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Protein

Allantoate amidohydrolase

Gene

allC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the anaerobic utilization of allantoin. Converts allantoate to (S)-ureidoglycolate and ammonia.1 Publication

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Pathwayi: (S)-allantoin degradation

This protein is involved in the pathway (S)-allantoin degradation, which is part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Zinc 11
Metal bindingi92Zinc 11
Metal bindingi92Zinc 21
Metal bindingi127Zinc 21
Metal bindingi190Zinc 11
Metal bindingi382Zinc 21

GO - Molecular functioni

  • allantoate deiminase activity Source: EcoCyc
  • manganese ion binding Source: EcoCyc

GO - Biological processi

  • allantoin assimilation pathway Source: EcoCyc
  • purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G6285-MONOMER.
ECOL316407:JW0504-MONOMER.
MetaCyc:G6285-MONOMER.
BRENDAi3.5.3.9. 2026.
UniPathwayiUPA00395.

Protein family/group databases

MEROPSiM20.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoate amidohydrolase (EC:3.5.3.-)
Alternative name(s):
Allantoate deiminase
Gene namesi
Name:allC
Synonyms:glxB7, ylbB
Ordered Locus Names:b0516, JW0504
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13623. allC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000619571 – 411Allantoate amidohydrolaseAdd BLAST411

Proteomic databases

PaxDbiP77425.
PRIDEiP77425.

Expressioni

Inductioni

By glyoxylate and allantoin under anaerobic conditions.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4261167. 17 interactors.
DIPiDIP-9088N.
IntActiP77425. 9 interactors.
STRINGi511145.b0516.

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 18Combined sources17
Beta strandi25 – 27Combined sources3
Helixi34 – 49Combined sources16
Beta strandi53 – 56Combined sources4
Beta strandi62 – 66Combined sources5
Beta strandi69 – 81Combined sources13
Helixi94 – 111Combined sources18
Beta strandi115 – 124Combined sources10
Beta strandi130 – 132Combined sources3
Helixi136 – 141Combined sources6
Helixi147 – 149Combined sources3
Turni150 – 152Combined sources3
Beta strandi156 – 158Combined sources3
Helixi161 – 167Combined sources7
Beta strandi183 – 191Combined sources9
Beta strandi193 – 195Combined sources3
Helixi196 – 199Combined sources4
Beta strandi203 – 210Combined sources8
Beta strandi212 – 221Combined sources10
Turni227 – 229Combined sources3
Helixi232 – 234Combined sources3
Helixi238 – 256Combined sources19
Beta strandi261 – 263Combined sources3
Beta strandi267 – 271Combined sources5
Beta strandi279 – 291Combined sources13
Helixi292 – 313Combined sources22
Beta strandi316 – 325Combined sources10
Helixi332 – 344Combined sources13
Beta strandi349 – 356Combined sources8
Helixi359 – 363Combined sources5
Turni364 – 366Combined sources3
Beta strandi369 – 374Combined sources6
Helixi377 – 379Combined sources3
Helixi390 – 408Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z2LX-ray2.25A/B2-411[»]
2IMOX-ray2.80A/B2-411[»]
4PXDX-ray2.20A/B1-411[»]
ProteinModelPortaliP77425.
SMRiP77425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77425.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20 family.Curated

Phylogenomic databases

eggNOGiENOG4105CE7. Bacteria.
COG0624. LUCA.
HOGENOMiHOG000241291.
InParanoidiP77425.
KOiK02083.
OMAiIVNFGDE.
PhylomeDBiP77425.

Family and domain databases

CDDicd03884. M20_bAS. 1 hit.
Gene3Di3.30.70.360. 1 hit.
InterProiIPR017591. Allantoate_amidohydrolase.
IPR010158. Amidase_Cbmase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF001235. Amidase_carbamoylase. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR03176. AllC. 1 hit.
TIGR01879. hydantase. 1 hit.

Sequencei

Sequence statusi: Complete.

