Phosphohistidine phosphatase sixA - Escherichia coli (strain K12)

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P76502 (SIXA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 93. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Phosphohistidine phosphatase sixA
EC=3.1.3.-

Alternative name(s):
RX6

Gene names

Name:	sixA
Synonyms:	yfcW
Ordered Locus Names:	b2340, JW2337

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay.
Sequence similarities	Belongs to the sixA phosphatase family.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from mutant phenotype. Source: EcoliWiki
Cellular component	cytoplasm Inferred from direct assay. Source: EcoliWiki
Molecular function	phosphohistidine phosphatase activity Inferred from direct assay. Source: EcoliWiki phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 161

161

Phosphohistidine phosphatase sixA

PRO_0000214568

Experimental info

Sequence conflict

T → K Ref.2

Secondary structure

161

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P76502 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 98D9470A4EBAAA57
Show »

FASTA

161

17,208

        10         20         30         40         50         60 
MQVFIMRHGD AALDAASDSV RPLTTNGCDE SRLMANWLKG QKVEIERVLV SPFLRAEQTL 

        70         80         90        100        110        120 
EEVGDCLNLP SSAEVLPELT PCGDVGLVSA YLQALTNEGV ASVLVISHLP LVGYLVAELC 

       130        140        150        160 
PGETPPMFTT SAIASVTLDE SGNGTFNWQM SPCNLKMAKA I

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An Escherichia coli protein that exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay." Ogino H., Matsubara M., Kato N., Nakamura Y., Mizuno T. Mol. Microbiol. 27:573-585(1998) [PubMed: 9489669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.
[2]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. Horiuchi T. DNA Res. 4:91-113(1997) [PubMed: 9205837] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 80. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D86298 Genomic DNA. Translation: BAA24878.1.
U00096 Genomic DNA. Translation: AAC75400.1.
AP009048 Genomic DNA. Translation: BAA16194.2.

PIR

B65007.

RefSeq

NP_416842.1. NC_000913.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UJB	X-ray	2.06	A	1-161	[»]
1UJC	X-ray	1.90	A	1-161	[»]

ProteinModelPortal

P76502.

SMR

P76502. Positions 1-156.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-10885N.

IntAct

P76502. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBESCT00000004299; EBESCP00000004299; EBESCG00000003505.
EBESCT00000017225; EBESCP00000016516; EBESCG00000016284.

GeneID

946815.

GenomeReviews

Gene locus JW2337 in contig AP009048_GR.
Gene locus b2340 in contig U00096_GR.

KEGG

ecj:JW2337.
eco:b2340.

PATRIC

32120053. VBIEscCol129921_2436.

Organism-specific databases

EchoBASE

EB3878.

EcoGene

EG14126. sixA.

Phylogenomic databases

eggNOG

COG2062.

GeneTree

EBGT00050000010354.

HOGENOM

HBG689426.

OMA

DESRQMA.

PhylomeDB

P76502.

ProtClustDB

PRK10848.

Enzyme and pathway databases

BioCyc

EcoCyc:G7211-MONOMER.

Gene expression databases

Genevestigator

P76502.

Family and domain databases

InterPro

IPR013078. His_Pase_superF_clade-1.
IPR004449. SixA_subgr.
[Graphical view]

K08296.

Pfam

PF00300. His_Phos_1. 1 hit.
[Graphical view]

SMART

SM00855. PGAM. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00249. SixA. 1 hit.

ProtoNet

Search...

Entry information

Entry name

SIXA_ECOLI

Accession

Primary (citable) accession number: P76502
Secondary accession number(s): P77784

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents