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Protein

Acetate CoA-transferase subunit beta

Gene

atoA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Pathway: short-chain fatty acid metabolism

This protein is involved in the pathway short-chain fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway short-chain fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461PROSITE-ProRule annotation

GO - Molecular functioni

  • acetate CoA-transferase activity Source: EcoliWiki

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:ATOA-MONOMER.
ECOL316407:JW2216-MONOMER.
MetaCyc:ATOA-MONOMER.
UniPathwayiUPA00656.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate CoA-transferase subunit beta (EC:2.8.3.8)
Alternative name(s):
Acetyl-CoA:acetoacetate CoA-transferase subunit beta
Gene namesi
Name:atoA
Ordered Locus Names:b2222, JW2216
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11670. atoA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Acetate CoA-transferase subunit betaPRO_0000157915Add
BLAST

Proteomic databases

PRIDEiP76459.

Interactioni

Subunit structurei

Heterodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
bamDP0AC022EBI-1128061,EBI-1128087

Protein-protein interaction databases

IntActiP76459. 4 interactions.
STRINGi511145.b2222.

Structurei

3D structure databases

ProteinModelPortaliP76459.
SMRiP76459. Positions 2-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2057.
HOGENOMiHOG000221245.
InParanoidiP76459.
KOiK01035.
OMAiGMEHCAK.
OrthoDBiEOG6HMXJG.
PhylomeDBiP76459.

Family and domain databases

InterProiIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEiPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKQRIARR VAQELRDGDI VNLGIGLPTM VANYLPEGIH ITLQSENGFL
60 70 80 90 100
GLGPVTTAHP DLVNAGGQPC GVLPGAAMFD SAMSFALIRG GHIDACVLGG
110 120 130 140 150
LQVDEEANLA NWVVPGKMVP GMGGAMDLVT GSRKVIIAME HCAKDGSAKI
160 170 180 190 200
LRRCTMPLTA QHAVHMLVTE LAVFRFIDGK MWLTEIADGC DLATVRAKTE
210
ARFEVAADLN TQRGDL
Length:216
Mass (Da):22,960
Last modified:February 1, 1997 - v1
Checksum:i3F3916D024614BAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75282.1.
AP009048 Genomic DNA. Translation: BAA16018.1.
PIRiD64992.
RefSeqiNP_416726.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC75282; AAC75282; b2222.
BAA16018; BAA16018; BAA16018.
GeneIDi946719.
KEGGiecj:Y75_p2185.
eco:b2222.
PATRICi32119803. VBIEscCol129921_2311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75282.1.
AP009048 Genomic DNA. Translation: BAA16018.1.
PIRiD64992.
RefSeqiNP_416726.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP76459.
SMRiP76459. Positions 2-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP76459. 4 interactions.
STRINGi511145.b2222.

Proteomic databases

PRIDEiP76459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75282; AAC75282; b2222.
BAA16018; BAA16018; BAA16018.
GeneIDi946719.
KEGGiecj:Y75_p2185.
eco:b2222.
PATRICi32119803. VBIEscCol129921_2311.

Organism-specific databases

EchoBASEiEB1621.
EcoGeneiEG11670. atoA.

Phylogenomic databases

eggNOGiCOG2057.
HOGENOMiHOG000221245.
InParanoidiP76459.
KOiK01035.
OMAiGMEHCAK.
OrthoDBiEOG6HMXJG.
PhylomeDBiP76459.

Enzyme and pathway databases

UniPathwayiUPA00656.
BioCyciEcoCyc:ATOA-MONOMER.
ECOL316407:JW2216-MONOMER.
MetaCyc:ATOA-MONOMER.

Miscellaneous databases

PROiP76459.

Family and domain databases

InterProiIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEiPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiATOA_ECOLI
AccessioniPrimary (citable) accession number: P76459
Secondary accession number(s): P94762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.