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P77489 (YAGR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative xanthine dehydrogenase YagR molybdenum-binding subunit

EC=1.17.1.4
Gene names
Name:yagR
Ordered Locus Names:b0284, JW0278
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length732 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Xanthine + NAD+ + H2O = urate + NADH.

Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactor

Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Subunit structure

Heterotrimer of YagR, YagS and YagT Potential.

Sequence similarities

Belongs to the xanthine dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 732732Putative xanthine dehydrogenase YagR molybdenum-binding subunit
PRO_0000166090

Sites

Metal binding2111Molybdenum Potential
Metal binding2421Molybdenum; via carbonyl oxygen Potential
Metal binding3501Molybdenum; via amide nitrogen Potential

Sequences

Sequence LengthMass (Da)Tools
P77489 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AF198715794F0138

FASTA73278,088
        10         20         30         40         50         60 
MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEEAPNAAY GYIVGSAIAK 

        70         80         90        100        110        120 
GRLTALDTDA AQKAPGVLAV ITASNAGALG KGDKNTARLL GGPTIEHYHQ AIALVVAETF 

       130        140        150        160        170        180 
EQARAAASLV QAHYRRNKGA YSLADEKQAV NQPPEDTPDK NVGDFDGAFT SAAVKIDATY 

       190        200        210        220        230        240 
TTPDQSHMAM EPHASMAVWD GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG 

       250        260        270        280        290        300 
GFGGKLFLRS DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT 

       310        320        330        340        350        360 
AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR APGEAPGLMA 

       370        380        390        400        410        420 
LEIAIDELAE KAGIDPVEFR ILNDTQVDPA DPTRCFSRRQ LIECLRTGAD KFGWKQRNAT 

       430        440        450        460        470        480 
PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR VHLEQNGTVT VETDMTDIGT GSYTILAQTA 

       490        500        510        520        530        540 
AEMLGVPLEQ VAVHLGDSSF PVSAGSGGQW GANTSTSGVY AACMKLREMI ASAVGFDPEQ 

       550        560        570        580        590        600 
SQFADGKITN GTRSATLHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG 

       610        620        630        640        650        660 
EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY FVNHDMAGYE 

       670        680        690        700        710        720 
VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA AIANAVYNAT GIRVRDYPIT 

       730 
LDKLLDKLPD VV 

« Hide

References

[1]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U73857 Genomic DNA. Translation: AAB18013.1.
U00096 Genomic DNA. Translation: AAC73387.1.
AP009048 Genomic DNA. Translation: BAE76068.1.
PIRD64754.
RefSeqNP_414818.1. NC_000913.3.
YP_488580.1. NC_007779.1.

3D structure databases

ProteinModelPortalP77489.
SMRP77489. Positions 16-728.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP77489. 10 interactions.
STRING511145.b0284.

Proteomic databases

PaxDbP77489.
PRIDEP77489.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73387; AAC73387; b0284.
BAE76068; BAE76068; BAE76068.
GeneID12932498.
944961.
KEGGecj:Y75_p0276.
eco:b0284.
PATRIC32115691. VBIEscCol129921_0288.

Organism-specific databases

EchoBASEEB3327.
EcoGeneEG13557. yagR.

Phylogenomic databases

eggNOGCOG1529.
HOGENOMHOG000244716.
KOK11177.
OMAEAIYHAD.
OrthoDBEOG6ZSP3F.
PhylomeDBP77489.
ProtClustDBCLSK879611.

Enzyme and pathway databases

BioCycEcoCyc:G6155-MONOMER.
ECOL316407:JW0278-MONOMER.
MetaCyc:G6155-MONOMER.

Gene expression databases

GenevestigatorP77489.

Family and domain databases

Gene3D3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProIPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view]
PfamPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view]
SMARTSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.
ProtoNetSearch...

Other

PROP77489.

Entry information

Entry nameYAGR_ECOLI
AccessionPrimary (citable) accession number: P77489
Secondary accession number(s): Q2MCD8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene