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P76458

- ATOD_ECOLI

UniProt

P76458 - ATOD_ECOLI

Protein

Acetate CoA-transferase subunit alpha

Gene

atoD

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

    Pathwayi

    GO - Molecular functioni

    1. acetate CoA-transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. short-chain fatty acid metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Enzyme and pathway databases

    BioCyciEcoCyc:ATOD-MONOMER.
    ECOL316407:JW2215-MONOMER.
    MetaCyc:ATOD-MONOMER.
    UniPathwayiUPA00656.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetate CoA-transferase subunit alpha (EC:2.8.3.8)
    Alternative name(s):
    Acetyl-CoA:acetoacetate-CoA transferase subunit alpha
    Gene namesi
    Name:atoD
    Ordered Locus Names:b2221, JW2215
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11669. atoD.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Acetate CoA-transferase subunit alphaPRO_0000157904Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP76458.

    Interactioni

    Subunit structurei

    Heterodimer.By similarity

    Protein-protein interaction databases

    DIPiDIP-9191N.
    IntActiP76458. 3 interactions.
    MINTiMINT-1293580.
    STRINGi511145.b2221.

    Structurei

    Secondary structure

    1
    220
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 63
    Helixi8 – 114
    Helixi12 – 143
    Beta strandi20 – 234
    Helixi33 – 4210
    Beta strandi46 – 505
    Helixi62 – 665
    Beta strandi70 – 778
    Helixi82 – 898
    Beta strandi92 – 976
    Helixi100 – 11112
    Beta strandi116 – 1205
    Turni121 – 1244
    Beta strandi133 – 1364
    Beta strandi139 – 1446
    Beta strandi149 – 16012
    Helixi169 – 1724
    Helixi175 – 1817
    Beta strandi182 – 19312
    Helixi200 – 2023
    Helixi207 – 2093
    Beta strandi212 – 2143

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K6DX-ray1.90A/B1-220[»]
    ProteinModelPortaliP76458.
    SMRiP76458. Positions 1-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP76458.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 307CoA-bindingSequence Analysis

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1788.
    HOGENOMiHOG000221244.
    KOiK01034.
    OMAiNKAGRNF.
    OrthoDBiEOG6HMXJG.
    PhylomeDBiP76458.

    Family and domain databases

    InterProiIPR012792. 3-oxoacid_CoA-transf_A.
    IPR004165. CoA_trans_fam_I.
    IPR004163. CoA_transf_BS.
    [Graphical view]
    PANTHERiPTHR13707. PTHR13707. 1 hit.
    PfamiPF01144. CoA_trans. 1 hit.
    [Graphical view]
    SMARTiSM00882. CoA_trans. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
    PROSITEiPS01273. COA_TRANSF_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P76458-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTKLMTLQD ATGFFRDGMT IMVGGFMGIG TPSRLVEALL ESGVRDLTLI    50
    ANDTAFVDTG IGPLIVNGRV RKVIASHIGT NPETGRRMIS GEMDVVLVPQ 100
    GTLIEQIRCG GAGLGGFLTP TGVGTVVEEG KQTLTLDGKT WLLERPLRAD 150
    LALIRAHRCD TLGNLTYQLS ARNFNPLIAL AADITLVEPD ELVETGELQP 200
    DHIVTPGAVI DHIIVSQESK 220
    Length:220
    Mass (Da):23,526
    Last modified:February 1, 1997 - v1
    Checksum:iD1DD69ECEBB2676D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC75281.1.
    AP009048 Genomic DNA. Translation: BAA16017.1.
    PIRiC64992.
    RefSeqiNP_416725.1. NC_000913.3.
    YP_490462.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75281; AAC75281; b2221.
    BAA16017; BAA16017; BAA16017.
    GeneIDi12930185.
    947525.
    KEGGiecj:Y75_p2184.
    eco:b2221.
    PATRICi32119801. VBIEscCol129921_2310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC75281.1 .
    AP009048 Genomic DNA. Translation: BAA16017.1 .
    PIRi C64992.
    RefSeqi NP_416725.1. NC_000913.3.
    YP_490462.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K6D X-ray 1.90 A/B 1-220 [» ]
    ProteinModelPortali P76458.
    SMRi P76458. Positions 1-219.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-9191N.
    IntActi P76458. 3 interactions.
    MINTi MINT-1293580.
    STRINGi 511145.b2221.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75281 ; AAC75281 ; b2221 .
    BAA16017 ; BAA16017 ; BAA16017 .
    GeneIDi 12930185.
    947525.
    KEGGi ecj:Y75_p2184.
    eco:b2221.
    PATRICi 32119801. VBIEscCol129921_2310.

    Organism-specific databases

    EchoBASEi EB1620.
    EcoGenei EG11669. atoD.

    Phylogenomic databases

    eggNOGi COG1788.
    HOGENOMi HOG000221244.
    KOi K01034.
    OMAi NKAGRNF.
    OrthoDBi EOG6HMXJG.
    PhylomeDBi P76458.

    Enzyme and pathway databases

    UniPathwayi UPA00656 .
    BioCyci EcoCyc:ATOD-MONOMER.
    ECOL316407:JW2215-MONOMER.
    MetaCyc:ATOD-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P76458.
    PROi P76458.

    Gene expression databases

    Genevestigatori P76458.

    Family and domain databases

    InterProi IPR012792. 3-oxoacid_CoA-transf_A.
    IPR004165. CoA_trans_fam_I.
    IPR004163. CoA_transf_BS.
    [Graphical view ]
    PANTHERi PTHR13707. PTHR13707. 1 hit.
    Pfami PF01144. CoA_trans. 1 hit.
    [Graphical view ]
    SMARTi SM00882. CoA_trans. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02429. pcaI_scoA_fam. 1 hit.
    PROSITEi PS01273. COA_TRANSF_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiATOD_ECOLI
    AccessioniPrimary (citable) accession number: P76458
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3