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P77231

- CITG_ECOLI

UniProt

P77231 - CITG_ECOLI

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Protein

2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Gene
citG, ybdT, b0613, JW0605
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.2 Publications

Catalytic activityi

ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. triphosphoribosyl-dephospho-CoA synthase activity Source: EcoCyc

GO - Biological processi

  1. phosphorylation Source: InterPro
  2. prosthetic group biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6339-MONOMER.
ECOL316407:JW0605-MONOMER.
MetaCyc:G6339-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC:2.4.2.52)
Short name:
2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase
Gene namesi
Name:citG
Synonyms:ybdT
Ordered Locus Names:b0613, JW0605
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13539. citG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2922922-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseUniRule annotationPRO_0000214664Add
BLAST

Proteomic databases

PaxDbiP77231.
PRIDEiP77231.

Expressioni

Inductioni

Repressed by H-NS. Part of the citCDEFXG operon.1 Publication

Gene expression databases

GenevestigatoriP77231.

Interactioni

Protein-protein interaction databases

IntActiP77231. 2 interactions.
STRINGi511145.b0613.

Structurei

3D structure databases

ProteinModelPortaliP77231.

Family & Domainsi

Sequence similaritiesi

Belongs to the CitG/MdcB family.

Phylogenomic databases

eggNOGiCOG1767.
HOGENOMiHOG000258582.
KOiK05966.
OMAiGLACENS.
OrthoDBiEOG6WHNRS.
PhylomeDBiP77231.

Family and domain databases

HAMAPiMF_00397. CitG.
InterProiIPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.

Sequencei

Sequence statusi: Complete.

P77231-1 [UniParc]FASTAAdd to Basket

« Hide

MSMPATSTKT TKLATSLIDE YALLGWRAML TEVNLSPKPG LVDRINCGAH    50
KDMALEDFHR SALAIQGWLP RFIEFGACSA EMAPEAVLHG LRPIGMACEG 100
DMFRATAGVN THKGSIFSLG LLCAAIGRLL QLNQPVTPTT VCSTAASFCR 150
GLTDRELRTN NSQLTAGQRL YQQLGLTGAR GEAEAGYPLV INHALPHYLT 200
LLDQGLDPEL ALLDTLLLLM AINGDTNVAS RGGEGGLRWL QREAQTLLQK 250
GGIRTPADLD YLRQFDRECI ERNLSPGGSA DLLILTWFLA QI 292
Length:292
Mass (Da):31,644
Last modified:February 1, 1997 - v1
Checksum:i0BE3C24BE33E0AE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82598 Genomic DNA. Translation: AAB40813.1.
U00096 Genomic DNA. Translation: AAC73714.1.
AP009048 Genomic DNA. Translation: BAE76353.1.
PIRiC64795.
RefSeqiNP_415146.1. NC_000913.3.
YP_488902.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73714; AAC73714; b0613.
BAE76353; BAE76353; BAE76353.
GeneIDi12930909.
946395.
KEGGiecj:Y75_p0602.
eco:b0613.
PATRICi32116406. VBIEscCol129921_0643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82598 Genomic DNA. Translation: AAB40813.1 .
U00096 Genomic DNA. Translation: AAC73714.1 .
AP009048 Genomic DNA. Translation: BAE76353.1 .
PIRi C64795.
RefSeqi NP_415146.1. NC_000913.3.
YP_488902.1. NC_007779.1.

3D structure databases

ProteinModelPortali P77231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P77231. 2 interactions.
STRINGi 511145.b0613.

Proteomic databases

PaxDbi P77231.
PRIDEi P77231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC73714 ; AAC73714 ; b0613 .
BAE76353 ; BAE76353 ; BAE76353 .
GeneIDi 12930909.
946395.
KEGGi ecj:Y75_p0602.
eco:b0613.
PATRICi 32116406. VBIEscCol129921_0643.

Organism-specific databases

EchoBASEi EB3309.
EcoGenei EG13539. citG.

Phylogenomic databases

eggNOGi COG1767.
HOGENOMi HOG000258582.
KOi K05966.
OMAi GLACENS.
OrthoDBi EOG6WHNRS.
PhylomeDBi P77231.

Enzyme and pathway databases

BioCyci EcoCyc:G6339-MONOMER.
ECOL316407:JW0605-MONOMER.
MetaCyc:G6339-MONOMER.

Miscellaneous databases

PROi P77231.

Gene expression databases

Genevestigatori P77231.

Family and domain databases

HAMAPi MF_00397. CitG.
InterProi IPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view ]
Pfami PF01874. CitG. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03125. citrate_citG. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."
    Schneider K., Dimroth P., Bott M.
    FEBS Lett. 483:165-168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Biosynthesis of the prosthetic group of citrate lyase."
    Schneider K., Dimroth P., Bott M.
    Biochemistry 39:9438-9450(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: BL21-DE3 and K12 / DH5-alpha.
  6. "Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
    Shimada T., Yamamoto K., Ishihama A.
    J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: OPERON STRUCTURE, INDUCTION.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiCITG_ECOLI
AccessioniPrimary (citable) accession number: P77231
Secondary accession number(s): Q2MBK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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