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P76459 (ATOA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetate CoA-transferase subunit beta

EC=2.8.3.8
Alternative name(s):
Acetyl-CoA:acetoacetate CoA-transferase subunit beta
Gene names
Name:atoA
Ordered Locus Names:b2222, JW2216
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Pathway

Lipid metabolism; short-chain fatty acid metabolism.

Subunit structure

Heterodimer By similarity.

Sequence similarities

Belongs to the 3-oxoacid CoA-transferase subunit B family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

bamDP0AC022EBI-1128061,EBI-1128087

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Acetate CoA-transferase subunit beta
PRO_0000157915

Sites

Active site461 By similarity

Sequences

Sequence LengthMass (Da)Tools
P76459 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 3F3916D024614BAE

FASTA21622,960
        10         20         30         40         50         60 
MDAKQRIARR VAQELRDGDI VNLGIGLPTM VANYLPEGIH ITLQSENGFL GLGPVTTAHP 

        70         80         90        100        110        120 
DLVNAGGQPC GVLPGAAMFD SAMSFALIRG GHIDACVLGG LQVDEEANLA NWVVPGKMVP 

       130        140        150        160        170        180 
GMGGAMDLVT GSRKVIIAME HCAKDGSAKI LRRCTMPLTA QHAVHMLVTE LAVFRFIDGK 

       190        200        210 
MWLTEIADGC DLATVRAKTE ARFEVAADLN TQRGDL 

« Hide

References

[1]"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map."
Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. expand/collapse author list , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:379-392(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00096 Genomic DNA. Translation: AAC75282.1.
AP009048 Genomic DNA. Translation: BAA16018.1.
PIRD64992.
RefSeqNP_416726.1. NC_000913.3.
YP_490463.1. NC_007779.1.

3D structure databases

ProteinModelPortalP76459.
SMRP76459. Positions 2-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP76459. 4 interactions.
STRING511145.b2222.

Proteomic databases

PRIDEP76459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75282; AAC75282; b2222.
BAA16018; BAA16018; BAA16018.
GeneID12933993.
946719.
KEGGecj:Y75_p2185.
eco:b2222.
PATRIC32119803. VBIEscCol129921_2311.

Organism-specific databases

EchoBASEEB1621.
EcoGeneEG11670. atoA.

Phylogenomic databases

eggNOGCOG2057.
HOGENOMHOG000221245.
KOK01035.
OMAGMEHCAK.
OrthoDBEOG6HMXJG.
PhylomeDBP76459.

Enzyme and pathway databases

BioCycEcoCyc:ATOA-MONOMER.
ECOL316407:JW2216-MONOMER.
MetaCyc:ATOA-MONOMER.
UniPathwayUPA00656.

Gene expression databases

GenevestigatorP76459.

Family and domain databases

InterProIPR012791. 3-oxoacid_CoA-transf_B.
IPR004165. CoA_trans_fam_I.
IPR004164. CoA_transf_AS.
[Graphical view]
PANTHERPTHR13707. PTHR13707. 1 hit.
PfamPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsTIGR02428. pcaJ_scoB_fam. 1 hit.
PROSITEPS01274. COA_TRANSF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP76459.

Entry information

Entry nameATOA_ECOLI
AccessionPrimary (citable) accession number: P76459
Secondary accession number(s): P94762
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene