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Protein

Protein CsiD

Gene

csiD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the control of utilization of gamma-aminobutyric acid.1 Publication

Cofactori

Fe cation1 PublicationNote: Binds 1 Fe cation per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi160Iron1 Publication1
Metal bindingi162Iron1 Publication1
Metal bindingi292Iron1 Publication1

GO - Molecular functioni

  • identical protein binding Source: EcoCyc
  • iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  • protein homotetramerization Source: EcoCyc
  • response to carbon starvation Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7394-MONOMER.
ECOL316407:JW5427-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CsiDCurated
Gene namesi
Name:csiD1 Publication
Synonyms:gab1 Publication, ygaT
Ordered Locus Names:b2659, JW5427
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13523. csiD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002181771 – 325Protein CsiDAdd BLAST325

Proteomic databases

EPDiP76621.
PaxDbiP76621.
PRIDEiP76621.

Expressioni

Inductioni

Expression is induced by RpoS during carbon starvation and at stationary phase. Is also regulated by cAMP-CRP and Lrp, which play the roles of a nearly essential activator and of a positive modulator, respectively. Repressed by CsiR.2 Publications

Interactioni

Subunit structurei

Homotetramer.1 Publication

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4259208. 6 interactors.
STRINGi511145.b2659.

Structurei

Secondary structure

1325
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 25Combined sources7
Beta strandi32 – 37Combined sources6
Helixi39 – 49Combined sources11
Helixi54 – 59Combined sources6
Helixi62 – 74Combined sources13
Turni75 – 77Combined sources3
Helixi79 – 88Combined sources10
Beta strandi94 – 99Combined sources6
Helixi105 – 107Combined sources3
Helixi108 – 122Combined sources15
Beta strandi123 – 125Combined sources3
Turni129 – 131Combined sources3
Beta strandi132 – 140Combined sources9
Beta strandi157 – 160Combined sources4
Beta strandi166 – 168Combined sources3
Beta strandi172 – 182Combined sources11
Beta strandi188 – 192Combined sources5
Helixi193 – 195Combined sources3
Helixi199 – 203Combined sources5
Helixi206 – 209Combined sources4
Beta strandi212 – 214Combined sources3
Beta strandi226 – 228Combined sources3
Beta strandi230 – 233Combined sources4
Beta strandi239 – 241Combined sources3
Turni245 – 247Combined sources3
Helixi253 – 267Combined sources15
Beta strandi273 – 275Combined sources3
Beta strandi282 – 286Combined sources5
Turni287 – 289Combined sources3
Beta strandi290 – 294Combined sources5
Beta strandi304 – 314Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JR7X-ray2.00A15-325[»]
ProteinModelPortaliP76621.
SMRiP76621.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76621.

Family & Domainsi

Sequence similaritiesi

Belongs to the CsiD family.Curated

Phylogenomic databases

eggNOGiENOG4105EK3. Bacteria.
ENOG410XQW4. LUCA.
HOGENOMiHOG000224333.
KOiK15737.
OMAiHNDGTFV.

Family and domain databases

HAMAPiMF_01083. CsiD. 1 hit.
InterProiIPR015038. Uncharacterised_CsiD.
[Graphical view]
PfamiPF08943. CsiD. 1 hit.
[Graphical view]
ProDomiPD135861. DUF_CsiD. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P76621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALTAVQNN AVDSGQDYSG FTLTPSAQSP RLLELTFTEQ TTKQFLEQVA
60 70 80 90 100
EWPVQALEYK SFLRFRVAKI LDDLCANQLQ PLLLKTLLNR AEGALLINAV
110 120 130 140 150
GVDDVKQADE MVKLATAVAH LIGRSNFDAM SGQYYARFVV KNVDNSDSYL
160 170 180 190 200
RQPHRVMELH NDGTYVEEIT DYVLMMKIDE QNMQGGNSLL LHLDDWEHLD
210 220 230 240 250
NYFRHPLARR PMRFAAPPSK NVSKDVFHPV FDVDQQGRPV MRYIDQFVQP
260 270 280 290 300
KDFEEGVWLS ELSDAIETSK GILSVPVPVG KFLLINNLFW LHGRDRFTPH
310 320
PDLRRELMRQ RGYFAYASNH YQTHQ
Length:325
Mass (Da):37,360
Last modified:June 1, 2001 - v2
Checksum:iAF403B3029E0B7F4
GO

Sequence cautioni

The sequence AAD10865 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152 – 153QP → HA in AAD10865 (Ref. 1) Curated2
Sequence conflicti212 – 213MR → IA in AAD10865 (Ref. 1) Curated2
Sequence conflicti310 – 311QR → HG in AAD10865 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68243 Genomic DNA. Translation: AAD10865.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75706.2.
AP009048 Genomic DNA. Translation: BAE76779.1.
PIRiD65045.
RefSeqiNP_417145.4. NC_000913.3.
WP_000993126.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75706; AAC75706; b2659.
BAE76779; BAE76779; BAE76779.
GeneIDi948076.
KEGGiecj:JW5427.
eco:b2659.
PATRICi32120708. VBIEscCol129921_2751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68243 Genomic DNA. Translation: AAD10865.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75706.2.
AP009048 Genomic DNA. Translation: BAE76779.1.
PIRiD65045.
RefSeqiNP_417145.4. NC_000913.3.
WP_000993126.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JR7X-ray2.00A15-325[»]
ProteinModelPortaliP76621.
SMRiP76621.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259208. 6 interactors.
STRINGi511145.b2659.

Proteomic databases

EPDiP76621.
PaxDbiP76621.
PRIDEiP76621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75706; AAC75706; b2659.
BAE76779; BAE76779; BAE76779.
GeneIDi948076.
KEGGiecj:JW5427.
eco:b2659.
PATRICi32120708. VBIEscCol129921_2751.

Organism-specific databases

EchoBASEiEB3295.
EcoGeneiEG13523. csiD.

Phylogenomic databases

eggNOGiENOG4105EK3. Bacteria.
ENOG410XQW4. LUCA.
HOGENOMiHOG000224333.
KOiK15737.
OMAiHNDGTFV.

Enzyme and pathway databases

BioCyciEcoCyc:G7394-MONOMER.
ECOL316407:JW5427-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP76621.
PROiP76621.

Family and domain databases

HAMAPiMF_01083. CsiD. 1 hit.
InterProiIPR015038. Uncharacterised_CsiD.
[Graphical view]
PfamiPF08943. CsiD. 1 hit.
[Graphical view]
ProDomiPD135861. DUF_CsiD. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiCSID_ECOLI
AccessioniPrimary (citable) accession number: P76621
Secondary accession number(s): Q2MAC7, Q9ZAZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.