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Protein

Probable iron export permease protein FetB

Gene

fetB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H2O2-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: EcoCyc

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciEcoCyc:G6267-MONOMER

Protein family/group databases

TCDBi3.A.1.139.2 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable iron export permease protein FetB
Gene namesi
Name:fetB
Synonyms:ybbM
Ordered Locus Names:b0491, JW5066
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13260 fetB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5PeriplasmicSequence analysis5
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Topological domaini27 – 35CytoplasmicSequence analysis9
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 91CytoplasmicSequence analysisAdd BLAST14
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 117PeriplasmicSequence analysis5
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 191CytoplasmicSequence analysisAdd BLAST53
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 218PeriplasmicSequence analysis6
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 259CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant exhibits increased sensitivity to H2O2 stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002178581 – 259Probable iron export permease protein FetBAdd BLAST259

Proteomic databases

PaxDbiP77307
PRIDEiP77307

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (FetA) and two transmembrane proteins (FetB).By similarity

Protein-protein interaction databases

BioGridi4259852, 251 interactors
STRINGi316385.ECDH10B_0448

Structurei

3D structure databases

ProteinModelPortaliP77307
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0014 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C4B Bacteria
COG0390 LUCA
HOGENOMiHOG000260834
InParanoidiP77307
KOiK02069
OMAiEPQYAIP
PhylomeDBiP77307

Family and domain databases

InterProiView protein in InterPro
IPR005226 UPF0014_fam
PANTHERiPTHR30028 PTHR30028, 1 hit
PfamiView protein in Pfam
PF03649 UPF0014, 1 hit
TIGRFAMsiTIGR00245 TIGR00245, 1 hit

Sequencei

Sequence statusi: Complete.

P77307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSHNITNES LALALMLVVV AILISHKEKL ALEKDILWSV GRAIIQLIIV
60 70 80 90 100
GYVLKYIFSV DDASLTLLMV LFICFNAAWN AQKRSKYIAK AFISSFIAIT
110 120 130 140 150
VGAGITLAVL ILSGSIEFIP MQVIPIAGMI AGNAMVAVGL CYNNLGQRVI
160 170 180 190 200
SEQQQIQEKL SLGATPKQAS AILIRDSIRA ALIPTVDSAK TVGLVSLPGM
210 220 230 240 250
MSGLIFAGID PVKAIKYQIM VTFMLLSTAS LSTIIACYLT YRKFYNSRHQ

LVVTQLKKK
Length:259
Mass (Da):28,165
Last modified:December 15, 1998 - v2
Checksum:i9AE9B134D1164E5D
GO

Sequence cautioni

The sequence AAB40245 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA Translation: AAB40245.1 Different initiation.
U00096 Genomic DNA Translation: AAC73593.2
AP009048 Genomic DNA Translation: BAE76270.1
RefSeqiNP_415024.4, NC_000913.3
WP_001295323.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73593; AAC73593; b0491
BAE76270; BAE76270; BAE76270
GeneIDi945137
KEGGiecj:JW5066
eco:b0491
PATRICifig|511145.12.peg.512

Similar proteinsi

Entry informationi

Entry nameiFETB_ECOLI
AccessioniPrimary (citable) accession number: P77307
Secondary accession number(s): Q2MBT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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