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Protein

Probable phospholipid-binding lipoprotein MlaA

Gene

mlaA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.1 Publication

Enzyme and pathway databases

BioCyciEcoCyc:G7216-MONOMER.

Protein family/group databases

TCDBi3.A.1.27.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-binding lipoprotein MlaA
Gene namesi
Name:mlaA
Synonyms:vacJ
Ordered Locus Names:b2346, JW2343
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14276. mlaA.

Subcellular locationi

  • Cell outer membrane 1 Publication; Lipid-anchor PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17PROSITE-ProRule annotationAdd BLAST17
ChainiPRO_000001821018 – 251Probable phospholipid-binding lipoprotein MlaAAdd BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi18N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi18S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP76506.
PRIDEiP76506.

Interactioni

Protein-protein interaction databases

BioGridi4260538. 150 interactors.
IntActiP76506. 4 interactors.
STRINGi316385.ECDH10B_2509.

Structurei

3D structure databases

ProteinModelPortaliP76506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MlaA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410903C. Bacteria.
COG2853. LUCA.
HOGENOMiHOG000220801.
InParanoidiP76506.
KOiK04754.
PhylomeDBiP76506.

Family and domain databases

InterProiView protein in InterPro
IPR007428. MlaA.
PANTHERiPTHR30035. PTHR30035. 1 hit.
PfamiView protein in Pfam
PF04333. MlaA. 1 hit.
PRINTSiPR01805. VACJLIPOPROT.
PROSITEiView protein in PROSITE
PS51257. PROKAR_LIPOPROTEIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRLSALAL GTTLLVGCAS SGTDQQGRSD PLEGFNRTMY NFNFNVLDPY
60 70 80 90 100
IVRPVAVAWR DYVPQPARNG LSNFTGNLEE PAVMVNYFLQ GDPYQGMVHF
110 120 130 140 150
TRFFLNTILG MGGFIDVAGM ANPKLQRTEP HRFGSTLGHY GVGYGPYVQL
160 170 180 190 200
PFYGSFTLRD DGGDMADGFY PVLSWLTWPM SVGKWTLEGI ETRAQLLDSD
210 220 230 240 250
GLLRQSSDPY IMVREAYFQR HDFIANGGEL KPQENPNAQA IQDDLKDIDS

E
Length:251
Mass (Da):28,042
Last modified:February 1, 1997 - v1
Checksum:iF008CD42CB8C75B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 4MKLR → YEAS no nucleotide entry (PubMed:9205837).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75406.1.
AP009048 Genomic DNA. Translation: BAA16206.2.
PIRiH65007.
RefSeqiNP_416848.1. NC_000913.3.
WP_000776765.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75406; AAC75406; b2346.
BAA16206; BAA16206; BAA16206.
GeneIDi945582.
KEGGiecj:JW2343.
eco:b2346.
PATRICifig|1411691.4.peg.4386.

Similar proteinsi

Entry informationi

Entry nameiMLAA_ECOLI
AccessioniPrimary (citable) accession number: P76506
Secondary accession number(s): P76941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families