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P77231 (CITG_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Short name=2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase
EC=2.4.2.52
Gene names
Name:citG
Synonyms:ybdT
Ordered Locus Names:b0613, JW0605
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA. Ref.4 Ref.5

Catalytic activity

ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine. HAMAP-Rule MF_00397

Induction

Repressed by H-NS. Part of the citCDEFXG operon. Ref.6

Sequence similarities

Belongs to the CitG/MdcB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2922922-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase HAMAP-Rule MF_00397
PRO_0000214664

Sequences

Sequence LengthMass (Da)Tools
P77231 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 0BE3C24BE33E0AE8

FASTA29231,644
        10         20         30         40         50         60 
MSMPATSTKT TKLATSLIDE YALLGWRAML TEVNLSPKPG LVDRINCGAH KDMALEDFHR 

        70         80         90        100        110        120 
SALAIQGWLP RFIEFGACSA EMAPEAVLHG LRPIGMACEG DMFRATAGVN THKGSIFSLG 

       130        140        150        160        170        180 
LLCAAIGRLL QLNQPVTPTT VCSTAASFCR GLTDRELRTN NSQLTAGQRL YQQLGLTGAR 

       190        200        210        220        230        240 
GEAEAGYPLV INHALPHYLT LLDQGLDPEL ALLDTLLLLM AINGDTNVAS RGGEGGLRWL 

       250        260        270        280        290 
QREAQTLLQK GGIRTPADLD YLRQFDRECI ERNLSPGGSA DLLILTWFLA QI 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."
Schneider K., Dimroth P., Bott M.
FEBS Lett. 483:165-168(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Biosynthesis of the prosthetic group of citrate lyase."
Schneider K., Dimroth P., Bott M.
Biochemistry 39:9438-9450(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: BL21-DE3 and K12 / DH5-alpha.
[6]"Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
Shimada T., Yamamoto K., Ishihama A.
J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: OPERON STRUCTURE, INDUCTION.
Strain: K12 / BW25113.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U82598 Genomic DNA. Translation: AAB40813.1.
U00096 Genomic DNA. Translation: AAC73714.1.
AP009048 Genomic DNA. Translation: BAE76353.1.
PIRC64795.
RefSeqNP_415146.1. NC_000913.3.
YP_488902.1. NC_007779.1.

3D structure databases

ProteinModelPortalP77231.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP77231. 2 interactions.
STRING511145.b0613.

Proteomic databases

PaxDbP77231.
PRIDEP77231.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73714; AAC73714; b0613.
BAE76353; BAE76353; BAE76353.
GeneID12930909.
946395.
KEGGecj:Y75_p0602.
eco:b0613.
PATRIC32116406. VBIEscCol129921_0643.

Organism-specific databases

EchoBASEEB3309.
EcoGeneEG13539. citG.

Phylogenomic databases

eggNOGCOG1767.
HOGENOMHOG000258582.
KOK05966.
OMADPESNGA.
OrthoDBEOG6WHNRS.
PhylomeDBP77231.
ProtClustDBPRK10096.

Enzyme and pathway databases

BioCycEcoCyc:G6339-MONOMER.
ECOL316407:JW0605-MONOMER.
MetaCyc:G6339-MONOMER.

Gene expression databases

GenevestigatorP77231.

Family and domain databases

HAMAPMF_00397. CitG.
InterProIPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsTIGR03125. citrate_citG. 1 hit.
ProtoNetSearch...

Other

PROP77231.

Entry information

Entry nameCITG_ECOLI
AccessionPrimary (citable) accession number: P77231
Secondary accession number(s): Q2MBK3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene