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P76578

- YFHM_ECOLI

UniProt

P76578 - YFHM_ECOLI

Protein

Uncharacterized lipoprotein YfhM

Gene

yfhM

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. endopeptidase inhibitor activity Source: EcoCyc

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: GOC

    Enzyme and pathway databases

    BioCyciEcoCyc:G7323-MONOMER.
    ECOL316407:JW2504-MONOMER.

    Protein family/group databases

    MEROPSiI39.008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized lipoprotein YfhM
    Gene namesi
    Name:yfhM
    Ordered Locus Names:b2520, JW2504
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13394. yfhM.

    Subcellular locationi

    Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

    GO - Cellular componenti

    1. integral component of external side of plasma membrane Source: EcoCyc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717PROSITE-ProRule annotationAdd
    BLAST
    Chaini18 – 16531636Uncharacterized lipoprotein YfhMPRO_0000013775Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi18 – 181N-palmitoyl cysteinePROSITE-ProRule annotation
    Lipidationi18 – 181S-diacylglycerol cysteinePROSITE-ProRule annotation

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP76578.
    PRIDEiP76578.

    Expressioni

    Gene expression databases

    GenevestigatoriP76578.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-28064N.
    IntActiP76578. 15 interactions.
    STRINGi511145.b2520.

    Structurei

    3D structure databases

    ProteinModelPortaliP76578.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1559 – 158931Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiCOG2373.
    HOGENOMiHOG000275932.
    KOiK06894.
    OMAiSSLRFWA.
    OrthoDBiEOG6X3W1C.
    PhylomeDBiP76578.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    InterProiIPR026284. A2-macglob_dom_prot_bac.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR021868. Alpha_2_Macroglob_MG1.
    IPR001599. Macroglobln_a2.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF11974. MG1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038980. A2M_bac. 1 hit.
    SUPFAMiSSF48239. SSF48239. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P76578-1 [UniParc]FASTAAdd to Basket

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    MKKLRVAACM LMLALAGCDN NDNAPTAVKK DAPSEVTKAA SSENASSAKL     50
    SVPERQKLAQ QSAGKVLTLL DLSEVQLDGA ATLVLTFSIP LDPDQDFSRV 100
    IHVVDKKSGK VDGAWELSDN LKELRLRHLE PKRDLIVTIG KEVKALNNAT 150
    FSKDYEKTIT TRDIQPSVGF ASRGSLLPGK VVEGLPVMAL NVNNVDVNFF 200
    RVKPESLPAF ISQWEYRNSL ANWQSDKLLQ MADLVYTGRF DLNPARNTRE 250
    KLLLPLGDIK PLQQAGVYLA VMNQAGRYDY SNPATLFTLS DIGVSAHRYH 300
    NRLDIFTQSL ENGAAQQGIE VSLLNEKGQT LTQATSDAQG HVQLENDKNA 350
    ALLLARKDGQ TTLLDLKLPA LDLAEFNIAG APGYSKQFFM FGPRDLYRPG 400
    ETVILNGLLR DADGKALPNQ PIKLDVIKPD GQVLRSVVSQ PENGLYHFTW 450
    PLDSNAATGM WHIRANTGDN QYRMWDFHVE DFMPERMALN LTGEKTPLTP 500
    KDEVKFSVVG YYLYGAPANG NTLQGQLFLR PLREAVSALP GFEFGDIAAE 550
    NLSRTLDEVQ LTLDDKGRGE VSTESQWKET HSPLQVIFQG SLLESGGRPV 600
    TRRAEQAIWP ADALPGIRPQ FASKSVYDYR TDSTVKQPIV DEGSNAAFDI 650
    VYSDAQGVKK AVSGLQVRLI RERRDYYWNW SEDEGWQSQF DQKDLIENEQ 700
    TLDLKADETG KVSFPVEWGA YRLEVKAPNE AVSSVRFWAG YSWQDNSDGS 750
    GAVRPDRVTL KLDKASYRPG DTIKLHIAAP TAGKGYAMVE SSEGPLWWQE 800
    IDVRAQGLDL TIPVDKTWNR HDLYLSTLVV RPGDKSRSAT PKRAVGVLHL 850
    PLGDENRRLD LALETPAKMR PNQPLTVKIK ASTKNGEKPK QVNVLVSAVD 900
    SGVLNITDYV TPDPWQAFFG QKRYGADIYD IYGQVIEGQG RLAALRFGGD 950
    GDELKRGGKP PVNHVNIVVQ QALPVTLNEQ GEGSVTLPIG DFNGELRVMA 1000
    QAWTADDFGS NESKVIVAAP VIAELNMPRF MASGDTSRLT LDITNLTDKP 1050
    QKLNVALTAS GLLELVSDSP AAVELAPGVR TTLFIPVRAL PGYGDGEIQA 1100
    TISGLALPGE TVADQHKQWK IGVRPAFPAQ TVNYGTALQP GETWAIPADG 1150
    LQNFSPVTLE GQLLLSGKPP LNIARYIKEL KAYPYGCLEQ TASGLFPSLY 1200
    TNAAQLQALG IKGDSDEKRR ASVDIGISRL LQMQRDNGGF ALWDKNGDEE 1250
    YWLTAYVMDF LVRAGEQGYS VPTDAINRGN ERLLRYLQDP GMMSIPYADN 1300
    LKASKFAVQS YAALVLARQQ KAPLGALREI WEHRADAASG LPLLQLGVAL 1350
    KTMGDATRGE EAIALALKTP RNSDERIWLG DYGSSLRDNA LMLSLLEENK 1400
    LLPDEQYTLL NTLSQQAFGE RWLSTQESNA LFLAARTIQD LPGKWQAQTS 1450
    FSAEQLTGEK AQNSNLNSDQ LVTLQVSNSG DQPLWLRMDA SGYPQSAPLP 1500
    ANNVLQIERH ILGTDGKSKS LDSLRSGDLV LVWLQVKASN SVPDALVVDL 1550
    LPAGLELENQ NLANGSASLE QSGGEVQNLL NQMQQASIKH IEFRDDRFVA 1600
    AVAVDEYQPV TLVYLARAVT PGTYQVPQPM VESMYVPQWR ATGAAEDLLI 1650
    VRP 1653
    Length:1,653
    Mass (Da):181,585
    Last modified:February 1, 1997 - v1
    Checksum:i13109EC5CDEB41A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC75573.1.
    AP009048 Genomic DNA. Translation: BAE76729.1.
    PIRiG65028.
    RefSeqiNP_417015.1. NC_000913.3.
    YP_490748.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75573; AAC75573; b2520.
    BAE76729; BAE76729; BAE76729.
    GeneIDi12931809.
    947302.
    KEGGiecj:Y75_p2473.
    eco:b2520.
    PATRICi32120433. VBIEscCol129921_2619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC75573.1 .
    AP009048 Genomic DNA. Translation: BAE76729.1 .
    PIRi G65028.
    RefSeqi NP_417015.1. NC_000913.3.
    YP_490748.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P76578.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-28064N.
    IntActi P76578. 15 interactions.
    STRINGi 511145.b2520.

    Protein family/group databases

    MEROPSi I39.008.

    Proteomic databases

    PaxDbi P76578.
    PRIDEi P76578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75573 ; AAC75573 ; b2520 .
    BAE76729 ; BAE76729 ; BAE76729 .
    GeneIDi 12931809.
    947302.
    KEGGi ecj:Y75_p2473.
    eco:b2520.
    PATRICi 32120433. VBIEscCol129921_2619.

    Organism-specific databases

    EchoBASEi EB3175.
    EcoGenei EG13394. yfhM.

    Phylogenomic databases

    eggNOGi COG2373.
    HOGENOMi HOG000275932.
    KOi K06894.
    OMAi SSLRFWA.
    OrthoDBi EOG6X3W1C.
    PhylomeDBi P76578.

    Enzyme and pathway databases

    BioCyci EcoCyc:G7323-MONOMER.
    ECOL316407:JW2504-MONOMER.

    Miscellaneous databases

    PROi P76578.

    Gene expression databases

    Genevestigatori P76578.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    InterProi IPR026284. A2-macglob_dom_prot_bac.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR021868. Alpha_2_Macroglob_MG1.
    IPR001599. Macroglobln_a2.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF11974. MG1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038980. A2M_bac. 1 hit.
    SUPFAMi SSF48239. SSF48239. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiYFHM_ECOLI
    AccessioniPrimary (citable) accession number: P76578
    Secondary accession number(s): Q2MAH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene

    External Data

    Dasty 3