P77091 (HOKE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein hokE

Gene names

Name:	hokE
Synonyms:	ybdY
Ordered Locus Names:	b4415, JW5084

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	50 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the hok/gef family.
Sequence caution	The sequence AAB40780.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to DNA damage stimulus Inferred from expression pattern. Source: EcoliWiki
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 50	50	Protein hokE		PRO_0000199036
Regions
	Transmembrane	5 – 25	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P77091 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 8AD9A981A6D46835	FASTA	50	5,564
	10 20 30 40 50 MLTKYALAAV IVLCLTVLGF TLLVGDSLCE FTVKERNIEF KAVLAYEPKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Multiple hok genes on the chromosome of Escherichia coli." Pedersen K., Gerdes K. Mol. Microbiol. 32:1090-1102(1999) [PubMed: 10361310] [Abstract] Cited for: DISCUSSION OF SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U82598 Genomic DNA. Translation: AAB40780.1. Different initiation. U00096 Genomic DNA. Translation: AAT48125.1. AP009048 Genomic DNA. Translation: BAA35222.2.
RefSeq	YP_025295.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P77091.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000001310; EBESCP00000001310; EBESCG00000001085. EBESCT00000014886; EBESCP00000014177; EBESCG00000013946.
GeneID	2847715.
GenomeReviews	Gene locus JW5084 in contig AP009048_GR. Gene locus b4415 in contig U00096_GR.
KEGG	ecj:JW5084. eco:b4415.
PATRIC	32116332. VBIEscCol129921_0606.
Organism-specific databases
EchoBASE	EB4049.
EcoGene	EG14302. hokE.
Phylogenomic databases
GeneTree	EBGT00050000009510.
HOGENOM	HBG473224.
ProtClustDB	CLSK513076.
Enzyme and pathway databases
BioCyc	EcoCyc:MONOMER0-1581.
Gene expression databases
Genevestigator	P77091.
Family and domain databases
InterPro	IPR000021. Hok/gef_toxin. IPR018084. Hok/gef_toxin_CS. [Graphical view]
Pfam	PF01848. HOK_GEF. 1 hit. [Graphical view]
PRINTS	PR00281. HOKGEFTOXIC.
ProDom	PD005979. Hok/gef_toxin. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00556. HOK_GEF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOKE_ECOLI

Accession

Primary (citable) accession number: P77091
Secondary accession number(s): Q9R7T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program