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Protein

HTH-type transcriptional regulator MurR

Gene

murR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator. Also represses its own transcription.1 Publication

Miscellaneous

Neither GlcNAc-6-P, GlcNAc, anhydroMurNAc, MurNAc, nor muramyl dipeptide have an effect on MurR binding to the operator site.

Pathwayi: N-acetylmuramate degradation

This protein regulates the pathway N-acetylmuramate degradation, which is part of Amino-sugar metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway N-acetylmuramate degradation and in Amino-sugar metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 56H-T-H motifSequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processCarbohydrate metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7262-MONOMER.
UniPathwayiUPA00342.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MurR
Alternative name(s):
MurPQ operon repressor
Gene namesi
Name:murR
Synonyms:yfeT
Ordered Locus Names:b2427, JW2420
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14161. murR.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene show an abolition of the extensive lag phase observed when grown on MurNAc and a 20-fold enhancement of murQ transcription.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686251 – 285HTH-type transcriptional regulator MurRAdd BLAST285

Proteomic databases

PaxDbiP77245.
PRIDEiP77245.

Expressioni

Inductioni

Repressed by itself and by the cAMP receptor protein crp.1 Publication

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

BioGridi4263047. 28 interactors.
DIPiDIP-12018N.
IntActiP77245. 12 interactors.
STRINGi316385.ECDH10B_2592.

Structurei

3D structure databases

ProteinModelPortaliP77245.
SMRiP77245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 77HTH rpiR-typeAdd BLAST77
Domaini128 – 268SISAdd BLAST141

Phylogenomic databases

eggNOGiENOG4108PSC. Bacteria.
COG1737. LUCA.
HOGENOMiHOG000027157.
InParanoidiP77245.
KOiK15835.
PhylomeDBiP77245.

Family and domain databases

CDDicd05013. SIS_RpiR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_02108. HTH_type_MurR. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR000281. HTH_RpiR.
IPR035472. RpiR-like_SIS.
IPR001347. SIS.
IPR022821. Tscrpt_reg_HTH_MurR.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.

Sequencei

Sequence statusi: Complete.

P77245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLTKISNA GSEFTENEQK IADFLQANVS ELQSVSSRQM AKQLGISQSS
60 70 80 90 100
IVKFAQKLGA QGFTELRMAL IGEYSASREK TNATALHLHS SITSDDSLEV
110 120 130 140 150
IARKLNREKE LALEQTCALL DYARLQKIIE VISKAPFIQI TGLGGSALVG
160 170 180 190 200
RDLSFKLMKI GYRVACEADT HVQATVSQAL KKGDVQIAIS YSGSKKEIVL
210 220 230 240 250
CAEAARKQGA TVIAITSLTD SPLRRLAHFT LDTVSGETEW RSSSMSTRTA
260 270 280
QNSVTDLLFV GLVQLNDVES LKMIQRSSEL TQRLK
Length:285
Mass (Da):31,192
Last modified:February 1, 1997 - v1
Checksum:i4235E45DB8B7C3A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75480.1.
AP009048 Genomic DNA. Translation: BAA16310.1.
PIRiB65017.
RefSeqiNP_416922.1. NC_000913.3.
WP_000966470.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75480; AAC75480; b2427.
BAA16310; BAA16310; BAA16310.
GeneIDi946568.
KEGGiecj:JW2420.
eco:b2427.
PATRICifig|1411691.4.peg.4304.

Similar proteinsi

Entry informationi

Entry nameiMURR_ECOLI
AccessioniPrimary (citable) accession number: P77245
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways