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Protein

Protein CsiD

Gene

csiD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the control of utilization of gamma-aminobutyric acid.1 Publication

Cofactori

Fe cation1 PublicationNote: Binds 1 Fe cation per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi160 – 1601Iron1 Publication
Metal bindingi162 – 1621Iron1 Publication
Metal bindingi292 – 2921Iron1 Publication

GO - Molecular functioni

  • identical protein binding Source: EcoCyc
  • iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  • protein homotetramerization Source: EcoCyc
  • response to carbon starvation Source: EcoCyc
Complete GO annotation...

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7394-MONOMER.
ECOL316407:JW5427-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CsiDCurated
Gene namesi
Name:csiD1 Publication
Synonyms:gab1 Publication, ygaT
Ordered Locus Names:b2659, JW5427
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13523. csiD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Protein CsiDPRO_0000218177Add
BLAST

Proteomic databases

EPDiP76621.
PaxDbiP76621.

Expressioni

Inductioni

Expression is induced by RpoS during carbon starvation and at stationary phase. Is also regulated by cAMP-CRP and Lrp, which play the roles of a nearly essential activator and of a positive modulator, respectively. Repressed by CsiR.2 Publications

Interactioni

Subunit structurei

Homotetramer.1 Publication

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4259208. 6 interactions.
STRINGi511145.b2659.

Structurei

Secondary structure

1
325
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 257Combined sources
Beta strandi32 – 376Combined sources
Helixi39 – 4911Combined sources
Helixi54 – 596Combined sources
Helixi62 – 7413Combined sources
Turni75 – 773Combined sources
Helixi79 – 8810Combined sources
Beta strandi94 – 996Combined sources
Helixi105 – 1073Combined sources
Helixi108 – 12215Combined sources
Beta strandi123 – 1253Combined sources
Turni129 – 1313Combined sources
Beta strandi132 – 1409Combined sources
Beta strandi157 – 1604Combined sources
Beta strandi166 – 1683Combined sources
Beta strandi172 – 18211Combined sources
Beta strandi188 – 1925Combined sources
Helixi193 – 1953Combined sources
Helixi199 – 2035Combined sources
Helixi206 – 2094Combined sources
Beta strandi212 – 2143Combined sources
Beta strandi226 – 2283Combined sources
Beta strandi230 – 2334Combined sources
Beta strandi239 – 2413Combined sources
Turni245 – 2473Combined sources
Helixi253 – 26715Combined sources
Beta strandi273 – 2753Combined sources
Beta strandi282 – 2865Combined sources
Turni287 – 2893Combined sources
Beta strandi290 – 2945Combined sources
Beta strandi304 – 31411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JR7X-ray2.00A15-325[»]
ProteinModelPortaliP76621.
SMRiP76621. Positions 15-325.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76621.

Family & Domainsi

Sequence similaritiesi

Belongs to the CsiD family.Curated

Phylogenomic databases

eggNOGiENOG4105EK3. Bacteria.
ENOG410XQW4. LUCA.
HOGENOMiHOG000224333.
KOiK15737.
OMAiHNDGTFV.

Family and domain databases

HAMAPiMF_01083. CsiD. 1 hit.
InterProiIPR015038. Uncharacterised_CsiD.
[Graphical view]
PfamiPF08943. CsiD. 1 hit.
[Graphical view]
ProDomiPD135861. DUF_CsiD. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P76621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALTAVQNN AVDSGQDYSG FTLTPSAQSP RLLELTFTEQ TTKQFLEQVA
60 70 80 90 100
EWPVQALEYK SFLRFRVAKI LDDLCANQLQ PLLLKTLLNR AEGALLINAV
110 120 130 140 150
GVDDVKQADE MVKLATAVAH LIGRSNFDAM SGQYYARFVV KNVDNSDSYL
160 170 180 190 200
RQPHRVMELH NDGTYVEEIT DYVLMMKIDE QNMQGGNSLL LHLDDWEHLD
210 220 230 240 250
NYFRHPLARR PMRFAAPPSK NVSKDVFHPV FDVDQQGRPV MRYIDQFVQP
260 270 280 290 300
KDFEEGVWLS ELSDAIETSK GILSVPVPVG KFLLINNLFW LHGRDRFTPH
310 320
PDLRRELMRQ RGYFAYASNH YQTHQ
Length:325
Mass (Da):37,360
Last modified:June 1, 2001 - v2
Checksum:iAF403B3029E0B7F4
GO

Sequence cautioni

The sequence AAD10865 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1532QP → HA in AAD10865 (Ref. 1) Curated
Sequence conflicti212 – 2132MR → IA in AAD10865 (Ref. 1) Curated
Sequence conflicti310 – 3112QR → HG in AAD10865 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68243 Genomic DNA. Translation: AAD10865.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75706.2.
AP009048 Genomic DNA. Translation: BAE76779.1.
PIRiD65045.
RefSeqiNP_417145.4. NC_000913.3.
WP_000993126.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75706; AAC75706; b2659.
BAE76779; BAE76779; BAE76779.
GeneIDi948076.
KEGGiecj:JW5427.
eco:b2659.
PATRICi32120708. VBIEscCol129921_2751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68243 Genomic DNA. Translation: AAD10865.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75706.2.
AP009048 Genomic DNA. Translation: BAE76779.1.
PIRiD65045.
RefSeqiNP_417145.4. NC_000913.3.
WP_000993126.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JR7X-ray2.00A15-325[»]
ProteinModelPortaliP76621.
SMRiP76621. Positions 15-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259208. 6 interactions.
STRINGi511145.b2659.

Proteomic databases

EPDiP76621.
PaxDbiP76621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75706; AAC75706; b2659.
BAE76779; BAE76779; BAE76779.
GeneIDi948076.
KEGGiecj:JW5427.
eco:b2659.
PATRICi32120708. VBIEscCol129921_2751.

Organism-specific databases

EchoBASEiEB3295.
EcoGeneiEG13523. csiD.

Phylogenomic databases

eggNOGiENOG4105EK3. Bacteria.
ENOG410XQW4. LUCA.
HOGENOMiHOG000224333.
KOiK15737.
OMAiHNDGTFV.

Enzyme and pathway databases

BioCyciEcoCyc:G7394-MONOMER.
ECOL316407:JW5427-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP76621.
PROiP76621.

Family and domain databases

HAMAPiMF_01083. CsiD. 1 hit.
InterProiIPR015038. Uncharacterised_CsiD.
[Graphical view]
PfamiPF08943. CsiD. 1 hit.
[Graphical view]
ProDomiPD135861. DUF_CsiD. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiCSID_ECOLI
AccessioniPrimary (citable) accession number: P76621
Secondary accession number(s): Q2MAC7, Q9ZAZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.