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Protein

Hydrogenase-4 component D

Gene

hyfD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-141.
ECOL316407:JW2469-MONOMER.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-4 component D (EC:1.-.-.-)
Gene namesi
Name:hyfD
Ordered Locus Names:b2484, JW2469
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14212. hyfD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001182271 – 479Hydrogenase-4 component DAdd BLAST479

Proteomic databases

PaxDbiP77416.
PRIDEiP77416.

Interactioni

Protein-protein interaction databases

BioGridi4259198. 13 interactors.
STRINGi511145.b2484.

Structurei

3D structure databases

ProteinModelPortaliP77416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
HOGENOMiHOG000219587.
InParanoidiP77416.
KOiK12139.
OMAiSLSVEYW.
PhylomeDBiP77416.

Family and domain databases

InterProiIPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLALTTLL LPFIGALVVS FSPQRRAAEW GVLFAALTTL CMLSLISAFY
60 70 80 90 100
QADKVAVTLT LVNVGDVALF GLVIDRVSTL ILFVVVFLGL LVTIYSTGYL
110 120 130 140 150
TDKNREHPHN GTNRYYAFLL VFIGAMAGLV LSSTLLGQLL FFEITGGCSW
160 170 180 190 200
ALISYYQSDK AQRSALKALL ITHIGSLGLY LAAATLFLQT GTFALSAMSE
210 220 230 240 250
LHGDARYLVY GGILFAAWGK SAQLPMQAWL PDAMEAPTPI SAYLHAASMV
260 270 280 290 300
KVGVYIFARA IIDGGNIPHV IGGVGMVMAL VTILYGFLMY LPQQDMKRLL
310 320 330 340 350
AWSTITQLGW MFFGLSLSIF GSRLALEGSI AYIVNHAFAK SLFFLVAGAL
360 370 380 390 400
SYSCGTRLLP RLRGVLHTLP LPGVGFCVAA LAITGVPPFN GFFSKFPLFA
410 420 430 440 450
AGFALSVEYW ILLPAMILLM IESVASFAWF IRWFGRVVPG KPSEAVADAA
460 470
PLPGSMRLVL IVLIVMSLIS SVIAATWLQ
Length:479
Mass (Da):51,755
Last modified:February 1, 1997 - v1
Checksum:i61777107CC9100F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88566.1.
U00096 Genomic DNA. Translation: AAC75537.1.
AP009048 Genomic DNA. Translation: BAA16372.1.
PIRiC65024.
RefSeqiNP_416979.1. NC_000913.3.
WP_000429104.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75537; AAC75537; b2484.
BAA16372; BAA16372; BAA16372.
GeneIDi947290.
KEGGiecj:JW2469.
eco:b2484.
PATRICi32120355. VBIEscCol129921_2580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88566.1.
U00096 Genomic DNA. Translation: AAC75537.1.
AP009048 Genomic DNA. Translation: BAA16372.1.
PIRiC65024.
RefSeqiNP_416979.1. NC_000913.3.
WP_000429104.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259198. 13 interactors.
STRINGi511145.b2484.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP77416.
PRIDEiP77416.

Protocols and materials databases

DNASUi947290.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75537; AAC75537; b2484.
BAA16372; BAA16372; BAA16372.
GeneIDi947290.
KEGGiecj:JW2469.
eco:b2484.
PATRICi32120355. VBIEscCol129921_2580.

Organism-specific databases

EchoBASEiEB3964.
EcoGeneiEG14212. hyfD.

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
HOGENOMiHOG000219587.
InParanoidiP77416.
KOiK12139.
OMAiSLSVEYW.
PhylomeDBiP77416.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-141.
ECOL316407:JW2469-MONOMER.

Miscellaneous databases

PROiP77416.

Family and domain databases

InterProiIPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYFD_ECOLI
AccessioniPrimary (citable) accession number: P77416
Secondary accession number(s): P76973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.