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Protein

Probable fimbrial chaperone EcpE

Gene

ecpE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity).By similarity

Miscellaneous

Not expressed under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywordsi

Molecular functionChaperone
Biological processFimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G6160-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone EcpE
Gene namesi
Name:ecpE
Synonyms:matF, yagV
Ordered Locus Names:b0289, JW5030
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13561 ecpE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001378728 – 236Probable fimbrial chaperone EcpEAdd BLAST209

Proteomic databases

PaxDbiP77263
PRIDEiP77263

Expressioni

Inductioni

Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity).By similarity

Interactioni

Protein-protein interaction databases

BioGridi4259789, 7 interactors
STRINGi316385.ECDH10B_0277

Structurei

3D structure databases

ProteinModelPortaliP77263
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EcpB/EcpE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108UD7 Bacteria
ENOG4111HA8 LUCA
HOGENOMiHOG000269457
KOiK21968
OMAiRPREVQF

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR008962 PapD-like_sf
SUPFAMiSSF49354 SSF49354, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRRRGVTLT KALLTAVCML AAPLTQAISV GNLTFSLPSE TDFVSKRVVN
60 70 80 90 100
NNKSARIYRI AISAIDSPGS SELRTRPVDG ELLFAPRQLA LQAGESEYFK
110 120 130 140 150
FYYHGPRDNR ERYYRVSFRE VPTRNHTRRS PTGGVVSTEP VVVMDTILVV
160 170 180 190 200
RPRQVQFKWS FDKVTGTVSN TGNTWFKLLI KPGCDSTEEE GDAWYLRPGD
210 220 230
VVHQPELRQP GNHYLVYNDK FIKISDSCPA KPPSAD
Length:236
Mass (Da):26,628
Last modified:July 15, 1998 - v2
Checksum:iAE2B9CE465FD3F1E
GO

Sequence cautioni

The sequence AAB18018 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18018.1 Different initiation.
U00096 Genomic DNA Translation: AAC73392.2
AP009048 Genomic DNA Translation: BAE76073.1
PIRiA64755
RefSeqiNP_414823.2, NC_000913.3
WP_001350485.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73392; AAC73392; b0289
BAE76073; BAE76073; BAE76073
GeneIDi946631
KEGGiecj:JW5030
eco:b0289
PATRICifig|511145.12.peg.293

Similar proteinsi

Entry informationi

Entry nameiECPE_ECOLI
AccessioniPrimary (citable) accession number: P77263
Secondary accession number(s): Q2MCD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health