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Protein

Uncharacterized lipoprotein YfhM

Gene

yfhM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: EcoCyc

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7323-MONOMER.
ECOL316407:JW2504-MONOMER.

Protein family/group databases

MEROPSiI39.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized lipoprotein YfhM
Gene namesi
Name:yfhM
Ordered Locus Names:b2520, JW2504
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13394. yfhM.

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  • integral component of external side of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717PROSITE-ProRule annotationAdd
BLAST
Chaini18 – 16531636Uncharacterized lipoprotein YfhMPRO_0000013775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi18 – 181N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi18 – 181S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP76578.
PRIDEiP76578.

Interactioni

Protein-protein interaction databases

DIPiDIP-28064N.
IntActiP76578. 15 interactions.
STRINGi511145.b2520.

Structurei

3D structure databases

ProteinModelPortaliP76578.
SMRiP76578. Positions 389-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1559 – 158931Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiCOG2373.
HOGENOMiHOG000275932.
InParanoidiP76578.
KOiK06894.
OMAiTAYAMDF.
OrthoDBiEOG6X3W1C.
PhylomeDBiP76578.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026284. A2-macglob_dom_prot_bac.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR021868. Alpha_2_Macroglob_MG1.
IPR001599. Macroglobln_a2.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF11974. MG1. 1 hit.
[Graphical view]
PIRSFiPIRSF038980. A2M_bac. 1 hit.
SUPFAMiSSF48239. SSF48239. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLRVAACM LMLALAGCDN NDNAPTAVKK DAPSEVTKAA SSENASSAKL
60 70 80 90 100
SVPERQKLAQ QSAGKVLTLL DLSEVQLDGA ATLVLTFSIP LDPDQDFSRV
110 120 130 140 150
IHVVDKKSGK VDGAWELSDN LKELRLRHLE PKRDLIVTIG KEVKALNNAT
160 170 180 190 200
FSKDYEKTIT TRDIQPSVGF ASRGSLLPGK VVEGLPVMAL NVNNVDVNFF
210 220 230 240 250
RVKPESLPAF ISQWEYRNSL ANWQSDKLLQ MADLVYTGRF DLNPARNTRE
260 270 280 290 300
KLLLPLGDIK PLQQAGVYLA VMNQAGRYDY SNPATLFTLS DIGVSAHRYH
310 320 330 340 350
NRLDIFTQSL ENGAAQQGIE VSLLNEKGQT LTQATSDAQG HVQLENDKNA
360 370 380 390 400
ALLLARKDGQ TTLLDLKLPA LDLAEFNIAG APGYSKQFFM FGPRDLYRPG
410 420 430 440 450
ETVILNGLLR DADGKALPNQ PIKLDVIKPD GQVLRSVVSQ PENGLYHFTW
460 470 480 490 500
PLDSNAATGM WHIRANTGDN QYRMWDFHVE DFMPERMALN LTGEKTPLTP
510 520 530 540 550
KDEVKFSVVG YYLYGAPANG NTLQGQLFLR PLREAVSALP GFEFGDIAAE
560 570 580 590 600
NLSRTLDEVQ LTLDDKGRGE VSTESQWKET HSPLQVIFQG SLLESGGRPV
610 620 630 640 650
TRRAEQAIWP ADALPGIRPQ FASKSVYDYR TDSTVKQPIV DEGSNAAFDI
660 670 680 690 700
VYSDAQGVKK AVSGLQVRLI RERRDYYWNW SEDEGWQSQF DQKDLIENEQ
710 720 730 740 750
TLDLKADETG KVSFPVEWGA YRLEVKAPNE AVSSVRFWAG YSWQDNSDGS
760 770 780 790 800
GAVRPDRVTL KLDKASYRPG DTIKLHIAAP TAGKGYAMVE SSEGPLWWQE
810 820 830 840 850
IDVRAQGLDL TIPVDKTWNR HDLYLSTLVV RPGDKSRSAT PKRAVGVLHL
860 870 880 890 900
PLGDENRRLD LALETPAKMR PNQPLTVKIK ASTKNGEKPK QVNVLVSAVD
910 920 930 940 950
SGVLNITDYV TPDPWQAFFG QKRYGADIYD IYGQVIEGQG RLAALRFGGD
960 970 980 990 1000
GDELKRGGKP PVNHVNIVVQ QALPVTLNEQ GEGSVTLPIG DFNGELRVMA
1010 1020 1030 1040 1050
QAWTADDFGS NESKVIVAAP VIAELNMPRF MASGDTSRLT LDITNLTDKP
1060 1070 1080 1090 1100
QKLNVALTAS GLLELVSDSP AAVELAPGVR TTLFIPVRAL PGYGDGEIQA
1110 1120 1130 1140 1150
TISGLALPGE TVADQHKQWK IGVRPAFPAQ TVNYGTALQP GETWAIPADG
1160 1170 1180 1190 1200
LQNFSPVTLE GQLLLSGKPP LNIARYIKEL KAYPYGCLEQ TASGLFPSLY
1210 1220 1230 1240 1250
TNAAQLQALG IKGDSDEKRR ASVDIGISRL LQMQRDNGGF ALWDKNGDEE
1260 1270 1280 1290 1300
YWLTAYVMDF LVRAGEQGYS VPTDAINRGN ERLLRYLQDP GMMSIPYADN
1310 1320 1330 1340 1350
LKASKFAVQS YAALVLARQQ KAPLGALREI WEHRADAASG LPLLQLGVAL
1360 1370 1380 1390 1400
KTMGDATRGE EAIALALKTP RNSDERIWLG DYGSSLRDNA LMLSLLEENK
1410 1420 1430 1440 1450
LLPDEQYTLL NTLSQQAFGE RWLSTQESNA LFLAARTIQD LPGKWQAQTS
1460 1470 1480 1490 1500
FSAEQLTGEK AQNSNLNSDQ LVTLQVSNSG DQPLWLRMDA SGYPQSAPLP
1510 1520 1530 1540 1550
ANNVLQIERH ILGTDGKSKS LDSLRSGDLV LVWLQVKASN SVPDALVVDL
1560 1570 1580 1590 1600
LPAGLELENQ NLANGSASLE QSGGEVQNLL NQMQQASIKH IEFRDDRFVA
1610 1620 1630 1640 1650
AVAVDEYQPV TLVYLARAVT PGTYQVPQPM VESMYVPQWR ATGAAEDLLI

