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Protein

Probable D,D-dipeptide transport system permease protein DdpC

Gene

ddpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YDDQ-MONOMER.
ECOL316407:JW1480-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.38. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D,D-dipeptide transport system permease protein DdpC
Gene namesi
Name:ddpC
Synonyms:yddQ
Ordered Locus Names:b1485, JW1480
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13788. ddpC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini55 – 96PeriplasmicSequence analysisAdd BLAST42
Transmembranei97 – 117HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini118 – 124CytoplasmicSequence analysis7
Transmembranei125 – 145HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei146 – 166HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini167 – 217CytoplasmicSequence analysisAdd BLAST51
Transmembranei218 – 238HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini239 – 260PeriplasmicSequence analysisAdd BLAST22
Transmembranei261 – 281HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini282 – 298CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000602451 – 298Probable D,D-dipeptide transport system permease protein DdpCAdd BLAST298

Proteomic databases

PaxDbiP77463.
PRIDEiP77463.

Expressioni

Inductioni

Induced by RpoS in stationary phase.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (DdpD and DdpF), two transmembrane proteins (DdpB and DdpC) and a solute-binding protein (DdpA).Curated

Protein-protein interaction databases

BioGridi4260963. 257 interactors.
IntActiP77463. 2 interactors.
STRINGi511145.b1485.

Structurei

3D structure databases

ProteinModelPortaliP77463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 282ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST186

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C2T. Bacteria.
COG1173. LUCA.
HOGENOMiHOG000171368.
InParanoidiP77463.
KOiK02034.
OMAiPDWGLDL.
PhylomeDBiP77463.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR025966. OppC_N.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
PF12911. OppC_N. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSEETSAV RPQKQTRFNG AKLVWMLKGS PLTVTSAVII VLMLLMMIFS
60 70 80 90 100
PWLATHDPNA IDLTARLLPP SAAHWFGTDE VGRDLFSRVL VGSQQSILAG
110 120 130 140 150
LVVVAIAGMI GSLLGCLSGV LGGRADAIIM RIMDIMLSIP SLVLTMALAA
160 170 180 190 200
ALGPSLFNAM LAIAIVRIPF YVRLARGQAL VVRQYTYVQA AKTFGASRWH
210 220 230 240 250
LINWHILRNS LPPLIVQASL DIGSAILMAA TLGFIGLGAQ QPSAEWGAMV
260 270 280 290
ANGRNYVLDQ WWYCAFPGAA ILLTAVGFNL FGDGIRDLLD PKAGGKQS
Length:298
Mass (Da):31,971
Last modified:February 1, 1997 - v1
Checksum:i721AB0225634AF6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74558.1.
AP009048 Genomic DNA. Translation: BAA15140.1.
PIRiH64901.
RefSeqiNP_416002.1. NC_000913.3.
WP_000979626.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74558; AAC74558; b1485.
BAA15140; BAA15140; BAA15140.
GeneIDi946028.
KEGGiecj:JW1480.
eco:b1485.
PATRICi32118264. VBIEscCol129921_1552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74558.1.
AP009048 Genomic DNA. Translation: BAA15140.1.
PIRiH64901.
RefSeqiNP_416002.1. NC_000913.3.
WP_000979626.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260963. 257 interactors.
IntActiP77463. 2 interactors.
STRINGi511145.b1485.

Protein family/group databases

TCDBi3.A.1.5.38. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP77463.
PRIDEiP77463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74558; AAC74558; b1485.
BAA15140; BAA15140; BAA15140.
GeneIDi946028.
KEGGiecj:JW1480.
eco:b1485.
PATRICi32118264. VBIEscCol129921_1552.

Organism-specific databases

EchoBASEiEB3549.
EcoGeneiEG13788. ddpC.

Phylogenomic databases

eggNOGiENOG4105C2T. Bacteria.
COG1173. LUCA.
HOGENOMiHOG000171368.
InParanoidiP77463.
KOiK02034.
OMAiPDWGLDL.
PhylomeDBiP77463.

Enzyme and pathway databases

BioCyciEcoCyc:YDDQ-MONOMER.
ECOL316407:JW1480-MONOMER.

Miscellaneous databases

PROiP77463.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR025966. OppC_N.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
PF12911. OppC_N. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDPC_ECOLI
AccessioniPrimary (citable) accession number: P77463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.