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Protein

Uncharacterized lipoprotein YfhM

Gene

yfhM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: EcoCyc

GO - Biological processi

  • negative regulation of endopeptidase activity Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7323-MONOMER.
ECOL316407:JW2504-MONOMER.

Protein family/group databases

MEROPSiI39.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized lipoprotein YfhM
Gene namesi
Name:yfhM
Ordered Locus Names:b2520, JW2504
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13394. yfhM.

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  • anchored component of external side of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717PROSITE-ProRule annotationAdd
BLAST
Chaini18 – 16531636Uncharacterized lipoprotein YfhMPRO_0000013775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi18 – 181N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi18 – 181S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP76578.
PRIDEiP76578.

Interactioni

Protein-protein interaction databases

BioGridi4260803. 184 interactions.
DIPiDIP-28064N.
IntActiP76578. 15 interactions.
STRINGi511145.b2520.

Structurei

Secondary structure

1
1653
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni58 – 647Combined sources
Beta strandi69 – 779Combined sources
Beta strandi80 – 8910Combined sources
Helixi97 – 1004Combined sources
Beta strandi101 – 1055Combined sources
Turni106 – 1083Combined sources
Beta strandi121 – 1266Combined sources
Beta strandi134 – 1396Combined sources
Beta strandi155 – 1606Combined sources
Beta strandi167 – 1737Combined sources
Beta strandi175 – 1773Combined sources
Helixi181 – 1833Combined sources
Beta strandi185 – 1917Combined sources
Beta strandi194 – 2029Combined sources
Helixi204 – 2063Combined sources
Helixi207 – 2159Combined sources
Turni216 – 2194Combined sources
Turni222 – 2243Combined sources
Helixi226 – 2294Combined sources
Beta strandi232 – 24110Combined sources
Beta strandi250 – 2545Combined sources
Helixi260 – 2634Combined sources
Beta strandi266 – 2738Combined sources
Beta strandi276 – 2783Combined sources
Beta strandi279 – 2813Combined sources
Beta strandi284 – 2896Combined sources
Beta strandi291 – 2999Combined sources
Beta strandi302 – 3098Combined sources
Turni310 – 3123Combined sources
Beta strandi320 – 3245Combined sources
Beta strandi326 – 3283Combined sources
Beta strandi330 – 3356Combined sources
Beta strandi340 – 3456Combined sources
Beta strandi352 – 3576Combined sources
Beta strandi360 – 3656Combined sources
Beta strandi385 – 3917Combined sources
Beta strandi395 – 3973Combined sources
Beta strandi402 – 4109Combined sources
Beta strandi422 – 4276Combined sources
Beta strandi433 – 4397Combined sources
Beta strandi445 – 4517Combined sources
Beta strandi459 – 4668Combined sources
Beta strandi468 – 4703Combined sources
Beta strandi473 – 4797Combined sources
Beta strandi486 – 4927Combined sources
Beta strandi504 – 5129Combined sources
Turni513 – 5153Combined sources
Beta strandi522 – 53110Combined sources
Beta strandi553 – 56210Combined sources
Beta strandi567 – 5737Combined sources
Beta strandi584 – 59310Combined sources
Beta strandi599 – 60810Combined sources
Beta strandi610 – 62112Combined sources
Beta strandi623 – 6286Combined sources
Turni629 – 6324Combined sources
Beta strandi633 – 6419Combined sources
Beta strandi644 – 65310Combined sources
