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Protein

Probable HTH-type transcriptional regulator YgaV

Gene

ygaV

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Functions as transcription repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi41 – 6020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7397-MONOMER.
ECOL316407:JW2642-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable HTH-type transcriptional regulator YgaV
Gene namesi
Name:ygaV
Ordered Locus Names:b2667, JW2642
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13524. ygaV.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Probable HTH-type transcriptional regulator YgaVPRO_0000160628Add
BLAST

Proteomic databases

PaxDbiP77295.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi4259220. 10 interactions.
IntActiP77295. 10 interactions.
STRINGi511145.b2667.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 76Combined sources
Helixi8 – 103Combined sources
Helixi11 – 2111Combined sources
Helixi24 – 3310Combined sources
Beta strandi38 – 403Combined sources
Helixi41 – 488Combined sources
Helixi52 – 6413Combined sources
Beta strandi67 – 726Combined sources
Beta strandi77 – 815Combined sources
Helixi84 – 9714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CUOX-ray2.00A/B/C/D1-99[»]
ProteinModelPortaliP77295.
SMRiP77295. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9993HTH arsR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41080HT. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP77295.
OMAiQQRADHA.
OrthoDBiEOG6B3684.
PhylomeDBiP77295.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELAQLQAS AEQAAALLKA MSHPKRLLIL CMLSGSPGTS AGELTRITGL
60 70 80 90
SASATSQHLA RMRDEGLIDS QRDAQRILYS IKNEAVNAII ATLKNVYCP
Length:99
Mass (Da):10,596
Last modified:February 1, 1997 - v1
Checksum:i93B9B32C62CC0223
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75714.1.
AP009048 Genomic DNA. Translation: BAA16530.1.
PIRiD65046.
RefSeqiNP_417153.1. NC_000913.3.
WP_000137280.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75714; AAC75714; b2667.
BAA16530; BAA16530; BAA16530.
GeneIDi947136.
KEGGiecj:JW2642.
eco:b2667.
PATRICi32120724. VBIEscCol129921_2759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75714.1.
AP009048 Genomic DNA. Translation: BAA16530.1.
PIRiD65046.
RefSeqiNP_417153.1. NC_000913.3.
WP_000137280.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CUOX-ray2.00A/B/C/D1-99[»]
ProteinModelPortaliP77295.
SMRiP77295. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259220. 10 interactions.
IntActiP77295. 10 interactions.
STRINGi511145.b2667.

Proteomic databases

PaxDbiP77295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75714; AAC75714; b2667.
BAA16530; BAA16530; BAA16530.
GeneIDi947136.
KEGGiecj:JW2642.
eco:b2667.
PATRICi32120724. VBIEscCol129921_2759.

Organism-specific databases

EchoBASEiEB3296.
EcoGeneiEG13524. ygaV.

Phylogenomic databases

eggNOGiENOG41080HT. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP77295.
OMAiQQRADHA.
OrthoDBiEOG6B3684.
PhylomeDBiP77295.

Enzyme and pathway databases

BioCyciEcoCyc:G7397-MONOMER.
ECOL316407:JW2642-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP77295.
PROiP77295.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "The ygaVP genes of Escherichia coli form a tributyltin-inducible operon."
    Gueune H., Durand M.-J., Thouand G., DuBow M.S.
    Appl. Environ. Microbiol. 74:1954-1958(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "The crystal structure of the predicted DNA-binding transcriptional regulator from E. coli."
    Midwest center for structural genomics (MCSG)
    Submitted (JUN-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiYGAV_ECOLI
AccessioniPrimary (citable) accession number: P77295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.