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Protein

Uncharacterized ABC transporter ATP-binding protein YphE

Gene

yphE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probably part of a binding-protein-dependent transport system YphDEF. Probably responsible for energy coupling to the transport system.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YPHE-MONOMER.
ECOL316407:JW2531-MONOMER.

Protein family/group databases

TCDBi3.A.1.2.27. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized ABC transporter ATP-binding protein YphE
Gene namesi
Name:yphE
Ordered Locus Names:b2547, JW2531
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13466. yphE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Uncharacterized ABC transporter ATP-binding protein YphEPRO_0000093197Add
BLAST

Proteomic databases

PaxDbiP77509.
PRIDEiP77509.

Interactioni

Protein-protein interaction databases

BioGridi4261315. 141 interactions.
DIPiDIP-12830N.
IntActiP77509. 7 interactions.
STRINGi511145.b2547.

Structurei

3D structure databases

ProteinModelPortaliP77509.
SMRiP77509. Positions 8-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 249242ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini261 – 499239ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108F37. Bacteria.
COG1129. LUCA.
InParanoidiP77509.
KOiK02056.
OMAiNEISPAN.
OrthoDBiEOG6QK4RR.
PhylomeDBiP77509.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTATEAVPV AKVVAGNKRY PGVVALDNVN FTLNKGEVRA LLGKNGAGKS
60 70 80 90 100
TLIRMLTGSE RPDSGDIWIG ETRLEGDEAT LTRRAAELGV RAVYQELSLV
110 120 130 140 150
EGLTVAENLC LGQWPRRNGM IDYLQMAQDA QRCLQALGVD VSPEQLVSTL
160 170 180 190 200
SPAQKQLVEI ARVMKGEPRV VILDEPTSSL ASAEVELVIS AVKKMSALGV
210 220 230 240 250
AVIYVSHRME EIRRIASCAT VMRDGQVAGD VMLENTSTHH IVSLMLGRDH
260 270 280 290 300
VDIAPVAPQE IVDQAVLEVR ALRHKPKLED ISFTLRRGEV LGIAGLLGAG
310 320 330 340 350
RSELLKAIVG LEEYEQGEIV INGEKITRPD YGDMLKRGIG YTPENRKEAG
360 370 380 390 400
IIPWLGVDEN TVLTNRQKIS ANGVLQWSTI RRLTEEVMQR MTVKAASSET
410 420 430 440 450
PIGTLSGGNQ QKVVIGRWVY AASQILLLDE PTRGVDIEAK QQIYRIVREL
460 470 480 490 500
AAEGKSVVFI SSEVEELPLV CDRILLLQHG TFSQEFHAPV NVDELMSAIL

SVH
Length:503
Mass (Da):55,016
Last modified:February 1, 1997 - v1
Checksum:i0D964916CE97A761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75600.1.
AP009048 Genomic DNA. Translation: BAA16449.1.
PIRiB65032.
RefSeqiNP_417042.1. NC_000913.3.
WP_000493470.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75600; AAC75600; b2547.
BAA16449; BAA16449; BAA16449.
GeneIDi948990.
KEGGiecj:JW2531.
eco:b2547.
PATRICi32120491. VBIEscCol129921_2648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75600.1.
AP009048 Genomic DNA. Translation: BAA16449.1.
PIRiB65032.
RefSeqiNP_417042.1. NC_000913.3.
WP_000493470.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77509.
SMRiP77509. Positions 8-480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261315. 141 interactions.
DIPiDIP-12830N.
IntActiP77509. 7 interactions.
STRINGi511145.b2547.

Protein family/group databases

TCDBi3.A.1.2.27. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP77509.
PRIDEiP77509.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75600; AAC75600; b2547.
BAA16449; BAA16449; BAA16449.
GeneIDi948990.
KEGGiecj:JW2531.
eco:b2547.
PATRICi32120491. VBIEscCol129921_2648.

Organism-specific databases

EchoBASEiEB3239.
EcoGeneiEG13466. yphE.

Phylogenomic databases

eggNOGiENOG4108F37. Bacteria.
COG1129. LUCA.
InParanoidiP77509.
KOiK02056.
OMAiNEISPAN.
OrthoDBiEOG6QK4RR.
PhylomeDBiP77509.

Enzyme and pathway databases

BioCyciEcoCyc:YPHE-MONOMER.
ECOL316407:JW2531-MONOMER.

Miscellaneous databases

PROiP77509.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiYPHE_ECOLI
AccessioniPrimary (citable) accession number: P77509
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 13, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.