P77396 (YPDC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized HTH-type transcriptional regulator YpdC

Gene names

Name:	ypdC
Ordered Locus Names:	b2382, JW2379

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities

Contains 1 HTH araC/xylS-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Uncharacterized HTH-type transcriptional regulator YpdC		PRO_0000194617
Regions
	DNA binding	200 – 219	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	P77396 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 6F6A2DCA15BA8E4D	FASTA	285	32,356
	10 20 30 40 50 60 MKAPGLPADQ QFFADLFSGL VLNPQLLGRV WFASQPASLP VGSLCIDFPR LDIVLRGEYG 70 80 90 100 110 120 NLLEAKQQRL VEGEMLFIPA RAANLPVNNK PVMLLSLVFA PTWLGLSFYD SRTTSLLHPA 130 140 150 160 170 180 RQIQLPSLQR GEGEAMLTAL THLSRSPLEQ NIIQPLVLSL LHLCRSVVNM PPGNSQPRGD 190 200 210 220 230 240 FLYHSICNWV QDNYAQPLTR ESVAQFFNIT PNHLSKLFAQ HGTMRFIEYV RWVRMAKARM 250 260 270 280 ILQKYHLSIH EVAQRCGFPD SDYFCRVFRR QFGLTPGEYS ARFQG

References

[1]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T. DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC75441.1. AP009048 Genomic DNA. Translation: BAA16252.1.
PIR	C65012.
RefSeq	NP_416883.1. NC_000913.2. YP_490624.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P77396.
SMR	P77396. Positions 187-281.
ModBase	Search...
Protein-protein interaction databases
IntAct	P77396. 2 interactions.
STRING	511145.b2382.
Protein family/group databases
AraC-XylS	Search...
Proteomic databases
PaxDb	P77396.
PRIDE	P77396.
Protocols and materials databases
DNASU	946856.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75441; AAC75441; b2382. BAA16252; BAA16252; BAA16252.
GeneID	12934015. 946856.
KEGG	ecj:Y75_p2349. eco:b2382.
PATRIC	32120143. VBIEscCol129921_2480.
Organism-specific databases
EchoBASE	EB3902.
EcoGene	EG14150. ypdC.
Phylogenomic databases
eggNOG	COG2207.
HOGENOM	HOG000274763.
OMA	RLFRRQF.
ProtClustDB	CLSK880376.
Enzyme and pathway databases
BioCyc	EcoCyc:G7245-MONOMER. ECOL316407:JW2379-MONOMER.
Gene expression databases
Genevestigator	P77396.
Family and domain databases
Gene3D	1.10.10.60. 2 hits.
InterPro	IPR009057. Homeodomain-like. IPR018060. HTH_AraC. IPR018062. HTH_AraC-typ_CS. IPR020449. Tscrpt_reg_HTH_AraC-type. [Graphical view]
Pfam	PF12833. HTH_18. 1 hit. [Graphical view]
PRINTS	PR00032. HTHARAC.
SMART	SM00342. HTH_ARAC. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits.
PROSITE	PS00041. HTH_ARAC_FAMILY_1. 1 hit. PS01124. HTH_ARAC_FAMILY_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YPDC_ECOLI

Accession

Primary (citable) accession number: P77396

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program