Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dipeptide and tripeptide permease A

Gene

dtpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.3 Publications

GO - Molecular functioni

  • antibiotic transporter activity Source: EcoCyc
  • dipeptide transmembrane transporter activity Source: EcoCyc
  • hydrogen ion transmembrane transporter activity Source: EcoCyc
  • peptide:proton symporter activity Source: EcoCyc
  • symporter activity Source: EcoliWiki
  • tripeptide transporter activity Source: EcoCyc

GO - Biological processi

  • antibiotic transport Source: EcoCyc
  • dipeptide transmembrane transport Source: EcoCyc
  • hydrogen ion transmembrane transport Source: EcoCyc
  • oligopeptide transport Source: EcoliWiki
  • protein transport Source: UniProtKB-KW
  • tripeptide transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B1634-MONOMER.
ECOL316407:JW1626-MONOMER.
MetaCyc:B1634-MONOMER.
BRENDAi3.6.3.43. 2026.

Protein family/group databases

TCDBi2.A.17.1.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide and tripeptide permease A
Gene namesi
Name:dtpA
Synonyms:tppB, ydgR
Ordered Locus Names:b1634, JW1626
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13939. dtpA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 44HelicalSequence analysisAdd BLAST23
Topological domaini45 – 59PeriplasmicSequence analysisAdd BLAST15
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 89CytoplasmicSequence analysis9
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111PeriplasmicSequence analysis1
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 153CytoplasmicSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 178PeriplasmicSequence analysis4
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 219CytoplasmicSequence analysisAdd BLAST20
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 246PeriplasmicSequence analysis6
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 274CytoplasmicSequence analysis7
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 320PeriplasmicSequence analysisAdd BLAST25
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 352CytoplasmicSequence analysisAdd BLAST11
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 378PeriplasmicSequence analysis5
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 414CytoplasmicSequence analysisAdd BLAST15
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 459PeriplasmicSequence analysisAdd BLAST24
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 500CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: EcoliWiki
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643231 – 500Dipeptide and tripeptide permease AAdd BLAST500

Proteomic databases

PaxDbiP77304.
PRIDEiP77304.

Expressioni

Inductioni

Transcriptionally activated by the EnvZ/OmpR regulatory system.1 Publication

Interactioni

Subunit structurei

Monomer (Probable). Has a crown-like structure with a diameter of 8 nm and a central density.Curated1 Publication

Protein-protein interaction databases

BioGridi4260260. 252 interactors.
STRINGi511145.b1634.

Structurei

3D structure databases

ProteinModelPortaliP77304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243449.
InParanoidiP77304.
KOiK03305.
OMAiWLLHNQG.
PhylomeDBiP77304.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01878. PTR2_DtpA_subfam. 1 hit.
InterProiIPR023517. AA/pep_transptr_DtpA.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTANQKPTE SVSLNAFKQP KAFYLIFSIE LWERFGYYGL QGIMAVYLVK
60 70 80 90 100
QLGMSEADSI TLFSSFSALV YGLVAIGGWL GDKVLGTKRV IMLGAIVLAI
110 120 130 140 150
GYALVAWSGH DAGIVYMGMA AIAVGNGLFK ANPSSLLSTC YEKNDPRLDG
160 170 180 190 200
AFTMYYMSVN IGSFFSMIAT PWLAAKYGWS VAFALSVVGL LITIVNFAFC
210 220 230 240 250
QRWVKQYGSK PDFEPINYRN LLLTIIGVVA LIAIATWLLH NQEVARMALG
260 270 280 290 300
VVAFGIVVIF GKEAFAMKGA ARRKMIVAFI LMLEAIIFFV LYSQMPTSLN
310 320 330 340 350
FFAIRNVEHS ILGLAVEPEQ YQALNPFWII IGSPILAAIY NKMGDTLPMP
360 370 380 390 400
TKFAIGMVMC SGAFLILPLG AKFASDAGIV SVSWLVASYG LQSIGELMIS
410 420 430 440 450
GLGLAMVAQL VPQRLMGFIM GSWFLTTAGA NLIGGYVAGM MAVPDNVTDP
460 470 480 490 500
LMSLEVYGRV FLQIGVATAV IAVLMLLTAP KLHRMTQDDA ADKAAKAAVA
Length:500
Mass (Da):53,991
Last modified:February 1, 1997 - v1
Checksum:iBFDCBE0BFC206C46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74706.1.
AP009048 Genomic DNA. Translation: BAA15395.1.
PIRiD64920.
RefSeqiNP_416151.1. NC_000913.3.
WP_000100932.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74706; AAC74706; b1634.
BAA15395; BAA15395; BAA15395.
GeneIDi947436.
KEGGiecj:JW1626.
eco:b1634.
PATRICi32118570. VBIEscCol129921_1705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74706.1.
AP009048 Genomic DNA. Translation: BAA15395.1.
PIRiD64920.
RefSeqiNP_416151.1. NC_000913.3.
WP_000100932.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260260. 252 interactors.
STRINGi511145.b1634.

Protein family/group databases

TCDBi2.A.17.1.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

Proteomic databases

PaxDbiP77304.
PRIDEiP77304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74706; AAC74706; b1634.
BAA15395; BAA15395; BAA15395.
GeneIDi947436.
KEGGiecj:JW1626.
eco:b1634.
PATRICi32118570. VBIEscCol129921_1705.

Organism-specific databases

EchoBASEiEB3698.
EcoGeneiEG13939. dtpA.

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243449.
InParanoidiP77304.
KOiK03305.
OMAiWLLHNQG.
PhylomeDBiP77304.

Enzyme and pathway databases

BioCyciEcoCyc:B1634-MONOMER.
ECOL316407:JW1626-MONOMER.
MetaCyc:B1634-MONOMER.
BRENDAi3.6.3.43. 2026.

Miscellaneous databases

PROiP77304.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01878. PTR2_DtpA_subfam. 1 hit.
InterProiIPR023517. AA/pep_transptr_DtpA.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDTPA_ECOLI
AccessioniPrimary (citable) accession number: P77304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.