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Protein

HTH-type transcriptional regulator PgrR

Gene

pgrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 40H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • sequence-specific DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central

GO - Biological processi

  • bacterial-type flagellum-dependent swarming motility Source: EcoCyc
  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: EcoCyc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G6664-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator PgrR
Alternative name(s):
Regulator of PG recycling
Gene namesi
Name:pgrR
Synonyms:ycjZ
Ordered Locus Names:b1328, JW1321
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13923. pgrR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001057821 – 299HTH-type transcriptional regulator PgrRAdd BLAST299

Proteomic databases

PaxDbiP77333.
PRIDEiP77333.

Interactioni

Protein-protein interaction databases

BioGridi4260154. 13 interactors.
DIPiDIP-11617N.
IntActiP77333. 7 interactors.
STRINGi316385.ECDH10B_1448.

Structurei

3D structure databases

ProteinModelPortaliP77333.
SMRiP77333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 61HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105EQ2. Bacteria.
ENOG410XRUN. LUCA.
HOGENOMiHOG000233519.
InParanoidiP77333.
PhylomeDBiP77333.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50931. HTH_LYSR. 1 hit.

Sequencei

Sequence statusi: Complete.

P77333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKREEIADLM AFVVVAEERS FTRAAARLSM AQSALSQIVR RIEERLGLRL
60 70 80 90 100
LTRTTRSVVP TEAGEHLLSV LGPMLHDIDS AMASLSDLQN RPSGTIRITT
110 120 130 140 150
VEHAAKTILL PAMRTFLKSH PEIDIQLTID YGLTDVVSER FDAGVRLGGE
160 170 180 190 200
MDKDMIAIRI GPDIPMAIVG SPDYFSRRSV PTSVSQLIDH QAINLYLPTS
210 220 230 240 250
GTANRWRLIR GGREVRVRME GQLLLNTIDL IIDAAIDGHG LAYLPYDQVE
260 270 280 290
RAIKEKKLIR VLDKFTPDLP GYHLYYPHRR HAGSAFSLFI DRLKYKGAV
Length:299
Mass (Da):33,482
Last modified:February 1, 1997 - v1
Checksum:i05FB892DD7D19413
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74410.1.
AP009048 Genomic DNA. Translation: BAA14921.1.
PIRiC64882.
RefSeqiNP_415844.1. NC_000913.3.
WP_000817708.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74410; AAC74410; b1328.
BAA14921; BAA14921; BAA14921.
GeneIDi945930.
KEGGiecj:JW1321.
eco:b1328.
PATRICifig|511145.12.peg.1386.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPGRR_ECOLI
AccessioniPrimary (citable) accession number: P77333
Secondary accession number(s): P76841
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene