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Protein

Hydrogenase-4 component F

Gene

hyfF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-143.
ECOL316407:JW2471-MONOMER.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-4 component F (EC:1.-.-.-)
Gene namesi
Name:hyfF
Ordered Locus Names:b2486, JW2471
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14214. hyfF.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001182281 – 526Hydrogenase-4 component FAdd BLAST526

Proteomic databases

PaxDbiP77437.
PRIDEiP77437.

Interactioni

Protein-protein interaction databases

BioGridi4262930. 7 interactors.
IntActiP77437. 1 interactor.
STRINGi511145.b2486.

Structurei

3D structure databases

ProteinModelPortaliP77437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JPZ. Bacteria.
COG0651. LUCA.
HOGENOMiHOG000020533.
InParanoidiP77437.
KOiK12141.
OMAiLAYMACT.
PhylomeDBiP77437.

Family and domain databases

InterProiIPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSVMFALL LLTPLLFSLL CFACRKRRLS ATRTVTVLHS LGITLLLILA
60 70 80 90 100
LWVVQTAADA GEIFAAGLWL HIDGLGGLFL AILGVIGFLT GIYSIGYMRH
110 120 130 140 150
EVAHGELSPV TLCDYYGFFH LFLFTMLLVV TSNNLIVMWA AIEATTLSSA
160 170 180 190 200
FLVGIYGQRS SLEAAWKYII ICTVGVAFGL FGTVLVYANA ASVMPQAEMA
210 220 230 240 250
IFWSEVLKQS SLLDPTLMLL AFVFLLIGFG TKTGLFPMHA WLPDAHSEAP
260 270 280 290 300
SPVSALLSAV LLNCALLVLI RYYIIICQAI GSDFPNRLLL IFGMLSVAVA
310 320 330 340 350
AFFILVQRDI KRLLAYSSVE NMGLVAVELG IGGPLGIFAA LLHILNHSLA
360 370 380 390 400
KTLLFCGSGN VLLKYGTRDL NVVCGMLKIM PFTAVLFGGG ALALAGMPPF
410 420 430 440 450
NIFLSEFMTI TAGLARNHLL IIVLLLLLLT LVLAGLVRMA ARVLMAKPPQ
460 470 480 490 500
AVNRGDLGWL TTSPMVILLV MMLAMGTHIP QPVIRILAGA STIVLSGTHD
510 520
LPAQRSTWHD FLPSGTASVS EKHSER
Length:526
Mass (Da):56,767
Last modified:February 1, 1997 - v1
Checksum:i229068F616880775
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88568.1.
U00096 Genomic DNA. Translation: AAC75539.1.
AP009048 Genomic DNA. Translation: BAA16374.1.
PIRiE65024.
RefSeqiNP_416981.1. NC_000913.3.
WP_000122577.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75539; AAC75539; b2486.
BAA16374; BAA16374; BAA16374.
GeneIDi946962.
KEGGiecj:JW2471.
eco:b2486.
PATRICi32120359. VBIEscCol129921_2582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88568.1.
U00096 Genomic DNA. Translation: AAC75539.1.
AP009048 Genomic DNA. Translation: BAA16374.1.
PIRiE65024.
RefSeqiNP_416981.1. NC_000913.3.
WP_000122577.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262930. 7 interactors.
IntActiP77437. 1 interactor.
STRINGi511145.b2486.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP77437.
PRIDEiP77437.

Protocols and materials databases

DNASUi946962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75539; AAC75539; b2486.
BAA16374; BAA16374; BAA16374.
GeneIDi946962.
KEGGiecj:JW2471.
eco:b2486.
PATRICi32120359. VBIEscCol129921_2582.

Organism-specific databases

EchoBASEiEB3966.
EcoGeneiEG14214. hyfF.

Phylogenomic databases

eggNOGiENOG4108JPZ. Bacteria.
COG0651. LUCA.
HOGENOMiHOG000020533.
InParanoidiP77437.
KOiK12141.
OMAiLAYMACT.
PhylomeDBiP77437.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-143.
ECOL316407:JW2471-MONOMER.

Miscellaneous databases

PROiP77437.

Family and domain databases

InterProiIPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYFF_ECOLI
AccessioniPrimary (citable) accession number: P77437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.