SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P77495

- PRPE_ECOLI

UniProt

P77495 - PRPE_ECOLI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Propionate--CoA ligase
Gene
prpE, yahU, b0335, JW0326
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity By similarity.

Catalytic activityi

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. propionate-CoA ligase activity Source: EcoCyc

GO - Biological processi

  1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6200-MONOMER.
ECOL316407:JW0326-MONOMER.
MetaCyc:G6200-MONOMER.
UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Propionate--CoA ligase (EC:6.2.1.17)
Alternative name(s):
Propionyl-CoA synthetase
Gene namesi
Name:prpE
Synonyms:yahU
Ordered Locus Names:b0335, JW0326
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13604. prpE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Propionate--CoA ligase
PRO_0000193188Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP77495.

Interactioni

Protein-protein interaction databases

IntActiP77495. 7 interactions.
STRINGi511145.b0335.

Structurei

3D structure databases

ProteinModelPortaliP77495.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01908.
OMAiLYFTKFP.
OrthoDBiEOG68WR2H.
PhylomeDBiP77495.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR012694. Propion_PrpE.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02316. propion_prpE. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77495-1 [UniParc]FASTAAdd to Basket

« Hide

MSFSEFYQRS INEPEQFWAE QARRIDWQTP FTQTLDHSNP PFARWFCEGR    50
TNLCHNAIDR WLEKQPEALA LIAVSSETEE ERTFTFRQLH DEVNAVASML 100
RSLGVQRGDR VLVYMPMIAE AHITLLACAR IGAIHSVVFG GFASHSVAAR 150
IDDAKPVLIV SADAGARGGK IIPYKKLLDD AISQAQHQPR HVLLVDRGLA 200
KMARVSGRDV DFASLRHQHI GARVPVAWLE SNETSCILYT SGTTGKPKGV 250
QRDVGGYAVA LATSMDTIFG GKAGSVFFCA SDIGWVVGHS YIVYAPLLAG 300
MATIVYEGLP TWPDCGVWWT IVEKYQVSRM FSAPTAIRVL KKFPTAEIRK 350
HDLSSLEVLY LAGEPLDEPT ASWVSNTLDV PVIDNYWQTE SGWPIMAIAR 400
GLDDRPTRLG SPGVPMYGYN VQLLNEVTGE PCGVNEKGML VVEGPLPPGC 450
IQTIWGDDGR FVKTYWSLFS RPVYATFDWG IRDADGYHFI LGRTDDVINV 500
AGHRLGTREI EESISSHPGV AEVAVVGVKD ALKGQVAVAF VIPKESDSLE 550
DRDVAHSQEK AIMALVDSQI GNFGRPAHVW FVSQLPKTRS GKMLRRTIQA 600
ICEGRDPGDL TTIDDPASLD QIRQAMEE 628
Length:628
Mass (Da):69,351
Last modified:February 1, 1997 - v1
Checksum:iB192E2E49ED900D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73857 Genomic DNA. Translation: AAB18059.1.
U00096 Genomic DNA. Translation: AAC73438.1.
AP009048 Genomic DNA. Translation: BAE76117.1.
PIRiG64760.
RefSeqiNP_414869.1. NC_000913.3.
YP_488629.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73438; AAC73438; b0335.
BAE76117; BAE76117; BAE76117.
GeneIDi12930817.
946891.
KEGGiecj:Y75_p0324.
eco:b0335.
PATRICi32115801. VBIEscCol129921_0342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73857 Genomic DNA. Translation: AAB18059.1 .
U00096 Genomic DNA. Translation: AAC73438.1 .
AP009048 Genomic DNA. Translation: BAE76117.1 .
PIRi G64760.
RefSeqi NP_414869.1. NC_000913.3.
YP_488629.1. NC_007779.1.

3D structure databases

ProteinModelPortali P77495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P77495. 7 interactions.
STRINGi 511145.b0335.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73438 ; AAC73438 ; b0335 .
BAE76117 ; BAE76117 ; BAE76117 .
GeneIDi 12930817.
946891.
KEGGi ecj:Y75_p0324.
eco:b0335.
PATRICi 32115801. VBIEscCol129921_0342.

Organism-specific databases

EchoBASEi EB3372.
EcoGenei EG13604. prpE.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01908.
OMAi LYFTKFP.
OrthoDBi EOG68WR2H.
PhylomeDBi P77495.

Enzyme and pathway databases

UniPathwayi UPA00946 .
BioCyci EcoCyc:G6200-MONOMER.
ECOL316407:JW0326-MONOMER.
MetaCyc:G6200-MONOMER.

Miscellaneous databases

PROi P77495.

Gene expression databases

Genevestigatori P77495.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR012694. Propion_PrpE.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02316. propion_prpE. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiPRPE_ECOLI
AccessioniPrimary (citable) accession number: P77495
Secondary accession number(s): Q2MC89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi