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Protein

Uncharacterized lipoprotein YfhM

Gene

yfhM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: EcoCyc

GO - Biological processi

  • negative regulation of endopeptidase activity Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7323-MONOMER.
ECOL316407:JW2504-MONOMER.

Protein family/group databases

MEROPSiI39.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized lipoprotein YfhM
Gene namesi
Name:yfhM
Ordered Locus Names:b2520, JW2504
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13394. yfhM.

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17PROSITE-ProRule annotationAdd BLAST17
ChainiPRO_000001377518 – 1653Uncharacterized lipoprotein YfhMAdd BLAST1636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi18N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi18S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP76578.
PRIDEiP76578.

Interactioni

Protein-protein interaction databases

BioGridi4260803. 184 interactors.
DIPiDIP-28064N.
IntActiP76578. 15 interactors.
STRINGi511145.b2520.

Structurei

Secondary structure

11653
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni58 – 64Combined sources7
Beta strandi69 – 77Combined sources9
Beta strandi80 – 89Combined sources10
Helixi97 – 100Combined sources4
Beta strandi101 – 105Combined sources5
Turni106 – 108Combined sources3
Beta strandi121 – 126Combined sources6
Beta strandi134 – 139Combined sources6
Beta strandi155 – 160Combined sources6
Beta strandi167 – 173Combined sources7
Beta strandi175 – 177Combined sources3
Helixi181 – 183Combined sources3
Beta strandi185 – 191Combined sources7
Beta strandi194 – 202Combined sources9
Helixi204 – 206Combined sources3
Helixi207 – 215Combined sources9
Turni216 – 219Combined sources4
Turni222 – 224Combined sources3
Helixi226 – 229Combined sources4
Beta strandi232 – 241Combined sources10
Beta strandi250 – 254Combined sources5
Helixi260 – 263Combined sources4
Beta strandi266 – 273Combined sources8
Beta strandi276 – 278Combined sources3
Beta strandi279 – 281Combined sources3
Beta strandi284 – 289Combined sources6
Beta strandi291 – 299Combined sources9
Beta strandi302 – 309Combined sources8
Turni310 – 312Combined sources3
Beta strandi320 – 324Combined sources5
Beta strandi326 – 328Combined sources3
Beta strandi330 – 335Combined sources6
Beta strandi340 – 345Combined sources6
Beta strandi352 – 357Combined sources6
Beta strandi360 – 365Combined sources6
Beta strandi385 – 391Combined sources7
Beta strandi395 – 397Combined sources3
Beta strandi402 – 410Combined sources9
Beta strandi422 – 427Combined sources6
Beta strandi433 – 439Combined sources7
Beta strandi445 – 451Combined sources7
Beta strandi459 – 466Combined sources8
Beta strandi468 – 470Combined sources3
Beta strandi473 – 479Combined sources7
Beta strandi486 – 492Combined sources7
Beta strandi504 – 512Combined sources9
Turni513 – 515Combined sources3
Beta strandi522 – 531Combined sources10
Beta strandi553 – 562Combined sources10
Beta strandi567 – 573Combined sources7
Beta strandi584 – 593Combined sources10
Beta strandi599 – 608Combined sources10
Beta strandi610 – 621Combined sources12
Beta strandi623 – 628Combined sources6
Turni629 – 632Combined sources4
Beta strandi633 – 641Combined sources9
Beta strandi644 – 653Combined sources10
Beta strandi662 – 671Combined sources10
Beta strandi695 – 704Combined sources10
