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Protein

Acetate CoA-transferase subunit beta

Gene

atoA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Pathwayi: short-chain fatty acid metabolism

This protein is involved in the pathway short-chain fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway short-chain fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46PROSITE-ProRule annotation1

GO - Molecular functioni

  • acetate CoA-transferase activity Source: EcoliWiki

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:ATOA-MONOMER.
ECOL316407:JW2216-MONOMER.
MetaCyc:ATOA-MONOMER.
UniPathwayiUPA00656.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate CoA-transferase subunit beta (EC:2.8.3.8)
Alternative name(s):
Acetyl-CoA:acetoacetate CoA-transferase subunit beta
Gene namesi
Name:atoA
Ordered Locus Names:b2222, JW2216
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11670. atoA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001579151 – 216Acetate CoA-transferase subunit betaAdd BLAST216

Proteomic databases

PaxDbiP76459.
PRIDEiP76459.

Interactioni

Subunit structurei

Heterodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
bamDP0AC022EBI-1128061,EBI-1128087

Protein-protein interaction databases

BioGridi4262987. 8 interactors.
IntActiP76459. 4 interactors.
STRINGi511145.b2222.

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Beta strandi20 – 23Combined sources4
Helixi27 – 33Combined sources7
Beta strandi42 – 45Combined sources4
Turni46 – 48Combined sources3
Beta strandi49 – 53Combined sources5
Beta strandi71 – 78Combined sources8
Helixi81 – 89Combined sources9
Beta strandi94 – 98Combined sources5
Beta strandi101 – 104Combined sources4
Helixi125 – 131Combined sources7
Beta strandi133 – 138Combined sources6
Beta strandi148 – 153Combined sources6
Beta strandi159 – 162Combined sources4
Beta strandi166 – 168Combined sources3
Beta strandi170 – 177Combined sources8
Beta strandi180 – 186Combined sources7
Helixi192 – 197Combined sources6
Turni207 – 210Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DBNX-ray2.55B/D/F/H1-216[»]
ProteinModelPortaliP76459.
SMRiP76459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QNJ. Bacteria.
COG2057. LUCA.
HOGENOMiHOG000221245.
InParanoidiP76459.
KOiK01035.
OMAiDDHYDPT.
PhylomeDBiP76459.

Family and domain databases

InterProiIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEiPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKQRIARR VAQELRDGDI VNLGIGLPTM VANYLPEGIH ITLQSENGFL
60 70 80 90 100
GLGPVTTAHP DLVNAGGQPC GVLPGAAMFD SAMSFALIRG GHIDACVLGG
110 120 130 140 150
LQVDEEANLA NWVVPGKMVP GMGGAMDLVT GSRKVIIAME HCAKDGSAKI
160 170 180 190 200
LRRCTMPLTA QHAVHMLVTE LAVFRFIDGK MWLTEIADGC DLATVRAKTE
210
ARFEVAADLN TQRGDL
Length:216
Mass (Da):22,960
Last modified:February 1, 1997 - v1
Checksum:i3F3916D024614BAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75282.1.
AP009048 Genomic DNA. Translation: BAA16018.1.
PIRiD64992.
RefSeqiNP_416726.1. NC_000913.3.
WP_000339065.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75282; AAC75282; b2222.
BAA16018; BAA16018; BAA16018.
GeneIDi946719.
KEGGiecj:JW2216.
eco:b2222.
PATRICi32119803. VBIEscCol129921_2311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75282.1.
AP009048 Genomic DNA. Translation: BAA16018.1.
PIRiD64992.
RefSeqiNP_416726.1. NC_000913.3.
WP_000339065.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DBNX-ray2.55B/D/F/H1-216[»]
ProteinModelPortaliP76459.
SMRiP76459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262987. 8 interactors.
IntActiP76459. 4 interactors.
STRINGi511145.b2222.

Proteomic databases

PaxDbiP76459.
PRIDEiP76459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75282; AAC75282; b2222.
BAA16018; BAA16018; BAA16018.
GeneIDi946719.
KEGGiecj:JW2216.
eco:b2222.
PATRICi32119803. VBIEscCol129921_2311.

Organism-specific databases

EchoBASEiEB1621.
EcoGeneiEG11670. atoA.

Phylogenomic databases

eggNOGiENOG4107QNJ. Bacteria.
COG2057. LUCA.
HOGENOMiHOG000221245.
InParanoidiP76459.
KOiK01035.
OMAiDDHYDPT.
PhylomeDBiP76459.

Enzyme and pathway databases

UniPathwayiUPA00656.
BioCyciEcoCyc:ATOA-MONOMER.
ECOL316407:JW2216-MONOMER.
MetaCyc:ATOA-MONOMER.

Miscellaneous databases

PROiP76459.

Family and domain databases

InterProiIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEiPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATOA_ECOLI
AccessioniPrimary (citable) accession number: P76459
Secondary accession number(s): P94762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.