VRP
Length:1,653
Mass (Da):181,585
Last modified:February 1, 1997 - v1
Checksum:i13109EC5CDEB41A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75573.1.
AP009048 Genomic DNA. Translation: BAE76729.1.
PIRiG65028.
RefSeqiNP_417015.1. NC_000913.3.
WP_000736312.1. NZ_CP010445.1.

Genome annotation databases

EnsemblBacteriaiAAC75573; AAC75573; b2520.
BAE76729; BAE76729; BAE76729.
GeneIDi947302.
KEGGieco:b2520.
PATRICi32120433. VBIEscCol129921_2619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75573.1.
AP009048 Genomic DNA. Translation: BAE76729.1.
PIRiG65028.
RefSeqiNP_417015.1. NC_000913.3.
WP_000736312.1. NZ_CP010445.1.

3D structure databases

ProteinModelPortaliP76578.
SMRiP76578. Positions 389-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-28064N.
IntActiP76578. 15 interactions.
STRINGi511145.b2520.

Protein family/group databases

MEROPSiI39.008.

Proteomic databases

PaxDbiP76578.
PRIDEiP76578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75573; AAC75573; b2520.
BAE76729; BAE76729; BAE76729.
GeneIDi947302.
KEGGieco:b2520.
PATRICi32120433. VBIEscCol129921_2619.

Organism-specific databases

EchoBASEiEB3175.
EcoGeneiEG13394. yfhM.

Phylogenomic databases

eggNOGiCOG2373.
HOGENOMiHOG000275932.
InParanoidiP76578.
KOiK06894.
OMAiTAYAMDF.
OrthoDBiEOG6X3W1C.
PhylomeDBiP76578.

Enzyme and pathway databases

BioCyciEcoCyc:G7323-MONOMER.
ECOL316407:JW2504-MONOMER.

Miscellaneous databases

PROiP76578.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026284. A2-macglob_dom_prot_bac.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR021868. Alpha_2_Macroglob_MG1.
IPR001599. Macroglobln_a2.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF11974. MG1. 1 hit.
[Graphical view]
PIRSFiPIRSF038980. A2M_bac. 1 hit.
SUPFAMiSSF48239. SSF48239. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiYFHM_ECOLI
AccessioniPrimary (citable) accession number: P76578
Secondary accession number(s): Q2MAH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.