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Protein

Probable fimbrial chaperone SfmC

Gene

sfmC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Fimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G6291-MONOMER.
ECOL316407:JW0520-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone SfmC
Gene namesi
Name:sfmC
Ordered Locus Names:b0531, JW0520
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13882. sfmC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 230207Probable fimbrial chaperone SfmCPRO_0000009275Add
BLAST

Proteomic databases

PaxDbiP77249.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4263219. 114 interactions.
IntActiP77249. 3 interactions.
STRINGi511145.b0531.

Structurei

3D structure databases

ProteinModelPortaliP77249.
SMRiP77249. Positions 26-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4108AF8. Bacteria.
ENOG410ZPTT. LUCA.
HOGENOMiHOG000260152.
KOiK07353.
OMAiMIAPKNS.
OrthoDBiEOG6QP10C.
PhylomeDBiP77249.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF02753. PapD_C. 1 hit.
PF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTKIKLLML IIFYLIISAS AHAAGGIALG ATRIIYPADA KQTAVWIRNS
60 70 80 90 100
HTNERFLVNS WIENSSGVKE KSFIITPPLF VSEPKSENTL RIIYTGPPLA
110 120 130 140 150
ADRESLFWMN VKTIPSVDKN ALNGRNVLQL AILSRMKLFL RPIQLQELPA
160 170 180 190 200
EAPDTLKFSR SGNYINVHNP SPFYVTLVNL QVGSQKLGNA MAAPRVNSQI
210 220 230
PLPSGVQGKL KFQTVNDYGS VTPVREVNLN
Length:230
Mass (Da):25,458
Last modified:February 1, 1997 - v1
Checksum:iD9B0CEEBB66C10D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40284.1.
U82598 Genomic DNA. Translation: AAB40729.1.
U00096 Genomic DNA. Translation: AAC73633.1.
AP009048 Genomic DNA. Translation: BAE76308.1.
PIRiB64785.
RefSeqiNP_415064.1. NC_000913.3.
WP_000988364.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73633; AAC73633; b0531.
BAE76308; BAE76308; BAE76308.
GeneIDi945367.
KEGGiecj:JW0520.
eco:b0531.
PATRICi32116222. VBIEscCol129921_0552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40284.1.
U82598 Genomic DNA. Translation: AAB40729.1.
U00096 Genomic DNA. Translation: AAC73633.1.
AP009048 Genomic DNA. Translation: BAE76308.1.
PIRiB64785.
RefSeqiNP_415064.1. NC_000913.3.
WP_000988364.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP77249.
SMRiP77249. Positions 26-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263219. 114 interactions.
IntActiP77249. 3 interactions.
STRINGi511145.b0531.

Proteomic databases

PaxDbiP77249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73633; AAC73633; b0531.
BAE76308; BAE76308; BAE76308.
GeneIDi945367.
KEGGiecj:JW0520.
eco:b0531.
PATRICi32116222. VBIEscCol129921_0552.

Organism-specific databases

EchoBASEiEB3641.
EcoGeneiEG13882. sfmC.

Phylogenomic databases

eggNOGiENOG4108AF8. Bacteria.
ENOG410ZPTT. LUCA.
HOGENOMiHOG000260152.
KOiK07353.
OMAiMIAPKNS.
OrthoDBiEOG6QP10C.
PhylomeDBiP77249.

Enzyme and pathway databases

BioCyciEcoCyc:G6291-MONOMER.
ECOL316407:JW0520-MONOMER.

Miscellaneous databases

PROiP77249.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF02753. PapD_C. 1 hit.
PF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
    Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
    Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiSFMC_ECOLI
AccessioniPrimary (citable) accession number: P77249
Secondary accession number(s): P77077, Q2MBP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.