P77538 (YFHR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein YfhR

Gene names

Name:	yfhR
Ordered Locus Names:	b2534, JW2518

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the serine esterase family.
Sequence caution	The sequence BAA16428.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Uncharacterized protein YfhR		PRO_0000169252
Regions
	Transmembrane	12 – 32	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P77538 [UniParc]. Last modified November 24, 2009. Version 4. Checksum: FB9ED6D7870A3FAA	FASTA	284	31,516
	10 20 30 40 50 60 MALPVNKRVP KILFILFVVA FCVYLVPRVA INFFYYPDDK IYGPDPWSAE SVEFTAKDGT 70 80 90 100 110 120 RLQGWFIPSS TGPADNAIAT IIHAHGNAGN MSAHWPLVSW LPERNFNVFM FDYRGFGKSK 130 140 150 160 170 180 GTPSQAGLLD DTQSAINVVR HRSDVNPQRL VLFGQSIGGA NILDVIGRGD REGIRAVILD 190 200 210 220 230 240 STFASYATIA NQMIPGSGYL LDESYSGENY IASVSPIPLL LIHGKADHVI PWQHSEKLYS 250 260 270 280 LAKEPKRLIL IPDGEHIDAF SDRHGDVYRE QMVDFILSAL NPQN

References

[1]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T. DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC75587.2. AP009048 Genomic DNA. Translation: BAA16428.1. Different initiation.
PIR	E65030.
RefSeq	NP_417029.4. NC_000913.2. YP_490762.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P77538.
SMR	P77538. Positions 210-260.
ModBase	Search...
Protein-protein interaction databases
IntAct	P77538. 5 interactions.
STRING	511145.b2534.
Proteomic databases
PRIDE	P77538.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75587; AAC75587; b2534. BAA16428; BAA16428; BAA16428.
GeneID	12931974. 945059.
KEGG	ecj:Y75_p2487. eco:b2534.
PATRIC	32120465. VBIEscCol129921_2635.
Organism-specific databases
EchoBASE	EB3226.
EcoGene	EG13453. yfhR.
Phylogenomic databases
eggNOG	COG1073.
HOGENOM	HOG000007143.
KO	K06889.
ProtClustDB	CLSK880424.
Enzyme and pathway databases
BioCyc	EcoCyc:G7328-MONOMER. ECOL316407:JW2518-MONOMER.
Gene expression databases
Genevestigator	P77538.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

YFHR_ECOLI

Accession

Primary (citable) accession number: P77538

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 99 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program