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P76578

- YFHM_ECOLI

UniProt

P76578 - YFHM_ECOLI

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Protein
Uncharacterized lipoprotein YfhM
Gene
yfhM, b2520, JW2504
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. endopeptidase inhibitor activity Source: EcoCyc
Complete GO annotation...

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7323-MONOMER.
ECOL316407:JW2504-MONOMER.

Protein family/group databases

MEROPSiI39.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized lipoprotein YfhM
Gene namesi
Name:yfhM
Ordered Locus Names:b2520, JW2504
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13394. yfhM.

Subcellular locationi

Cell membrane; Lipid-anchor Reviewed prediction

GO - Cellular componenti

  1. integral component of external side of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 16531636Uncharacterized lipoprotein YfhM
PRO_0000013775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi18 – 181N-palmitoyl cysteine Reviewed prediction
Lipidationi18 – 181S-diacylglycerol cysteine Reviewed prediction

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP76578.
PRIDEiP76578.

Expressioni

Gene expression databases

GenevestigatoriP76578.

Interactioni

Protein-protein interaction databases

DIPiDIP-28064N.
IntActiP76578. 15 interactions.
STRINGi511145.b2520.

Structurei

3D structure databases

ProteinModelPortaliP76578.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1559 – 158931 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiCOG2373.
HOGENOMiHOG000275932.
KOiK06894.
OMAiSSLRFWA.
OrthoDBiEOG6X3W1C.
PhylomeDBiP76578.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026284. A2-macglob_dom_prot_bac.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR021868. Alpha_2_Macroglob_MG1.
IPR001599. Macroglobln_a2.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF11974. MG1. 1 hit.
[Graphical view]
PIRSFiPIRSF038980. A2M_bac. 1 hit.
SUPFAMiSSF48239. SSF48239. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76578-1 [UniParc]FASTAAdd to Basket

