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P77495 (PRPE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Propionate--CoA ligase

EC=6.2.1.17
Alternative name(s):
Propionyl-CoA synthetase
Gene names
Name:prpE
Synonyms:yahU
Ordered Locus Names:b0335, JW0326
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity By similarity.

Catalytic activity

ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.

Pathway

Organic acid metabolism; propanoate degradation.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Propionate--CoA ligase
PRO_0000193188

Sequences

Sequence LengthMass (Da)Tools
P77495 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: B192E2E49ED900D8

FASTA62869,351
        10         20         30         40         50         60 
MSFSEFYQRS INEPEQFWAE QARRIDWQTP FTQTLDHSNP PFARWFCEGR TNLCHNAIDR 

        70         80         90        100        110        120 
WLEKQPEALA LIAVSSETEE ERTFTFRQLH DEVNAVASML RSLGVQRGDR VLVYMPMIAE 

       130        140        150        160        170        180 
AHITLLACAR IGAIHSVVFG GFASHSVAAR IDDAKPVLIV SADAGARGGK IIPYKKLLDD 

       190        200        210        220        230        240 
AISQAQHQPR HVLLVDRGLA KMARVSGRDV DFASLRHQHI GARVPVAWLE SNETSCILYT 

       250        260        270        280        290        300 
SGTTGKPKGV QRDVGGYAVA LATSMDTIFG GKAGSVFFCA SDIGWVVGHS YIVYAPLLAG 

       310        320        330        340        350        360 
MATIVYEGLP TWPDCGVWWT IVEKYQVSRM FSAPTAIRVL KKFPTAEIRK HDLSSLEVLY 

       370        380        390        400        410        420 
LAGEPLDEPT ASWVSNTLDV PVIDNYWQTE SGWPIMAIAR GLDDRPTRLG SPGVPMYGYN 

       430        440        450        460        470        480 
VQLLNEVTGE PCGVNEKGML VVEGPLPPGC IQTIWGDDGR FVKTYWSLFS RPVYATFDWG 

       490        500        510        520        530        540 
IRDADGYHFI LGRTDDVINV AGHRLGTREI EESISSHPGV AEVAVVGVKD ALKGQVAVAF 

       550        560        570        580        590        600 
VIPKESDSLE DRDVAHSQEK AIMALVDSQI GNFGRPAHVW FVSQLPKTRS GKMLRRTIQA 

       610        620 
ICEGRDPGDL TTIDDPASLD QIRQAMEE 

« Hide

References

[1]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U73857 Genomic DNA. Translation: AAB18059.1.
U00096 Genomic DNA. Translation: AAC73438.1.
AP009048 Genomic DNA. Translation: BAE76117.1.
PIRG64760.
RefSeqNP_414869.1. NC_000913.3.
YP_488629.1. NC_007779.1.

3D structure databases

ProteinModelPortalP77495.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP77495. 7 interactions.
STRING511145.b0335.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73438; AAC73438; b0335.
BAE76117; BAE76117; BAE76117.
GeneID12930817.
946891.
KEGGecj:Y75_p0324.
eco:b0335.
PATRIC32115801. VBIEscCol129921_0342.

Organism-specific databases

EchoBASEEB3372.
EcoGeneEG13604. prpE.

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHOG000229981.
KOK01908.
OMALYFTKFP.
OrthoDBEOG68WR2H.
PhylomeDBP77495.

Enzyme and pathway databases

BioCycEcoCyc:G6200-MONOMER.
ECOL316407:JW0326-MONOMER.
MetaCyc:G6200-MONOMER.
UniPathwayUPA00946.

Gene expression databases

GenevestigatorP77495.

Family and domain databases

InterProIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR012694. Propion_PrpE.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR02316. propion_prpE. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP77495.

Entry information

Entry namePRPE_ECOLI
AccessionPrimary (citable) accession number: P77495
Secondary accession number(s): Q2MC89
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene