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P77495

- PRPE_ECOLI

UniProt

P77495 - PRPE_ECOLI

Protein

Propionate--CoA ligase

Gene

prpE

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity By similarity.By similarity

    Catalytic activityi

    ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. propionate-CoA ligase activity Source: EcoCyc

    GO - Biological processi

    1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:G6200-MONOMER.
    ECOL316407:JW0326-MONOMER.
    MetaCyc:G6200-MONOMER.
    UniPathwayiUPA00946.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Propionate--CoA ligase (EC:6.2.1.17)
    Alternative name(s):
    Propionyl-CoA synthetase
    Gene namesi
    Name:prpE
    Synonyms:yahU
    Ordered Locus Names:b0335, JW0326
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13604. prpE.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628Propionate--CoA ligasePRO_0000193188Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP77495.

    Interactioni

    Protein-protein interaction databases

    IntActiP77495. 7 interactions.
    STRINGi511145.b0335.

    Structurei

    3D structure databases

    ProteinModelPortaliP77495.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0365.
    HOGENOMiHOG000229981.
    KOiK01908.
    OMAiLYFTKFP.
    OrthoDBiEOG68WR2H.
    PhylomeDBiP77495.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR012694. Propion_PrpE.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02316. propion_prpE. 1 hit.
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P77495-1 [UniParc]FASTAAdd to Basket

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    MSFSEFYQRS INEPEQFWAE QARRIDWQTP FTQTLDHSNP PFARWFCEGR    50
    TNLCHNAIDR WLEKQPEALA LIAVSSETEE ERTFTFRQLH DEVNAVASML 100
    RSLGVQRGDR VLVYMPMIAE AHITLLACAR IGAIHSVVFG GFASHSVAAR 150
    IDDAKPVLIV SADAGARGGK IIPYKKLLDD AISQAQHQPR HVLLVDRGLA 200
    KMARVSGRDV DFASLRHQHI GARVPVAWLE SNETSCILYT SGTTGKPKGV 250
    QRDVGGYAVA LATSMDTIFG GKAGSVFFCA SDIGWVVGHS YIVYAPLLAG 300
    MATIVYEGLP TWPDCGVWWT IVEKYQVSRM FSAPTAIRVL KKFPTAEIRK 350
    HDLSSLEVLY LAGEPLDEPT ASWVSNTLDV PVIDNYWQTE SGWPIMAIAR 400
    GLDDRPTRLG SPGVPMYGYN VQLLNEVTGE PCGVNEKGML VVEGPLPPGC 450
    IQTIWGDDGR FVKTYWSLFS RPVYATFDWG IRDADGYHFI LGRTDDVINV 500
    AGHRLGTREI EESISSHPGV AEVAVVGVKD ALKGQVAVAF VIPKESDSLE 550
    DRDVAHSQEK AIMALVDSQI GNFGRPAHVW FVSQLPKTRS GKMLRRTIQA 600
    ICEGRDPGDL TTIDDPASLD QIRQAMEE 628
    Length:628
    Mass (Da):69,351
    Last modified:February 1, 1997 - v1
    Checksum:iB192E2E49ED900D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73857 Genomic DNA. Translation: AAB18059.1.
    U00096 Genomic DNA. Translation: AAC73438.1.
    AP009048 Genomic DNA. Translation: BAE76117.1.
    PIRiG64760.
    RefSeqiNP_414869.1. NC_000913.3.
    YP_488629.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73438; AAC73438; b0335.
    BAE76117; BAE76117; BAE76117.
    GeneIDi12930817.
    946891.
    KEGGiecj:Y75_p0324.
    eco:b0335.
    PATRICi32115801. VBIEscCol129921_0342.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73857 Genomic DNA. Translation: AAB18059.1 .
    U00096 Genomic DNA. Translation: AAC73438.1 .
    AP009048 Genomic DNA. Translation: BAE76117.1 .
    PIRi G64760.
    RefSeqi NP_414869.1. NC_000913.3.
    YP_488629.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P77495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P77495. 7 interactions.
    STRINGi 511145.b0335.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73438 ; AAC73438 ; b0335 .
    BAE76117 ; BAE76117 ; BAE76117 .
    GeneIDi 12930817.
    946891.
    KEGGi ecj:Y75_p0324.
    eco:b0335.
    PATRICi 32115801. VBIEscCol129921_0342.

    Organism-specific databases

    EchoBASEi EB3372.
    EcoGenei EG13604. prpE.

    Phylogenomic databases

    eggNOGi COG0365.
    HOGENOMi HOG000229981.
    KOi K01908.
    OMAi LYFTKFP.
    OrthoDBi EOG68WR2H.
    PhylomeDBi P77495.

    Enzyme and pathway databases

    UniPathwayi UPA00946 .
    BioCyci EcoCyc:G6200-MONOMER.
    ECOL316407:JW0326-MONOMER.
    MetaCyc:G6200-MONOMER.

    Miscellaneous databases

    PROi P77495.

    Gene expression databases

    Genevestigatori P77495.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR012694. Propion_PrpE.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02316. propion_prpE. 1 hit.
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiPRPE_ECOLI
    AccessioniPrimary (citable) accession number: P77495
    Secondary accession number(s): Q2MC89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3