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Protein

Uncharacterized fimbrial-like protein YfcR

Gene

yfcR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7206-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YfcR
Gene namesi
Name:yfcR
Ordered Locus Names:b2335, JW2332
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14121 yfcR

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001377329 – 170Uncharacterized fimbrial-like protein YfcRAdd BLAST142

Proteomic databases

PaxDbiP76501
PRIDEiP76501

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260531, 13 interactors
IntActiP76501, 4 interactors
STRINGi316385.ECDH10B_2497

Structurei

3D structure databases

ProteinModelPortaliP76501
SMRiP76501
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105NEV Bacteria
ENOG4111X56 LUCA
HOGENOMiHOG000122523
OMAiTPARWMK

Family and domain databases

Gene3Di2.60.40.1090, 1 hit
InterProiView protein in InterPro
IPR000259 Adhesion_dom_fimbrial
IPR036937 Adhesion_dom_fimbrial_sf
IPR008966 Adhesion_dom_sf
PfamiView protein in Pfam
PF00419 Fimbrial, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGGVMSQKF VVGAGLLVCS VCSLSAMAGS KPVDLILRVL VDAPPPCSIK
60 70 80 90 100
GSQVEFGNMI ADNVDGTNYR QDAKYTLNCT NSLANDLRMQ LKGNTSTING
110 120 130 140 150
ETVLSTNITG LGIRIENSAD NSLFAVGENS WTPFNINNQP QLKAVPVKAS
160 170
GAQLAAGEFN ASLTMVVDYQ
Length:170
Mass (Da):17,890
Last modified:February 1, 1997 - v1
Checksum:i30CCDE3829E3FFDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75395.1
AP009048 Genomic DNA Translation: BAE76692.1
PIRiE65006
RefSeqiNP_416838.1, NC_000913.3
WP_001311011.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75395; AAC75395; b2335
BAE76692; BAE76692; BAE76692
GeneIDi946818
KEGGiecj:JW2332
eco:b2335
PATRICifig|1411691.4.peg.4397

Similar proteinsi

Entry informationi

Entry nameiYFCR_ECOLI
AccessioniPrimary (citable) accession number: P76501
Secondary accession number(s): Q2MAL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health