Beta strandi710 – 715Combined sources6
Beta strandi718 – 726Combined sources9
Beta strandi732 – 740Combined sources9
Turni748 – 751Combined sources4
Beta strandi759 – 765Combined sources7
Beta strandi772 – 778Combined sources7
Beta strandi786 – 790Combined sources5
Beta strandi795 – 797Combined sources3
Beta strandi808 – 813Combined sources6
Beta strandi824 – 831Combined sources8
Beta strandi842 – 849Combined sources8
Helixi855 – 857Combined sources3
Beta strandi860 – 864Combined sources5
Beta strandi867 – 869Combined sources3
Beta strandi873 – 882Combined sources10
Turni884 – 886Combined sources3
Beta strandi893 – 900Combined sources8
Helixi901 – 904Combined sources4
Turni905 – 908Combined sources4
Helixi914 – 919Combined sources6
Beta strandi927 – 931Combined sources5
Helixi932 – 934Combined sources3
Helixi952 – 957Combined sources6
Beta strandi969 – 971Combined sources3
Beta strandi981 – 988Combined sources8
Beta strandi994 – 1006Combined sources13
Beta strandi1008 – 1017Combined sources10
Beta strandi1020 – 1026Combined sources7
Beta strandi1029 – 1031Combined sources3
Beta strandi1036 – 1045Combined sources10
Beta strandi1047 – 1049Combined sources3
Beta strandi1051 – 1061Combined sources11
Beta strandi1063 – 1067Combined sources5
Beta strandi1072 – 1075Combined sources4
Beta strandi1080 – 1089Combined sources10
Beta strandi1091 – 1103Combined sources13
Beta strandi1108 – 1110Combined sources3
Beta strandi1115 – 1124Combined sources10
Beta strandi1130 – 1138Combined sources9
Beta strandi1143 – 1145Combined sources3
Turni1150 – 1153Combined sources4
Turni1156 – 1158Combined sources3
Beta strandi1160 – 1168Combined sources9
Helixi1173 – 1175Combined sources3
Beta strandi1178 – 1180Combined sources3
Helixi1188 – 1193Combined sources6
Helixi1196 – 1199Combined sources4
Helixi1203 – 1209Combined sources7
Helixi1216 – 1232Combined sources17
Beta strandi1240 – 1243Combined sources4
Helixi1251 – 1266Combined sources16
Helixi1273 – 1288Combined sources16
Helixi1290 – 1292Combined sources3
Helixi1301 – 1317Combined sources17
Turni1318 – 1320Combined sources3
Helixi1324 – 1332Combined sources9
Helixi1333 – 1336Combined sources4
Helixi1340 – 1353Combined sources14
Helixi1356 – 1366Combined sources11
Beta strandi1379 – 1381Combined sources3
Helixi1385 – 1398Combined sources14
Helixi1403 – 1418Combined sources16
Helixi1425 – 1435Combined sources11
Turni1436 – 1440Combined sources5
Beta strandi1445 – 1449Combined sources5
Beta strandi1456 – 1460Combined sources5
Beta strandi1462 – 1467Combined sources6
Helixi1468 – 1472Combined sources5
Beta strandi1475 – 1478Combined sources4
Beta strandi1480 – 1482Combined sources3
Beta strandi1484 – 1492Combined sources9
Beta strandi1494 – 1496Combined sources3
Beta strandi1502 – 1513Combined sources12
Beta strandi1516 – 1518Combined sources3
Beta strandi1523 – 1525Combined sources3
Beta strandi1529 – 1540Combined sources12
Beta strandi1542 – 1550Combined sources9
Beta strandi1555 – 1557Combined sources3
Helixi1563 – 1565Combined sources3
Helixi1569 – 1572Combined sources4
Helixi1574 – 1576Combined sources3
Helixi1577 – 1585Combined sources9
Beta strandi1586 – 1593Combined sources8
Beta strandi1595 – 1605Combined sources11
Beta strandi1610 – 1618Combined sources9
Beta strandi1622 – 1624Combined sources3
Beta strandi1630 – 1635Combined sources6
Beta strandi1639 – 1642Combined sources4