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MKKLRVAACM LMLALAGCDN NDNAPTAVKK DAPSEVTKAA SSENASSAKL     50
SVPERQKLAQ QSAGKVLTLL DLSEVQLDGA ATLVLTFSIP LDPDQDFSRV 100
IHVVDKKSGK VDGAWELSDN LKELRLRHLE PKRDLIVTIG KEVKALNNAT 150
FSKDYEKTIT TRDIQPSVGF ASRGSLLPGK VVEGLPVMAL NVNNVDVNFF 200
RVKPESLPAF ISQWEYRNSL ANWQSDKLLQ MADLVYTGRF DLNPARNTRE 250
KLLLPLGDIK PLQQAGVYLA VMNQAGRYDY SNPATLFTLS DIGVSAHRYH 300
NRLDIFTQSL ENGAAQQGIE VSLLNEKGQT LTQATSDAQG HVQLENDKNA 350
ALLLARKDGQ TTLLDLKLPA LDLAEFNIAG APGYSKQFFM FGPRDLYRPG 400
ETVILNGLLR DADGKALPNQ PIKLDVIKPD GQVLRSVVSQ PENGLYHFTW 450
PLDSNAATGM WHIRANTGDN QYRMWDFHVE DFMPERMALN LTGEKTPLTP 500
KDEVKFSVVG YYLYGAPANG NTLQGQLFLR PLREAVSALP GFEFGDIAAE 550
NLSRTLDEVQ LTLDDKGRGE VSTESQWKET HSPLQVIFQG SLLESGGRPV 600
TRRAEQAIWP ADALPGIRPQ FASKSVYDYR TDSTVKQPIV DEGSNAAFDI 650
VYSDAQGVKK AVSGLQVRLI RERRDYYWNW SEDEGWQSQF DQKDLIENEQ 700
TLDLKADETG KVSFPVEWGA YRLEVKAPNE AVSSVRFWAG YSWQDNSDGS 750
GAVRPDRVTL KLDKASYRPG DTIKLHIAAP TAGKGYAMVE SSEGPLWWQE 800
IDVRAQGLDL TIPVDKTWNR HDLYLSTLVV RPGDKSRSAT PKRAVGVLHL 850
PLGDENRRLD LALETPAKMR PNQPLTVKIK ASTKNGEKPK QVNVLVSAVD 900
SGVLNITDYV TPDPWQAFFG QKRYGADIYD IYGQVIEGQG RLAALRFGGD 950
GDELKRGGKP PVNHVNIVVQ QALPVTLNEQ GEGSVTLPIG DFNGELRVMA 1000
QAWTADDFGS NESKVIVAAP VIAELNMPRF MASGDTSRLT LDITNLTDKP 1050
QKLNVALTAS GLLELVSDSP AAVELAPGVR TTLFIPVRAL PGYGDGEIQA 1100
TISGLALPGE TVADQHKQWK IGVRPAFPAQ TVNYGTALQP GETWAIPADG 1150
LQNFSPVTLE GQLLLSGKPP LNIARYIKEL KAYPYGCLEQ TASGLFPSLY 1200
TNAAQLQALG IKGDSDEKRR ASVDIGISRL LQMQRDNGGF ALWDKNGDEE 1250
YWLTAYVMDF LVRAGEQGYS VPTDAINRGN ERLLRYLQDP GMMSIPYADN 1300
LKASKFAVQS YAALVLARQQ KAPLGALREI WEHRADAASG LPLLQLGVAL 1350
KTMGDATRGE EAIALALKTP RNSDERIWLG DYGSSLRDNA LMLSLLEENK 1400
LLPDEQYTLL NTLSQQAFGE RWLSTQESNA LFLAARTIQD LPGKWQAQTS 1450
FSAEQLTGEK AQNSNLNSDQ LVTLQVSNSG DQPLWLRMDA SGYPQSAPLP 1500
ANNVLQIERH ILGTDGKSKS LDSLRSGDLV LVWLQVKASN SVPDALVVDL 1550
LPAGLELENQ NLANGSASLE QSGGEVQNLL NQMQQASIKH IEFRDDRFVA 1600
AVAVDEYQPV TLVYLARAVT PGTYQVPQPM VESMYVPQWR ATGAAEDLLI 1650
VRP 1653
Length:1,653
Mass (Da):181,585
Last modified:February 1, 1997 - v1
Checksum:i13109EC5CDEB41A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC75573.1.
AP009048 Genomic DNA. Translation: BAE76729.1.
PIRiG65028.
RefSeqiNP_417015.1. NC_000913.3.
YP_490748.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75573; AAC75573; b2520.
BAE76729; BAE76729; BAE76729.
GeneIDi12931809.
947302.
KEGGiecj:Y75_p2473.
eco:b2520.
PATRICi32120433. VBIEscCol129921_2619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC75573.1 .
AP009048 Genomic DNA. Translation: BAE76729.1 .
PIRi G65028.
RefSeqi NP_417015.1. NC_000913.3.
YP_490748.1. NC_007779.1.

3D structure databases

ProteinModelPortali P76578.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-28064N.
IntActi P76578. 15 interactions.
STRINGi 511145.b2520.

Protein family/group databases

MEROPSi I39.008.

Proteomic databases

PaxDbi P76578.
PRIDEi P76578.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75573 ; AAC75573 ; b2520 .
BAE76729 ; BAE76729 ; BAE76729 .
GeneIDi 12931809.
947302.
KEGGi ecj:Y75_p2473.
eco:b2520.
PATRICi 32120433. VBIEscCol129921_2619.

Organism-specific databases

EchoBASEi EB3175.
EcoGenei EG13394. yfhM.

Phylogenomic databases

eggNOGi COG2373.
HOGENOMi HOG000275932.
KOi K06894.
OMAi SSLRFWA.
OrthoDBi EOG6X3W1C.
PhylomeDBi P76578.

Enzyme and pathway databases

BioCyci EcoCyc:G7323-MONOMER.
ECOL316407:JW2504-MONOMER.

Miscellaneous databases

PROi P76578.

Gene expression databases

Genevestigatori P76578.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
InterProi IPR026284. A2-macglob_dom_prot_bac.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR021868. Alpha_2_Macroglob_MG1.
IPR001599. Macroglobln_a2.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF11974. MG1. 1 hit.
[Graphical view ]
PIRSFi PIRSF038980. A2M_bac. 1 hit.
SUPFAMi SSF48239. SSF48239. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiYFHM_ECOLI
AccessioniPrimary (citable) accession number: P76578
Secondary accession number(s): Q2MAH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

External Data

Dasty 3

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