ID   YGAZ_ECOLI              Reviewed;         245 AA.
AC   P76630; Q2MAC2;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 140.
DE   RecName: Full=Inner membrane protein YgaZ;
GN   Name=ygaZ; OrderedLocusNames=b2682, JW2657;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the AzlC family. {ECO:0000305}.
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DR   EMBL; U00096; AAC75729.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76784.1; -; Genomic_DNA.
DR   PIR; C65048; C65048.
DR   RefSeq; NP_417167.1; NC_000913.3.
DR   RefSeq; WP_000445651.1; NZ_LN832404.1.
DR   AlphaFoldDB; P76630; -.
DR   BioGRID; 4262948; 16.
DR   ComplexPortal; CPX-5888; ygaZH putative valine exporter complex.
DR   STRING; 511145.b2682; -.
DR   TCDB; 2.A.78.1.3; the branched chain amino acid exporter (liv-e) family.
DR   PaxDb; 511145-b2682; -.
DR   EnsemblBacteria; AAC75729; AAC75729; b2682.
DR   GeneID; 945093; -.
DR   KEGG; ecj:JW2657; -.
DR   KEGG; eco:b2682; -.
DR   PATRIC; fig|1411691.4.peg.4058; -.
DR   EchoBASE; EB3299; -.
DR   eggNOG; COG1296; Bacteria.
DR   HOGENOM; CLU_065777_3_1_6; -.
DR   InParanoid; P76630; -.
DR   OMA; MADENWA; -.
DR   OrthoDB; 6711132at2; -.
DR   PhylomeDB; P76630; -.
DR   BioCyc; EcoCyc:G7405-MONOMER; -.
DR   BioCyc; MetaCyc:G7405-MONOMER; -.
DR   PRO; PR:P76630; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; ISM:EcoCyc.
DR   GO; GO:1902495; C:transmembrane transporter complex; NAS:ComplexPortal.
DR   GO; GO:1903785; P:L-valine transmembrane transport; IDA:EcoCyc.
DR   InterPro; IPR011606; Brnchd-chn_aa_trnsp_permease.
DR   PANTHER; PTHR34979; INNER MEMBRANE PROTEIN YGAZ; 1.
DR   PANTHER; PTHR34979:SF1; INNER MEMBRANE PROTEIN YGAZ; 1.
DR   Pfam; PF03591; AzlC; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..245
FT                   /note="Inner membrane protein YgaZ"
FT                   /id="PRO_0000111781"
FT   TOPO_DOM        1..24
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..63
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..109
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..140
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..172
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..205
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        227..245
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   245 AA;  26108 MW;  22ACE8AB8D7D651B CRC64;
     MESPTPQPAP GSATFMEGCK DSLPIVISYI PVAFAFGLNA TRLGFSPLES VFFSCIIYAG
     ASQFVITAML AAGSSLWIAA LTVMAMDVRH VLYGPSLRSR IIQRLQKSKT ALWAFGLTDE
     VFAAATAKLV RNNRRWSENW MIGIAFSSWS SWVFGTVIGA FSGSGLLQGY PAVEAALGFM
     LPALFMSFLL ASFQRKQSLC VTAALVGALA GVTLFSIPVA ILAGIVCGCL TALIQAFWQG
     APDEL
//