Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-cystine transporter YdjN

Gene

ydjN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in L-cystine transport. Can probably also transport L-cysteine. Mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys).1 Publication

Enzyme regulationi

Inhibited by L-cystine and L-cysteine, and to a lesser extent by D-cystine.1 Publication

GO - Molecular functioni

  • cysteine transmembrane transporter activity Source: EcoCyc
  • L-cystine transmembrane transporter activity Source: EcoCyc
  • symporter activity Source: InterPro

GO - Biological processi

  • cysteine transport Source: EcoCyc
  • L-cystine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G6934-MONOMER.
ECOL316407:JW1718-MONOMER.

Protein family/group databases

TCDBi2.A.23.1.8. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
L-cystine transporter YdjNCurated
Gene namesi
Name:ydjN
Ordered Locus Names:b1729, JW1718
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13990. ydjN.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence analysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

The fliY-ydjN and yecS-ydjN double mutants are completely resistant to both L-selenaproline and L-selenocystine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463L-cystine transporter YdjNPRO_0000202121Add
BLAST

Proteomic databases

PaxDbiP77529.

Interactioni

Protein-protein interaction databases

BioGridi4259522. 156 interactions.
DIPiDIP-11776N.
STRINGi511145.b1729.

Structurei

3D structure databases

ProteinModelPortaliP77529.
SMRiP77529. Positions 32-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ETY. Bacteria.
COG1823. LUCA.
HOGENOMiHOG000208777.
InParanoidiP77529.
KOiK06956.
OMAiPITFIKK.
PhylomeDBiP77529.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.

Sequencei

Sequence statusi: Complete.

P77529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFPLIANIV VFVVLLFALA QTRHKQWSLA KKVLVGLVMG VVFGLALHTI
60 70 80 90 100
YGSDSQVLKD SVQWFNIVGN GYVQLLQMIV MPLVFASILS AVARLHNASQ
110 120 130 140 150
LGKISFLTIG TLLFTTLIAA LVGVLVTNLF GLTAEGLVQG GAETARLNAI
160 170 180 190 200
ESNYVGKVSD LSVPQLVLSF IPKNPFADLT GANPTSIISV VIFAAFLGVA
210 220 230 240 250
ALKLLKDDAP KGERVLAAID TLQSWVMKLV RLVMQLTPYG VLALMTKVVA
260 270 280 290 300
GSNLQDIIKL GSFVVASYLG LLIMFAVHGI LLGINGVSPL KYFRKVWPVL
310 320 330 340 350
TFAFTSRSSA ASIPLNVEAQ TRRLGVPESI ASFAASFGAT IGQNGCAGLY
360 370 380 390 400
PAMLAVMVAP TVGINPLDPM WIATLVGIVT VSSAGVAGVG GGATFAALIV
410 420 430 440 450
LPAMGLPVTL VALLISVEPL IDMGRTALNV SGSMTAGTLT SQWLKQTDKA
460
ILDSEDDAEL AHH
Length:463
Mass (Da):48,662
Last modified:February 1, 1997 - v1
Checksum:i7D45D8A354D2885C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74799.1.
AP009048 Genomic DNA. Translation: BAA15509.1.
PIRiA64932.
RefSeqiNP_416243.1. NC_000913.3.
WP_001010696.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74799; AAC74799; b1729.
BAA15509; BAA15509; BAA15509.
GeneIDi946238.
KEGGiecj:JW1718.
eco:b1729.
PATRICi32118765. VBIEscCol129921_1800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74799.1.
AP009048 Genomic DNA. Translation: BAA15509.1.
PIRiA64932.
RefSeqiNP_416243.1. NC_000913.3.
WP_001010696.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77529.
SMRiP77529. Positions 32-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259522. 156 interactions.
DIPiDIP-11776N.
STRINGi511145.b1729.

Protein family/group databases

TCDBi2.A.23.1.8. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Proteomic databases

PaxDbiP77529.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74799; AAC74799; b1729.
BAA15509; BAA15509; BAA15509.
GeneIDi946238.
KEGGiecj:JW1718.
eco:b1729.
PATRICi32118765. VBIEscCol129921_1800.

Organism-specific databases

EchoBASEiEB3746.
EcoGeneiEG13990. ydjN.

Phylogenomic databases

eggNOGiENOG4108ETY. Bacteria.
COG1823. LUCA.
HOGENOMiHOG000208777.
InParanoidiP77529.
KOiK06956.
OMAiPITFIKK.
PhylomeDBiP77529.

Enzyme and pathway databases

BioCyciEcoCyc:G6934-MONOMER.
ECOL316407:JW1718-MONOMER.

Miscellaneous databases

PROiP77529.

Family and domain databases

Gene3Di1.10.3860.10. 1 hit.
InterProiIPR001991. Na-dicarboxylate_symporter.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYDJN_ECOLI
AccessioniPrimary (citable) accession number: P77529
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.