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Protein

Protein HokE

Gene

hokE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1581.
ECOL316407:JW5084-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HokE
Gene namesi
Name:hokE
Synonyms:ybdY
Ordered Locus Names:b4415, JW5084
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14302. hokE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5050Protein HokEPRO_0000199036Add
BLAST

Proteomic databases

PaxDbiP77091.

Interactioni

Protein-protein interaction databases

BioGridi4260712. 218 interactions.
STRINGi511145.b4415.

Structurei

3D structure databases

ProteinModelPortaliP77091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hok/gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107635. Bacteria.
ENOG410Z5SJ. LUCA.
HOGENOMiHOG000041219.
KOiK18922.
OMAiTKERSME.
OrthoDBiEOG6TR0M8.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P77091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKYALAAV IVLCLTVLGF TLLVGDSLCE FTVKERNIEF KAVLAYEPKK
Length:50
Mass (Da):5,564
Last modified:July 15, 1998 - v2
Checksum:i8AD9A981A6D46835
GO

Sequence cautioni

The sequence AAB40780.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40780.1. Different initiation.
U00096 Genomic DNA. Translation: AAT48125.1.
AP009048 Genomic DNA. Translation: BAA35222.2.
RefSeqiWP_000956455.1. NZ_LN832404.1.
YP_025295.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48125; AAT48125; b4415.
BAA35222; BAA35222; BAA35222.
GeneIDi2847715.
KEGGiecj:JW5084.
eco:b4415.
PATRICi32116332. VBIEscCol129921_0606.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40780.1. Different initiation.
U00096 Genomic DNA. Translation: AAT48125.1.
AP009048 Genomic DNA. Translation: BAA35222.2.
RefSeqiWP_000956455.1. NZ_LN832404.1.
YP_025295.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP77091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260712. 218 interactions.
STRINGi511145.b4415.

Proteomic databases

PaxDbiP77091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48125; AAT48125; b4415.
BAA35222; BAA35222; BAA35222.
GeneIDi2847715.
KEGGiecj:JW5084.
eco:b4415.
PATRICi32116332. VBIEscCol129921_0606.

Organism-specific databases

EchoBASEiEB4049.
EcoGeneiEG14302. hokE.

Phylogenomic databases

eggNOGiENOG4107635. Bacteria.
ENOG410Z5SJ. LUCA.
HOGENOMiHOG000041219.
KOiK18922.
OMAiTKERSME.
OrthoDBiEOG6TR0M8.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1581.
ECOL316407:JW5084-MONOMER.

Miscellaneous databases

PROiP77091.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Multiple hok genes on the chromosome of Escherichia coli."
    Pedersen K., Gerdes K.
    Mol. Microbiol. 32:1090-1102(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiHOKE_ECOLI
AccessioniPrimary (citable) accession number: P77091
Secondary accession number(s): Q9R7T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 13, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.