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P77495

- PRPE_ECOLI

UniProt

P77495 - PRPE_ECOLI

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Protein

Propionate--CoA ligase

Gene

prpE

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity).By similarity

Catalytic activityi

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. propionate-CoA ligase activity Source: EcoCyc

GO - Biological processi

  1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6200-MONOMER.
ECOL316407:JW0326-MONOMER.
MetaCyc:G6200-MONOMER.
UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Propionate--CoA ligase (EC:6.2.1.17)
Alternative name(s):
Propionyl-CoA synthetase
Gene namesi
Name:prpE
Synonyms:yahU
Ordered Locus Names:b0335, JW0326
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13604. prpE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Propionate--CoA ligasePRO_0000193188Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP77495.

Interactioni

Protein-protein interaction databases

IntActiP77495. 7 interactions.
STRINGi511145.b0335.

Structurei

3D structure databases

ProteinModelPortaliP77495.
SMRiP77495. Positions 7-622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
InParanoidiP77495.
KOiK01908.
OMAiLYFTKFP.
OrthoDBiEOG68WR2H.
PhylomeDBiP77495.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR012694. Propion_PrpE.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02316. propion_prpE. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77495-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFSEFYQRS INEPEQFWAE QARRIDWQTP FTQTLDHSNP PFARWFCEGR
60 70 80 90 100
TNLCHNAIDR WLEKQPEALA LIAVSSETEE ERTFTFRQLH DEVNAVASML
110 120 130 140 150
RSLGVQRGDR VLVYMPMIAE AHITLLACAR IGAIHSVVFG GFASHSVAAR
160 170 180 190 200
IDDAKPVLIV SADAGARGGK IIPYKKLLDD AISQAQHQPR HVLLVDRGLA
210 220 230 240 250
KMARVSGRDV DFASLRHQHI GARVPVAWLE SNETSCILYT SGTTGKPKGV
260 270 280 290 300
QRDVGGYAVA LATSMDTIFG GKAGSVFFCA SDIGWVVGHS YIVYAPLLAG
310 320 330 340 350
MATIVYEGLP TWPDCGVWWT IVEKYQVSRM FSAPTAIRVL KKFPTAEIRK
360 370 380 390 400
HDLSSLEVLY LAGEPLDEPT ASWVSNTLDV PVIDNYWQTE SGWPIMAIAR
410 420 430 440 450
GLDDRPTRLG SPGVPMYGYN VQLLNEVTGE PCGVNEKGML VVEGPLPPGC
460 470 480 490 500
IQTIWGDDGR FVKTYWSLFS RPVYATFDWG IRDADGYHFI LGRTDDVINV
510 520 530 540 550
AGHRLGTREI EESISSHPGV AEVAVVGVKD ALKGQVAVAF VIPKESDSLE
560 570 580 590 600
DRDVAHSQEK AIMALVDSQI GNFGRPAHVW FVSQLPKTRS GKMLRRTIQA
610 620
ICEGRDPGDL TTIDDPASLD QIRQAMEE
Length:628
Mass (Da):69,351
Last modified:February 1, 1997 - v1
Checksum:iB192E2E49ED900D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18059.1.
U00096 Genomic DNA. Translation: AAC73438.1.
AP009048 Genomic DNA. Translation: BAE76117.1.
PIRiG64760.
RefSeqiNP_414869.1. NC_000913.3.
YP_488629.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73438; AAC73438; b0335.
BAE76117; BAE76117; BAE76117.
GeneIDi12930817.
946891.
KEGGiecj:Y75_p0324.
eco:b0335.
PATRICi32115801. VBIEscCol129921_0342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18059.1 .
U00096 Genomic DNA. Translation: AAC73438.1 .
AP009048 Genomic DNA. Translation: BAE76117.1 .
PIRi G64760.
RefSeqi NP_414869.1. NC_000913.3.
YP_488629.1. NC_007779.1.

3D structure databases

ProteinModelPortali P77495.
SMRi P77495. Positions 7-622.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P77495. 7 interactions.
STRINGi 511145.b0335.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73438 ; AAC73438 ; b0335 .
BAE76117 ; BAE76117 ; BAE76117 .
GeneIDi 12930817.
946891.
KEGGi ecj:Y75_p0324.
eco:b0335.
PATRICi 32115801. VBIEscCol129921_0342.

Organism-specific databases

EchoBASEi EB3372.
EcoGenei EG13604. prpE.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
InParanoidi P77495.
KOi K01908.
OMAi LYFTKFP.
OrthoDBi EOG68WR2H.
PhylomeDBi P77495.

Enzyme and pathway databases

UniPathwayi UPA00946 .
BioCyci EcoCyc:G6200-MONOMER.
ECOL316407:JW0326-MONOMER.
MetaCyc:G6200-MONOMER.

Miscellaneous databases

PROi P77495.

Gene expression databases

Genevestigatori P77495.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR012694. Propion_PrpE.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02316. propion_prpE. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiPRPE_ECOLI
AccessioniPrimary (citable) accession number: P77495
Secondary accession number(s): Q2MC89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3