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P77328 (YBBY_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative purine permease YbbY
Gene names
Name:ybbY
Synonyms:glxB4
Ordered Locus Names:b0513, JW0501
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Induction

By glyoxylate.

Sequence similarities

Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. [View classification]

Sequence caution

The sequence AAB40265.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Putative purine permease YbbY
PRO_0000165963

Regions

Topological domain1 – 1717Periplasmic Potential
Transmembrane18 – 3821Helical; Potential
Topological domain39 – 424Cytoplasmic Potential
Transmembrane43 – 6321Helical; Potential
Topological domain64 – 685Periplasmic Potential
Transmembrane69 – 8921Helical; Potential
Topological domain90 – 10213Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 1307Periplasmic Potential
Transmembrane131 – 15121Helical; Potential
Topological domain152 – 16918Cytoplasmic Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 1966Periplasmic Potential
Transmembrane197 – 21721Helical; Potential
Topological domain218 – 23013Cytoplasmic Potential
Transmembrane231 – 25121Helical; Potential
Topological domain252 – 28837Periplasmic Potential
Transmembrane289 – 30921Helical; Potential
Topological domain310 – 31910Cytoplasmic Potential
Transmembrane320 – 34021Helical; Potential
Topological domain341 – 3455Periplasmic Potential
Transmembrane346 – 36621Helical; Potential
Topological domain367 – 37913Cytoplasmic Potential
Transmembrane380 – 40021Helical; Potential
Topological domain401 – 4077Periplasmic Potential
Transmembrane408 – 42821Helical; Potential
Topological domain429 – 4335Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P77328 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 0728F25A521B2193

FASTA43347,239
        10         20         30         40         50         60 
MFNFAVSRES LLSGFQWFFF IFCNTVVVPP TLLSAFQLPQ SSLLTLTQYA FLATALACFA 

        70         80         90        100        110        120 
QAFCGHRRAI MEGPGGLWWG TILTITLGEA SRGTPINDIA TSLAVGIALS GVLTMLIGFS 

       130        140        150        160        170        180 
GLGHRLARLF TPSVMVLFML MLGAQLTTIF FKGMLGLPFG IADPNFKIQL PPFALSVAVM 

       190        200        210        220        230        240 
CLVLAMIIFL PQRFARYGLL VGTITGWLLW YFCFPSSHSL SGELHWQWFP LGSGGALSPG 

       250        260        270        280        290        300 
IILTAVITGL VNISNTYGAI RGTDVFYPQQ GAGNTRYRRS FVATGFMTLI TVPLAVIPFS 

       310        320        330        340        350        360 
PFVSSIGLLT QTGDYTRRSF IYGSVICLLV ALVPALTRLF CSIPLPVSSA VMLVSYLPLL 

       370        380        390        400        410        420 
FSALVFSQQI TFTARNIYRL ALPLFVGIFL MALPPVYLQD LPLTLRPLLS NGLLVGILLA 

       430 
VLMDNLIPWE RIE

« Hide

References

« Hide 'large scale' references
[1]"Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli."
Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J.
J. Bacteriol. 181:7479-7484(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12 / ECL1.
[2]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U89279 Genomic DNA. Translation: AAB93854.1.
U82664 Genomic DNA. Translation: AAB40265.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73615.2.
AP009048 Genomic DNA. Translation: BAE76291.1.
RefSeqNP_415046.4. NC_000913.2.
YP_488803.1. NC_007779.1.

3D structure databases

ProteinModelPortalP77328.
ModBaseSearch...

Protein-protein interaction databases

STRING511145.b0513.

Protocols and materials databases

DNASU945131.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73615; AAC73615; b0513.
BAE76291; BAE76291; BAE76291.
GeneID12930878.
945131.
KEGGecj:Y75_p0499.
eco:b0513.
PATRIC32116183. VBIEscCol129921_0533.

Organism-specific databases

EchoBASEEB3385.
EcoGeneEG13620. ybbY.

Phylogenomic databases

eggNOGCOG2233.
HOGENOMHOG000117723.
OMAEGPAGIW.
ProtClustDBPRK11412.

Enzyme and pathway databases

BioCycEcoCyc:G6282-MONOMER.
ECOL316407:JW0501-MONOMER.

Gene expression databases

GenevestigatorP77328.

Family and domain databases

InterProIPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERPTHR11119. PTHR11119. 1 hit.
PfamPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEPS01116. XANTH_URACIL_PERMASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYBBY_ECOLI
AccessionPrimary (citable) accession number: P77328
Secondary accession number(s): Q2MBR5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 1, 2000
Last modified: May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

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