P77425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITHFRQAIE ETLPWLSSFG ADPAGGMTRL LYSPEWLETQ QQFKKRMAAS
60 70 80 90 100
GLETRFDEVG NLYGRLNGTE YPQEVVLSGS HIDTVVNGGN LDGQFGALAA
110 120 130 140 150
WLAIDWLKTQ YGAPLRTVEV VAMAEEEGSR FPYVFWGSKN IFGLANPDDV
160 170 180 190 200
RNICDAKGNS FVDAMKACGF TLPNAPLTPR QDIKAFVELH IEQGCVLESN
210 220 230 240 250
GQSIGVVNAI VGQRRYTVTL NGESNHAGTT PMGYRRDTVY AFSRICHQSV
260 270 280 290 300
EKAKRMGDPL VLTFGKVEPR PNTVNVVPGK TTFTIDCRHT DAAVLRDFTQ
310 320 330 340 350
QLENDMRAIC DEMDIGIDID LWMDEEPVPM NKELVATLTE LCEREKLNYR
360 370 380 390 400
VMHSGAGHDA QIFAPRVPTC MIFIPSINGI SHNPAERTNI TDLAEGVKTL
410
ALMLYQLAWQ K
Length:411
Mass (Da):45,694
Last modified:February 1, 1997 - v1
Checksum:iC55D1EF854A8F513
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA. Translation: AAB93857.1.
U82664 Genomic DNA. Translation: AAB40268.1.
U00096 Genomic DNA. Translation: AAC73618.1.
AP009048 Genomic DNA. Translation: BAE76294.1.
PIRiC64783.
RefSeqiNP_415049.1. NC_000913.3.
WP_001310618.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73618; AAC73618; b0516.
BAE76294; BAE76294; BAE76294.
GeneIDi945150.
KEGGiecj:JW0504.
eco:b0516.
PATRICi32116189. VBIEscCol129921_0536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA. Translation: AAB93857.1.
U82664 Genomic DNA. Translation: AAB40268.1.
U00096 Genomic DNA. Translation: AAC73618.1.
AP009048 Genomic DNA. Translation: BAE76294.1.
PIRiC64783.
RefSeqiNP_415049.1. NC_000913.3.
WP_001310618.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z2LX-ray2.25A/B2-411[»]
2IMOX-ray2.80A/B2-411[»]
4PXDX-ray2.20A/B1-411[»]
ProteinModelPortaliP77425.
SMRiP77425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261167. 17 interactors.
DIPiDIP-9088N.
IntActiP77425. 9 interactors.
STRINGi511145.b0516.

Protein family/group databases

MEROPSiM20.976.

Proteomic databases

PaxDbiP77425.
PRIDEiP77425.

Protocols and materials databases

DNASUi945150.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73618; AAC73618; b0516.
BAE76294; BAE76294; BAE76294.
GeneIDi945150.
KEGGiecj:JW0504.
eco:b0516.
PATRICi32116189. VBIEscCol129921_0536.

Organism-specific databases

EchoBASEiEB3388.
EcoGeneiEG13623. allC.

Phylogenomic databases

eggNOGiENOG4105CE7. Bacteria.
COG0624. LUCA.
HOGENOMiHOG000241291.
InParanoidiP77425.
KOiK02083.
OMAiIVNFGDE.
PhylomeDBiP77425.

Enzyme and pathway databases

UniPathwayiUPA00395.
BioCyciEcoCyc:G6285-MONOMER.
ECOL316407:JW0504-MONOMER.
MetaCyc:G6285-MONOMER.
BRENDAi3.5.3.9. 2026.

Miscellaneous databases

EvolutionaryTraceiP77425.
PROiP77425.

Family and domain databases

CDDicd03884. M20_bAS. 1 hit.
Gene3Di3.30.70.360. 1 hit.
InterProiIPR017591. Allantoate_amidohydrolase.
IPR010158. Amidase_Cbmase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF001235. Amidase_carbamoylase. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR03176. AllC. 1 hit.
TIGR01879. hydantase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALLC_ECOLI
AccessioniPrimary (citable) accession number: P77425
Secondary accession number(s): Q2MBR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.