P77249 (SFMC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein SfmC

Gene names

Name:	sfmC
Ordered Locus Names:	b0531, JW0520

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the biogenesis of SfmA fimbriae. Binds and interact with SfmH By similarity.
Subcellular location	Periplasm Potential.
Sequence similarities	Belongs to the periplasmic pilus chaperone family. Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Fimbrium biogenesis
Cellular component	Periplasm
Domain	Immunoglobulin domain Signal
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall organization Inferred from electronic annotation. Source: InterPro pilus organization Inferred from electronic annotation. Source: InterPro
Cellular_component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 230	207	Chaperone protein SfmC		PRO_0000009275

Sequences

	Sequence		Length	Mass (Da)
	P77249 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: D9B0CEEBB66C10D3	FASTA	230	25,458
	10 20 30 40 50 60 MMTKIKLLML IIFYLIISAS AHAAGGIALG ATRIIYPADA KQTAVWIRNS HTNERFLVNS 70 80 90 100 110 120 WIENSSGVKE KSFIITPPLF VSEPKSENTL RIIYTGPPLA ADRESLFWMN VKTIPSVDKN 130 140 150 160 170 180 ALNGRNVLQL AILSRMKLFL RPIQLQELPA EAPDTLKFSR SGNYINVHNP SPFYVTLVNL 190 200 210 220 230 QVGSQKLGNA MAAPRVNSQI PLPSGVQGKL KFQTVNDYGS VTPVREVNLN

References

[1]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U82664 Genomic DNA. Translation: AAB40284.1. U82598 Genomic DNA. Translation: AAB40729.1. U00096 Genomic DNA. Translation: AAC73633.1. AP009048 Genomic DNA. Translation: BAE76308.1.
PIR	B64785.
RefSeq	NP_415064.1. NC_000913.2. YP_488820.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P77249.
SMR	P77249. Positions 26-223.
ModBase	Search...
Protein-protein interaction databases
IntAct	P77249. 3 interactions.
STRING	511145.b0531.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC73633; AAC73633; b0531. BAE76308; BAE76308; BAE76308.
GeneID	12934225. 945367.
KEGG	ecj:Y75_p0517. eco:b0531.
PATRIC	32116222. VBIEscCol129921_0552.
Organism-specific databases
EchoBASE	EB3641.
EcoGene	EG13882. sfmC.
Phylogenomic databases
eggNOG	COG3121.
HOGENOM	HOG000260152.
KO	K07353.
OMA	KERYLVN.
ProtClustDB	PRK15195.
Enzyme and pathway databases
BioCyc	EcoCyc:G6291-MONOMER. ECOL316407:JW0520-MONOMER.
Gene expression databases
Genevestigator	P77249.
Family and domain databases
Gene3D	2.60.40.1070. 1 hit. 2.60.40.360. 1 hit.
InterPro	IPR008962. PapD-like. IPR001829. Pili_assmbl_chaperone_bac. IPR016148. Pili_assmbl_chaperone_C. IPR018046. Pili_assmbl_chaperone_CS. IPR016147. Pili_assmbl_chaperone_N_bac. [Graphical view]
Pfam	PF02753. Pili_assembly_C. 1 hit. PF00345. Pili_assembly_N. 1 hit. [Graphical view]
PRINTS	PR00969. CHAPERONPILI.
SUPFAM	SSF49354. PapD-like. 1 hit. SSF49584. Pili_assmbl_chaperone_C_bac. 1 hit.
PROSITE	PS00635. PILI_CHAPERONE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SFMC_ECOLI

Accession

Primary (citable) accession number: P77249
Secondary accession number(s): P77077, Q2MBP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program