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Protein

Lipopolysaccharide biosynthesis protein WzxC

Gene

wzxC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7097-MONOMER.
ECOL316407:JW2031-MONOMER.
UniPathwayiUPA00030.

Protein family/group databases

TCDBi2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide biosynthesis protein WzxC
Gene namesi
Name:wzxC
Synonyms:wzx
Ordered Locus Names:b2046, JW2031
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13576. wzxC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 42PeriplasmicSequence analysis9
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 81CytoplasmicSequence analysisAdd BLAST18
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 104PeriplasmicSequence analysis2
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 157CytoplasmicSequence analysisAdd BLAST32
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 236PeriplasmicSequence analysisAdd BLAST58
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 288CytoplasmicSequence analysisAdd BLAST31
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 322PeriplasmicSequence analysisAdd BLAST13
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 364CytoplasmicSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386PeriplasmicSequence analysis1
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 417CytoplasmicSequence analysis10
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 445PeriplasmicSequence analysis7
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 492CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001664531 – 492Lipopolysaccharide biosynthesis protein WzxCAdd BLAST492

Proteomic databases

PaxDbiP77377.
PRIDEiP77377.

Interactioni

Protein-protein interaction databases

BioGridi4263313. 412 interactors.
DIPiDIP-11136N.
IntActiP77377. 1 interactor.
MINTiMINT-1312635.
STRINGi511145.b2046.

Structurei

3D structure databases

ProteinModelPortaliP77377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polysaccharide synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105PSV. Bacteria.
COG2244. LUCA.
HOGENOMiHOG000121955.
InParanoidiP77377.
KOiK16695.
OMAiEMKRQFC.
PhylomeDBiP77377.

Sequencei

Sequence statusi: Complete.

P77377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLREKTISG AKWSAIATVI IIGLGLVQMT VLARIIDNHQ FGLLTVSLVI
60 70 80 90 100
IALADTLSDF GIANSIIQRK EISHLELTTL YWLNVGLGIV VCVAVFLLSD
110 120 130 140 150
LIGDVLNNPD LAPLIKTLSL AFVVIPHGQQ FRALMQKELE FNKIGMIETS
160 170 180 190 200
AVLAGFTCTV VSAHFWPLAM TAILGYLVNS AVRTLLFGYF GRKIYRPGLH
210 220 230 240 250
FSLASVAPNL RFGAWLTADS IINYLNTNLS TLVLARILGA GVAGGYNLAY
260 270 280 290 300
NVAVVPPMKL NPIITRVLFP AFAKIQDDTE KLRVNFYKLL SVVGIINFPA
310 320 330 340 350
LLGLMVVSNN FVPLVFGEKW NSIIPVLQLL CVVGLLRSVG NPIGSLLMAK
360 370 380 390 400
ARVDISFKFN VFKTFLFIPA IVIGGQMAGA IGVTLGFLLV QIINTILSYF
410 420 430 440 450
VMIKPVLGSS YRQYILSLWL PFYLSLPTLV VSYALGIVLK GQLALGMLLA
460 470 480 490
VQIATGVLAF VVMIVLSRHP LVVEVKRQFC RSEKMKMLLR AG
Length:492
Mass (Da):53,693
Last modified:February 1, 1997 - v1
Checksum:i893E505759363A80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77849.1.
U00096 Genomic DNA. Translation: AAC75107.1.
AP009048 Genomic DNA. Translation: BAA15899.1.
PIRiE64970.
RefSeqiNP_416550.1. NC_000913.3.
WP_000058424.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75107; AAC75107; b2046.
BAA15899; BAA15899; BAA15899.
GeneIDi946581.
KEGGiecj:JW2031.
eco:b2046.
PATRICi32119425. VBIEscCol129921_2123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77849.1.
U00096 Genomic DNA. Translation: AAC75107.1.
AP009048 Genomic DNA. Translation: BAA15899.1.
PIRiE64970.
RefSeqiNP_416550.1. NC_000913.3.
WP_000058424.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263313. 412 interactors.
DIPiDIP-11136N.
IntActiP77377. 1 interactor.
MINTiMINT-1312635.
STRINGi511145.b2046.

Protein family/group databases

TCDBi2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Proteomic databases

PaxDbiP77377.
PRIDEiP77377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75107; AAC75107; b2046.
BAA15899; BAA15899; BAA15899.
GeneIDi946581.
KEGGiecj:JW2031.
eco:b2046.
PATRICi32119425. VBIEscCol129921_2123.

Organism-specific databases

EchoBASEiEB3346.
EcoGeneiEG13576. wzxC.

Phylogenomic databases

eggNOGiENOG4105PSV. Bacteria.
COG2244. LUCA.
HOGENOMiHOG000121955.
InParanoidiP77377.
KOiK16695.
OMAiEMKRQFC.
PhylomeDBiP77377.

Enzyme and pathway databases

UniPathwayiUPA00030.
BioCyciEcoCyc:G7097-MONOMER.
ECOL316407:JW2031-MONOMER.

Miscellaneous databases

PROiP77377.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiWZXC_ECOLI
AccessioniPrimary (citable) accession number: P77377
Secondary accession number(s): O08001, O08002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.