P77319 (HSCC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein HscC

Alternative name(s):
Hsc62

Gene names

Name:	hscC
Synonyms:	ybeW
Ordered Locus Names:	b0650, JW0645

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable chaperone. Has ATPase activity. Not stimulated by DnaJ.
Induction	By heat shock. Activated up to a temperature of 40 degrees Celsius, after which levels decrease.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from mutant phenotype PubMed 12183460. Source: EcoCyc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from direct assay Ref.5. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Chaperone protein HscC		PRO_0000078659

Sequences

	Sequence		Length	Mass (Da)
	P77319 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 899EBAC81F69EF8F	FASTA	556	61,986
	10 20 30 40 50 60 MDNAELAIGI DLGTTNSLIA VWKDGAAQLI PNKFGEYLTP SIISMDENNH ILVGKPAVSR 70 80 90 100 110 120 RTSHPDKTAA LFKRAMGSNT NWRLGSDTFN APELSSLVLR SLKEDAEEFL QRPIKDVVIS 130 140 150 160 170 180 VPAYFSDEQR KHTRLAAELA GLNAVRLINE PTAAAMAYGL HTQQNTRSLV FDLGGGTFDV 190 200 210 220 230 240 TVLEYATPVI EVHASAGDNF LGGEDFTHML VDEVLKRADV ARTTLNESEL AALYACVEAA 250 260 270 280 290 300 KCSNQSPLHI RWQYQEETRE CEFYENELED LWLPLLNRLR VPIEQALRDA RLKPSQIDSL 310 320 330 340 350 360 VLVGGASQMP LVQRIAVRLF GKLPYQSYDP STIVALGAAI QAACRLRSED IEEVILTDIC 370 380 390 400 410 420 PYSLGVEVNR QGVSGIFSPI IERNTTVPVS RVETYSTMHP EQDSITVNVY QGENHKVKNN 430 440 450 460 470 480 ILVESFDVPL KKTGAYQSID IRFSYDINGL LEVDVLLEDG SVKSRVINHS PVTLSAQQIE 490 500 510 520 530 540 ESRTRLSALK IYPRDMLINR TFKAKLEELW ARALGDEREE IGRVITDFDA ALQSNDMARV 550 DEVRRRASDY LAIEIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Hsc62, a new DnaK homologue of Escherichia coli." Yoshimune K., Yoshimura T., Esaki N. Biochem. Biophys. Res. Commun. 250:115-118(1998) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U82598 Genomic DNA. Translation: AAB40851.1. U00096 Genomic DNA. Translation: AAC73751.1. AP009048 Genomic DNA. Translation: BAA35297.1.
PIR	H64799.
RefSeq	NP_415183.1. NC_000913.2. YP_488941.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P77319.
SMR	P77319. Positions 5-541.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9942N.
IntAct	P77319. 32 interactions.
STRING	511145.b0650.
Proteomic databases
PaxDb	P77319.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73751; AAC73751; b0650. BAA35297; BAA35297; BAA35297.
GeneID	12934363. 945218.
KEGG	ecj:Y75_p0640. eco:b0650.
PATRIC	32116483. VBIEscCol129921_0681.
Organism-specific databases
EchoBASE	EB3417.
EcoGene	EG13653. hscC.
Phylogenomic databases
eggNOG	COG0443.
HOGENOM	HOG000228137.
KO	K04045.
OMA	THMLVDD.
ProtClustDB	CLSK879716.
Enzyme and pathway databases
BioCyc	EcoCyc:G6357-MONOMER. ECOL316407:JW0645-MONOMER.
Gene expression databases
Genevestigator	P77319.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 2 hits. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSCC_ECOLI

Accession

Primary (citable) accession number: P77319

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program