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Protein

Probable HTH-type transcriptional regulator YgaV

Gene

ygaV

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Functions as transcription repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi41 – 6020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7397-MONOMER.
ECOL316407:JW2642-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable HTH-type transcriptional regulator YgaV
Gene namesi
Name:ygaV
Ordered Locus Names:b2667, JW2642
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13524. ygaV.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Probable HTH-type transcriptional regulator YgaVPRO_0000160628Add
BLAST

Proteomic databases

PaxDbiP77295.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi4259220. 10 interactions.
IntActiP77295. 10 interactions.
STRINGi511145.b2667.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 76Combined sources
Helixi8 – 103Combined sources
Helixi11 – 2111Combined sources
Helixi24 – 3310Combined sources
Beta strandi38 – 403Combined sources
Helixi41 – 488Combined sources
Helixi52 – 6413Combined sources
Beta strandi67 – 726Combined sources
Beta strandi77 – 815Combined sources
Helixi84 – 9714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CUOX-ray2.00A/B/C/D1-99[»]
ProteinModelPortaliP77295.
SMRiP77295. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP77295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9993HTH arsR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41080HT. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP77295.
OMAiGERCVSE.
PhylomeDBiP77295.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELAQLQAS AEQAAALLKA MSHPKRLLIL CMLSGSPGTS AGELTRITGL
60 70 80 90
SASATSQHLA RMRDEGLIDS QRDAQRILYS IKNEAVNAII ATLKNVYCP
Length:99
Mass (Da):10,596
Last modified:February 1, 1997 - v1
Checksum:i93B9B32C62CC0223
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75714.1.
AP009048 Genomic DNA. Translation: BAA16530.1.
PIRiD65046.
RefSeqiNP_417153.1. NC_000913.3.
WP_000137280.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75714; AAC75714; b2667.
BAA16530; BAA16530; BAA16530.
GeneIDi947136.
KEGGiecj:JW2642.
eco:b2667.
PATRICi32120724. VBIEscCol129921_2759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75714.1.
AP009048 Genomic DNA. Translation: BAA16530.1.
PIRiD65046.
RefSeqiNP_417153.1. NC_000913.3.
WP_000137280.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CUOX-ray2.00A/B/C/D1-99[»]
ProteinModelPortaliP77295.
SMRiP77295. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259220. 10 interactions.
IntActiP77295. 10 interactions.
STRINGi511145.b2667.

Proteomic databases

PaxDbiP77295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75714; AAC75714; b2667.
BAA16530; BAA16530; BAA16530.
GeneIDi947136.
KEGGiecj:JW2642.
eco:b2667.
PATRICi32120724. VBIEscCol129921_2759.

Organism-specific databases

EchoBASEiEB3296.
EcoGeneiEG13524. ygaV.

Phylogenomic databases

eggNOGiENOG41080HT. Bacteria.
COG0640. LUCA.
HOGENOMiHOG000144506.
InParanoidiP77295.
OMAiGERCVSE.
PhylomeDBiP77295.

Enzyme and pathway databases

BioCyciEcoCyc:G7397-MONOMER.
ECOL316407:JW2642-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP77295.
PROiP77295.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYGAV_ECOLI
AccessioniPrimary (citable) accession number: P77295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.