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Protein

2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Gene

citG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.2 Publications

Catalytic activityi

ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • triphosphoribosyl-dephospho-CoA synthase activity Source: EcoCyc

GO - Biological processi

  • phosphorylation Source: InterPro
  • prosthetic group biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6339-MONOMER.
ECOL316407:JW0605-MONOMER.
MetaCyc:G6339-MONOMER.
BRENDAi2.4.2.52. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (EC:2.4.2.52)
Short name:
2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase
Gene namesi
Name:citG
Synonyms:ybdT
Ordered Locus Names:b0613, JW0605
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13539. citG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2922922-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthasePRO_0000214664Add
BLAST

Proteomic databases

PaxDbiP77231.
PRIDEiP77231.

Expressioni

Inductioni

Repressed by H-NS. Part of the citCDEFXG operon.1 Publication

Gene expression databases

GenevestigatoriP77231.

Interactioni

Protein-protein interaction databases

IntActiP77231. 2 interactions.
STRINGi511145.b0613.

Structurei

3D structure databases

ProteinModelPortaliP77231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CitG/MdcB family.Curated

Phylogenomic databases

eggNOGiCOG1767.
HOGENOMiHOG000258582.
InParanoidiP77231.
KOiK05966.
OMAiCFSKEDT.
OrthoDBiEOG6WHNRS.
PhylomeDBiP77231.

Family and domain databases

HAMAPiMF_00397. CitG.
InterProiIPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.

Sequencei

Sequence statusi: Complete.

P77231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMPATSTKT TKLATSLIDE YALLGWRAML TEVNLSPKPG LVDRINCGAH
60 70 80 90 100
KDMALEDFHR SALAIQGWLP RFIEFGACSA EMAPEAVLHG LRPIGMACEG
110 120 130 140 150
DMFRATAGVN THKGSIFSLG LLCAAIGRLL QLNQPVTPTT VCSTAASFCR
160 170 180 190 200
GLTDRELRTN NSQLTAGQRL YQQLGLTGAR GEAEAGYPLV INHALPHYLT
210 220 230 240 250
LLDQGLDPEL ALLDTLLLLM AINGDTNVAS RGGEGGLRWL QREAQTLLQK
260 270 280 290
GGIRTPADLD YLRQFDRECI ERNLSPGGSA DLLILTWFLA QI
Length:292
Mass (Da):31,644
Last modified:February 1, 1997 - v1
Checksum:i0BE3C24BE33E0AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40813.1.
U00096 Genomic DNA. Translation: AAC73714.1.
AP009048 Genomic DNA. Translation: BAE76353.1.
PIRiC64795.
RefSeqiNP_415146.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC73714; AAC73714; b0613.
BAE76353; BAE76353; BAE76353.
GeneIDi946395.
KEGGiecj:Y75_p0602.
eco:b0613.
PATRICi32116406. VBIEscCol129921_0643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40813.1.
U00096 Genomic DNA. Translation: AAC73714.1.
AP009048 Genomic DNA. Translation: BAE76353.1.
PIRiC64795.
RefSeqiNP_415146.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP77231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP77231. 2 interactions.
STRINGi511145.b0613.

Proteomic databases

PaxDbiP77231.
PRIDEiP77231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73714; AAC73714; b0613.
BAE76353; BAE76353; BAE76353.
GeneIDi946395.
KEGGiecj:Y75_p0602.
eco:b0613.
PATRICi32116406. VBIEscCol129921_0643.

Organism-specific databases

EchoBASEiEB3309.
EcoGeneiEG13539. citG.

Phylogenomic databases

eggNOGiCOG1767.
HOGENOMiHOG000258582.
InParanoidiP77231.
KOiK05966.
OMAiCFSKEDT.
OrthoDBiEOG6WHNRS.
PhylomeDBiP77231.

Enzyme and pathway databases

BioCyciEcoCyc:G6339-MONOMER.
ECOL316407:JW0605-MONOMER.
MetaCyc:G6339-MONOMER.
BRENDAi2.4.2.52. 2026.

Miscellaneous databases

PROiP77231.

Gene expression databases

GenevestigatoriP77231.

Family and domain databases

HAMAPiMF_00397. CitG.
InterProiIPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."
    Schneider K., Dimroth P., Bott M.
    FEBS Lett. 483:165-168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Biosynthesis of the prosthetic group of citrate lyase."
    Schneider K., Dimroth P., Bott M.
    Biochemistry 39:9438-9450(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: BL21-DE3 and K12 / DH5-alpha.
  6. "Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux."
    Shimada T., Yamamoto K., Ishihama A.
    J. Bacteriol. 191:4562-4571(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: OPERON STRUCTURE, INDUCTION.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiCITG_ECOLI
AccessioniPrimary (citable) accession number: P77231
Secondary accession number(s): Q2MBK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 27, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.