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Protein

Putative dimethyl sulfoxide reductase chain YnfE

Gene

ynfE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi60Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi64Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi96Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi196MolybdenumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciEcoCyc:G6845-MONOMER
MetaCyc:G6845-MONOMER

Protein family/group databases

TCDBi5.A.3.3.1 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dimethyl sulfoxide reductase chain YnfE (EC:1.8.99.-)
Short name:
DMSO reductase
Gene namesi
Name:ynfE
Ordered Locus Names:b1587, JW1579
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13843 ynfE

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Tat-type signalPROSITE-ProRule annotationAdd BLAST43
ChainiPRO_000001914744 – 808Putative dimethyl sulfoxide reductase chain YnfEAdd BLAST765

Post-translational modificationi

Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Proteomic databases

PaxDbiP77374
PRIDEiP77374

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
dmsDP698533EBI-556186,EBI-4406374

Protein-protein interaction databases

BioGridi4261571, 9 interactors
DIPiDIP-12765N
IntActiP77374, 5 interactors
STRINGi316385.ECDH10B_1720

Structurei

3D structure databases

ProteinModelPortaliP77374
SMRiP77374
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 1104Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4107QY8 Bacteria
COG0243 LUCA
HOGENOMiHOG000284390
InParanoidiP77374
KOiK07309
OMAiFGFHYKA
PhylomeDBiP77374

Family and domain databases

InterProiView protein in InterPro
IPR011888 Anaer_DMSO_reductase
IPR009010 Asp_de-COase-like_dom_sf
IPR006657 MoPterin_dinucl-bd_dom
IPR006656 Mopterin_OxRdtase
IPR006963 Mopterin_OxRdtase_4Fe-4S_dom
IPR006655 Mopterin_OxRdtase_prok_CS
IPR006311 TAT_signal
PfamiView protein in Pfam
PF04879 Molybdop_Fe4S4, 1 hit
PF00384 Molybdopterin, 1 hit
PF01568 Molydop_binding, 1 hit
SMARTiView protein in SMART
SM00926 Molybdop_Fe4S4, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
TIGRFAMsiTIGR02166 dmsA_ynfE, 1 hit
PROSITEiView protein in PROSITE
PS51669 4FE4S_MOW_BIS_MGD, 1 hit
PS00932 MOLYBDOPTERIN_PROK_3, 1 hit
PS51318 TAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNERMVGI SRRTLVKSTA IGSLALAAGG FSLPFTLRNA AAAVQQAREK
60 70 80 90 100
VVWGACSVNC GSRCALRLHV KDNEVTWVET DNTGSDEYGN HQVRACLRGR
110 120 130 140 150
SIRRRINHPD RLNYPMKRVG KRGEGKFERI SWDEALDTIA SSLKKTVEQY
160 170 180 190 200
GNEAVYIQYS SGIVGGNMTR SSPSASAVKR LMNCYGGSLN QYGSYSTAQI
210 220 230 240 250
SCAMPYTYGS NDGNSTTDIE NSKLVVMFGN NPAETRMSGG GITYLLEKAR
260 270 280 290 300
EKSNAKMIVI DPRYTDTAAG REDEWLPIRP GTDAALVAGI AWVLINENLV
310 320 330 340 350
DQPFLDKYCV GYDEKTLPAD APKNGHYKAY ILGEGDDKTA KTPQWASQIT
360 370 380 390 400
GIPEDRIIKL AREIGTAKPA YICQGWGPQR QANGELTARA IAMLPILTGN
410 420 430 440 450
VGISGGNSGA RESTYTITIE RLPVLDNPVK TSISCFSWTD AIDHGPQMTA
460 470 480 490 500
IRDGVRGKDK LDVPIKFIWN YAGNTLVNQH SDINKTHEIL QDESKCEMIV
510 520 530 540 550
VIENFMTSSA KYADILLPDL MTVEQEDIIP NDYAGNMGYL IFLQPVTSEK
560 570 580 590 600
FERKPIYWIL SEVAKRLGPD VYQKFTEGRT QEQWLQHLYA KMLAKDPALP
610 620 630 640 650
SYDELKKMGI YKRKDPNGHF VAYKAFRDDP EANPLKTPSG KIEIYSSRLA
660 670 680 690 700
EIARTWELEK DEVISPLPVY ASTFEGWNSP ERRTFPLQLF GFHYKSRTHS
710 720 730 740 750
TYGNIDLLKA ACRQEVWINP IDAQKRGIAN GDMVRVFNHR GEVRLPAKVT
760 770 780 790 800
PRILPGVSAM GQGAWHEANM SGDKIDHGGC VNTLTTLRPS PLAKGNPQHT

NLVEIEKI
Length:808
Mass (Da):89,780
Last modified:February 1, 1997 - v1
Checksum:iE7A6A626C9E46449
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74659.1
AP009048 Genomic DNA Translation: BAA15311.1
PIRiE64914
RefSeqiNP_416104.1, NC_000913.3
WP_000041675.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74659; AAC74659; b1587
BAA15311; BAA15311; BAA15311
GeneIDi946135
KEGGiecj:JW1579
eco:b1587
PATRICifig|1411691.4.peg.675

Similar proteinsi

Entry informationi

Entry nameiYNFE_ECOLI
AccessioniPrimary (citable) accession number: P77374
Secondary accession number(s): P77291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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