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Protein

Probable fimbrial chaperone EcpB

Gene

ecpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity).By similarity

Miscellaneous

Not expressed under classical laboratory conditions, but is functional when constitutively expressed (PubMed:11466275 and PubMed:20522494).

Keywordsi

Molecular functionChaperone
Biological processFimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:G6163-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fimbrial chaperone EcpB
Gene namesi
Name:ecpB
Synonyms:matC, yagY
Ordered Locus Names:b0292, JW0286
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13564 ecpB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001378921 – 222Probable fimbrial chaperone EcpBAdd BLAST202

Proteomic databases

PaxDbiP77188
PRIDEiP77188

Expressioni

Inductioni

Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity).By similarity

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ispGP626202EBI-1113651,EBI-550338

Protein-protein interaction databases

BioGridi4259791, 5 interactors
IntActiP77188, 53 interactors
STRINGi316385.ECDH10B_0280

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 30Combined sources5
Beta strandi35 – 43Combined sources9
Beta strandi45 – 47Combined sources3
Beta strandi49 – 59Combined sources11
Beta strandi75 – 79Combined sources5
Beta strandi81 – 85Combined sources5
Beta strandi89 – 97Combined sources9
Beta strandi106 – 113Combined sources8
Beta strandi136 – 143Combined sources8
Beta strandi152 – 155Combined sources4
Beta strandi158 – 161Combined sources4
Beta strandi163 – 165Combined sources3
Beta strandi167 – 177Combined sources11
Helixi178 – 180Combined sources3
Beta strandi184 – 190Combined sources7
Beta strandi195 – 197Combined sources3
Beta strandi199 – 201Combined sources3
Beta strandi209 – 214Combined sources6
Beta strandi217 – 222Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DFKX-ray2.40A21-222[»]
ProteinModelPortaliP77188
SMRiP77188
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EcpB/EcpE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108NN8 Bacteria
ENOG41119MM LUCA
HOGENOMiHOG000269492
KOiK21965
OMAiKENYFVM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR008962 PapD-like_sf
SUPFAMiSSF49354 SSF49354, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P77188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKHLLPLAL LFSGISPAQA LDVGDISSFM NSDSSTLSKT IKNSTDSGRL
60 70 80 90 100
INIRLERLSS PLDDGQVISM DKPDELLLTP ASLLLPAQAS EVIRFFYKGP
110 120 130 140 150
ADEKERYYRI VWFDQALSDA QRDNANRSAV ATASARIGTI LVVAPRQANY
160 170 180 190 200
HFQYANGSLT NTGNATLRIL AYGPCLKAAN GKECKENYYL MPGKSRRFTR
210 220
VDTADNKGRV ALWQGDKFIP VK
Length:222
Mass (Da):24,517
Last modified:February 1, 1997 - v1
Checksum:i2B47AE6230FCC8D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73857 Genomic DNA Translation: AAB18021.1
U00096 Genomic DNA Translation: AAC73395.1
AP009048 Genomic DNA Translation: BAE76076.1
PIRiD64755
RefSeqiNP_414826.1, NC_000913.3
WP_000716398.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73395; AAC73395; b0292
BAE76076; BAE76076; BAE76076
GeneIDi948806
KEGGiecj:JW0286
eco:b0292
PATRICifig|511145.12.peg.296

Similar proteinsi

Entry informationi

Entry nameiECPB_ECOLI
AccessioniPrimary (citable) accession number: P77188
Secondary accession number(s): Q2MCD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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