Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hydrogenase-4 component H

Gene

hyfH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Probable electron transfer protein for hydrogenase 4.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi43Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi46Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi50Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi75Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi78Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi81Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi85Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-144

Protein family/group databases

TCDBi3.D.1.9.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-4 component H
Gene namesi
Name:hyfH1 Publication
Ordered Locus Names:b2488, JW2473
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14216 hyfH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592681 – 181Hydrogenase-4 component HAdd BLAST181

Proteomic databases

PaxDbiP77423
PRIDEiP77423

Interactioni

Protein-protein interaction databases

BioGridi4261172, 19 interactors
STRINGi316385.ECDH10B_2654

Structurei

3D structure databases

ProteinModelPortaliP77423
SMRiP77423
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 604Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
Domaini66 – 954Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1143 LUCA
HOGENOMiHOG000278697
InParanoidiP77423
KOiK12143
OMAiMACPANA
PhylomeDBiP77423

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
PfamiView protein in Pfam
PF12838 Fer4_7, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P77423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLLKTIMR AGTATVKYPF APLEVSPGFR GKPDLMPSQC IACGACACAC
60 70 80 90 100
PANALTIQTD DQQNSRTWQL YLGRCIYCGR CEEVCPTRAI QLTNNFELTV
110 120 130 140 150
TNKADLYTRA TFHLQRCSRC ERPFAPQKTI ALAAELLAQQ QNAPQNREML
160 170 180
WAQASVCPEC KQRATLINDD TDVLLVAKEQ L
Length:181
Mass (Da):20,159
Last modified:February 1, 1997 - v1
Checksum:i5DBBA3C7C7EBD885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA Translation: AAB88570.1
U00096 Genomic DNA Translation: AAC75541.1
AP009048 Genomic DNA Translation: BAA16376.1
PIRiG65024
RefSeqiNP_416983.1, NC_000913.3
WP_000916055.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75541; AAC75541; b2488
BAA16376; BAA16376; BAA16376
GeneIDi946965
KEGGiecj:JW2473
eco:b2488
PATRICifig|1411691.4.peg.4251

Similar proteinsi

Entry informationi

Entry nameiHYFH_ECOLI
AccessioniPrimary (citable) accession number: P77423
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health