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Protein

Uncharacterized fimbrial-like protein YfcR

Gene

yfcR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7206-MONOMER.
ECOL316407:JW2332-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YfcR
Gene namesi
Name:yfcR
Ordered Locus Names:b2335, JW2332
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14121. yfcR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001377329 – 170Uncharacterized fimbrial-like protein YfcRAdd BLAST142

Proteomic databases

PaxDbiP76501.
PRIDEiP76501.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260531. 13 interactors.
IntActiP76501. 4 interactors.
STRINGi511145.b2335.

Structurei

3D structure databases

ProteinModelPortaliP76501.
SMRiP76501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105NEV. Bacteria.
ENOG4111X56. LUCA.
HOGENOMiHOG000122523.
OMAiNTASNFT.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGGVMSQKF VVGAGLLVCS VCSLSAMAGS KPVDLILRVL VDAPPPCSIK
60 70 80 90 100
GSQVEFGNMI ADNVDGTNYR QDAKYTLNCT NSLANDLRMQ LKGNTSTING
110 120 130 140 150
ETVLSTNITG LGIRIENSAD NSLFAVGENS WTPFNINNQP QLKAVPVKAS
160 170
GAQLAAGEFN ASLTMVVDYQ
Length:170
Mass (Da):17,890
Last modified:February 1, 1997 - v1
Checksum:i30CCDE3829E3FFDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75395.1.
AP009048 Genomic DNA. Translation: BAE76692.1.
PIRiE65006.
RefSeqiNP_416838.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC75395; AAC75395; b2335.
BAE76692; BAE76692; BAE76692.
GeneIDi946818.
KEGGiecj:JW2332.
eco:b2335.
PATRICi32120043. VBIEscCol129921_2431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75395.1.
AP009048 Genomic DNA. Translation: BAE76692.1.
PIRiE65006.
RefSeqiNP_416838.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP76501.
SMRiP76501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260531. 13 interactors.
IntActiP76501. 4 interactors.
STRINGi511145.b2335.

Proteomic databases

PaxDbiP76501.
PRIDEiP76501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75395; AAC75395; b2335.
BAE76692; BAE76692; BAE76692.
GeneIDi946818.
KEGGiecj:JW2332.
eco:b2335.
PATRICi32120043. VBIEscCol129921_2431.

Organism-specific databases

EchoBASEiEB3874.
EcoGeneiEG14121. yfcR.

Phylogenomic databases

eggNOGiENOG4105NEV. Bacteria.
ENOG4111X56. LUCA.
HOGENOMiHOG000122523.
OMAiNTASNFT.

Enzyme and pathway databases

BioCyciEcoCyc:G7206-MONOMER.
ECOL316407:JW2332-MONOMER.

Miscellaneous databases

PROiP76501.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYFCR_ECOLI
AccessioniPrimary (citable) accession number: P76501
Secondary accession number(s): Q2MAL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.