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Protein

Putative outer membrane usher protein YfcU

Gene

yfcU

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. Probably involved in the export and assembly of fimbrial subunits across the outer membrane.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Caution

Could be the product of a pseudogene. This sequence is interrupted by a stop codon.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processFimbrium biogenesis, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7209-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative outer membrane usher protein YfcU
Gene namesi
Name:yfcU
Synonyms:yfcT
Ordered Locus Names:b4661, JW2334/JW2335
ORF Names:b2337, b2338
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14124 yfcU

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000933230 – 881Putative outer membrane usher protein YfcUAdd BLAST852

Proteomic databases

PRIDEiP77196

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261776, 11 interactors
4262083, 222 interactors
DIPiDIP-11989N
IntActiP77196, 20 interactors
STRINGi316385.ECDH10B_2500

Structurei

3D structure databases

ProteinModelPortaliP77196
SMRiP77196
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial export usher family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4106PG1 Bacteria
COG3188 LUCA
HOGENOMiHOG000260138
InParanoidiP77196
OMAiTQCEAAL
PhylomeDBiP77196

Family and domain databases

InterProiView protein in InterPro
IPR000015 Fimb_usher
IPR018030 Fimbrial_membr_usher_CS
IPR025949 PapC-like_C
IPR025885 PapC_N
IPR037224 PapC_N_sf
PANTHERiPTHR30451 PTHR30451, 1 hit
PfamiView protein in Pfam
PF13953 PapC_C, 1 hit
PF13954 PapC_N, 1 hit
PF00577 Usher, 1 hit
SUPFAMiSSF141729 SSF141729, 1 hit
PROSITEiView protein in PROSITE
PS01151 FIMBRIAL_USHER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDHSLFRLR ILPWCIALAM SGSYSSVWAE DDIQFDSRFL ELKGDTKIDL
60 70 80 90 100
KRFSSQGYVE PGKYNLQVQL NKQPLAEEYD IYWYAGEDDV SKSYACLTPE
110 120 130 140 150
LVAQFGLKED VAKNLQWSHD GKCLKPGQLE GVEIKADLSQ SALVISLPQA
160 170 180 190 200
YLEYTWPDWD PPSRWDDGIS GIIADYSITA QTRHEENGGD DSNEISGNGT
210 220 230 240 250
VGVNLGPWRM RADWQTNYQH TRSNDDDDEF GGDDTQKKWE WSRYYAWRAL
260 270 280 290 300
PSLKAKLALG EDYLNSDIFD GFNYVGGSVS TDDQMLPPNL RGYAPDISGV
310 320 330 340 350
AHTTAKVTVS QMGRVIYETQ VPAGPFRIQD LGDSVSGTLH IRIEEQNGQV
360 370 380 390 400
QEYDISTASM PYLTRPGQVR YKIMMGRPQE WGHHVEGGFF SGAEASWGIA
410 420 430 440 450
NGWSLYGGAL GDENYQSAAL GVGRDLSTFG AVAFDVTHSH TKLDKDTAYG
460 470 480 490 500
KGSLDGNSFR VSYSKDFDQL NSRVTFAGYR FSEENFMTMS EYLDASDSEM
510 520 530 540 550
VRTGNDKEMY TATYNQNFRD AGVSVYLNYT RHTYWDREEQ TNYNIMLSHY
560 570 580 590 600
FNMGSIRNMS VSLTGYRYEY DNRADKGMYI SLSMPWGDNS TVSYNGNYGS
610 620 630 640 650
GTDSSQVGYF SRVDDATHYQ LNIGTSDKHT SVDGYYSHDG SLAQVDLSAN
660 670 680 690 700
YHEGQYTSAG LSLQGGATLT THGGALHRTQ NMGGTRLLID ADGVADVPVE
710 720 730 740 750
GNGAAVYTNM FGKAVVSDVN NYYRNQAYID LNKLPENAEA TQSVVQATLT
760 770 780 790 800
EGAIGYRKFA VISGQKAMAV LRLQDGSHPP FGAEVKNDNE QTVGLVDDDG
810 820 830 840 850
SVYLAGVKPG EHMSVFWSGV AHCDINLPDP LPADLFNGLL LPCQHKGNVA
860 870 880
PVVPDDIKPV IQEQTQQVTP TDPPVSVSAN Q
Length:881
Mass (Da):97,490
Last modified:January 9, 2007 - v3
Checksum:i48B392C1AE2C9111
GO

Sequence cautioni

The sequence BAA16191 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA16192 differs from that shown. Reason: Erroneous termination at position 579. Translated as Tyr.Curated
The sequence U00096 differs from that shown. Reason: Erroneous termination at position 579. Translated as Tyr.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA No translation available.
AP009048 Genomic DNA Translation: BAA16191.1 Different initiation.
AP009048 Genomic DNA Translation: BAA16192.1 Sequence problems.
PIRiG65006
H65006

Genome annotation databases

EnsemblBacteriaiBAA16191; BAA16191; BAA16191
BAA16192; BAA16192; BAA16192
KEGGiecj:JW2334
ecj:JW2335

Similar proteinsi

Entry informationi

Entry nameiYFCU_ECOLI
AccessioniPrimary (citable) accession number: P77196
Secondary accession number(s): P77532
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: March 28, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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