Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable fimbrial chaperone SfmC

Gene

sfmC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processFimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G6291-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone SfmC
Gene namesi
Name:sfmC
Ordered Locus Names:b0531, JW0520
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13882 sfmC

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000927524 – 230Probable fimbrial chaperone SfmCAdd BLAST207

Proteomic databases

PaxDbiP77249
PRIDEiP77249

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263219, 114 interactors
IntActiP77249, 3 interactors
STRINGi316385.ECDH10B_0487

Structurei

3D structure databases

ProteinModelPortaliP77249
SMRiP77249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4108AF8 Bacteria
ENOG410ZPTT LUCA
HOGENOMiHOG000260152
KOiK07353
OMAiYLINAWI
PhylomeDBiP77249

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR008962 PapD-like_sf
IPR036316 Pili_assmbl_chap_C_dom_sf
IPR001829 Pili_assmbl_chaperone_bac
IPR016148 Pili_assmbl_chaperone_C
IPR018046 Pili_assmbl_chaperone_CS
IPR016147 Pili_assmbl_chaperone_N
PfamiView protein in Pfam
PF02753 PapD_C, 1 hit
PF00345 PapD_N, 1 hit
PRINTSiPR00969 CHAPERONPILI
SUPFAMiSSF49354 SSF49354, 1 hit
SSF49584 SSF49584, 1 hit
PROSITEiView protein in PROSITE
PS00635 PILI_CHAPERONE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTKIKLLML IIFYLIISAS AHAAGGIALG ATRIIYPADA KQTAVWIRNS
60 70 80 90 100
HTNERFLVNS WIENSSGVKE KSFIITPPLF VSEPKSENTL RIIYTGPPLA
110 120 130 140 150
ADRESLFWMN VKTIPSVDKN ALNGRNVLQL AILSRMKLFL RPIQLQELPA
160 170 180 190 200
EAPDTLKFSR SGNYINVHNP SPFYVTLVNL QVGSQKLGNA MAAPRVNSQI
210 220 230
PLPSGVQGKL KFQTVNDYGS VTPVREVNLN
Length:230
Mass (Da):25,458
Last modified:February 1, 1997 - v1
Checksum:iD9B0CEEBB66C10D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA Translation: AAB40284.1
U82598 Genomic DNA Translation: AAB40729.1
U00096 Genomic DNA Translation: AAC73633.1
AP009048 Genomic DNA Translation: BAE76308.1
PIRiB64785
RefSeqiNP_415064.1, NC_000913.3
WP_000988364.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73633; AAC73633; b0531
BAE76308; BAE76308; BAE76308
GeneIDi945367
KEGGiecj:JW0520
eco:b0531
PATRICifig|1411691.4.peg.1747

Similar proteinsi

Entry informationi

Entry nameiSFMC_ECOLI
AccessioniPrimary (citable) accession number: P77249
Secondary accession number(s): P77077, Q2MBP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health