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Protein

Putative Rz endopeptidase from lambdoid prophage Rac

Gene

rzpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase, Protease

Enzyme and pathway databases

BioCyciEcoCyc:G6686-MONOMER.
ECOL316407:JW5212-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Rz endopeptidase from lambdoid prophage Rac (EC:3.4.-.-)
Gene namesi
Name:rzpR
Ordered Locus Names:b1362, JW5212
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13366. rzpR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 147›147Putative Rz endopeptidase from lambdoid prophage RacPRO_0000077573Add
BLAST

Proteomic databases

PRIDEiP77551.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
xerCP0A8P62EBI-9135212,EBI-1133806

Protein-protein interaction databases

IntActiP77551. 4 interactions.
STRINGi316407.85674926.

Structurei

3D structure databases

ProteinModelPortaliP77551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000119352.
KOiK14744.
OMAiHIKAVCP.
PhylomeDBiP77551.

Family and domain databases

InterProiIPR004929. Bacteriophage_Rz-type_lysis.
[Graphical view]
PfamiPF03245. Phage_lysis. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P77551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ISALVICIVV CLSWGVNHYR DNAIAYKEQR DKNARELKLA NAAITEMQMR
60 70 80 90 100
QRDVAALDAK YTKELADAKA ENDALRDDVA AGRRRLHIKA VCQSVREATT
110 120 130 140
ASGVDNAASP RLADTAERDY FTLRERLVMM QAQLEGAQQY ITEQCLK
Length:147
Mass (Da):16,486
Last modified:December 1, 2000 - v2
Checksum:i2F4E85F6663A7692
GO

Sequence cautioni

The sequence BAA14959.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAA14959.1. Different initiation.
PIRiE64886.

Genome annotation databases

EnsemblBacteriaiBAA14959; BAA14959; BAA14959.
KEGGiecj:JW5212.
PATRICi48662017. VBIEscCol107702_1372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAA14959.1. Different initiation.
PIRiE64886.

3D structure databases

ProteinModelPortaliP77551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP77551. 4 interactions.
STRINGi316407.85674926.

Proteomic databases

PRIDEiP77551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA14959; BAA14959; BAA14959.
KEGGiecj:JW5212.
PATRICi48662017. VBIEscCol107702_1372.

Organism-specific databases

EchoBASEiEB3149.
EcoGeneiEG13366. rzpR.

Phylogenomic databases

HOGENOMiHOG000119352.
KOiK14744.
OMAiHIKAVCP.
PhylomeDBiP77551.

Enzyme and pathway databases

BioCyciEcoCyc:G6686-MONOMER.
ECOL316407:JW5212-MONOMER.

Family and domain databases

InterProiIPR004929. Bacteriophage_Rz-type_lysis.
[Graphical view]
PfamiPF03245. Phage_lysis. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiRZPR_ECOLI
AccessioniPrimary (citable) accession number: P77551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.