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Protein

Hydrogenase-4 component D

Gene

hyfD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-141.
ECOL316407:JW2469-MONOMER.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase-4 component D (EC:1.-.-.-)
Gene namesi
Name:hyfD
Ordered Locus Names:b2484, JW2469
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14212. hyfD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence analysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Transmembranei369 – 38921HelicalSequence analysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence analysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence analysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Hydrogenase-4 component DPRO_0000118227Add
BLAST

Proteomic databases

PaxDbiP77416.

Interactioni

Protein-protein interaction databases

BioGridi4259198. 13 interactions.
STRINGi511145.b2484.

Structurei

3D structure databases

ProteinModelPortaliP77416.
SMRiP77416. Positions 3-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
HOGENOMiHOG000219587.
InParanoidiP77416.
KOiK12139.
OMAiSLSVEYW.
PhylomeDBiP77416.

Family and domain databases

InterProiIPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLALTTLL LPFIGALVVS FSPQRRAAEW GVLFAALTTL CMLSLISAFY
60 70 80 90 100
QADKVAVTLT LVNVGDVALF GLVIDRVSTL ILFVVVFLGL LVTIYSTGYL
110 120 130 140 150
TDKNREHPHN GTNRYYAFLL VFIGAMAGLV LSSTLLGQLL FFEITGGCSW
160 170 180 190 200
ALISYYQSDK AQRSALKALL ITHIGSLGLY LAAATLFLQT GTFALSAMSE
210 220 230 240 250
LHGDARYLVY GGILFAAWGK SAQLPMQAWL PDAMEAPTPI SAYLHAASMV
260 270 280 290 300
KVGVYIFARA IIDGGNIPHV IGGVGMVMAL VTILYGFLMY LPQQDMKRLL
310 320 330 340 350
AWSTITQLGW MFFGLSLSIF GSRLALEGSI AYIVNHAFAK SLFFLVAGAL
360 370 380 390 400
SYSCGTRLLP RLRGVLHTLP LPGVGFCVAA LAITGVPPFN GFFSKFPLFA
410 420 430 440 450
AGFALSVEYW ILLPAMILLM IESVASFAWF IRWFGRVVPG KPSEAVADAA
460 470
PLPGSMRLVL IVLIVMSLIS SVIAATWLQ
Length:479
Mass (Da):51,755
Last modified:February 1, 1997 - v1
Checksum:i61777107CC9100F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88566.1.
U00096 Genomic DNA. Translation: AAC75537.1.
AP009048 Genomic DNA. Translation: BAA16372.1.
PIRiC65024.
RefSeqiNP_416979.1. NC_000913.3.
WP_000429104.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75537; AAC75537; b2484.
BAA16372; BAA16372; BAA16372.
GeneIDi947290.
KEGGiecj:JW2469.
eco:b2484.
PATRICi32120355. VBIEscCol129921_2580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63654 Genomic DNA. Translation: AAB88566.1.
U00096 Genomic DNA. Translation: AAC75537.1.
AP009048 Genomic DNA. Translation: BAA16372.1.
PIRiC65024.
RefSeqiNP_416979.1. NC_000913.3.
WP_000429104.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77416.
SMRiP77416. Positions 3-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259198. 13 interactions.
STRINGi511145.b2484.

Protein family/group databases

TCDBi3.D.1.9.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiP77416.

Protocols and materials databases

DNASUi947290.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75537; AAC75537; b2484.
BAA16372; BAA16372; BAA16372.
GeneIDi947290.
KEGGiecj:JW2469.
eco:b2484.
PATRICi32120355. VBIEscCol129921_2580.

Organism-specific databases

EchoBASEiEB3964.
EcoGeneiEG14212. hyfD.

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
HOGENOMiHOG000219587.
InParanoidiP77416.
KOiK12139.
OMAiSLSVEYW.
PhylomeDBiP77416.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-141.
ECOL316407:JW2469-MONOMER.

Miscellaneous databases

PROiP77416.

Family and domain databases

InterProiIPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHYFD_ECOLI
AccessioniPrimary (citable) accession number: P77416
Secondary accession number(s): P76973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.