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Protein

Toxic protein HokE

Gene

hokE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Toxic component of a type I toxin-antitoxin (TA) system; if it expressed it could be neutralized by antisense antitoxin RNA SokE (Probable).1 Publication

Miscellaneous

Interrupted by an IS186 element, which silences the locus in strain K12 MG1655.1 Publication

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-1581.

Names & Taxonomyi

Protein namesi
Recommended name:
Toxic protein HokE
Gene namesi
Name:hokE1 Publication
Synonyms:ybdY
Ordered Locus Names:b4415, JW5084
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14302. hokE.

Subcellular locationi

  • Cell inner membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990361 – 50Toxic protein HokEAdd BLAST50

Proteomic databases

PaxDbiP77091.
PRIDEiP77091.

Interactioni

Protein-protein interaction databases

BioGridi4260712. 218 interactors.

Structurei

3D structure databases

ProteinModelPortaliP77091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Hok/Gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107635. Bacteria.
ENOG410Z5SJ. LUCA.
HOGENOMiHOG000041219.
KOiK18922.

Family and domain databases

InterProiView protein in InterPro
IPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
PfamiView protein in Pfam
PF01848. HOK_GEF. 1 hit.
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005979. Hok/gef_toxin. 1 hit.
PROSITEiView protein in PROSITE
PS00556. HOK_GEF. 1 hit.

Sequencei

Sequence statusi: Complete.

P77091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKYALAAV IVLCLTVLGF TLLVGDSLCE FTVKERNIEF KAVLAYEPKK
Length:50
Mass (Da):5,564
Last modified:July 15, 1998 - v2
Checksum:i8AD9A981A6D46835
GO

Sequence cautioni

The sequence AAB40780 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40780.1. Different initiation.
U00096 Genomic DNA. Translation: AAT48125.1.
AP009048 Genomic DNA. Translation: BAA35222.2.
RefSeqiWP_000956455.1. NZ_LN832404.1.
YP_025295.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48125; AAT48125; b4415.
BAA35222; BAA35222; BAA35222.
GeneIDi2847715.
KEGGiecj:JW5084.
eco:b4415.
PATRICifig|511145.12.peg.606.

Similar proteinsi

Entry informationi

Entry nameiHOKE_ECOLI
AccessioniPrimary (citable) accession number: P77091
Secondary accession number(s): Q9R7T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: January 31, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families