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Protein

Dipeptide and tripeptide permease A

Gene

dtpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate.3 Publications

GO - Molecular functioni

  • antibiotic transporter activity Source: EcoCyc
  • dipeptide transmembrane transporter activity Source: EcoCyc
  • hydrogen ion transmembrane transporter activity Source: EcoCyc
  • peptide:proton symporter activity Source: EcoCyc
  • symporter activity Source: EcoliWiki
  • tripeptide transporter activity Source: EcoCyc

GO - Biological processi

  • antibiotic transport Source: EcoCyc
  • dipeptide transmembrane transport Source: EcoCyc
  • hydrogen ion transmembrane transport Source: EcoCyc
  • oligopeptide transport Source: EcoliWiki
  • protein transport Source: UniProtKB-KW
  • tripeptide transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:B1634-MONOMER.
ECOL316407:JW1626-MONOMER.
MetaCyc:B1634-MONOMER.
BRENDAi3.6.3.43. 2026.

Protein family/group databases

TCDBi2.A.17.1.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptide and tripeptide permease A
Gene namesi
Name:dtpA
Synonyms:tppB, ydgR
Ordered Locus Names:b1634, JW1626
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13939. dtpA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence analysisAdd
BLAST
Transmembranei22 – 4423HelicalSequence analysisAdd
BLAST
Topological domaini45 – 5915PeriplasmicSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 899CytoplasmicSequence analysis
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Topological domaini111 – 1111PeriplasmicSequence analysis
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST
Topological domaini133 – 15321CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Topological domaini175 – 1784PeriplasmicSequence analysis
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 21920CytoplasmicSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Topological domaini241 – 2466PeriplasmicSequence analysis
Transmembranei247 – 26721HelicalSequence analysisAdd
BLAST
Topological domaini268 – 2747CytoplasmicSequence analysis
Transmembranei275 – 29521HelicalSequence analysisAdd
BLAST
Topological domaini296 – 32025PeriplasmicSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Topological domaini342 – 35211CytoplasmicSequence analysisAdd
BLAST
Transmembranei353 – 37321HelicalSequence analysisAdd
BLAST
Topological domaini374 – 3785PeriplasmicSequence analysis
Transmembranei379 – 39921HelicalSequence analysisAdd
BLAST
Topological domaini400 – 41415CytoplasmicSequence analysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence analysisAdd
BLAST
Topological domaini436 – 45924PeriplasmicSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Topological domaini481 – 50020CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: EcoliWiki
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Dipeptide and tripeptide permease APRO_0000064323Add
BLAST

Proteomic databases

PaxDbiP77304.

Expressioni

Inductioni

Transcriptionally activated by the EnvZ/OmpR regulatory system.1 Publication

Interactioni

Subunit structurei

Monomer (Probable). Has a crown-like structure with a diameter of 8 nm and a central density.Curated1 Publication

Protein-protein interaction databases

BioGridi4260260. 252 interactions.
STRINGi511145.b1634.

Structurei

3D structure databases

ProteinModelPortaliP77304.
SMRiP77304. Positions 22-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243449.
InParanoidiP77304.
KOiK03305.
OMAiWLLHNQG.
PhylomeDBiP77304.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01878. PTR2_DtpA_subfam. 1 hit.
InterProiIPR023517. AA/pep_transptr_DtpA.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTANQKPTE SVSLNAFKQP KAFYLIFSIE LWERFGYYGL QGIMAVYLVK
60 70 80 90 100
QLGMSEADSI TLFSSFSALV YGLVAIGGWL GDKVLGTKRV IMLGAIVLAI
110 120 130 140 150
GYALVAWSGH DAGIVYMGMA AIAVGNGLFK ANPSSLLSTC YEKNDPRLDG
160 170 180 190 200
AFTMYYMSVN IGSFFSMIAT PWLAAKYGWS VAFALSVVGL LITIVNFAFC
210 220 230 240 250
QRWVKQYGSK PDFEPINYRN LLLTIIGVVA LIAIATWLLH NQEVARMALG
260 270 280 290 300
VVAFGIVVIF GKEAFAMKGA ARRKMIVAFI LMLEAIIFFV LYSQMPTSLN
310 320 330 340 350
FFAIRNVEHS ILGLAVEPEQ YQALNPFWII IGSPILAAIY NKMGDTLPMP
360 370 380 390 400
TKFAIGMVMC SGAFLILPLG AKFASDAGIV SVSWLVASYG LQSIGELMIS
410 420 430 440 450
GLGLAMVAQL VPQRLMGFIM GSWFLTTAGA NLIGGYVAGM MAVPDNVTDP
460 470 480 490 500
LMSLEVYGRV FLQIGVATAV IAVLMLLTAP KLHRMTQDDA ADKAAKAAVA
Length:500
Mass (Da):53,991
Last modified:February 1, 1997 - v1
Checksum:iBFDCBE0BFC206C46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74706.1.
AP009048 Genomic DNA. Translation: BAA15395.1.
PIRiD64920.
RefSeqiNP_416151.1. NC_000913.3.
WP_000100932.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74706; AAC74706; b1634.
BAA15395; BAA15395; BAA15395.
GeneIDi947436.
KEGGiecj:JW1626.
eco:b1634.
PATRICi32118570. VBIEscCol129921_1705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74706.1.
AP009048 Genomic DNA. Translation: BAA15395.1.
PIRiD64920.
RefSeqiNP_416151.1. NC_000913.3.
WP_000100932.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77304.
SMRiP77304. Positions 22-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260260. 252 interactions.
STRINGi511145.b1634.

Protein family/group databases

TCDBi2.A.17.1.2. the proton-dependent oligopeptide transporter (pot/ptr) family.

Proteomic databases

PaxDbiP77304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74706; AAC74706; b1634.
BAA15395; BAA15395; BAA15395.
GeneIDi947436.
KEGGiecj:JW1626.
eco:b1634.
PATRICi32118570. VBIEscCol129921_1705.

Organism-specific databases

EchoBASEiEB3698.
EcoGeneiEG13939. dtpA.

Phylogenomic databases

eggNOGiENOG4105DUX. Bacteria.
COG3104. LUCA.
HOGENOMiHOG000243449.
InParanoidiP77304.
KOiK03305.
OMAiWLLHNQG.
PhylomeDBiP77304.

Enzyme and pathway databases

BioCyciEcoCyc:B1634-MONOMER.
ECOL316407:JW1626-MONOMER.
MetaCyc:B1634-MONOMER.
BRENDAi3.6.3.43. 2026.

Miscellaneous databases

PROiP77304.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01878. PTR2_DtpA_subfam. 1 hit.
InterProiIPR023517. AA/pep_transptr_DtpA.
IPR005279. Dipep/tripep_permease.
IPR020846. MFS_dom.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00924. yjdL_sub1_fam. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDTPA_ECOLI
AccessioniPrimary (citable) accession number: P77304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.