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Protein

Inner membrane protein YgaZ

Gene

ygaZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. efflux transmembrane transporter activity Source: EcoCyc
  2. L-valine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  1. cation transmembrane transport Source: GOC
  2. L-alpha-amino acid transmembrane transport Source: GOC
  3. L-amino acid transport Source: GOC
  4. transmembrane transport Source: GOC
  5. valine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7405-MONOMER.
ECOL316407:JW2657-MONOMER.
MetaCyc:G7405-MONOMER.

Protein family/group databases

TCDBi2.A.78.1.3. the branched chain amino acid exporter (liv-e) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein YgaZ
Gene namesi
Name:ygaZ
Ordered Locus Names:b2682, JW2657
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13528. ygaZ.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Topological domaini46 – 6318PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Topological domaini85 – 10925CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 14010PeriplasmicSequence Analysis
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 17211CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Topological domaini194 – 20512PeriplasmicSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Topological domaini227 – 24519CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Inner membrane protein YgaZPRO_0000111781Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP76630.

Interactioni

Protein-protein interaction databases

STRINGi511145.b2682.

Structurei

3D structure databases

ProteinModelPortaliP76630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AzlC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1296.
HOGENOMiHOG000013807.
InParanoidiP76630.
OMAiKDNRRWS.
OrthoDBiEOG6K9QNJ.
PhylomeDBiP76630.

Family and domain databases

InterProiIPR011606. Brnchd-chn_aa_trnsp_permease.
[Graphical view]
PfamiPF03591. AzlC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPTPQPAP GSATFMEGCK DSLPIVISYI PVAFAFGLNA TRLGFSPLES
60 70 80 90 100
VFFSCIIYAG ASQFVITAML AAGSSLWIAA LTVMAMDVRH VLYGPSLRSR
110 120 130 140 150
IIQRLQKSKT ALWAFGLTDE VFAAATAKLV RNNRRWSENW MIGIAFSSWS
160 170 180 190 200
SWVFGTVIGA FSGSGLLQGY PAVEAALGFM LPALFMSFLL ASFQRKQSLC
210 220 230 240
VTAALVGALA GVTLFSIPVA ILAGIVCGCL TALIQAFWQG APDEL
Length:245
Mass (Da):26,108
Last modified:February 1, 1997 - v1
Checksum:i22ACE8AB8D7D651B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75729.1.
AP009048 Genomic DNA. Translation: BAE76784.1.
PIRiC65048.
RefSeqiNP_417167.1. NC_000913.3.
YP_490896.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75729; AAC75729; b2682.
BAE76784; BAE76784; BAE76784.
GeneIDi12933954.
945093.
KEGGiecj:Y75_p2625.
eco:b2682.
PATRICi32120756. VBIEscCol129921_2775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75729.1.
AP009048 Genomic DNA. Translation: BAE76784.1.
PIRiC65048.
RefSeqiNP_417167.1. NC_000913.3.
YP_490896.1. NC_007779.1.

3D structure databases

ProteinModelPortaliP76630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b2682.

Protein family/group databases

TCDBi2.A.78.1.3. the branched chain amino acid exporter (liv-e) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75729; AAC75729; b2682.
BAE76784; BAE76784; BAE76784.
GeneIDi12933954.
945093.
KEGGiecj:Y75_p2625.
eco:b2682.
PATRICi32120756. VBIEscCol129921_2775.

Organism-specific databases

EchoBASEiEB3299.
EcoGeneiEG13528. ygaZ.

Phylogenomic databases

eggNOGiCOG1296.
HOGENOMiHOG000013807.
InParanoidiP76630.
OMAiKDNRRWS.
OrthoDBiEOG6K9QNJ.
PhylomeDBiP76630.

Enzyme and pathway databases

BioCyciEcoCyc:G7405-MONOMER.
ECOL316407:JW2657-MONOMER.
MetaCyc:G7405-MONOMER.

Miscellaneous databases

PROiP76630.

Gene expression databases

GenevestigatoriP76630.

Family and domain databases

InterProiIPR011606. Brnchd-chn_aa_trnsp_permease.
[Graphical view]
PfamiPF03591. AzlC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYGAZ_ECOLI
AccessioniPrimary (citable) accession number: P76630
Secondary accession number(s): Q2MAC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.