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P77489

- YAGR_ECOLI

UniProt

P77489 - YAGR_ECOLI

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Protein
Putative xanthine dehydrogenase YagR molybdenum-binding subunit
Gene
yagR, b0284, JW0278
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi211 – 2111Molybdenum Reviewed prediction
Metal bindingi242 – 2421Molybdenum; via carbonyl oxygen Reviewed prediction
Metal bindingi350 – 3501Molybdenum; via amide nitrogen Reviewed prediction

GO - Molecular functioni

  1. molybdenum ion binding Source: EcoCyc
  2. oxidoreductase activity, acting on the aldehyde or oxo group of donors Source: EcoCyc
  3. protein binding Source: EcoliWiki
  4. xanthine dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: EcoliWiki
  2. purine nucleobase metabolic process Source: UniProtKB-KW
  3. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciEcoCyc:G6155-MONOMER.
ECOL316407:JW0278-MONOMER.
MetaCyc:G6155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase YagR molybdenum-binding subunit (EC:1.17.1.4)
Gene namesi
Name:yagR
Ordered Locus Names:b0284, JW0278
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13557. yagR.

Subcellular locationi

GO - Cellular componenti

  1. periplasmic space Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Putative xanthine dehydrogenase YagR molybdenum-binding subunit
PRO_0000166090Add
BLAST

Proteomic databases

PaxDbiP77489.
PRIDEiP77489.

Expressioni

Gene expression databases

GenevestigatoriP77489.

Interactioni

Subunit structurei

Heterotrimer of YagR, YagS and YagT Reviewed prediction.

Protein-protein interaction databases

IntActiP77489. 10 interactions.
STRINGi511145.b0284.

Structurei

3D structure databases

ProteinModelPortaliP77489.
SMRiP77489. Positions 16-728.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1529.
HOGENOMiHOG000244716.
KOiK11177.
OMAiTHNLGEC.
OrthoDBiEOG6ZSP3F.
PhylomeDBiP77489.

Family and domain databases

Gene3Di3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view]
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.

Sequencei

Sequence statusi: Complete.

P77489-1 [UniParc]FASTAAdd to Basket

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MKFDKPAGEN PIDQLKVVGR PHDRIDGPLK TTGTARYAYE WHEEAPNAAY    50
GYIVGSAIAK GRLTALDTDA AQKAPGVLAV ITASNAGALG KGDKNTARLL 100
GGPTIEHYHQ AIALVVAETF EQARAAASLV QAHYRRNKGA YSLADEKQAV 150
NQPPEDTPDK NVGDFDGAFT SAAVKIDATY TTPDQSHMAM EPHASMAVWD 200
GNKLTLWTSN QMIDWCRTDL AKTLKVPVEN VRIISPYIGG GFGGKLFLRS 250
DALLAALAAR AVKRPVKVML PRPSIPNNTT HRPATLQHLR IGADQSGKIT 300
AISHESWSGN LPGGTPETAV QQSELLYAGA NRHTGLRLAT LDLPEGNAMR 350
APGEAPGLMA LEIAIDELAE KAGIDPVEFR ILNDTQVDPA DPTRCFSRRQ 400
LIECLRTGAD KFGWKQRNAT PGQVRDGEWL VGHGVAAGFR NNLLEKSGAR 450
VHLEQNGTVT VETDMTDIGT GSYTILAQTA AEMLGVPLEQ VAVHLGDSSF 500
PVSAGSGGQW GANTSTSGVY AACMKLREMI ASAVGFDPEQ SQFADGKITN 550
GTRSATLHEA TAGGRLTAEE SIEFGTLSKE YQQSTFAGHF VEVGVHSATG 600
EVRVRRMLAV CAAGRILNPK TARSQVIGAM TMGMGAALME ELAVDDRLGY 650
FVNHDMAGYE VPVHADIPKQ EVIFLDDTDP ISSPMKAKGV GELGLCGVSA 700
AIANAVYNAT GIRVRDYPIT LDKLLDKLPD VV 732
Length:732
Mass (Da):78,088
Last modified:February 1, 1997 - v1
Checksum:iAF198715794F0138
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73857 Genomic DNA. Translation: AAB18013.1.
U00096 Genomic DNA. Translation: AAC73387.1.
AP009048 Genomic DNA. Translation: BAE76068.1.
PIRiD64754.
RefSeqiNP_414818.1. NC_000913.3.
YP_488580.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73387; AAC73387; b0284.
BAE76068; BAE76068; BAE76068.
GeneIDi12932498.
944961.
KEGGiecj:Y75_p0276.
eco:b0284.
PATRICi32115691. VBIEscCol129921_0288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73857 Genomic DNA. Translation: AAB18013.1 .
U00096 Genomic DNA. Translation: AAC73387.1 .
AP009048 Genomic DNA. Translation: BAE76068.1 .
PIRi D64754.
RefSeqi NP_414818.1. NC_000913.3.
YP_488580.1. NC_007779.1.

3D structure databases

ProteinModelPortali P77489.
SMRi P77489. Positions 16-728.
ModBasei Search...

Protein-protein interaction databases

IntActi P77489. 10 interactions.
STRINGi 511145.b0284.

Proteomic databases

PaxDbi P77489.
PRIDEi P77489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73387 ; AAC73387 ; b0284 .
BAE76068 ; BAE76068 ; BAE76068 .
GeneIDi 12932498.
944961.
KEGGi ecj:Y75_p0276.
eco:b0284.
PATRICi 32115691. VBIEscCol129921_0288.

Organism-specific databases

EchoBASEi EB3327.
EcoGenei EG13557. yagR.

Phylogenomic databases

eggNOGi COG1529.
HOGENOMi HOG000244716.
KOi K11177.
OMAi THNLGEC.
OrthoDBi EOG6ZSP3F.
PhylomeDBi P77489.

Enzyme and pathway databases

BioCyci EcoCyc:G6155-MONOMER.
ECOL316407:JW0278-MONOMER.
MetaCyc:G6155-MONOMER.

Miscellaneous databases

PROi P77489.

Gene expression databases

Genevestigatori P77489.

Family and domain databases

Gene3Di 3.30.365.10. 6 hits.
3.90.1170.50. 1 hit.
InterProi IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
[Graphical view ]
Pfami PF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
[Graphical view ]
SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiYAGR_ECOLI
AccessioniPrimary (citable) accession number: P77489
Secondary accession number(s): Q2MCD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi