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Protein

Probable fimbrial chaperone EcpB

Gene

ecpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity).By similarity

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Fimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G6163-MONOMER.
ECOL316407:JW0286-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone EcpB
Gene namesi
Name:ecpB
Synonyms:matC, yagY
Ordered Locus Names:b0292, JW0286
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13564. ecpB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001378921 – 222Probable fimbrial chaperone EcpBAdd BLAST202

Proteomic databases

PaxDbiP77188.
PRIDEiP77188.

Expressioni

Inductioni

Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity).By similarity

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ispGP626202EBI-1113651,EBI-550338

Protein-protein interaction databases

BioGridi4259791. 5 interactors.
IntActiP77188. 53 interactors.
STRINGi511145.b0292.

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 30Combined sources5
Beta strandi35 – 43Combined sources9
Beta strandi45 – 47Combined sources3
Beta strandi49 – 59Combined sources11
Beta strandi75 – 79Combined sources5
Beta strandi81 – 85Combined sources5
Beta strandi89 – 97Combined sources9
Beta strandi106 – 113Combined sources8
Beta strandi136 – 143Combined sources8
Beta strandi152 – 155Combined sources4
Beta strandi158 – 161Combined sources4
Beta strandi163 – 165Combined sources3
Beta strandi167 – 177Combined sources11
Helixi178 – 180Combined sources3
Beta strandi184 – 190Combined sources7
Beta strandi195 – 197Combined sources3
Beta strandi199 – 201Combined sources3
Beta strandi209 – 214Combined sources6
Beta strandi217 – 222Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DFKX-ray2.40A21-222[»]
ProteinModelPortaliP77188.
SMRiP77188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EcpB/EcpE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108NN8. Bacteria.
ENOG41119MM. LUCA.
HOGENOMiHOG000269492.
OMAiKVIPMDK.

Family and domain databases

InterProiIPR008962. PapD-like.
[Graphical view]
SUPFAMiSSF49354. SSF49354. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKHLLPLAL LFSGISPAQA LDVGDISSFM NSDSSTLSKT IKNSTDSGRL
60 70 80 90 100
INIRLERLSS PLDDGQVISM DKPDELLLTP ASLLLPAQAS EVIRFFYKGP
110 120 130 140 150
ADEKERYYRI VWFDQALSDA QRDNANRSAV ATASARIGTI LVVAPRQANY
160 170 180 190 200
HFQYANGSLT NTGNATLRIL AYGPCLKAAN GKECKENYYL MPGKSRRFTR
210 220
VDTADNKGRV ALWQGDKFIP VK
Length:222
Mass (Da):24,517
Last modified:February 1, 1997 - v1
Checksum:i2B47AE6230FCC8D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18021.1.
U00096 Genomic DNA. Translation: AAC73395.1.
AP009048 Genomic DNA. Translation: BAE76076.1.
PIRiD64755.
RefSeqiNP_414826.1. NC_000913.3.
WP_000716398.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73395; AAC73395; b0292.
BAE76076; BAE76076; BAE76076.
GeneIDi948806.
KEGGiecj:JW0286.
eco:b0292.
PATRICi32115707. VBIEscCol129921_0296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA. Translation: AAB18021.1.
U00096 Genomic DNA. Translation: AAC73395.1.
AP009048 Genomic DNA. Translation: BAE76076.1.
PIRiD64755.
RefSeqiNP_414826.1. NC_000913.3.
WP_000716398.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DFKX-ray2.40A21-222[»]
ProteinModelPortaliP77188.
SMRiP77188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259791. 5 interactors.
IntActiP77188. 53 interactors.
STRINGi511145.b0292.

Proteomic databases

PaxDbiP77188.
PRIDEiP77188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73395; AAC73395; b0292.
BAE76076; BAE76076; BAE76076.
GeneIDi948806.
KEGGiecj:JW0286.
eco:b0292.
PATRICi32115707. VBIEscCol129921_0296.

Organism-specific databases

EchoBASEiEB3334.
EcoGeneiEG13564. ecpB.

Phylogenomic databases

eggNOGiENOG4108NN8. Bacteria.
ENOG41119MM. LUCA.
HOGENOMiHOG000269492.
OMAiKVIPMDK.

Enzyme and pathway databases

BioCyciEcoCyc:G6163-MONOMER.
ECOL316407:JW0286-MONOMER.

Miscellaneous databases

PROiP77188.

Family and domain databases

InterProiIPR008962. PapD-like.
[Graphical view]
SUPFAMiSSF49354. SSF49354. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiECPB_ECOLI
AccessioniPrimary (citable) accession number: P77188
Secondary accession number(s): Q2MCD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Not expressed under classical laboratory conditions, but is functional when constitutively expressed (PubMed:11466275 and PubMed:20522494).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.