Beta strandi662 – 67110Combined sources
Beta strandi695 – 70410Combined sources
Beta strandi710 – 7156Combined sources
Beta strandi718 – 7269Combined sources
Beta strandi732 – 7409Combined sources
Turni748 – 7514Combined sources
Beta strandi759 – 7657Combined sources
Beta strandi772 – 7787Combined sources
Beta strandi786 – 7905Combined sources
Beta strandi795 – 7973Combined sources
Beta strandi808 – 8136Combined sources
Beta strandi824 – 8318Combined sources
Beta strandi842 – 8498Combined sources
Helixi855 – 8573Combined sources
Beta strandi860 – 8645Combined sources
Beta strandi867 – 8693Combined sources
Beta strandi873 – 88210Combined sources
Turni884 – 8863Combined sources
Beta strandi893 – 9008Combined sources
Helixi901 – 9044Combined sources
Turni905 – 9084Combined sources
Helixi914 – 9196Combined sources
Beta strandi927 – 9315Combined sources
Helixi932 – 9343Combined sources
Helixi952 – 9576Combined sources
Beta strandi969 – 9713Combined sources
Beta strandi981 – 9888Combined sources
Beta strandi994 – 100613Combined sources
Beta strandi1008 – 101710Combined sources
Beta strandi1020 – 10267Combined sources
Beta strandi1029 – 10313Combined sources
Beta strandi1036 – 104510Combined sources
Beta strandi1047 – 10493Combined sources
Beta strandi1051 – 106111Combined sources
Beta strandi1063 – 10675Combined sources
Beta strandi1072 – 10754Combined sources
Beta strandi1080 – 108910Combined sources
Beta strandi1091 – 110313Combined sources
Beta strandi1108 – 11103Combined sources
Beta strandi1115 – 112410Combined sources
Beta strandi1130 – 11389Combined sources
Beta strandi1143 – 11453Combined sources
Turni1150 – 11534Combined sources
Turni1156 – 11583Combined sources
Beta strandi1160 – 11689Combined sources
Helixi1173 – 11753Combined sources
Beta strandi1178 – 11803Combined sources
Helixi1188 – 11936Combined sources
Helixi1196 – 11994Combined sources
Helixi1203 – 12097Combined sources
Helixi1216 – 123217Combined sources
Beta strandi1240 – 12434Combined sources
Helixi1251 – 126616Combined sources
Helixi1273 – 128816Combined sources
Helixi1290 – 12923Combined sources
Helixi1301 – 131717Combined sources
Turni1318 – 13203Combined sources
Helixi1324 – 13329Combined sources
Helixi1333 – 13364Combined sources
Helixi1340 – 135314Combined sources
Helixi1356 – 136611Combined sources
Beta strandi1379 – 13813Combined sources
Helixi1385 – 139814Combined sources
Helixi1403 – 141816Combined sources
Helixi1425 – 143511Combined sources
Turni1436 – 14405Combined sources
Beta strandi1445 – 14495Combined sources
Beta strandi1456 – 14605Combined sources
Beta strandi1462 – 14676Combined sources
Helixi1468 – 14725Combined sources
Beta strandi1475 – 14784Combined sources
Beta strandi1480 – 14823Combined sources
Beta strandi1484 – 14929Combined sources
Beta strandi1494 – 14963Combined sources
Beta strandi1502 – 151312Combined sources
Beta strandi1516 – 15183Combined sources
Beta strandi1523 – 15253Combined sources
Beta strandi1529 – 154012Combined sources
Beta strandi1542 – 15509Combined sources
Beta strandi1555 – 15573Combined sources
Helixi1563 – 15653Combined sources
Helixi1569 – 15724Combined sources
Helixi1574 – 15763Combined sources
Helixi1577 – 15859Combined sources
Beta strandi1586 – 15938Combined sources
Beta strandi1595 – 160511Combined sources
Beta strandi1610 – 16189Combined sources
Beta strandi1622 – 16243Combined sources
Beta strandi1630 – 16356Combined sources
Beta strandi1639 – 16424Combined sources
