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P77072 (MERB_ECOLX) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alkylmercury lyase
EC=4.99.1.2
Alternative name(s):
Organomercurial lyase
Gene names
Name:merB
Encoded onPlasmid IncM R831b
OrganismEscherichia coli
Taxonomic identifier562 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase By similarity. HAMAP-Rule MF_00714

Catalytic activity

An alkylmercury + H+ = an alkane + Hg2+. HAMAP-Rule MF_00714

Sequence similarities

Belongs to the MerB family.

Ontologies

Keywords
   Biological processMercuric resistance
   LigandMercury
   Molecular functionLyase
   Technical term3D-structure
Plasmid
Gene Ontology (GO)
   Biological_processorganomercury catabolic process

Inferred from electronic annotation. Source: InterPro

response to mercury ion

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionalkylmercury lyase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Alkylmercury lyase HAMAP-Rule MF_00714
PRO_0000220356

Secondary structure

1 ............................................ 212
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P77072 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 7FE9DFA8A95F490A

FASTA21223,035
        10         20         30         40         50         60 
MKLAPYILEL LTSVNRTNGT ADLLVPLLRE LAKGRPVSRT TLAGILDWPA ERVAAVLEQA 

        70         80         90        100        110        120 
TSTEYDKDGN IIGYGLTLRE TSYVFEIDDR RLYAWCALDT LIFPALIGRT ARVSSHCAAT 

       130        140        150        160        170        180 
GAPVSLTVSP SEIQAVEPAG MAVSLVLPQE AADVRQSFCC HVHFFASVPT AEDWASKHQG 

       190        200        210 
LEGLAIVSVH EAFGLGQEFN RHLLQTMSSR TP

« Hide

References

[1]"Nucleotide sequence of the organomercury resistance (OMR) locus."
Tolle C., Totis P., Summers A.O.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U77087 Genomic DNA. Translation: AAB49639.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1S6LNMR-A1-212[»]
3F0OX-ray1.76A/B1-212[»]
3F0PX-ray1.64A/B1-212[»]
3F2FX-ray1.98A/B1-212[»]
3F2GX-ray1.78A/B1-212[»]
3F2HX-ray2.00A/B1-212[»]
3FN8X-ray1.88A/B1-212[»]
ProteinModelPortalP77072.
SMRP77072. Positions 21-212.
ModBaseSearch...

Proteomic databases

PRIDEP77072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-3304.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_00714. MerB.
InterProIPR004927. MerB.
IPR024259. MerB_HTH_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF12324. HTH_15. 1 hit.
PF03243. MerB. 1 hit.
[Graphical view]
PIRSFPIRSF001458. MerB. 1 hit.
PRINTSPR01699. ORGNOHGLYASE.
ProtoNetSearch...

Other

EvolutionaryTraceP77072.

Entry information

Entry nameMERB_ECOLX
AccessionPrimary (citable) accession number: P77072
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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