Beta strandi1649 – 1652Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RTDX-ray3.65A23-1653[»]
4ZIQX-ray2.55A40-1653[»]
4ZIUX-ray2.70A1018-1653[»]
4ZJGX-ray2.30A40-385[»]
4ZJHX-ray1.60A163-368[»]
5A42electron microscopy16.00A40-1653[»]
ProteinModelPortaliP76578.
SMRiP76578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1559 – 1589Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG4105DN3. Bacteria.
COG2373. LUCA.
HOGENOMiHOG000275932.
InParanoidiP76578.
KOiK06894.
OMAiTAYAMDF.
PhylomeDBiP76578.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026284. A2-macglob_dom_prot_bac.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR021868. Alpha_2_Macroglob_MG1.
IPR001599. Macroglobln_a2.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF11974. MG1. 1 hit.
[Graphical view]
PIRSFiPIRSF038980. A2M_bac. 1 hit.
SMARTiSM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLRVAACM LMLALAGCDN NDNAPTAVKK DAPSEVTKAA SSENASSAKL
60 70 80 90 100
SVPERQKLAQ QSAGKVLTLL DLSEVQLDGA ATLVLTFSIP LDPDQDFSRV
110 120 130 140 150
IHVVDKKSGK VDGAWELSDN LKELRLRHLE PKRDLIVTIG KEVKALNNAT
160 170 180 190 200
FSKDYEKTIT TRDIQPSVGF ASRGSLLPGK VVEGLPVMAL NVNNVDVNFF
210 220 230 240 250
RVKPESLPAF ISQWEYRNSL ANWQSDKLLQ MADLVYTGRF DLNPARNTRE
260 270 280 290 300
KLLLPLGDIK PLQQAGVYLA VMNQAGRYDY SNPATLFTLS DIGVSAHRYH
310 320 330 340 350
NRLDIFTQSL ENGAAQQGIE VSLLNEKGQT LTQATSDAQG HVQLENDKNA
360 370 380 390 400
ALLLARKDGQ TTLLDLKLPA LDLAEFNIAG APGYSKQFFM FGPRDLYRPG
410 420 430 440 450
ETVILNGLLR DADGKALPNQ PIKLDVIKPD GQVLRSVVSQ PENGLYHFTW
460 470 480 490 500
PLDSNAATGM WHIRANTGDN QYRMWDFHVE DFMPERMALN LTGEKTPLTP
510 520 530 540 550
KDEVKFSVVG YYLYGAPANG NTLQGQLFLR PLREAVSALP GFEFGDIAAE
560 570 580 590 600
NLSRTLDEVQ LTLDDKGRGE VSTESQWKET HSPLQVIFQG SLLESGGRPV
610 620 630 640 650
TRRAEQAIWP ADALPGIRPQ FASKSVYDYR TDSTVKQPIV DEGSNAAFDI
660 670 680 690 700
VYSDAQGVKK AVSGLQVRLI RERRDYYWNW SEDEGWQSQF DQKDLIENEQ
710 720 730 740 750
TLDLKADETG KVSFPVEWGA YRLEVKAPNE AVSSVRFWAG YSWQDNSDGS
760 770 780 790 800
GAVRPDRVTL KLDKASYRPG DTIKLHIAAP TAGKGYAMVE SSEGPLWWQE
810 820 830 840 850
IDVRAQGLDL TIPVDKTWNR HDLYLSTLVV RPGDKSRSAT PKRAVGVLHL
860 870 880 890 900
PLGDENRRLD LALETPAKMR PNQPLTVKIK ASTKNGEKPK QVNVLVSAVD
910 920 930 940 950
SGVLNITDYV TPDPWQAFFG QKRYGADIYD IYGQVIEGQG RLAALRFGGD
960 970 980 990 1000
GDELKRGGKP PVNHVNIVVQ QALPVTLNEQ GEGSVTLPIG DFNGELRVMA
1010 1020 1030 1040 1050
QAWTADDFGS NESKVIVAAP VIAELNMPRF MASGDTSRLT LDITNLTDKP
1060 1070 1080 1090 1100
QKLNVALTAS GLLELVSDSP AAVELAPGVR TTLFIPVRAL PGYGDGEIQA
1110 1120 1130 1140 1150
TISGLALPGE TVADQHKQWK IGVRPAFPAQ TVNYGTALQP GETWAIPADG
1160 1170 1180 1190 1200
LQNFSPVTLE GQLLLSGKPP LNIARYIKEL KAYPYGCLEQ TASGLFPSLY
1210 1220 1230 1240 1250
TNAAQLQALG IKGDSDEKRR ASVDIGISRL LQMQRDNGGF ALWDKNGDEE
1260 1270 1280 1290 1300
YWLTAYVMDF LVRAGEQGYS VPTDAINRGN ERLLRYLQDP GMMSIPYADN
1310 1320 1330 1340 1350
LKASKFAVQS YAALVLARQQ KAPLGALREI WEHRADAASG LPLLQLGVAL
1360 1370 1380 1390 1400
KTMGDATRGE EAIALALKTP RNSDERIWLG DYGSSLRDNA LMLSLLEENK
1410 1420 1430 1440 1450
LLPDEQYTLL NTLSQQAFGE RWLSTQESNA LFLAARTIQD LPGKWQAQTS
1460 1470 1480 1490 1500
FSAEQLTGEK AQNSNLNSDQ LVTLQVSNSG DQPLWLRMDA SGYPQSAPLP
1510 1520 1530 1540 1550
ANNVLQIERH ILGTDGKSKS LDSLRSGDLV LVWLQVKASN SVPDALVVDL
1560 1570 1580 1590 1600
LPAGLELENQ NLANGSASLE QSGGEVQNLL NQMQQASIKH IEFRDDRFVA
1610 1620 1630 1640 1650
AVAVDEYQPV TLVYLARAVT PGTYQVPQPM VESMYVPQWR ATGAAEDLLI

