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Protein

Chaperone protein HscC

Gene

hscC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable chaperone. Has ATPase activity. Not stimulated by DnaJ.

GO - Molecular functioni

  • ATPase activity Source: EcoCyc
  • ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6357-MONOMER.
ECOL316407:JW0645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HscC
Alternative name(s):
Hsc62
Gene namesi
Name:hscC
Synonyms:ybeW
Ordered Locus Names:b0650, JW0645
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13653. hscC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Chaperone protein HscCPRO_0000078659Add
BLAST

Proteomic databases

PaxDbiP77319.

Expressioni

Inductioni

By heat shock. Activated up to a temperature of 40 degrees Celsius, after which levels decrease.

Interactioni

Protein-protein interaction databases

BioGridi4263357. 10 interactions.
DIPiDIP-9942N.
IntActiP77319. 33 interactions.
STRINGi511145.b0650.

Structurei

3D structure databases

ProteinModelPortaliP77319.
SMRiP77319. Positions 5-541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105F7F. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228137.
InParanoidiP77319.
KOiK04045.
OMAiREEDWRI.
PhylomeDBiP77319.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNAELAIGI DLGTTNSLIA VWKDGAAQLI PNKFGEYLTP SIISMDENNH
60 70 80 90 100
ILVGKPAVSR RTSHPDKTAA LFKRAMGSNT NWRLGSDTFN APELSSLVLR
110 120 130 140 150
SLKEDAEEFL QRPIKDVVIS VPAYFSDEQR KHTRLAAELA GLNAVRLINE
160 170 180 190 200
PTAAAMAYGL HTQQNTRSLV FDLGGGTFDV TVLEYATPVI EVHASAGDNF
210 220 230 240 250
LGGEDFTHML VDEVLKRADV ARTTLNESEL AALYACVEAA KCSNQSPLHI
260 270 280 290 300
RWQYQEETRE CEFYENELED LWLPLLNRLR VPIEQALRDA RLKPSQIDSL
310 320 330 340 350
VLVGGASQMP LVQRIAVRLF GKLPYQSYDP STIVALGAAI QAACRLRSED
360 370 380 390 400
IEEVILTDIC PYSLGVEVNR QGVSGIFSPI IERNTTVPVS RVETYSTMHP
410 420 430 440 450
EQDSITVNVY QGENHKVKNN ILVESFDVPL KKTGAYQSID IRFSYDINGL
460 470 480 490 500
LEVDVLLEDG SVKSRVINHS PVTLSAQQIE ESRTRLSALK IYPRDMLINR
510 520 530 540 550
TFKAKLEELW ARALGDEREE IGRVITDFDA ALQSNDMARV DEVRRRASDY

LAIEIP
Length:556
Mass (Da):61,986
Last modified:February 1, 1997 - v1
Checksum:i899EBAC81F69EF8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40851.1.
U00096 Genomic DNA. Translation: AAC73751.1.
AP009048 Genomic DNA. Translation: BAA35297.1.
PIRiH64799.
RefSeqiNP_415183.1. NC_000913.3.
WP_000367875.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73751; AAC73751; b0650.
BAA35297; BAA35297; BAA35297.
GeneIDi945218.
KEGGiecj:JW0645.
eco:b0650.
PATRICi32116483. VBIEscCol129921_0681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40851.1.
U00096 Genomic DNA. Translation: AAC73751.1.
AP009048 Genomic DNA. Translation: BAA35297.1.
PIRiH64799.
RefSeqiNP_415183.1. NC_000913.3.
WP_000367875.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77319.
SMRiP77319. Positions 5-541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263357. 10 interactions.
DIPiDIP-9942N.
IntActiP77319. 33 interactions.
STRINGi511145.b0650.

Proteomic databases

PaxDbiP77319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73751; AAC73751; b0650.
BAA35297; BAA35297; BAA35297.
GeneIDi945218.
KEGGiecj:JW0645.
eco:b0650.
PATRICi32116483. VBIEscCol129921_0681.

Organism-specific databases

EchoBASEiEB3417.
EcoGeneiEG13653. hscC.

Phylogenomic databases

eggNOGiENOG4105F7F. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228137.
InParanoidiP77319.
KOiK04045.
OMAiREEDWRI.
PhylomeDBiP77319.

Enzyme and pathway databases

BioCyciEcoCyc:G6357-MONOMER.
ECOL316407:JW0645-MONOMER.

Miscellaneous databases

PROiP77319.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSCC_ECOLI
AccessioniPrimary (citable) accession number: P77319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.