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P77231

- CITG_ECOLI

UniProt

P77231 - CITG_ECOLI

Protein

2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Gene

citG

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.2 Publications

    Catalytic activityi

    ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. triphosphoribosyl-dephospho-CoA synthase activity Source: EcoCyc

    GO - Biological processi

    1. phosphorylation Source: InterPro
    2. prosthetic group biosynthetic process Source: EcoCyc

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:G6339-MONOMER.
    ECOL316407:JW0605-MONOMER.
    MetaCyc:G6339-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC:2.4.2.52)
    Short name:
    2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase
    Gene namesi
    Name:citG
    Synonyms:ybdT
    Ordered Locus Names:b0613, JW0605
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13539. citG.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2922922-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthasePRO_0000214664Add
    BLAST

    Proteomic databases

    PaxDbiP77231.
    PRIDEiP77231.

    Expressioni

    Inductioni

    Repressed by H-NS. Part of the citCDEFXG operon.1 Publication

    Gene expression databases

    GenevestigatoriP77231.

    Interactioni

    Protein-protein interaction databases

    IntActiP77231. 2 interactions.
    STRINGi511145.b0613.

    Structurei

    3D structure databases

    ProteinModelPortaliP77231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CitG/MdcB family.Curated

    Phylogenomic databases

    eggNOGiCOG1767.
    HOGENOMiHOG000258582.
    KOiK05966.
    OMAiGLACENS.
    OrthoDBiEOG6WHNRS.
    PhylomeDBiP77231.

    Family and domain databases

    HAMAPiMF_00397. CitG.
    InterProiIPR002736. CitG.
    IPR017551. TriPribosyl-deP-CoA_syn_CitG.
    [Graphical view]
    PfamiPF01874. CitG. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03125. citrate_citG. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P77231-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMPATSTKT TKLATSLIDE YALLGWRAML TEVNLSPKPG LVDRINCGAH    50
    KDMALEDFHR SALAIQGWLP RFIEFGACSA EMAPEAVLHG LRPIGMACEG 100
    DMFRATAGVN THKGSIFSLG LLCAAIGRLL QLNQPVTPTT VCSTAASFCR 150
    GLTDRELRTN NSQLTAGQRL YQQLGLTGAR GEAEAGYPLV INHALPHYLT 200
    LLDQGLDPEL ALLDTLLLLM AINGDTNVAS RGGEGGLRWL QREAQTLLQK 250
    GGIRTPADLD YLRQFDRECI ERNLSPGGSA DLLILTWFLA QI 292
    Length:292
    Mass (Da):31,644
    Last modified:February 1, 1997 - v1
    Checksum:i0BE3C24BE33E0AE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82598 Genomic DNA. Translation: AAB40813.1.
    U00096 Genomic DNA. Translation: AAC73714.1.
    AP009048 Genomic DNA. Translation: BAE76353.1.
    PIRiC64795.
    RefSeqiNP_415146.1. NC_000913.3.
    YP_488902.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73714; AAC73714; b0613.
    BAE76353; BAE76353; BAE76353.
    GeneIDi12930909.
    946395.
    KEGGiecj:Y75_p0602.
    eco:b0613.
    PATRICi32116406. VBIEscCol129921_0643.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82598 Genomic DNA. Translation: AAB40813.1 .
    U00096 Genomic DNA. Translation: AAC73714.1 .
    AP009048 Genomic DNA. Translation: BAE76353.1 .
    PIRi C64795.
    RefSeqi NP_415146.1. NC_000913.3.
    YP_488902.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P77231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P77231. 2 interactions.
    STRINGi 511145.b0613.

    Proteomic databases

    PaxDbi P77231.
    PRIDEi P77231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73714 ; AAC73714 ; b0613 .
    BAE76353 ; BAE76353 ; BAE76353 .
    GeneIDi 12930909.
    946395.
    KEGGi ecj:Y75_p0602.
    eco:b0613.
    PATRICi 32116406. VBIEscCol129921_0643.

    Organism-specific databases

    EchoBASEi EB3309.
    EcoGenei EG13539. citG.

    Phylogenomic databases

    eggNOGi COG1767.
    HOGENOMi HOG000258582.
    KOi K05966.
    OMAi GLACENS.
    OrthoDBi EOG6WHNRS.
    PhylomeDBi P77231.

    Enzyme and pathway databases

    BioCyci EcoCyc:G6339-MONOMER.
    ECOL316407:JW0605-MONOMER.
    MetaCyc:G6339-MONOMER.

    Miscellaneous databases

    PROi P77231.

    Gene expression databases

    Genevestigatori P77231.

    Family and domain databases

    HAMAPi MF_00397. CitG.
    InterProi IPR002736. CitG.
    IPR017551. TriPribosyl-deP-CoA_syn_CitG.
    [Graphical view ]
    Pfami PF01874. CitG. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03125. citrate_citG. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."
      Schneider K., Dimroth P., Bott M.
      FEBS Lett. 483:165-168(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Biosynthesis of the prosthetic group of citrate lyase."
      Schneider K., Dimroth P., Bott M.
      Biochemistry 39:9438-9450(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: BL21-DE3 and K12 / DH5-alpha.
    6. "Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
      Shimada T., Yamamoto K., Ishihama A.
      J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: OPERON STRUCTURE, INDUCTION.
      Strain: K12 / BW25113.

    Entry informationi

    Entry nameiCITG_ECOLI
    AccessioniPrimary (citable) accession number: P77231
    Secondary accession number(s): Q2MBK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3