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Protein

Protein HokE

Gene

hokE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1581.
ECOL316407:JW5084-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HokE
Gene namesi
Name:hokE
Synonyms:ybdY
Ordered Locus Names:b4415, JW5084
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14302. hokE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990361 – 50Protein HokEAdd BLAST50

Proteomic databases

PaxDbiP77091.
PRIDEiP77091.

Interactioni

Protein-protein interaction databases

BioGridi4260712. 218 interactors.
STRINGi511145.b4415.

Structurei

3D structure databases

ProteinModelPortaliP77091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hok/gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107635. Bacteria.
ENOG410Z5SJ. LUCA.
HOGENOMiHOG000041219.
KOiK18922.
OMAiTKERSME.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKYALAAV IVLCLTVLGF TLLVGDSLCE FTVKERNIEF KAVLAYEPKK
Length:50
Mass (Da):5,564
Last modified:July 15, 1998 - v2
Checksum:i8AD9A981A6D46835
GO

Sequence cautioni

The sequence AAB40780 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40780.1. Different initiation.
U00096 Genomic DNA. Translation: AAT48125.1.
AP009048 Genomic DNA. Translation: BAA35222.2.
RefSeqiWP_000956455.1. NZ_LN832404.1.
YP_025295.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48125; AAT48125; b4415.
BAA35222; BAA35222; BAA35222.
GeneIDi2847715.
KEGGiecj:JW5084.
eco:b4415.
PATRICi32116332. VBIEscCol129921_0606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40780.1. Different initiation.
U00096 Genomic DNA. Translation: AAT48125.1.
AP009048 Genomic DNA. Translation: BAA35222.2.
RefSeqiWP_000956455.1. NZ_LN832404.1.
YP_025295.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP77091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260712. 218 interactors.
STRINGi511145.b4415.

Proteomic databases

PaxDbiP77091.
PRIDEiP77091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48125; AAT48125; b4415.
BAA35222; BAA35222; BAA35222.
GeneIDi2847715.
KEGGiecj:JW5084.
eco:b4415.
PATRICi32116332. VBIEscCol129921_0606.

Organism-specific databases

EchoBASEiEB4049.
EcoGeneiEG14302. hokE.

Phylogenomic databases

eggNOGiENOG4107635. Bacteria.
ENOG410Z5SJ. LUCA.
HOGENOMiHOG000041219.
KOiK18922.
OMAiTKERSME.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1581.
ECOL316407:JW5084-MONOMER.

Miscellaneous databases

PROiP77091.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOKE_ECOLI
AccessioniPrimary (citable) accession number: P77091
Secondary accession number(s): Q9R7T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.