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P77489

- YAGR_ECOLI

UniProt

P77489 - YAGR_ECOLI

Protein

Putative xanthine dehydrogenase YagR molybdenum-binding subunit

Gene

yagR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Xanthine + NAD+ + H2O = urate + NADH.
    Hypoxanthine + NAD+ + H2O = xanthine + NADH.

    Cofactori

    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi211 – 2111MolybdenumSequence Analysis
    Metal bindingi242 – 2421Molybdenum; via carbonyl oxygenSequence Analysis
    Metal bindingi350 – 3501Molybdenum; via amide nitrogenSequence Analysis

    GO - Molecular functioni

    1. molybdenum ion binding Source: EcoCyc
    2. oxidoreductase activity, acting on the aldehyde or oxo group of donors Source: EcoCyc
    3. protein binding Source: EcoliWiki
    4. xanthine dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: EcoliWiki
    2. purine nucleobase metabolic process Source: UniProtKB-KW
    3. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Purine metabolism, Purine salvage

    Keywords - Ligandi

    Metal-binding, Molybdenum, NAD

    Enzyme and pathway databases

    BioCyciEcoCyc:G6155-MONOMER.
    ECOL316407:JW0278-MONOMER.
    MetaCyc:G6155-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative xanthine dehydrogenase YagR molybdenum-binding subunit (EC:1.17.1.4)
    Gene namesi
    Name:yagR
    Ordered Locus Names:b0284, JW0278
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13557. yagR.

    Subcellular locationi

    GO - Cellular componenti

    1. periplasmic space Source: EcoCyc

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 732732Putative xanthine dehydrogenase YagR molybdenum-binding subunitPRO_0000166090Add
    BLAST

    Proteomic databases

    PaxDbiP77489.
    PRIDEiP77489.

    Expressioni

    Gene expression databases

    GenevestigatoriP77489.

    Interactioni

    Subunit structurei

    Heterotrimer of YagR, YagS and YagT.Curated

    Protein-protein interaction databases

    IntActiP77489. 10 interactions.
    STRINGi511145.b0284.

    Structurei

    3D structure databases

    ProteinModelPortaliP77489.
    SMRiP77489. Positions 16-728.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xanthine dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1529.
    HOGENOMiHOG000244716.
    KOiK11177.
    OMAiTHNLGEC.
    OrthoDBiEOG6ZSP3F.
    PhylomeDBiP77489.

    Family and domain databases

    Gene3Di3.30.365.10. 6 hits.
    3.90.1170.50. 1 hit.
    InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    [Graphical view]
    PfamiPF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    [Graphical view]
    SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54665. SSF54665. 1 hit.
    SSF56003. SSF56003. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P77489-1 [UniParc]FASTAAdd to Basket

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    MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEEAPNAAY    50
    GYIVGSAIAK GRLTALDTDA AQKAPGVLAV ITASNAGALG KGDKNTARLL 100
    GGPTIEHYHQ AIALVVAETF EQARAAASLV QAHYRRNKGA YSLADEKQAV 150
    NQPPEDTPDK NVGDFDGAFT SAAVKIDATY TTPDQSHMAM EPHASMAVWD 200
    GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG GFGGKLFLRS 250
    DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT 300
    AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR 350
    APGEAPGLMA LEIAIDELAE KAGIDPVEFR ILNDTQVDPA DPTRCFSRRQ 400
    LIECLRTGAD KFGWKQRNAT PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR 450
    VHLEQNGTVT VETDMTDIGT GSYTILAQTA AEMLGVPLEQ VAVHLGDSSF 500
    PVSAGSGGQW GANTSTSGVY AACMKLREMI ASAVGFDPEQ SQFADGKITN 550
    GTRSATLHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG 600
    EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY 650
    FVNHDMAGYE VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA 700
    AIANAVYNAT GIRVRDYPIT LDKLLDKLPD VV 732
    Length:732
    Mass (Da):78,088
    Last modified:February 1, 1997 - v1
    Checksum:iAF198715794F0138
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73857 Genomic DNA. Translation: AAB18013.1.
    U00096 Genomic DNA. Translation: AAC73387.1.
    AP009048 Genomic DNA. Translation: BAE76068.1.
    PIRiD64754.
    RefSeqiNP_414818.1. NC_000913.3.
    YP_488580.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73387; AAC73387; b0284.
    BAE76068; BAE76068; BAE76068.
    GeneIDi12932498.
    944961.
    KEGGiecj:Y75_p0276.
    eco:b0284.
    PATRICi32115691. VBIEscCol129921_0288.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73857 Genomic DNA. Translation: AAB18013.1 .
    U00096 Genomic DNA. Translation: AAC73387.1 .
    AP009048 Genomic DNA. Translation: BAE76068.1 .
    PIRi D64754.
    RefSeqi NP_414818.1. NC_000913.3.
    YP_488580.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P77489.
    SMRi P77489. Positions 16-728.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P77489. 10 interactions.
    STRINGi 511145.b0284.

    Proteomic databases

    PaxDbi P77489.
    PRIDEi P77489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73387 ; AAC73387 ; b0284 .
    BAE76068 ; BAE76068 ; BAE76068 .
    GeneIDi 12932498.
    944961.
    KEGGi ecj:Y75_p0276.
    eco:b0284.
    PATRICi 32115691. VBIEscCol129921_0288.

    Organism-specific databases

    EchoBASEi EB3327.
    EcoGenei EG13557. yagR.

    Phylogenomic databases

    eggNOGi COG1529.
    HOGENOMi HOG000244716.
    KOi K11177.
    OMAi THNLGEC.
    OrthoDBi EOG6ZSP3F.
    PhylomeDBi P77489.

    Enzyme and pathway databases

    BioCyci EcoCyc:G6155-MONOMER.
    ECOL316407:JW0278-MONOMER.
    MetaCyc:G6155-MONOMER.

    Miscellaneous databases

    PROi P77489.

    Gene expression databases

    Genevestigatori P77489.

    Family and domain databases

    Gene3Di 3.30.365.10. 6 hits.
    3.90.1170.50. 1 hit.
    InterProi IPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    [Graphical view ]
    Pfami PF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    [Graphical view ]
    SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54665. SSF54665. 1 hit.
    SSF56003. SSF56003. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiYAGR_ECOLI
    AccessioniPrimary (citable) accession number: P77489
    Secondary accession number(s): Q2MCD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3