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Protein

Probable D,D-dipeptide transport system permease protein DdpC

Gene

ddpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YDDQ-MONOMER.
ECOL316407:JW1480-MONOMER.
RETL1328306-WGS:GSTH-4083-MONOMER.
RETL1328306-WGS:GSTH-4558-MONOMER.
RETL1328306-WGS:GSTH-4923-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.38. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D,D-dipeptide transport system permease protein DdpC
Gene namesi
Name:ddpC
Synonyms:yddQ
Ordered Locus Names:b1485, JW1480
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13788. ddpC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini55 – 9642PeriplasmicSequence analysisAdd
BLAST
Transmembranei97 – 11721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini118 – 1247CytoplasmicSequence analysis
Transmembranei125 – 14521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei146 – 16621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini167 – 21751CytoplasmicSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini239 – 26022PeriplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini282 – 29817CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Probable D,D-dipeptide transport system permease protein DdpCPRO_0000060245Add
BLAST

Proteomic databases

PaxDbiP77463.
PRIDEiP77463.

Expressioni

Inductioni

Induced by RpoS in stationary phase.1 Publication

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (DdpD and DdpF), two transmembrane proteins (DdpB and DdpC) and a solute-binding protein (DdpA).Curated

Protein-protein interaction databases

BioGridi4260963. 257 interactions.
IntActiP77463. 2 interactions.
STRINGi511145.b1485.

Structurei

3D structure databases

ProteinModelPortaliP77463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 282186ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C2T. Bacteria.
COG1173. LUCA.
HOGENOMiHOG000171368.
InParanoidiP77463.
KOiK02034.
OMAiQIKNYEY.
OrthoDBiEOG6T7N3V.
PhylomeDBiP77463.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR025966. OppC_N.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
PF12911. OppC_N. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSEETSAV RPQKQTRFNG AKLVWMLKGS PLTVTSAVII VLMLLMMIFS
60 70 80 90 100
PWLATHDPNA IDLTARLLPP SAAHWFGTDE VGRDLFSRVL VGSQQSILAG
110 120 130 140 150
LVVVAIAGMI GSLLGCLSGV LGGRADAIIM RIMDIMLSIP SLVLTMALAA
160 170 180 190 200
ALGPSLFNAM LAIAIVRIPF YVRLARGQAL VVRQYTYVQA AKTFGASRWH
210 220 230 240 250
LINWHILRNS LPPLIVQASL DIGSAILMAA TLGFIGLGAQ QPSAEWGAMV
260 270 280 290
ANGRNYVLDQ WWYCAFPGAA ILLTAVGFNL FGDGIRDLLD PKAGGKQS
Length:298
Mass (Da):31,971
Last modified:February 1, 1997 - v1
Checksum:i721AB0225634AF6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74558.1.
AP009048 Genomic DNA. Translation: BAA15140.1.
PIRiH64901.
RefSeqiNP_416002.1. NC_000913.3.
WP_000979626.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74558; AAC74558; b1485.
BAA15140; BAA15140; BAA15140.
GeneIDi946028.
KEGGiecj:JW1480.
eco:b1485.
PATRICi32118264. VBIEscCol129921_1552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74558.1.
AP009048 Genomic DNA. Translation: BAA15140.1.
PIRiH64901.
RefSeqiNP_416002.1. NC_000913.3.
WP_000979626.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260963. 257 interactions.
IntActiP77463. 2 interactions.
STRINGi511145.b1485.

Protein family/group databases

TCDBi3.A.1.5.38. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP77463.
PRIDEiP77463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74558; AAC74558; b1485.
BAA15140; BAA15140; BAA15140.
GeneIDi946028.
KEGGiecj:JW1480.
eco:b1485.
PATRICi32118264. VBIEscCol129921_1552.

Organism-specific databases

EchoBASEiEB3549.
EcoGeneiEG13788. ddpC.

Phylogenomic databases

eggNOGiENOG4105C2T. Bacteria.
COG1173. LUCA.
HOGENOMiHOG000171368.
InParanoidiP77463.
KOiK02034.
OMAiQIKNYEY.
OrthoDBiEOG6T7N3V.
PhylomeDBiP77463.

Enzyme and pathway databases

BioCyciEcoCyc:YDDQ-MONOMER.
ECOL316407:JW1480-MONOMER.
RETL1328306-WGS:GSTH-4083-MONOMER.
RETL1328306-WGS:GSTH-4558-MONOMER.
RETL1328306-WGS:GSTH-4923-MONOMER.

Miscellaneous databases

PROiP77463.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR025966. OppC_N.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
PF12911. OppC_N. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function."
    Lessard I.A.D., Pratt S.D., McCafferty D.G., Bussiere D.E., Hutchins C., Wanner B.L., Katz L., Walsh C.T.
    Chem. Biol. 5:489-504(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function?"
    Lessard I.A.D., Walsh C.T.
    Proc. Natl. Acad. Sci. U.S.A. 96:11028-11032(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  6. "Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis."
    Drew D., Sjoestrand D., Nilsson J., Urbig T., Chin C.-N., de Gier J.-W., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 99:2690-2695(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
    Strain: K12 / JM109 / ATCC 53323.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiDDPC_ECOLI
AccessioniPrimary (citable) accession number: P77463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.