS RNMSIPDTWA VDKNGVPTTD PFAVHALLPA AGPKGYGLMM MIDVLSGVLL 

       250        260        270        280        290        300 
GLPFGRQVSS MYDDLHAGRN LGQLHIVINP NFFSSSELFR QHLSQTMREL NAITPAPGFN 

       310        320        330        340 
QVYYPGQDQD IKQRKAAVEG IEIVDDIYQY LISDALYNTS YETKNPFAQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli." Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J. J. Bacteriol. 181:7479-7484(1999) [PubMed: 10601204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: K12 / ECL1.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U89279 Genomic DNA. Translation: AAB93858.1.
U82664 Genomic DNA. Translation: AAB40269.1.
U00096 Genomic DNA. Translation: AAC73619.1.
AP009048 Genomic DNA. Translation: BAE76295.1.

PIR

D64783.

RefSeq

NP_415050.1. NC_000913.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XRH	X-ray	2.25	A/B/C/D/E/F/G/H	2-349	[»]

ProteinModelPortal

P77555.

SMR

P77555. Positions 2-342.

ModBase

Search...

Protein-protein interaction databases

IntAct

P77555. 5 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBESCT00000002741; EBESCP00000002741; EBESCG00000002232.
EBESCT00000018306; EBESCP00000017597; EBESCG00000017360.

GeneID

948342.

GenomeReviews

Gene locus JW0505 in contig AP009048_GR.
Gene locus b0517 in contig U00096_GR.

KEGG

ecj:JW0505.
eco:b0517.

PATRIC

32116191. VBIEscCol129921_0537.

Organism-specific databases

EchoBASE

EB3389.

EcoGene

EG13624. allD.

Phylogenomic databases

eggNOG

COG2055.

GeneTree

EBGT00050000009495.

HOGENOM

HBG553037.

OMA

FTNTSPC.

PhylomeDB

P77555.

ProtClustDB

PRK15025.

Enzyme and pathway databases

BioCyc

EcoCyc:G6286-MONOMER.
MetaCyc:G6286-MONOMER.

Gene expression databases

Genevestigator

P77555.

Family and domain databases

InterPro

IPR003767. Malate/L-lactate_DH.
IPR017590. Ureidoglycolate_dehydrogenase.
[Graphical view]

K00073.

PANTHER

PTHR11091. MDH_LDH. 1 hit.

Pfam

PF02615. Ldh_2. 1 hit.
[Graphical view]

SUPFAM

SSF89733. MDH_LDH. 1 hit.

TIGRFAMs

TIGR03175. AllD. 1 hit.

ProtoNet

Search...

Entry information

Entry name

ALLD_ECOLI

Accession

Primary (citable) accession number: P77555
Secondary accession number(s): Q2MBR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents