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Protein

Putative xanthine dehydrogenase YagR molybdenum-binding subunit

Gene

yagR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi211 – 2111MolybdenumSequence Analysis
Metal bindingi242 – 2421Molybdenum; via carbonyl oxygenSequence Analysis
Metal bindingi350 – 3501Molybdenum; via amide nitrogenSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciEcoCyc:G6155-MONOMER.
ECOL316407:JW0278-MONOMER.
MetaCyc:G6155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase YagR molybdenum-binding subunit (EC:1.17.1.4)
Gene namesi
Name:yagR
Ordered Locus Names:b0284, JW0278
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13557. yagR.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • periplasmic space Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Putative xanthine dehydrogenase YagR molybdenum-binding subunitPRO_0000166090Add
BLAST

Proteomic databases

PaxDbiP77489.
PRIDEiP77489.

Interactioni

Subunit structurei

Heterotrimer of YagR, YagS and YagT.Curated

Protein-protein interaction databases

IntActiP77489. 10 interactions.
STRINGi511145.b0284.

Structurei

3D structure databases

ProteinModelPortaliP77489.
SMRiP77489. Positions 16-728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1529.
HOGENOMiHOG000244716.
InParanoidiP77489.
KOiK11177.
OMAiVITYKNA.
OrthoDBiEOG6ZSP3F.
PhylomeDBiP77489.

Family and domain databases

Gene3Di3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view]
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.

Sequencei

Sequence statusi: Complete.

P77489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEEAPNAAY
60 70 80 90 100
GYIVGSAIAK GRLTALDTDA AQKAPGVLAV ITASNAGALG KGDKNTARLL
110 120 130 140 150
GGPTIEHYHQ AIALVVAETF EQARAAASLV QAHYRRNKGA YSLADEKQAV
160 170 180 190 200
NQPPEDTPDK NVGDFDGAFT SAAVKIDATY TTPDQSHMAM EPHASMAVWD
210 220 230 240 250
GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG GFGGKLFLRS
260 270 280 290 300
DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT
310 320 330 340 350
AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR
360 370 380 390 400
APGEAPGLMA LEIAIDELAE KAGIDPVEFR ILNDTQVDPA DPTRCFSRRQ
410 420 430 440 450
LIECLRTGAD KFGWKQRNAT PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR
460 470 480 490 500
VHLEQNGTVT VETDMTDIGT GSYTILAQTA AEMLGVPLEQ VAVHLGDSSF
510 520 530 540 550
PVSAGSGGQW GANTSTSGVY AACMKLREMI ASAVGFDPEQ SQFADGKITN
560 570 580 590 600
GTRSATLHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG
610 620 630 640 650
EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY
660 670 680 690 700
FVNHDMAGYE VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA
710 720 730
AIANAVYNAT GIRVRDYPIT LDKLLDKLPD VV
Length:732
Mass (Da):78,088
Last modified:February 1, 1997 - v1
Checksum:iAF198715794F0138
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18013.1.
U00096 Genomic DNA. Translation: AAC73387.1.
AP009048 Genomic DNA. Translation: BAE76068.1.
PIRiD64754.
RefSeqiNP_414818.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC73387; AAC73387; b0284.
BAE76068; BAE76068; BAE76068.
GeneIDi944961.
KEGGiecj:Y75_p0276.
eco:b0284.
PATRICi32115691. VBIEscCol129921_0288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18013.1.
U00096 Genomic DNA. Translation: AAC73387.1.
AP009048 Genomic DNA. Translation: BAE76068.1.
PIRiD64754.
RefSeqiNP_414818.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP77489.
SMRiP77489. Positions 16-728.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP77489. 10 interactions.
STRINGi511145.b0284.

Proteomic databases

PaxDbiP77489.
PRIDEiP77489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73387; AAC73387; b0284.
BAE76068; BAE76068; BAE76068.
GeneIDi944961.
KEGGiecj:Y75_p0276.
eco:b0284.
PATRICi32115691. VBIEscCol129921_0288.

Organism-specific databases

EchoBASEiEB3327.
EcoGeneiEG13557. yagR.

Phylogenomic databases

eggNOGiCOG1529.
HOGENOMiHOG000244716.
InParanoidiP77489.
KOiK11177.
OMAiVITYKNA.
OrthoDBiEOG6ZSP3F.
PhylomeDBiP77489.

Enzyme and pathway databases

BioCyciEcoCyc:G6155-MONOMER.
ECOL316407:JW0278-MONOMER.
MetaCyc:G6155-MONOMER.

Miscellaneous databases

PROiP77489.

Family and domain databases

Gene3Di3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view]
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiYAGR_ECOLI
AccessioniPrimary (citable) accession number: P77489
Secondary accession number(s): Q2MCD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.