Beta strandi1649 – 16524Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RTDX-ray3.65A23-1653[»]
4ZIQX-ray2.55A40-1653[»]
4ZIUX-ray2.70A1018-1653[»]
4ZJGX-ray2.30A40-385[»]
4ZJHX-ray1.60A163-368[»]
5A42electron microscopy16.00A40-1653[»]
ProteinModelPortaliP76578.
SMRiP76578. Positions 57-1653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1559 – 158931Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG4105DN3. Bacteria.
COG2373. LUCA.
HOGENOMiHOG000275932.
InParanoidiP76578.
KOiK06894.
OMAiTAYAMDF.
PhylomeDBiP76578.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026284. A2-macglob_dom_prot_bac.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR021868. Alpha_2_Macroglob_MG1.
IPR001599. Macroglobln_a2.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF11974. MG1. 1 hit.
[Graphical view]
PIRSFiPIRSF038980. A2M_bac. 1 hit.
SMARTiSM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLRVAACM LMLALAGCDN NDNAPTAVKK DAPSEVTKAA SSENASSAKL
60 70 80 90 100
SVPERQKLAQ QSAGKVLTLL DLSEVQLDGA ATLVLTFSIP LDPDQDFSRV
110 120 130 140 150
IHVVDKKSGK VDGAWELSDN LKELRLRHLE PKRDLIVTIG KEVKALNNAT
160 170 180 190 200
FSKDYEKTIT TRDIQPSVGF ASRGSLLPGK VVEGLPVMAL NVNNVDVNFF
210 220 230 240 250
RVKPESLPAF ISQWEYRNSL ANWQSDKLLQ MADLVYTGRF DLNPARNTRE
260 270 280 290 300
KLLLPLGDIK PLQQAGVYLA VMNQAGRYDY SNPATLFTLS DIGVSAHRYH
310 320 330 340 350
NRLDIFTQSL ENGAAQQGIE VSLLNEKGQT LTQATSDAQG HVQLENDKNA
360 370 380 390 400
ALLLARKDGQ TTLLDLKLPA LDLAEFNIAG APGYSKQFFM FGPRDLYRPG
410 420 430 440 450
ETVILNGLLR DADGKALPNQ PIKLDVIKPD GQVLRSVVSQ PENGLYHFTW
460 470 480 490 500
PLDSNAATGM WHIRANTGDN QYRMWDFHVE DFMPERMALN LTGEKTPLTP
510 520 530 540 550
KDEVKFSVVG YYLYGAPANG NTLQGQLFLR PLREAVSALP GFEFGDIAAE
560 570 580 590 600
NLSRTLDEVQ LTLDDKGRGE VSTESQWKET HSPLQVIFQG SLLESGGRPV
610 620 630 640 650
TRRAEQAIWP ADALPGIRPQ FASKSVYDYR TDSTVKQPIV DEGSNAAFDI
660 670 680 690 700
VYSDAQGVKK AVSGLQVRLI RERRDYYWNW SEDEGWQSQF DQKDLIENEQ
710 720 730 740 750
TLDLKADETG KVSFPVEWGA YRLEVKAPNE AVSSVRFWAG YSWQDNSDGS
760 770 780 790 800
GAVRPDRVTL KLDKASYRPG DTIKLHIAAP TAGKGYAMVE SSEGPLWWQE
810 820 830 840 850
IDVRAQGLDL TIPVDKTWNR HDLYLSTLVV RPGDKSRSAT PKRAVGVLHL
860 870 880 890 900
PLGDENRRLD LALETPAKMR PNQPLTVKIK ASTKNGEKPK QVNVLVSAVD
910 920 930 940 950
SGVLNITDYV TPDPWQAFFG QKRYGADIYD IYGQVIEGQG RLAALRFGGD
960 970 980 990 1000
GDELKRGGKP PVNHVNIVVQ QALPVTLNEQ GEGSVTLPIG DFNGELRVMA
1010 1020 1030 1040 1050
QAWTADDFGS NESKVIVAAP VIAELNMPRF MASGDTSRLT LDITNLTDKP
1060 1070 1080 1090 1100
QKLNVALTAS GLLELVSDSP AAVELAPGVR TTLFIPVRAL PGYGDGEIQA
1110 1120 1130 1140 1150
TISGLALPGE TVADQHKQWK IGVRPAFPAQ TVNYGTALQP GETWAIPADG
1160 1170 1180 1190 1200
LQNFSPVTLE GQLLLSGKPP LNIARYIKEL KAYPYGCLEQ TASGLFPSLY
1210 1220 1230 1240 1250
TNAAQLQALG IKGDSDEKRR ASVDIGISRL LQMQRDNGGF ALWDKNGDEE
1260 1270 1280 1290 1300
YWLTAYVMDF LVRAGEQGYS VPTDAINRGN ERLLRYLQDP GMMSIPYADN
1310 1320 1330 1340 1350
LKASKFAVQS YAALVLARQQ KAPLGALREI WEHRADAASG LPLLQLGVAL
1360 1370 1380 1390 1400
KTMGDATRGE EAIALALKTP RNSDERIWLG DYGSSLRDNA LMLSLLEENK
1410 1420 1430 1440 1450
LLPDEQYTLL NTLSQQAFGE RWLSTQESNA LFLAARTIQD LPGKWQAQTS
1460 1470 1480 1490 1500
FSAEQLTGEK AQNSNLNSDQ LVTLQVSNSG DQPLWLRMDA SGYPQSAPLP
1510 1520 1530 1540 1550
ANNVLQIERH ILGTDGKSKS LDSLRSGDLV LVWLQVKASN SVPDALVVDL
1560 1570 1580 1590 1600
LPAGLELENQ NLANGSASLE QSGGEVQNLL NQMQQASIKH IEFRDDRFVA
1610 1620 1630 1640 1650
AVAVDEYQPV TLVYLARAVT PGTYQVPQPM VESMYVPQWR ATGAAEDLLI

