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Protein

Probable iron export ATP-binding protein FetA

Gene

fetA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H2O2-mediated oxidative stress. Probably responsible for energy coupling to the transport system.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: EcoCyc
  • ion transport Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YBBL-MONOMER.

Protein family/group databases

TCDBi3.A.1.139.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable iron export ATP-binding protein FetA (EC:3.6.3.-)
Gene namesi
Name:fetA
Synonyms:ybbL
Ordered Locus Names:b0490, JW0479
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13259. fetA.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant exhibits increased sensitivity to H2O2 stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000931551 – 225Probable iron export ATP-binding protein FetAAdd BLAST225

Proteomic databases

PaxDbiP77279.
PRIDEiP77279.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (FetA) and two transmembrane proteins (FetB).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
groLP0A6F52EBI-560090,EBI-543750

Protein-protein interaction databases

BioGridi4259847. 148 interactors.
DIPiDIP-11320N.
IntActiP77279. 6 interactors.
MINTiMINT-1269507.
STRINGi316385.ECDH10B_0447.

Structurei

3D structure databases

ProteinModelPortaliP77279.
SMRiP77279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 225ABC transporterPROSITE-ProRule annotationAdd BLAST218

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG41083J0. Bacteria.
COG4619. LUCA.
InParanoidiP77279.
KOiK02068.
PhylomeDBiP77279.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P77279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQENSPLLQL QNVGYLAGDA KILNNINFSL RAGEFKLITG PSGCGKSTLL
60 70 80 90 100
KIVASLISPT SGTLLFEGED VSTLKPEIYR QQVSYCAQTP TLFGDTVYDN
110 120 130 140 150
LIFPWQIRNR QPDPAIFLDF LERFALPDSI LTKNIAELSG GEKQRISLIR
160 170 180 190 200
NLQFMPKVLL LDEITSALDE SNKHNVNEMI HRYVREQNIA VLWVTHDKDE
210 220
INHADKVITL QPHAGEMQEA RYELA
Length:225
Mass (Da):25,382
Last modified:February 1, 1997 - v1
Checksum:i0E2E07A5E0B7793D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40244.1.
U00096 Genomic DNA. Translation: AAC73592.1.
AP009048 Genomic DNA. Translation: BAE76269.1.
PIRiA64780.
RefSeqiNP_415023.1. NC_000913.3.
WP_001157540.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73592; AAC73592; b0490.
BAE76269; BAE76269; BAE76269.
GeneIDi946990.
KEGGiecj:JW0479.
eco:b0490.
PATRICifig|511145.12.peg.511.

Similar proteinsi

Entry informationi

Entry nameiFETA_ECOLI
AccessioniPrimary (citable) accession number: P77279
Secondary accession number(s): Q2MBT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families