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Protein

Probable fimbrial chaperone EcpE

Gene

ecpE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity).By similarity

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Fimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G6160-MONOMER.
ECOL316407:JW5030-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone EcpE
Gene namesi
Name:ecpE
Synonyms:matF, yagV
Ordered Locus Names:b0289, JW5030
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13561. ecpE.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001378728 – 236Probable fimbrial chaperone EcpEAdd BLAST209

Proteomic databases

PaxDbiP77263.
PRIDEiP77263.

Expressioni

Inductioni

Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity).By similarity

Interactioni

Protein-protein interaction databases

BioGridi4259789. 7 interactors.
STRINGi511145.b0289.

Structurei

3D structure databases

ProteinModelPortaliP77263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EcpB/EcpE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108UD7. Bacteria.
ENOG4111HA8. LUCA.
HOGENOMiHOG000269457.
OMAiMEPVVVM.

Family and domain databases

InterProiIPR008962. PapD-like.
[Graphical view]
SUPFAMiSSF49354. SSF49354. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRRRGVTLT KALLTAVCML AAPLTQAISV GNLTFSLPSE TDFVSKRVVN
60 70 80 90 100
NNKSARIYRI AISAIDSPGS SELRTRPVDG ELLFAPRQLA LQAGESEYFK
110 120 130 140 150
FYYHGPRDNR ERYYRVSFRE VPTRNHTRRS PTGGVVSTEP VVVMDTILVV
160 170 180 190 200
RPRQVQFKWS FDKVTGTVSN TGNTWFKLLI KPGCDSTEEE GDAWYLRPGD
210 220 230
VVHQPELRQP GNHYLVYNDK FIKISDSCPA KPPSAD
Length:236
Mass (Da):26,628
Last modified:July 15, 1998 - v2
Checksum:iAE2B9CE465FD3F1E
GO

Sequence cautioni

The sequence AAB18018 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18018.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73392.2.
AP009048 Genomic DNA. Translation: BAE76073.1.
PIRiA64755.
RefSeqiNP_414823.2. NC_000913.3.
WP_001350485.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73392; AAC73392; b0289.
BAE76073; BAE76073; BAE76073.
GeneIDi946631.
KEGGiecj:JW5030.
eco:b0289.
PATRICi32115701. VBIEscCol129921_0293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18018.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73392.2.
AP009048 Genomic DNA. Translation: BAE76073.1.
PIRiA64755.
RefSeqiNP_414823.2. NC_000913.3.
WP_001350485.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259789. 7 interactors.
STRINGi511145.b0289.

Proteomic databases

PaxDbiP77263.
PRIDEiP77263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73392; AAC73392; b0289.
BAE76073; BAE76073; BAE76073.
GeneIDi946631.
KEGGiecj:JW5030.
eco:b0289.
PATRICi32115701. VBIEscCol129921_0293.

Organism-specific databases

EchoBASEiEB3331.
EcoGeneiEG13561. ecpE.

Phylogenomic databases

eggNOGiENOG4108UD7. Bacteria.
ENOG4111HA8. LUCA.
HOGENOMiHOG000269457.
OMAiMEPVVVM.

Enzyme and pathway databases

BioCyciEcoCyc:G6160-MONOMER.
ECOL316407:JW5030-MONOMER.

Miscellaneous databases

PROiP77263.

Family and domain databases

InterProiIPR008962. PapD-like.
[Graphical view]
SUPFAMiSSF49354. SSF49354. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiECPE_ECOLI
AccessioniPrimary (citable) accession number: P77263
Secondary accession number(s): Q2MCD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Not expressed under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.