VRP
Length:1,653
Mass (Da):181,585
Last modified:February 1, 1997 - v1
Checksum:i13109EC5CDEB41A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75573.1.
AP009048 Genomic DNA. Translation: BAE76729.1.
PIRiG65028.
RefSeqiNP_417015.1. NC_000913.3.
WP_000736312.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75573; AAC75573; b2520.
BAE76729; BAE76729; BAE76729.
GeneIDi947302.
KEGGiecj:JW2504.
eco:b2520.
PATRICi32120433. VBIEscCol129921_2619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75573.1.
AP009048 Genomic DNA. Translation: BAE76729.1.
PIRiG65028.
RefSeqiNP_417015.1. NC_000913.3.
WP_000736312.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RTDX-ray3.65A23-1653[»]
4ZIQX-ray2.55A40-1653[»]
4ZIUX-ray2.70A1018-1653[»]
4ZJGX-ray2.30A40-385[»]
4ZJHX-ray1.60A163-368[»]
5A42electron microscopy16.00A40-1653[»]
ProteinModelPortaliP76578.
SMRiP76578. Positions 57-1653.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260803. 184 interactions.
DIPiDIP-28064N.
IntActiP76578. 15 interactions.
STRINGi511145.b2520.

Protein family/group databases

MEROPSiI39.008.

Proteomic databases

PaxDbiP76578.
PRIDEiP76578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75573; AAC75573; b2520.
BAE76729; BAE76729; BAE76729.
GeneIDi947302.
KEGGiecj:JW2504.
eco:b2520.
PATRICi32120433. VBIEscCol129921_2619.

Organism-specific databases

EchoBASEiEB3175.
EcoGeneiEG13394. yfhM.

Phylogenomic databases

eggNOGiENOG4105DN3. Bacteria.
COG2373. LUCA.
HOGENOMiHOG000275932.
InParanoidiP76578.
KOiK06894.
OMAiTAYAMDF.
PhylomeDBiP76578.

Enzyme and pathway databases

BioCyciEcoCyc:G7323-MONOMER.
ECOL316407:JW2504-MONOMER.

Miscellaneous databases

PROiP76578.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026284. A2-macglob_dom_prot_bac.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR021868. Alpha_2_Macroglob_MG1.
IPR001599. Macroglobln_a2.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF11974. MG1. 1 hit.
[Graphical view]
PIRSFiPIRSF038980. A2M_bac. 1 hit.
SMARTiSM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYFHM_ECOLI
AccessioniPrimary (citable) accession number: P76578
Secondary accession number(s): Q2MAH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.