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Protein

Uncharacterized fimbrial-like protein YfcV

Gene

yfcV

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7210-MONOMER.
ECOL316407:JW2336-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YfcV
Gene namesi
Name:yfcV
Ordered Locus Names:b2339, JW2336
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14125. yfcV.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001377426 – 187Uncharacterized fimbrial-like protein YfcVAdd BLAST162

Proteomic databases

PaxDbiP77288.
PRIDEiP77288.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263168. 8 interactors.
IntActiP77288. 1 interactor.
STRINGi511145.b2339.

Structurei

3D structure databases

ProteinModelPortaliP77288.
SMRiP77288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000260127.
OMAiGPANADN.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKFVKTAIA AAMVMGAFTS TATIAAGNNG TARFYGTIED SVCSIVPDDH
60 70 80 90 100
KLEVDMGDIG AEKLKNNGTT TPKNFQIRLQ DCVFDTQETM TTTFTGTVSS
110 120 130 140 150
ANSGNYYTIF NTDTGAAFNN VSLAIGDSLG TSYKSGMGID QKIVKDTATN
160 170 180
KGKAKQTLNF KAWLVGAADA PDLGNFEANT TFQITYL
Length:187
Mass (Da):19,851
Last modified:February 1, 1997 - v1
Checksum:i9BAE027695988940
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75399.1.
AP009048 Genomic DNA. Translation: BAA16193.1.
PIRiA65007.
RefSeqiNP_416841.1. NC_000913.3.
WP_000033316.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75399; AAC75399; b2339.
BAA16193; BAA16193; BAA16193.
GeneIDi949109.
KEGGiecj:JW2336.
eco:b2339.
PATRICi32120051. VBIEscCol129921_2435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75399.1.
AP009048 Genomic DNA. Translation: BAA16193.1.
PIRiA65007.
RefSeqiNP_416841.1. NC_000913.3.
WP_000033316.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77288.
SMRiP77288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263168. 8 interactors.
IntActiP77288. 1 interactor.
STRINGi511145.b2339.

Proteomic databases

PaxDbiP77288.
PRIDEiP77288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75399; AAC75399; b2339.
BAA16193; BAA16193; BAA16193.
GeneIDi949109.
KEGGiecj:JW2336.
eco:b2339.
PATRICi32120051. VBIEscCol129921_2435.

Organism-specific databases

EchoBASEiEB3877.
EcoGeneiEG14125. yfcV.

Phylogenomic databases

HOGENOMiHOG000260127.
OMAiGPANADN.

Enzyme and pathway databases

BioCyciEcoCyc:G7210-MONOMER.
ECOL316407:JW2336-MONOMER.

Miscellaneous databases

PROiP77288.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYFCV_ECOLI
AccessioniPrimary (citable) accession number: P77288
Secondary accession number(s): P76940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.