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Protein

Putative cyclic-di-GMP phosphodiesterase YlaB

Gene

ylaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a c-di-GMP phosphodiesterase. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria (By similarity).By similarity

Catalytic activityi

Cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

c-di-GMP

Enzyme and pathway databases

BioCyciEcoCyc:G6252-MONOMER.
ECOL316407:JW5062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cyclic-di-GMP phosphodiesterase YlaB (EC:3.1.4.52)
Gene namesi
Name:ylaB
Ordered Locus Names:b0457, JW5062
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14237. ylaB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001686331 – 516Putative cyclic-di-GMP phosphodiesterase YlaBAdd BLAST516

Proteomic databases

PaxDbiP77473.
PRIDEiP77473.

Expressioni

Inductioni

Expressed during transition into stationary phase, at both 28 and 37 degrees Celsius. Expression is RpoS dependent.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261748. 11 interactors.
STRINGi511145.b0457.

Structurei

3D structure databases

ProteinModelPortaliP77473.
SMRiP77473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 516EALPROSITE-ProRule annotationAdd BLAST249

Sequence similaritiesi

Contains 1 EAL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41066DG. Bacteria.
COG4943. LUCA.
HOGENOMiHOG000117610.
InParanoidiP77473.
OMAiSQQHISI.
PhylomeDBiP77473.

Family and domain databases

CDDicd01948. EAL. 1 hit.
Gene3Di3.20.20.450. 1 hit.
InterProiIPR024744. CSS-motif_dom.
IPR001633. EAL_dom.
[Graphical view]
PfamiPF12792. CSS-motif. 1 hit.
PF00563. EAL. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTRHLVGLI SGVLILSVLL PVGLSIWLAH QQVETSFIEE LDTYSSRVAI
60 70 80 90 100
RANKVATQGK DALQELERWQ GAACSEAHLM EMRRVSYSYR YIQEVAYIDN
110 120 130 140 150
NVPQCSSLEH ESPPDTFPEP GKISKDGYRV WLTSHNDLGI IRYMVAMGTA
160 170 180 190 200
HYVVMIDPAS FIDVIPYSSW QIDAAIIGNA HNVVITSSDE IAQGIITRLQ
210 220 230 240 250
KTPGEHIENN GIIYDILPLP EMNISIITWA STKMLQKGWH RQVFIWLPLG
260 270 280 290 300
LVIGLLAAMF VLRILRRIQS PHHRLQDAIE NRDICVHYQP IVSLANGKIV
310 320 330 340 350
GAEALARWPQ TDGSWLSPDS FIPLAQQTGL SEPLTLLIIR SVFEDMGDWL
360 370 380 390 400
RQHPQQHISI NLESPVLTSE KIPQLLRDMI NHYQVNPRQI ALELTEREFA
410 420 430 440 450
DPKTSAPIIS RYREAGHEIY LDDFGTGYSS LSYLQDLDVD ILKIDKSFVD
460 470 480 490 500
ALEYKNVTPH IIEMAKTLKL KMVAEGIETS KQEEWLRQHG VHYGQGWLYS
510
KALPKEDFLR WAEQHL
Length:516
Mass (Da):58,720
Last modified:July 11, 2001 - v2
Checksum:i3FC1355E51CF6464
GO

Sequence cautioni

The sequence AAB40212 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40212.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73559.2.
AP009048 Genomic DNA. Translation: BAE76236.1.
PIRiH64775.
RefSeqiNP_414990.2. NC_000913.3.
WP_001310610.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73559; AAC73559; b0457.
BAE76236; BAE76236; BAE76236.
GeneIDi948951.
KEGGiecj:JW5062.
eco:b0457.
PATRICi32116067. VBIEscCol129921_0475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40212.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73559.2.
AP009048 Genomic DNA. Translation: BAE76236.1.
PIRiH64775.
RefSeqiNP_414990.2. NC_000913.3.
WP_001310610.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77473.
SMRiP77473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261748. 11 interactors.
STRINGi511145.b0457.

Proteomic databases

PaxDbiP77473.
PRIDEiP77473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73559; AAC73559; b0457.
BAE76236; BAE76236; BAE76236.
GeneIDi948951.
KEGGiecj:JW5062.
eco:b0457.
PATRICi32116067. VBIEscCol129921_0475.

Organism-specific databases

EchoBASEiEB3988.
EcoGeneiEG14237. ylaB.

Phylogenomic databases

eggNOGiENOG41066DG. Bacteria.
COG4943. LUCA.
HOGENOMiHOG000117610.
InParanoidiP77473.
OMAiSQQHISI.
PhylomeDBiP77473.

Enzyme and pathway databases

BioCyciEcoCyc:G6252-MONOMER.
ECOL316407:JW5062-MONOMER.

Miscellaneous databases

PROiP77473.

Family and domain databases

CDDicd01948. EAL. 1 hit.
Gene3Di3.20.20.450. 1 hit.
InterProiIPR024744. CSS-motif_dom.
IPR001633. EAL_dom.
[Graphical view]
PfamiPF12792. CSS-motif. 1 hit.
PF00563. EAL. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYLAB_ECOLI
AccessioniPrimary (citable) accession number: P77473
Secondary accession number(s): Q2MBX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2001
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.