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Protein

Phosphohistidine phosphatase SixA

Gene

sixA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay.

GO - Molecular functioni

  • phosphohistidine phosphatase activity Source: EcoliWiki
  • phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  • cellular protein modification process Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciEcoCyc:G7211-MONOMER.
ECOL316407:JW2337-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphohistidine phosphatase SixA (EC:3.1.3.-)
Alternative name(s):
RX6
Gene namesi
Name:sixA
Synonyms:yfcW
Ordered Locus Names:b2340, JW2337
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14126. sixA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002145681 – 161Phosphohistidine phosphatase SixAAdd BLAST161

Proteomic databases

PaxDbiP76502.
PRIDEiP76502.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
torIQ2EES93EBI-548621,EBI-9154838

Protein-protein interaction databases

BioGridi4260532. 16 interactors.
DIPiDIP-10885N.
IntActiP76502. 9 interactors.
STRINGi511145.b2340.

Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Beta strandi15 – 17Combined sources3
Helixi18 – 20Combined sources3
Helixi25 – 40Combined sources16
Beta strandi47 – 50Combined sources4
Helixi54 – 66Combined sources13
Helixi77 – 79Combined sources3
Helixi85 – 98Combined sources14
Beta strandi102 – 107Combined sources6
Helixi111 – 119Combined sources9
Beta strandi133 – 138Combined sources6
Beta strandi144 – 150Combined sources7
Helixi152 – 154Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UJBX-ray2.06A1-161[»]
1UJCX-ray1.90A1-161[»]
ProteinModelPortaliP76502.
SMRiP76502.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76502.

Family & Domainsi

Sequence similaritiesi

Belongs to the SixA phosphatase family.Curated

Phylogenomic databases

eggNOGiENOG4108BY2. Bacteria.
COG2062. LUCA.
HOGENOMiHOG000238872.
InParanoidiP76502.
KOiK08296.
OMAiMQVLIMR.
PhylomeDBiP76502.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR004449. SixA.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR00249. sixA. 1 hit.

Sequencei

Sequence statusi: Complete.

P76502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVFIMRHGD AALDAASDSV RPLTTNGCDE SRLMANWLKG QKVEIERVLV
60 70 80 90 100
SPFLRAEQTL EEVGDCLNLP SSAEVLPELT PCGDVGLVSA YLQALTNEGV
110 120 130 140 150
ASVLVISHLP LVGYLVAELC PGETPPMFTT SAIASVTLDE SGNGTFNWQM
160
SPCNLKMAKA I
Length:161
Mass (Da):17,208
Last modified:February 1, 1997 - v1
Checksum:i98D9470A4EBAAA57
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80T → K (PubMed:9205837).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86298 Genomic DNA. Translation: BAA24878.1.
U00096 Genomic DNA. Translation: AAC75400.1.
AP009048 Genomic DNA. Translation: BAA16194.2.
PIRiB65007.
RefSeqiNP_416842.1. NC_000913.3.
WP_001195819.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75400; AAC75400; b2340.
BAA16194; BAA16194; BAA16194.
GeneIDi946815.
KEGGiecj:JW2337.
eco:b2340.
PATRICi32120053. VBIEscCol129921_2436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86298 Genomic DNA. Translation: BAA24878.1.
U00096 Genomic DNA. Translation: AAC75400.1.
AP009048 Genomic DNA. Translation: BAA16194.2.
PIRiB65007.
RefSeqiNP_416842.1. NC_000913.3.
WP_001195819.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UJBX-ray2.06A1-161[»]
1UJCX-ray1.90A1-161[»]
ProteinModelPortaliP76502.
SMRiP76502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260532. 16 interactors.
DIPiDIP-10885N.
IntActiP76502. 9 interactors.
STRINGi511145.b2340.

Proteomic databases

PaxDbiP76502.
PRIDEiP76502.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75400; AAC75400; b2340.
BAA16194; BAA16194; BAA16194.
GeneIDi946815.
KEGGiecj:JW2337.
eco:b2340.
PATRICi32120053. VBIEscCol129921_2436.

Organism-specific databases

EchoBASEiEB3878.
EcoGeneiEG14126. sixA.

Phylogenomic databases

eggNOGiENOG4108BY2. Bacteria.
COG2062. LUCA.
HOGENOMiHOG000238872.
InParanoidiP76502.
KOiK08296.
OMAiMQVLIMR.
PhylomeDBiP76502.

Enzyme and pathway databases

BioCyciEcoCyc:G7211-MONOMER.
ECOL316407:JW2337-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP76502.
PROiP76502.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR004449. SixA.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR00249. sixA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIXA_ECOLI
AccessioniPrimary (citable) accession number: P76502
Secondary accession number(s): P77784
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.