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P77377

- WZXC_ECOLI

UniProt

P77377 - WZXC_ECOLI

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Protein
Lipopolysaccharide biosynthesis protein WzxC
Gene
wzxC, wzx, b2046, JW2031
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Pathwayi

GO - Biological processi

  1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7097-MONOMER.
ECOL316407:JW2031-MONOMER.
UniPathwayiUPA00030.

Protein family/group databases

TCDBi2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide biosynthesis protein WzxC
Gene namesi
Name:wzxC
Synonyms:wzx
Ordered Locus Names:b2046, JW2031
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13576. wzxC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Topological domaini34 – 429Periplasmic Reviewed prediction
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Topological domaini64 – 8118Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 1042Periplasmic Reviewed prediction
Transmembranei105 – 12521Helical; Reviewed prediction
Add
BLAST
Topological domaini126 – 15732Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei158 – 17821Helical; Reviewed prediction
Add
BLAST
Topological domaini179 – 23658Periplasmic Reviewed prediction
Add
BLAST
Transmembranei237 – 25721Helical; Reviewed prediction
Add
BLAST
Topological domaini258 – 28831Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei289 – 30921Helical; Reviewed prediction
Add
BLAST
Topological domaini310 – 32213Periplasmic Reviewed prediction
Add
BLAST
Transmembranei323 – 34321Helical; Reviewed prediction
Add
BLAST
Topological domaini344 – 36421Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei365 – 38521Helical; Reviewed prediction
Add
BLAST
Topological domaini386 – 3861Periplasmic Reviewed prediction
Transmembranei387 – 40721Helical; Reviewed prediction
Add
BLAST
Topological domaini408 – 41710Cytoplasmic Reviewed prediction
Transmembranei418 – 43821Helical; Reviewed prediction
Add
BLAST
Topological domaini439 – 4457Periplasmic Reviewed prediction
Transmembranei446 – 46621Helical; Reviewed prediction
Add
BLAST
Topological domaini467 – 49226Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Lipopolysaccharide biosynthesis protein WzxC
PRO_0000166453Add
BLAST

Proteomic databases

PaxDbiP77377.
PRIDEiP77377.

Expressioni

Gene expression databases

GenevestigatoriP77377.

Interactioni

Protein-protein interaction databases

DIPiDIP-11136N.
IntActiP77377. 1 interaction.
MINTiMINT-1312635.
STRINGi511145.b2046.

Structurei

3D structure databases

ProteinModelPortaliP77377.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2244.
HOGENOMiHOG000121955.
KOiK16695.
OMAiVEMKRQF.
OrthoDBiEOG6WHNQ7.
PhylomeDBiP77377.

Family and domain databases

InterProiIPR002797. Polysacc_synth.
[Graphical view]
PfamiPF01943. Polysacc_synt. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77377-1 [UniParc]FASTAAdd to Basket

« Hide

MSLREKTISG AKWSAIATVI IIGLGLVQMT VLARIIDNHQ FGLLTVSLVI    50
IALADTLSDF GIANSIIQRK EISHLELTTL YWLNVGLGIV VCVAVFLLSD 100
LIGDVLNNPD LAPLIKTLSL AFVVIPHGQQ FRALMQKELE FNKIGMIETS 150
AVLAGFTCTV VSAHFWPLAM TAILGYLVNS AVRTLLFGYF GRKIYRPGLH 200
FSLASVAPNL RFGAWLTADS IINYLNTNLS TLVLARILGA GVAGGYNLAY 250
NVAVVPPMKL NPIITRVLFP AFAKIQDDTE KLRVNFYKLL SVVGIINFPA 300
LLGLMVVSNN FVPLVFGEKW NSIIPVLQLL CVVGLLRSVG NPIGSLLMAK 350
ARVDISFKFN VFKTFLFIPA IVIGGQMAGA IGVTLGFLLV QIINTILSYF 400
VMIKPVLGSS YRQYILSLWL PFYLSLPTLV VSYALGIVLK GQLALGMLLA 450
VQIATGVLAF VVMIVLSRHP LVVEVKRQFC RSEKMKMLLR AG 492
Length:492
Mass (Da):53,693
Last modified:February 1, 1997 - v1
Checksum:i893E505759363A80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38473 Genomic DNA. Translation: AAC77849.1.
U00096 Genomic DNA. Translation: AAC75107.1.
AP009048 Genomic DNA. Translation: BAA15899.1.
PIRiE64970.
RefSeqiNP_416550.1. NC_000913.3.
YP_490288.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75107; AAC75107; b2046.
BAA15899; BAA15899; BAA15899.
GeneIDi12934319.
946581.
KEGGiecj:Y75_p2009.
eco:b2046.
PATRICi32119425. VBIEscCol129921_2123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38473 Genomic DNA. Translation: AAC77849.1 .
U00096 Genomic DNA. Translation: AAC75107.1 .
AP009048 Genomic DNA. Translation: BAA15899.1 .
PIRi E64970.
RefSeqi NP_416550.1. NC_000913.3.
YP_490288.1. NC_007779.1.

3D structure databases

ProteinModelPortali P77377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-11136N.
IntActi P77377. 1 interaction.
MINTi MINT-1312635.
STRINGi 511145.b2046.

Protein family/group databases

TCDBi 2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Proteomic databases

PaxDbi P77377.
PRIDEi P77377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75107 ; AAC75107 ; b2046 .
BAA15899 ; BAA15899 ; BAA15899 .
GeneIDi 12934319.
946581.
KEGGi ecj:Y75_p2009.
eco:b2046.
PATRICi 32119425. VBIEscCol129921_2123.

Organism-specific databases

EchoBASEi EB3346.
EcoGenei EG13576. wzxC.

Phylogenomic databases

eggNOGi COG2244.
HOGENOMi HOG000121955.
KOi K16695.
OMAi VEMKRQF.
OrthoDBi EOG6WHNQ7.
PhylomeDBi P77377.

Enzyme and pathway databases

UniPathwayi UPA00030 .
BioCyci EcoCyc:G7097-MONOMER.
ECOL316407:JW2031-MONOMER.

Miscellaneous databases

PROi P77377.

Gene expression databases

Genevestigatori P77377.

Family and domain databases

InterProi IPR002797. Polysacc_synth.
[Graphical view ]
Pfami PF01943. Polysacc_synt. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid."
    Stevenson G., Andrianopoulos K., Hobbs M., Reeves P.R.
    J. Bacteriol. 178:4885-4893(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiWZXC_ECOLI
AccessioniPrimary (citable) accession number: P77377
Secondary accession number(s): O08001, O08002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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