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Protein

2-hydroxy-3-oxopropionate reductase

Gene

glxR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glycerate + NAD(P)+ = 2-hydroxy-3-oxopropanoate + NAD(P)H.

Pathwayi: glycolate degradation

This protein is involved in step 3 of the subpathway that synthesizes 3-phospho-D-glycerate from glycolate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glyoxylate carboligase (gcl)
  3. 2-hydroxy-3-oxopropionate reductase (glxR)
  4. Glycerate 3-kinase (glxK)
This subpathway is part of the pathway glycolate degradation, which is itself part of Organic acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-phospho-D-glycerate from glycolate, the pathway glycolate degradation and in Organic acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94NADBy similarity1
Active sitei169By similarity1
Binding sitei237NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 18NADBy similarityAdd BLAST15

GO - Molecular functioni

GO - Biological processi

  • allantoin assimilation pathway Source: EcoCyc
  • cellular response to DNA damage stimulus Source: EcoliWiki
  • glycolate catabolic process Source: UniProtKB-UniPathway
  • glyoxylate catabolic process Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:G6278-MONOMER
MetaCyc:G6278-MONOMER
UniPathwayiUPA00864; UER00832

Names & Taxonomyi

Protein namesi
Recommended name:
2-hydroxy-3-oxopropionate reductase (EC:1.1.1.60)
Alternative name(s):
Tartronate semialdehyde reductase
Short name:
TSAR
Gene namesi
Name:glxR
Synonyms:glxB1, ybbQ
Ordered Locus Names:b0509, JW0497
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13265 glxR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730611 – 2922-hydroxy-3-oxopropionate reductaseAdd BLAST292

Proteomic databases

PaxDbiP77161
PRIDEiP77161

Expressioni

Inductioni

By glyoxylate.

Interactioni

Protein-protein interaction databases

BioGridi4262821, 16 interactors
IntActiP77161, 9 interactors
STRINGi316385.ECDH10B_0465

Structurei

3D structure databases

ProteinModelPortaliP77161
SMRiP77161
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CF3 Bacteria
COG2084 LUCA
HOGENOMiHOG000219608
InParanoidiP77161
KOiK00042
OMAiSCKIANQ
PhylomeDBiP77161

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006115 6PGDH_NADP-bd
IPR015815 HIBADH-related
IPR036291 NAD(P)-bd_dom_sf
IPR029154 NADP-bd
IPR006398 Tartro_sem_red
PfamiView protein in Pfam
PF14833 NAD_binding_11, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000103 HIBADH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01505 tartro_sem_red, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit

Sequencei

Sequence statusi: Complete.

P77161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGFIGLGI MGTPMAINLA RAGHQLHVTT IGPVADELLS LGAVSVETAR
60 70 80 90 100
QVTEASDIIF IMVPDTPQVE EVLFGENGCT KASLKGKTIV DMSSISPIET
110 120 130 140 150
KRFARQVNEL GGDYLDAPVS GGEIGAREGT LSIMVGGDEA VFERVKPLFE
160 170 180 190 200
LLGKNITLVG GNGDGQTCKV ANQIIVALNI EAVSEALLFA SKAGADPVRV
210 220 230 240 250
RQALMGGFAS SRILEVHGER MIKRTFNPGF KIALHQKDLN LALQSAKALA
260 270 280 290
LNLPNTATCQ ELFNTCAANG GSQLDHSALV QALELMANHK LA
Length:292
Mass (Da):30,801
Last modified:February 1, 1997 - v1
Checksum:i5D5263231F2910F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89279 Genomic DNA Translation: AAB93851.1
U82664 Genomic DNA Translation: AAB40262.1
U00096 Genomic DNA Translation: AAC73611.1
AP009048 Genomic DNA Translation: BAE76287.1
PIRiD64782
RefSeqiNP_415042.1, NC_000913.3
WP_000765839.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73611; AAC73611; b0509
BAE76287; BAE76287; BAE76287
GeneIDi945146
KEGGiecj:JW0497
eco:b0509
PATRICifig|1411691.4.peg.1768

Similar proteinsi

Entry informationi

Entry nameiGLXR_ECOLI
AccessioniPrimary (citable) accession number: P77161
Secondary accession number(s): Q2MBR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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