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P76458 (ATOD_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
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Names and origin

Protein namesRecommended name:
Acetate CoA-transferase subunit alpha
EC=2.8.3.8
Alternative name(s):
Acetyl-CoA:acetoacetate-CoA transferase subunit alpha
Gene names
Name:atoD
Ordered Locus Names:b2221, JW2215
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Pathway

Lipid metabolism; short-chain fatty acid metabolism.

Subunit structure

Heterodimer By similarity.

Sequence similarities

Belongs to the 3-oxoacid CoA-transferase subunit A family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processfatty acid metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionacetate CoA-transferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

groLP0A6F51EBI-555870,EBI-543750

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Acetate CoA-transferase subunit alpha
PRO_0000157904

Regions

Region24 – 307CoA-binding Potential

Secondary structure

1 .......................................... 220
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P76458 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: D1DD69ECEBB2676D

FASTA22023,526
        10         20         30         40         50         60 
MKTKLMTLQD ATGFFRDGMT IMVGGFMGIG TPSRLVEALL ESGVRDLTLI ANDTAFVDTG 

        70         80         90        100        110        120 
IGPLIVNGRV RKVIASHIGT NPETGRRMIS GEMDVVLVPQ GTLIEQIRCG GAGLGGFLTP 

       130        140        150        160        170        180 
TGVGTVVEEG KQTLTLDGKT WLLERPLRAD LALIRAHRCD TLGNLTYQLS ARNFNPLIAL 

       190        200        210        220 
AADITLVEPD ELVETGELQP DHIVTPGAVI DHIIVSQESK

« Hide

References

[1]"A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map."
Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S. expand/collapse author list , Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y., Horiuchi T.
DNA Res. 3:379-392(1996) [PubMed: 9097040] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00096 Genomic DNA. Translation: AAC75281.1.
AP009048 Genomic DNA. Translation: BAA16017.1.
PIRC64992.
RefSeqNP_416725.1. NC_000913.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K6DX-ray1.90A/B1-220[»]
ProteinModelPortalP76458.
SMRP76458. Positions 1-219.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-9191N.
IntActP76458. 2 interactions.
MINTMINT-1293580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000001359; EBESCP00000001359; EBESCG00000001130.
EBESCT00000015784; EBESCP00000015075; EBESCG00000014844.
GeneID947525.
GenomeReviewsGene locus JW2215 in contig AP009048_GR.
Gene locus b2221 in contig U00096_GR.
KEGGecj:JW2215.
eco:b2221.
PATRIC32119801. VBIEscCol129921_2310.

Organism-specific databases

EchoBASEEB1620.
EcoGeneEG11669. atoD.

Phylogenomic databases

eggNOGCOG1788.
GeneTreeEBGT00050000008789.
HOGENOMHBG288750.
OMAVDTGVGP.
PhylomeDBP76458.
ProtClustDBPRK09920.

Enzyme and pathway databases

BioCycEcoCyc:ATOD-MONOMER.
MetaCyc:ATOD-MONOMER.

Gene expression databases

GenevestigatorP76458.

Family and domain databases

InterProIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans.
IPR004163. CoA_transf_BS.
[Graphical view]
KOK01034.
PANTHERPTHR13707. CoA_trans. 1 hit.
PfamPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsTIGR02429. PcaI_scoA_fam. 1 hit.
PROSITEPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATOD_ECOLI
AccessionPrimary (citable) accession number: P76458
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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