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P77377

- WZXC_ECOLI

UniProt

P77377 - WZXC_ECOLI

Protein

Lipopolysaccharide biosynthesis protein WzxC

Gene

wzxC

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Pathwayi

    GO - Biological processi

    1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciEcoCyc:G7097-MONOMER.
    ECOL316407:JW2031-MONOMER.
    UniPathwayiUPA00030.

    Protein family/group databases

    TCDBi2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipopolysaccharide biosynthesis protein WzxC
    Gene namesi
    Name:wzxC
    Synonyms:wzx
    Ordered Locus Names:b2046, JW2031
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13576. wzxC.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Lipopolysaccharide biosynthesis protein WzxCPRO_0000166453Add
    BLAST

    Proteomic databases

    PaxDbiP77377.
    PRIDEiP77377.

    Expressioni

    Gene expression databases

    GenevestigatoriP77377.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-11136N.
    IntActiP77377. 1 interaction.
    MINTiMINT-1312635.
    STRINGi511145.b2046.

    Structurei

    3D structure databases

    ProteinModelPortaliP77377.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini34 – 429PeriplasmicSequence Analysis
    Topological domaini64 – 8118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 1042PeriplasmicSequence Analysis
    Topological domaini126 – 15732CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 23658PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 28831CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini310 – 32213PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini344 – 36421CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini386 – 3861PeriplasmicSequence Analysis
    Topological domaini408 – 41710CytoplasmicSequence Analysis
    Topological domaini439 – 4457PeriplasmicSequence Analysis
    Topological domaini467 – 49226CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polysaccharide synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2244.
    HOGENOMiHOG000121955.
    KOiK16695.
    OMAiVEMKRQF.
    OrthoDBiEOG6WHNQ7.
    PhylomeDBiP77377.

    Family and domain databases

    InterProiIPR002797. Polysacc_synth.
    [Graphical view]
    PfamiPF01943. Polysacc_synt. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P77377-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLREKTISG AKWSAIATVI IIGLGLVQMT VLARIIDNHQ FGLLTVSLVI    50
    IALADTLSDF GIANSIIQRK EISHLELTTL YWLNVGLGIV VCVAVFLLSD 100
    LIGDVLNNPD LAPLIKTLSL AFVVIPHGQQ FRALMQKELE FNKIGMIETS 150
    AVLAGFTCTV VSAHFWPLAM TAILGYLVNS AVRTLLFGYF GRKIYRPGLH 200
    FSLASVAPNL RFGAWLTADS IINYLNTNLS TLVLARILGA GVAGGYNLAY 250
    NVAVVPPMKL NPIITRVLFP AFAKIQDDTE KLRVNFYKLL SVVGIINFPA 300
    LLGLMVVSNN FVPLVFGEKW NSIIPVLQLL CVVGLLRSVG NPIGSLLMAK 350
    ARVDISFKFN VFKTFLFIPA IVIGGQMAGA IGVTLGFLLV QIINTILSYF 400
    VMIKPVLGSS YRQYILSLWL PFYLSLPTLV VSYALGIVLK GQLALGMLLA 450
    VQIATGVLAF VVMIVLSRHP LVVEVKRQFC RSEKMKMLLR AG 492
    Length:492
    Mass (Da):53,693
    Last modified:February 1, 1997 - v1
    Checksum:i893E505759363A80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38473 Genomic DNA. Translation: AAC77849.1.
    U00096 Genomic DNA. Translation: AAC75107.1.
    AP009048 Genomic DNA. Translation: BAA15899.1.
    PIRiE64970.
    RefSeqiNP_416550.1. NC_000913.3.
    YP_490288.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75107; AAC75107; b2046.
    BAA15899; BAA15899; BAA15899.
    GeneIDi12934319.
    946581.
    KEGGiecj:Y75_p2009.
    eco:b2046.
    PATRICi32119425. VBIEscCol129921_2123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38473 Genomic DNA. Translation: AAC77849.1 .
    U00096 Genomic DNA. Translation: AAC75107.1 .
    AP009048 Genomic DNA. Translation: BAA15899.1 .
    PIRi E64970.
    RefSeqi NP_416550.1. NC_000913.3.
    YP_490288.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P77377.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-11136N.
    IntActi P77377. 1 interaction.
    MINTi MINT-1312635.
    STRINGi 511145.b2046.

    Protein family/group databases

    TCDBi 2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

    Proteomic databases

    PaxDbi P77377.
    PRIDEi P77377.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75107 ; AAC75107 ; b2046 .
    BAA15899 ; BAA15899 ; BAA15899 .
    GeneIDi 12934319.
    946581.
    KEGGi ecj:Y75_p2009.
    eco:b2046.
    PATRICi 32119425. VBIEscCol129921_2123.

    Organism-specific databases

    EchoBASEi EB3346.
    EcoGenei EG13576. wzxC.

    Phylogenomic databases

    eggNOGi COG2244.
    HOGENOMi HOG000121955.
    KOi K16695.
    OMAi VEMKRQF.
    OrthoDBi EOG6WHNQ7.
    PhylomeDBi P77377.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    BioCyci EcoCyc:G7097-MONOMER.
    ECOL316407:JW2031-MONOMER.

    Miscellaneous databases

    PROi P77377.

    Gene expression databases

    Genevestigatori P77377.

    Family and domain databases

    InterProi IPR002797. Polysacc_synth.
    [Graphical view ]
    Pfami PF01943. Polysacc_synt. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid."
      Stevenson G., Andrianopoulos K., Hobbs M., Reeves P.R.
      J. Bacteriol. 178:4885-4893(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "Global topology analysis of the Escherichia coli inner membrane proteome."
      Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
      Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiWZXC_ECOLI
    AccessioniPrimary (citable) accession number: P77377
    Secondary accession number(s): O08001, O08002
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3