Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Porin OmpL

Gene

ompL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is unknown.1 Publication

GO - Molecular functioni

  • porin activity Source: EcoCyc

GO - Biological processi

  • arabinose transport Source: EcoliWiki
  • galactose transport Source: EcoliWiki
  • glucose import Source: EcoliWiki
  • ion transport Source: UniProtKB-KW
  • transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7814-MONOMER.
ECOL316407:JW3846-MONOMER.

Protein family/group databases

TCDBi1.B.35.2.2. the oligogalacturonate-specific porin (kdgm) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Porin OmpL
Gene namesi
Name:ompL
Synonyms:yshA
Ordered Locus Names:b3875, JW3846
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13374. ompL.

Subcellular locationi

  • Cell outer membrane 1 Publication

GO - Cellular componenti

  • cell outer membrane Source: EcoliWiki
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 230210Porin OmpLPRO_0000016605Add
BLAST

Proteomic databases

PaxDbiP76773.

Interactioni

Protein-protein interaction databases

BioGridi4262635. 211 interactions.
IntActiP76773. 21 interactions.
STRINGi511145.b3875.

Structurei

3D structure databases

ProteinModelPortaliP76773.
SMRiP76773. Positions 27-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108KUC. Bacteria.
ENOG410XRD5. LUCA.
HOGENOMiHOG000005069.
OMAiWLPYLEL.
OrthoDBiEOG6H1PZG.

Family and domain databases

InterProiIPR009331. Oligogalacturonate-sp_porin.
[Graphical view]
PfamiPF06178. KdgM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKINAIILL SSLTSASVFA GAYVENREAY NLASDQGEVM LRVGYNFDMG
60 70 80 90 100
AGIMLTNTYN FQREDELKHG YNEIEGWYPL FKPTDKLTIQ PGGLINDKSI
110 120 130 140 150
GSGGAVYLDV NYKFVPWFNL TVRNRYNHNN YSSTDLSGEL DNNDTYEIGT
160 170 180 190 200
YWNFKITDKF SYTFEPHYFM RVNDFNSSNG KDHHWEITNT FRYRINEHWL
210 220 230
PYFELRWLDR NVEPYHREQN QIRIGTKYFF
Length:230
Mass (Da):27,200
Last modified:February 1, 1997 - v1
Checksum:i94743DA530F276CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03009.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76872.1.
AP009048 Genomic DNA. Translation: BAE77434.1.
PIRiF65192.
RefSeqiNP_418311.1. NC_000913.3.
WP_000723465.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76872; AAC76872; b3875.
BAE77434; BAE77434; BAE77434.
GeneIDi948366.
KEGGiecj:JW3846.
eco:b3875.
PATRICi32123253. VBIEscCol129921_3987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03009.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76872.1.
AP009048 Genomic DNA. Translation: BAE77434.1.
PIRiF65192.
RefSeqiNP_418311.1. NC_000913.3.
WP_000723465.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76773.
SMRiP76773. Positions 27-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262635. 211 interactions.
IntActiP76773. 21 interactions.
STRINGi511145.b3875.

Protein family/group databases

TCDBi1.B.35.2.2. the oligogalacturonate-specific porin (kdgm) family.

Proteomic databases

PaxDbiP76773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76872; AAC76872; b3875.
BAE77434; BAE77434; BAE77434.
GeneIDi948366.
KEGGiecj:JW3846.
eco:b3875.
PATRICi32123253. VBIEscCol129921_3987.

Organism-specific databases

EchoBASEiEB3156.
EcoGeneiEG13374. ompL.

Phylogenomic databases

eggNOGiENOG4108KUC. Bacteria.
ENOG410XRD5. LUCA.
HOGENOMiHOG000005069.
OMAiWLPYLEL.
OrthoDBiEOG6H1PZG.

Enzyme and pathway databases

BioCyciEcoCyc:G7814-MONOMER.
ECOL316407:JW3846-MONOMER.

Miscellaneous databases

PROiP76773.

Family and domain databases

InterProiIPR009331. Oligogalacturonate-sp_porin.
[Graphical view]
PfamiPF06178. KdgM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
    Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION.
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Protein folding in the periplasm in the absence of primary oxidant DsbA: modulation of redox potential in periplasmic space via OmpL porin."
    Dartigalongue C., Nikaido H., Raina S.
    EMBO J. 19:5980-5988(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-25, CHANNEL FUNCTION, SUBCELLULAR LOCATION.
  5. "The OmpL porin does not modulate redox potential in the periplasmic space of Escherichia coli."
    Sardesai A.A., Genevaux P., Schwager F., Ang D., Georgopoulos C.
    EMBO J. 22:1461-1466(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12.

Entry informationi

Entry nameiOMPL_ECOLI
AccessioniPrimary (citable) accession number: P76773
Secondary accession number(s): Q2M8H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

In contrast to PubMed:11080145, PubMed:12660153 demonstrates that OmpL actually plays no perceptible role in modulating redox potential in the periplasm of E.coli.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.