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Protein

Uncharacterized fimbrial-like protein YfcP

Gene

yfcP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7204-MONOMER.
ECOL316407:JW2330-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YfcP
Gene namesi
Name:yfcP
Ordered Locus Names:b2333, JW2330
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14119. yfcP.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 179152Uncharacterized fimbrial-like protein YfcPPRO_0000009256Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 83Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP76499.
PRIDEiP76499.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259569. 11 interactions.
STRINGi511145.b2333.

Structurei

3D structure databases

ProteinModelPortaliP76499.
SMRiP76499. Positions 28-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105US4. Bacteria.
ENOG4111UQM. LUCA.
HOGENOMiHOG000260127.
InParanoidiP76499.
OMAiIGMETTD.
OrthoDBiEOG6MSS33.
PhylomeDBiP76499.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSMIQSGG YVLLAGLILA MSSTLFAADN NLHFSGNLLS KSCALVVDGQ
60 70 80 90 100
YLAEVRFPTV SRQDLNVAGQ SARVPVVFKL KDCKGPAGYN VKVTLTGVED
110 120 130 140 150
SEQPGFLALD TSSTAQGVGI GMEKTDGMQV AINNTNGATF ALTNGNNDIN
160 170
FRAWLQAKSG RDVTIGEFTA SLTATFEYI
Length:179
Mass (Da):18,951
Last modified:February 1, 1997 - v1
Checksum:i189D4355126CEA5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75393.1.
AP009048 Genomic DNA. Translation: BAE76690.1.
PIRiC65006.
RefSeqiNP_416836.1. NC_000913.3.
WP_001043398.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75393; AAC75393; b2333.
BAE76690; BAE76690; BAE76690.
GeneIDi946788.
KEGGiecj:JW2330.
eco:b2333.
PATRICi32120039. VBIEscCol129921_2429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75393.1.
AP009048 Genomic DNA. Translation: BAE76690.1.
PIRiC65006.
RefSeqiNP_416836.1. NC_000913.3.
WP_001043398.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76499.
SMRiP76499. Positions 28-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259569. 11 interactions.
STRINGi511145.b2333.

Proteomic databases

PaxDbiP76499.
PRIDEiP76499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75393; AAC75393; b2333.
BAE76690; BAE76690; BAE76690.
GeneIDi946788.
KEGGiecj:JW2330.
eco:b2333.
PATRICi32120039. VBIEscCol129921_2429.

Organism-specific databases

EchoBASEiEB3872.
EcoGeneiEG14119. yfcP.

Phylogenomic databases

eggNOGiENOG4105US4. Bacteria.
ENOG4111UQM. LUCA.
HOGENOMiHOG000260127.
InParanoidiP76499.
OMAiIGMETTD.
OrthoDBiEOG6MSS33.
PhylomeDBiP76499.

Enzyme and pathway databases

BioCyciEcoCyc:G7204-MONOMER.
ECOL316407:JW2330-MONOMER.

Miscellaneous databases

PROiP76499.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
    Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
    Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYFCP_ECOLI
AccessioniPrimary (citable) accession number: P76499
Secondary accession number(s): Q2MAL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.