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Protein

Esterase YpfH

Gene

ypfH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Displays esterase activity toward palmitoyl-CoA and pNP-butyrate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111Charge relay systemBy similarity
Active sitei159 – 1591Charge relay systemBy similarity
Active sitei191 – 1911Charge relay systemBy similarity

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: EcoCyc
  • hydrolase activity, acting on ester bonds Source: EcoliWiki
  • palmitoyl-(protein) hydrolase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciEcoCyc:G7296-MONOMER.
ECOL316407:JW5396-MONOMER.
BRENDAi3.1.2.2. 2026.

Protein family/group databases

ESTHERiecoli-ypfh. LYsophospholipase_carboxylesterase.
MEROPSiS09.A43.

Names & Taxonomyi

Protein namesi
Recommended name:
Esterase YpfH (EC:3.1.-.-)
Gene namesi
Name:ypfH
Ordered Locus Names:b2473, JW5396
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14195. ypfH.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Esterase YpfHPRO_0000102276Add
BLAST

Proteomic databases

PaxDbiP76561.
PRIDEiP76561.

Interactioni

Protein-protein interaction databases

BioGridi4259532. 2 interactions.
IntActiP76561. 1 interaction.
STRINGi511145.b2473.

Structurei

3D structure databases

ProteinModelPortaliP76561.
SMRiP76561. Positions 15-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4106KED. Bacteria.
COG0400. LUCA.
HOGENOMiHOG000260141.
InParanoidiP76561.
KOiK06999.
OMAiVPKHYFD.
PhylomeDBiP76561.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

P76561-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHDHFVVQS PDKPAQQLLL LFHGVGDNPV AMGEIGNWFA PLFPDALVVS
60 70 80 90 100
VGGAEPSGNP AGRQWFSVQG ITEDNRQARV DAIMPTFIET VRYWQKQSGV
110 120 130 140 150
GANATALIGF SQGAIMVLES IKAEPGLASR VIAFNGRYAS LPETASTATT
160 170 180 190 200
IHLIHGGEDP VIDLAHAVAA QEALISAGGD VTLDIVEDLG HAIDNRSMQF
210 220 230
ALDHLRYTIP KHYFDEALSG GKPGDDDVIE MM
Length:232
Mass (Da):24,855
Last modified:May 30, 2000 - v2
Checksum:iE046F9D642076B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75526.2.
AP009048 Genomic DNA. Translation: BAE76722.1.
PIRiH65022.
RefSeqiNP_416968.2. NC_000913.3.
WP_000679799.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75526; AAC75526; b2473.
BAE76722; BAE76722; BAE76722.
GeneIDi947571.
KEGGiecj:JW5396.
eco:b2473.
PATRICi32120331. VBIEscCol129921_2568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75526.2.
AP009048 Genomic DNA. Translation: BAE76722.1.
PIRiH65022.
RefSeqiNP_416968.2. NC_000913.3.
WP_000679799.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76561.
SMRiP76561. Positions 15-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259532. 2 interactions.
IntActiP76561. 1 interaction.
STRINGi511145.b2473.

Protein family/group databases

ESTHERiecoli-ypfh. LYsophospholipase_carboxylesterase.
MEROPSiS09.A43.

Proteomic databases

PaxDbiP76561.
PRIDEiP76561.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75526; AAC75526; b2473.
BAE76722; BAE76722; BAE76722.
GeneIDi947571.
KEGGiecj:JW5396.
eco:b2473.
PATRICi32120331. VBIEscCol129921_2568.

Organism-specific databases

EchoBASEiEB3947.
EcoGeneiEG14195. ypfH.

Phylogenomic databases

eggNOGiENOG4106KED. Bacteria.
COG0400. LUCA.
HOGENOMiHOG000260141.
InParanoidiP76561.
KOiK06999.
OMAiVPKHYFD.
PhylomeDBiP76561.

Enzyme and pathway databases

BioCyciEcoCyc:G7296-MONOMER.
ECOL316407:JW5396-MONOMER.
BRENDAi3.1.2.2. 2026.

Miscellaneous databases

PROiP76561.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR003140. PLipase/COase/thioEstase.
[Graphical view]
PfamiPF02230. Abhydrolase_2. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYPFH_ECOLI
AccessioniPrimary (citable) accession number: P76561
Secondary accession number(s): Q2MAI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.