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Protein

Lipopolysaccharide biosynthesis protein WzxC

Gene

wzxC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Pathway:ilipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7097-MONOMER.
ECOL316407:JW2031-MONOMER.
UniPathwayiUPA00030.

Protein family/group databases

TCDBi2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide biosynthesis protein WzxC
Gene namesi
Name:wzxC
Synonyms:wzx
Ordered Locus Names:b2046, JW2031
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13576. wzxC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 429PeriplasmicSequence Analysis
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Topological domaini64 – 8118CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 1042PeriplasmicSequence Analysis
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 15732CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Topological domaini179 – 23658PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Topological domaini258 – 28831CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence AnalysisAdd
BLAST
Topological domaini310 – 32213PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST
Topological domaini344 – 36421CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence AnalysisAdd
BLAST
Topological domaini386 – 3861PeriplasmicSequence Analysis
Transmembranei387 – 40721HelicalSequence AnalysisAdd
BLAST
Topological domaini408 – 41710CytoplasmicSequence Analysis
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Topological domaini439 – 4457PeriplasmicSequence Analysis
Transmembranei446 – 46621HelicalSequence AnalysisAdd
BLAST
Topological domaini467 – 49226CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Lipopolysaccharide biosynthesis protein WzxCPRO_0000166453Add
BLAST

Proteomic databases

PaxDbiP77377.
PRIDEiP77377.

Interactioni

Protein-protein interaction databases

DIPiDIP-11136N.
IntActiP77377. 1 interaction.
MINTiMINT-1312635.
STRINGi511145.b2046.

Structurei

3D structure databases

ProteinModelPortaliP77377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polysaccharide synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2244.
HOGENOMiHOG000121955.
InParanoidiP77377.
KOiK16695.
OMAiADLAFYW.
OrthoDBiEOG6WHNQ7.
PhylomeDBiP77377.

Family and domain databases

InterProiIPR002797. Polysacc_synth.
[Graphical view]
PfamiPF01943. Polysacc_synt. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLREKTISG AKWSAIATVI IIGLGLVQMT VLARIIDNHQ FGLLTVSLVI
60 70 80 90 100
IALADTLSDF GIANSIIQRK EISHLELTTL YWLNVGLGIV VCVAVFLLSD
110 120 130 140 150
LIGDVLNNPD LAPLIKTLSL AFVVIPHGQQ FRALMQKELE FNKIGMIETS
160 170 180 190 200
AVLAGFTCTV VSAHFWPLAM TAILGYLVNS AVRTLLFGYF GRKIYRPGLH
210 220 230 240 250
FSLASVAPNL RFGAWLTADS IINYLNTNLS TLVLARILGA GVAGGYNLAY
260 270 280 290 300
NVAVVPPMKL NPIITRVLFP AFAKIQDDTE KLRVNFYKLL SVVGIINFPA
310 320 330 340 350
LLGLMVVSNN FVPLVFGEKW NSIIPVLQLL CVVGLLRSVG NPIGSLLMAK
360 370 380 390 400
ARVDISFKFN VFKTFLFIPA IVIGGQMAGA IGVTLGFLLV QIINTILSYF
410 420 430 440 450
VMIKPVLGSS YRQYILSLWL PFYLSLPTLV VSYALGIVLK GQLALGMLLA
460 470 480 490
VQIATGVLAF VVMIVLSRHP LVVEVKRQFC RSEKMKMLLR AG
Length:492
Mass (Da):53,693
Last modified:February 1, 1997 - v1
Checksum:i893E505759363A80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77849.1.
U00096 Genomic DNA. Translation: AAC75107.1.
AP009048 Genomic DNA. Translation: BAA15899.1.
PIRiE64970.
RefSeqiNP_416550.1. NC_000913.3.
WP_000058424.1. NZ_CP010445.1.

Genome annotation databases

EnsemblBacteriaiAAC75107; AAC75107; b2046.
BAA15899; BAA15899; BAA15899.
GeneIDi946581.
KEGGieco:b2046.
PATRICi32119425. VBIEscCol129921_2123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA. Translation: AAC77849.1.
U00096 Genomic DNA. Translation: AAC75107.1.
AP009048 Genomic DNA. Translation: BAA15899.1.
PIRiE64970.
RefSeqiNP_416550.1. NC_000913.3.
WP_000058424.1. NZ_CP010445.1.

3D structure databases

ProteinModelPortaliP77377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-11136N.
IntActiP77377. 1 interaction.
MINTiMINT-1312635.
STRINGi511145.b2046.

Protein family/group databases

TCDBi2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Proteomic databases

PaxDbiP77377.
PRIDEiP77377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75107; AAC75107; b2046.
BAA15899; BAA15899; BAA15899.
GeneIDi946581.
KEGGieco:b2046.
PATRICi32119425. VBIEscCol129921_2123.

Organism-specific databases

EchoBASEiEB3346.
EcoGeneiEG13576. wzxC.

Phylogenomic databases

eggNOGiCOG2244.
HOGENOMiHOG000121955.
InParanoidiP77377.
KOiK16695.
OMAiADLAFYW.
OrthoDBiEOG6WHNQ7.
PhylomeDBiP77377.

Enzyme and pathway databases

UniPathwayiUPA00030.
BioCyciEcoCyc:G7097-MONOMER.
ECOL316407:JW2031-MONOMER.

Miscellaneous databases

PROiP77377.

Family and domain databases

InterProiIPR002797. Polysacc_synth.
[Graphical view]
PfamiPF01943. Polysacc_synt. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid."
    Stevenson G., Andrianopoulos K., Hobbs M., Reeves P.R.
    J. Bacteriol. 178:4885-4893(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiWZXC_ECOLI
AccessioniPrimary (citable) accession number: P77377
Secondary accession number(s): O08001, O08002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: July 22, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.