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Protein

Uncharacterized sulfatase YdeN

Gene

ydeN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661CalciumBy similarity
Metal bindingi67 – 671CalciumBy similarity
Metal bindingi132 – 1321Calcium; via 3-oxoalanineBy similarity
Active sitei185 – 1851Sequence analysis
Metal bindingi345 – 3451CalciumBy similarity
Metal bindingi346 – 3461CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6788-MONOMER.
ECOL316407:JW5243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized sulfatase YdeN (EC:3.1.6.-)
Gene namesi
Name:ydeN
Ordered Locus Names:b1498, JW5243
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13796. ydeN.

Subcellular locationi

GO - Cellular componenti

  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 560531Uncharacterized sulfatase YdeNPRO_0000033449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei132 – 13213-oxoalanine (Ser)By similarity

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Proteomic databases

EPDiP77318.
PaxDbiP77318.
PRIDEiP77318.

Interactioni

Protein-protein interaction databases

BioGridi4260850. 11 interactions.
DIPiDIP-11682N.
IntActiP77318. 1 interaction.
STRINGi511145.b1498.

Structurei

3D structure databases

ProteinModelPortaliP77318.
SMRiP77318. Positions 57-528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105ENH. Bacteria.
COG3119. LUCA.
HOGENOMiHOG000135352.
InParanoidiP77318.
KOiK01138.
OMAiTPRFHPK.
PhylomeDBiP77318.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 3 hits.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSALKKSVV STSISLILAS GMAAFAAHAA DDVKLKATKT NVAFSDFTPT
60 70 80 90 100
EYSTKGKPNI IVLTMDDLGY GQLPFDKGSF DPKTMENREV VDTYKIGIDK
110 120 130 140 150
AIEAAQKSTP TLLSLMDEGV RFTNGYVAHG VSGPSRAAIM TGRAPARFGV
160 170 180 190 200
YSNTDAQDGI PLTETFLPEL FQNHGYYTAA VGKWHLSKIS NVPVPEDKQT
210 220 230 240 250
RDYHDNFTTF SAEEWQPQNR GFDYFMGFHA AGTAYYNSPS LFKNRERVPA
260 270 280 290 300
KGYISDQLTD EAIGVVDRAK TLDQPFMLYL AYNAPHLPND NPAPDQYQKQ
310 320 330 340 350
FNTGSQTADN YYASVYSVDQ GVKRILEQLK KNGQYDNTII LFTSDNGAVI
360 370 380 390 400
DGPLPLNGAQ KGYKSQTYPG GTHTPMFMWW KGKLQPGNYD KLISAMDFYP
410 420 430 440 450
TALDAADISI PKDLKLDGVS LLPWLQDKKQ GEPHKNLTWI TSYSHWFDEE
460 470 480 490 500
NIPFWDNYHK FVRHQSDDYP HNPNTEDLSQ FSYTVRNNDY SLVYTVENNQ
510 520 530 540 550
LGLYKLTDLQ QKDNLAAANP QVVKEMQGVV REFIDSSQPP LSEVNQEKFN
560
NIKKALSEAK
Length:560
Mass (Da):62,802
Last modified:December 1, 2000 - v2
Checksum:i67ED7FF7696C7A9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74571.2.
AP009048 Genomic DNA. Translation: BAA15169.2.
PIRiE64903.
RefSeqiNP_416015.2. NC_000913.3.
WP_001295684.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74571; AAC74571; b1498.
BAA15169; BAA15169; BAA15169.
GeneIDi945957.
KEGGiecj:JW5243.
eco:b1498.
PATRICi32118290. VBIEscCol129921_1565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74571.2.
AP009048 Genomic DNA. Translation: BAA15169.2.
PIRiE64903.
RefSeqiNP_416015.2. NC_000913.3.
WP_001295684.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77318.
SMRiP77318. Positions 57-528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260850. 11 interactions.
DIPiDIP-11682N.
IntActiP77318. 1 interaction.
STRINGi511145.b1498.

Proteomic databases

EPDiP77318.
PaxDbiP77318.
PRIDEiP77318.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74571; AAC74571; b1498.
BAA15169; BAA15169; BAA15169.
GeneIDi945957.
KEGGiecj:JW5243.
eco:b1498.
PATRICi32118290. VBIEscCol129921_1565.

Organism-specific databases

EchoBASEiEB3557.
EcoGeneiEG13796. ydeN.

Phylogenomic databases

eggNOGiENOG4105ENH. Bacteria.
COG3119. LUCA.
HOGENOMiHOG000135352.
InParanoidiP77318.
KOiK01138.
OMAiTPRFHPK.
PhylomeDBiP77318.

Enzyme and pathway databases

BioCyciEcoCyc:G6788-MONOMER.
ECOL316407:JW5243-MONOMER.

Miscellaneous databases

PROiP77318.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 3 hits.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYDEN_ECOLI
AccessioniPrimary (citable) accession number: P77318
Secondary accession number(s): P78159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.