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P77377

- WZXC_ECOLI

UniProt

P77377 - WZXC_ECOLI

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Protein

Lipopolysaccharide biosynthesis protein WzxC

Gene

wzxC

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Pathwayi

GO - Biological processi

  1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:G7097-MONOMER.
ECOL316407:JW2031-MONOMER.
UniPathwayiUPA00030.

Protein family/group databases

TCDBi2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide biosynthesis protein WzxC
Gene namesi
Name:wzxC
Synonyms:wzx
Ordered Locus Names:b2046, JW2031
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13576. wzxC.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Lipopolysaccharide biosynthesis protein WzxCPRO_0000166453Add
BLAST

Proteomic databases

PaxDbiP77377.
PRIDEiP77377.

Expressioni

Gene expression databases

GenevestigatoriP77377.

Interactioni

Protein-protein interaction databases

DIPiDIP-11136N.
IntActiP77377. 1 interaction.
MINTiMINT-1312635.
STRINGi511145.b2046.

Structurei

3D structure databases

ProteinModelPortaliP77377.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini34 – 429PeriplasmicSequence Analysis
Topological domaini64 – 8118CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini103 – 1042PeriplasmicSequence Analysis
Topological domaini126 – 15732CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini179 – 23658PeriplasmicSequence AnalysisAdd
BLAST
Topological domaini258 – 28831CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini310 – 32213PeriplasmicSequence AnalysisAdd
BLAST
Topological domaini344 – 36421CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini386 – 3861PeriplasmicSequence Analysis
Topological domaini408 – 41710CytoplasmicSequence Analysis
Topological domaini439 – 4457PeriplasmicSequence Analysis
Topological domaini467 – 49226CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence AnalysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence AnalysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the polysaccharide synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2244.
HOGENOMiHOG000121955.
InParanoidiP77377.
KOiK16695.
OMAiVEMKRQF.
OrthoDBiEOG6WHNQ7.
PhylomeDBiP77377.

Family and domain databases

InterProiIPR002797. Polysacc_synth.
[Graphical view]
PfamiPF01943. Polysacc_synt. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77377-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLREKTISG AKWSAIATVI IIGLGLVQMT VLARIIDNHQ FGLLTVSLVI
60 70 80 90 100
IALADTLSDF GIANSIIQRK EISHLELTTL YWLNVGLGIV VCVAVFLLSD
110 120 130 140 150
LIGDVLNNPD LAPLIKTLSL AFVVIPHGQQ FRALMQKELE FNKIGMIETS
160 170 180 190 200
AVLAGFTCTV VSAHFWPLAM TAILGYLVNS AVRTLLFGYF GRKIYRPGLH
210 220 230 240 250
FSLASVAPNL RFGAWLTADS IINYLNTNLS TLVLARILGA GVAGGYNLAY
260 270 280 290 300
NVAVVPPMKL NPIITRVLFP AFAKIQDDTE KLRVNFYKLL SVVGIINFPA
310 320 330 340 350
LLGLMVVSNN FVPLVFGEKW NSIIPVLQLL CVVGLLRSVG NPIGSLLMAK
360 370 380 390 400
ARVDISFKFN VFKTFLFIPA IVIGGQMAGA IGVTLGFLLV QIINTILSYF
410 420 430 440 450
VMIKPVLGSS YRQYILSLWL PFYLSLPTLV VSYALGIVLK GQLALGMLLA
460 470 480 490
VQIATGVLAF VVMIVLSRHP LVVEVKRQFC RSEKMKMLLR AG
Length:492
Mass (Da):53,693
Last modified:February 1, 1997 - v1
Checksum:i893E505759363A80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38473 Genomic DNA. Translation: AAC77849.1.
U00096 Genomic DNA. Translation: AAC75107.1.
AP009048 Genomic DNA. Translation: BAA15899.1.
PIRiE64970.
RefSeqiNP_416550.1. NC_000913.3.
YP_490288.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75107; AAC75107; b2046.
BAA15899; BAA15899; BAA15899.
GeneIDi12934319.
946581.
KEGGiecj:Y75_p2009.
eco:b2046.
PATRICi32119425. VBIEscCol129921_2123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38473 Genomic DNA. Translation: AAC77849.1 .
U00096 Genomic DNA. Translation: AAC75107.1 .
AP009048 Genomic DNA. Translation: BAA15899.1 .
PIRi E64970.
RefSeqi NP_416550.1. NC_000913.3.
YP_490288.1. NC_007779.1.

3D structure databases

ProteinModelPortali P77377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-11136N.
IntActi P77377. 1 interaction.
MINTi MINT-1312635.
STRINGi 511145.b2046.

Protein family/group databases

TCDBi 2.A.66.2.7. the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.

Proteomic databases

PaxDbi P77377.
PRIDEi P77377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75107 ; AAC75107 ; b2046 .
BAA15899 ; BAA15899 ; BAA15899 .
GeneIDi 12934319.
946581.
KEGGi ecj:Y75_p2009.
eco:b2046.
PATRICi 32119425. VBIEscCol129921_2123.

Organism-specific databases

EchoBASEi EB3346.
EcoGenei EG13576. wzxC.

Phylogenomic databases

eggNOGi COG2244.
HOGENOMi HOG000121955.
InParanoidi P77377.
KOi K16695.
OMAi VEMKRQF.
OrthoDBi EOG6WHNQ7.
PhylomeDBi P77377.

Enzyme and pathway databases

UniPathwayi UPA00030 .
BioCyci EcoCyc:G7097-MONOMER.
ECOL316407:JW2031-MONOMER.

Miscellaneous databases

PROi P77377.

Gene expression databases

Genevestigatori P77377.

Family and domain databases

InterProi IPR002797. Polysacc_synth.
[Graphical view ]
Pfami PF01943. Polysacc_synt. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid."
    Stevenson G., Andrianopoulos K., Hobbs M., Reeves P.R.
    J. Bacteriol. 178:4885-4893(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiWZXC_ECOLI
AccessioniPrimary (citable) accession number: P77377
Secondary accession number(s): O08001, O08002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3