P77196 (YFCU_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative outer membrane usher protein YfcU

Gene names

Name:	yfcU
Ordered Locus Names:	b4661, JW2334/JW2335
ORF Names:	b2337, b2338

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	881 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Function	Involved in the export and assembly of a fimbrial subunit across the outer membrane By similarity.
Subcellular location	Cell outer membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the fimbrial export usher family.
Caution	Could be the product of a pseudogene.
Sequence caution	The sequence BAA16191.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA16192.1 differs from that shown. Reason: Erroneous termination at position 579. Translated as Tyr. The sequence U00096 differs from that shown. Reason: Erroneous termination at position 579. Translated as Tyr.

Ontologies

Keywords
Biological process	Fimbrium biogenesis Transport
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal Transmembrane Transmembrane beta strand
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 881	852	Putative outer membrane usher protein YfcU		PRO_0000009332

Sequences

	Sequence		Length	Mass (Da)
	P77196 [UniParc]. Last modified January 9, 2007. Version 3. Checksum: 48B392C1AE2C9111	FASTA	881	97,490
	10 20 30 40 50 60 MPDHSLFRLR ILPWCIALAM SGSYSSVWAE DDIQFDSRFL ELKGDTKIDL KRFSSQGYVE 70 80 90 100 110 120 PGKYNLQVQL NKQPLAEEYD IYWYAGEDDV SKSYACLTPE LVAQFGLKED VAKNLQWSHD 130 140 150 160 170 180 GKCLKPGQLE GVEIKADLSQ SALVISLPQA YLEYTWPDWD PPSRWDDGIS GIIADYSITA 190 200 210 220 230 240 QTRHEENGGD DSNEISGNGT VGVNLGPWRM RADWQTNYQH TRSNDDDDEF GGDDTQKKWE 250 260 270 280 290 300 WSRYYAWRAL PSLKAKLALG EDYLNSDIFD GFNYVGGSVS TDDQMLPPNL RGYAPDISGV 310 320 330 340 350 360 AHTTAKVTVS QMGRVIYETQ VPAGPFRIQD LGDSVSGTLH IRIEEQNGQV QEYDISTASM 370 380 390 400 410 420 PYLTRPGQVR YKIMMGRPQE WGHHVEGGFF SGAEASWGIA NGWSLYGGAL GDENYQSAAL 430 440 450 460 470 480 GVGRDLSTFG AVAFDVTHSH TKLDKDTAYG KGSLDGNSFR VSYSKDFDQL NSRVTFAGYR 490 500 510 520 530 540 FSEENFMTMS EYLDASDSEM VRTGNDKEMY TATYNQNFRD AGVSVYLNYT RHTYWDREEQ 550 560 570 580 590 600 TNYNIMLSHY FNMGSIRNMS VSLTGYRYEY DNRADKGMYI SLSMPWGDNS TVSYNGNYGS 610 620 630 640 650 660 GTDSSQVGYF SRVDDATHYQ LNIGTSDKHT SVDGYYSHDG SLAQVDLSAN YHEGQYTSAG 670 680 690 700 710 720 LSLQGGATLT THGGALHRTQ NMGGTRLLID ADGVADVPVE GNGAAVYTNM FGKAVVSDVN 730 740 750 760 770 780 NYYRNQAYID LNKLPENAEA TQSVVQATLT EGAIGYRKFA VISGQKAMAV LRLQDGSHPP 790 800 810 820 830 840 FGAEVKNDNE QTVGLVDDDG SVYLAGVKPG EHMSVFWSGV AHCDINLPDP LPADLFNGLL 850 860 870 880 LPCQHKGNVA PVVPDDIKPV IQEQTQQVTP TDPPVSVSAN Q

References

[1]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T. DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. No translation available. AP009048 Genomic DNA. Translation: BAA16191.1. Different initiation. AP009048 Genomic DNA. Translation: BAA16192.1. Sequence problems.
PIR	G65006. H65006.
RefSeq	YP_490579.1. NC_007779.1. YP_490580.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P77196.
SMR	P77196. Positions 172-670, 764-843.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-11989N.
IntAct	P77196. 20 interactions.
STRING	316407.yfcU.
Proteomic databases
PRIDE	P77196.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA16191; BAA16191; BAA16191. BAA16192; BAA16192; BAA16192.
GeneID	12932782. 12933089.
KEGG	ecj:Y75_p2303. ecj:Y75_p2304.
PATRIC	48664076. VBIEscCol107702_2379.
Organism-specific databases
EchoBASE	EB3876.
EcoGene	EG14124. yfcU.
Phylogenomic databases
eggNOG	COG3188.
HOGENOM	HOG000260138.
OMA	NQSQIAQ.
Enzyme and pathway databases
BioCyc	EcoCyc:G7208-MONOMER. EcoCyc:G7209-MONOMER. ECOL316407:JW2334-MONOMER. ECOL316407:JW2335-MONOMER.
Gene expression databases
Genevestigator	P77196.
Family and domain databases
InterPro	IPR000015. Fimb_usher. IPR018030. Fimbrial_membr_usher_CS. IPR025949. PapC-like_C. IPR025885. PapC_N_dom. [Graphical view]
Pfam	PF13953. PapC_C. 1 hit. PF13954. PapC_N. 1 hit. PF00577. Usher. 1 hit. [Graphical view]
PROSITE	PS01151. FIMBRIAL_USHER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YFCU_ECOLI

Accession

Primary (citable) accession number: P77196
Secondary accession number(s): P77532

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program