VRP
Length:1,653
Mass (Da):181,585
Last modified:February 1, 1997 - v1
Checksum:i13109EC5CDEB41A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75573.1.
AP009048 Genomic DNA. Translation: BAE76729.1.
PIRiG65028.
RefSeqiNP_417015.1. NC_000913.3.
WP_000736312.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75573; AAC75573; b2520.
BAE76729; BAE76729; BAE76729.
GeneIDi947302.
KEGGiecj:JW2504.
eco:b2520.
PATRICi32120433. VBIEscCol129921_2619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75573.1.
AP009048 Genomic DNA. Translation: BAE76729.1.
PIRiG65028.
RefSeqiNP_417015.1. NC_000913.3.
WP_000736312.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RTDX-ray3.65A23-1653[»]
4ZIQX-ray2.55A40-1653[»]
4ZIUX-ray2.70A1018-1653[»]
4ZJGX-ray2.30A40-385[»]
4ZJHX-ray1.60A163-368[»]
5A42electron microscopy16.00A40-1653[»]
ProteinModelPortaliP76578.
SMRiP76578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260803. 184 interactors.
DIPiDIP-28064N.
IntActiP76578. 15 interactors.
STRINGi511145.b2520.

Protein family/group databases

MEROPSiI39.008.

Proteomic databases

PaxDbiP76578.
PRIDEiP76578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75573; AAC75573; b2520.
BAE76729; BAE76729; BAE76729.
GeneIDi947302.
KEGGiecj:JW2504.
eco:b2520.
PATRICi32120433. VBIEscCol129921_2619.

Organism-specific databases

EchoBASEiEB3175.
EcoGeneiEG13394. yfhM.

Phylogenomic databases

eggNOGiENOG4105DN3. Bacteria.
COG2373. LUCA.
HOGENOMiHOG000275932.
InParanoidiP76578.
KOiK06894.
OMAiTAYAMDF.
PhylomeDBiP76578.

Enzyme and pathway databases

BioCyciEcoCyc:G7323-MONOMER.
ECOL316407:JW2504-MONOMER.

Miscellaneous databases

PROiP76578.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026284. A2-macglob_dom_prot_bac.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR021868. Alpha_2_Macroglob_MG1.
IPR001599. Macroglobln_a2.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF11974. MG1. 1 hit.
[Graphical view]
PIRSFiPIRSF038980. A2M_bac. 1 hit.
SMARTiSM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYFHM_ECOLI
AccessioniPrimary (citable) accession number: P76578
Secondary accession number(s): Q2MAH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.