Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable iron export permease protein FetB

Gene

fetB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H2O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:G6267-MONOMER.
ECOL316407:JW5066-MONOMER.

Protein family/group databases

TCDBi3.A.1.139.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable iron export permease protein FetB
Gene namesi
Name:fetB
Synonyms:ybbM
Ordered Locus Names:b0491, JW5066
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13260. fetB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55PeriplasmicSequence analysis
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Topological domaini27 – 359CytoplasmicSequence analysis
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 9114CytoplasmicSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Topological domaini113 – 1175PeriplasmicSequence analysis
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Topological domaini139 – 19153CytoplasmicSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 2186PeriplasmicSequence analysis
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Topological domaini240 – 25920CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant exhibits increased sensitivity to H2O2 stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Probable iron export permease protein FetBPRO_0000217858Add
BLAST

Proteomic databases

PaxDbiP77307.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (FetA) and two transmembrane proteins (FetB).By similarity

Protein-protein interaction databases

BioGridi4259852. 228 interactions.
STRINGi511145.b0491.

Structurei

3D structure databases

ProteinModelPortaliP77307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0014 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C4B. Bacteria.
COG0390. LUCA.
HOGENOMiHOG000260834.
InParanoidiP77307.
KOiK02069.
OMAiPWYEPQY.
PhylomeDBiP77307.

Family and domain databases

InterProiIPR005226. UPF0014_fam.
[Graphical view]
PANTHERiPTHR30028:SF0. PTHR30028:SF0. 1 hit.
PfamiPF03649. UPF0014. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00245. TIGR00245. 1 hit.

Sequencei

Sequence statusi: Complete.

P77307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSHNITNES LALALMLVVV AILISHKEKL ALEKDILWSV GRAIIQLIIV
60 70 80 90 100
GYVLKYIFSV DDASLTLLMV LFICFNAAWN AQKRSKYIAK AFISSFIAIT
110 120 130 140 150
VGAGITLAVL ILSGSIEFIP MQVIPIAGMI AGNAMVAVGL CYNNLGQRVI
160 170 180 190 200
SEQQQIQEKL SLGATPKQAS AILIRDSIRA ALIPTVDSAK TVGLVSLPGM
210 220 230 240 250
MSGLIFAGID PVKAIKYQIM VTFMLLSTAS LSTIIACYLT YRKFYNSRHQ

LVVTQLKKK
Length:259
Mass (Da):28,165
Last modified:December 15, 1998 - v2
Checksum:i9AE9B134D1164E5D
GO

Sequence cautioni

The sequence AAB40245 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40245.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73593.2.
AP009048 Genomic DNA. Translation: BAE76270.1.
RefSeqiNP_415024.4. NC_000913.3.
WP_001295323.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73593; AAC73593; b0491.
BAE76270; BAE76270; BAE76270.
GeneIDi945137.
KEGGiecj:JW5066.
eco:b0491.
PATRICi32116141. VBIEscCol129921_0512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40245.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73593.2.
AP009048 Genomic DNA. Translation: BAE76270.1.
RefSeqiNP_415024.4. NC_000913.3.
WP_001295323.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259852. 228 interactions.
STRINGi511145.b0491.

Protein family/group databases

TCDBi3.A.1.139.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP77307.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73593; AAC73593; b0491.
BAE76270; BAE76270; BAE76270.
GeneIDi945137.
KEGGiecj:JW5066.
eco:b0491.
PATRICi32116141. VBIEscCol129921_0512.

Organism-specific databases

EchoBASEiEB3048.
EcoGeneiEG13260. fetB.

Phylogenomic databases

eggNOGiENOG4105C4B. Bacteria.
COG0390. LUCA.
HOGENOMiHOG000260834.
InParanoidiP77307.
KOiK02069.
OMAiPWYEPQY.
PhylomeDBiP77307.

Enzyme and pathway databases

BioCyciEcoCyc:G6267-MONOMER.
ECOL316407:JW5066-MONOMER.

Miscellaneous databases

PROiP77307.

Family and domain databases

InterProiIPR005226. UPF0014_fam.
[Graphical view]
PANTHERiPTHR30028:SF0. PTHR30028:SF0. 1 hit.
PfamiPF03649. UPF0014. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00245. TIGR00245. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFETB_ECOLI
AccessioniPrimary (citable) accession number: P77307
Secondary accession number(s): Q2MBT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.