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Protein

Acetate CoA-transferase subunit alpha

Gene

atoD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Pathwayi: short-chain fatty acid metabolism

This protein is involved in the pathway short-chain fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway short-chain fatty acid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:ATOD-MONOMER.
ECOL316407:JW2215-MONOMER.
MetaCyc:ATOD-MONOMER.
BRENDAi2.8.3.8. 2026.
UniPathwayiUPA00656.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate CoA-transferase subunit alpha (EC:2.8.3.8)
Alternative name(s):
Acetyl-CoA:acetoacetate-CoA transferase subunit alpha
Gene namesi
Name:atoD
Ordered Locus Names:b2221, JW2215
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11669. atoD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001579041 – 220Acetate CoA-transferase subunit alphaAdd BLAST220

Proteomic databases

PaxDbiP76458.
PRIDEiP76458.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

BioGridi4259179. 16 interactors.
DIPiDIP-9191N.
IntActiP76458. 3 interactors.
MINTiMINT-1293580.
STRINGi511145.b2221.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Helixi8 – 11Combined sources4
Helixi12 – 14Combined sources3
Beta strandi20 – 23Combined sources4
Helixi33 – 42Combined sources10
Beta strandi46 – 50Combined sources5
Helixi62 – 66Combined sources5
Beta strandi70 – 77Combined sources8
Helixi82 – 89Combined sources8
Beta strandi92 – 97Combined sources6
Helixi100 – 111Combined sources12
Beta strandi116 – 120Combined sources5
Turni121 – 124Combined sources4
Helixi126 – 128Combined sources3
Beta strandi133 – 136Combined sources4
Beta strandi139 – 144Combined sources6
Beta strandi149 – 160Combined sources12
Helixi169 – 172Combined sources4
Helixi175 – 181Combined sources7
Beta strandi182 – 193Combined sources12
Helixi200 – 202Combined sources3
Helixi207 – 209Combined sources3
Beta strandi212 – 214Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K6DX-ray1.90A/B1-220[»]
5DBNX-ray2.55A/C/E/G1-220[»]
ProteinModelPortaliP76458.
SMRiP76458.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76458.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 30CoA-bindingSequence analysis7

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QP7. Bacteria.
COG1788. LUCA.
HOGENOMiHOG000221244.
InParanoidiP76458.
KOiK01034.
OMAiVKAHRAD.
PhylomeDBiP76458.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKLMTLQD ATGFFRDGMT IMVGGFMGIG TPSRLVEALL ESGVRDLTLI
60 70 80 90 100
ANDTAFVDTG IGPLIVNGRV RKVIASHIGT NPETGRRMIS GEMDVVLVPQ
110 120 130 140 150
GTLIEQIRCG GAGLGGFLTP TGVGTVVEEG KQTLTLDGKT WLLERPLRAD
160 170 180 190 200
LALIRAHRCD TLGNLTYQLS ARNFNPLIAL AADITLVEPD ELVETGELQP
210 220
DHIVTPGAVI DHIIVSQESK
Length:220
Mass (Da):23,526
Last modified:February 1, 1997 - v1
Checksum:iD1DD69ECEBB2676D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75281.1.
AP009048 Genomic DNA. Translation: BAA16017.1.
PIRiC64992.
RefSeqiNP_416725.1. NC_000913.3.
WP_000850540.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75281; AAC75281; b2221.
BAA16017; BAA16017; BAA16017.
GeneIDi947525.
KEGGiecj:JW2215.
eco:b2221.
PATRICi32119801. VBIEscCol129921_2310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75281.1.
AP009048 Genomic DNA. Translation: BAA16017.1.
PIRiC64992.
RefSeqiNP_416725.1. NC_000913.3.
WP_000850540.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K6DX-ray1.90A/B1-220[»]
5DBNX-ray2.55A/C/E/G1-220[»]
ProteinModelPortaliP76458.
SMRiP76458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259179. 16 interactors.
DIPiDIP-9191N.
IntActiP76458. 3 interactors.
MINTiMINT-1293580.
STRINGi511145.b2221.

Proteomic databases

PaxDbiP76458.
PRIDEiP76458.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75281; AAC75281; b2221.
BAA16017; BAA16017; BAA16017.
GeneIDi947525.
KEGGiecj:JW2215.
eco:b2221.
PATRICi32119801. VBIEscCol129921_2310.

Organism-specific databases

EchoBASEiEB1620.
EcoGeneiEG11669. atoD.

Phylogenomic databases

eggNOGiENOG4107QP7. Bacteria.
COG1788. LUCA.
HOGENOMiHOG000221244.
InParanoidiP76458.
KOiK01034.
OMAiVKAHRAD.
PhylomeDBiP76458.

Enzyme and pathway databases

UniPathwayiUPA00656.
BioCyciEcoCyc:ATOD-MONOMER.
ECOL316407:JW2215-MONOMER.
MetaCyc:ATOD-MONOMER.
BRENDAi2.8.3.8. 2026.

Miscellaneous databases

EvolutionaryTraceiP76458.
PROiP76458.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATOD_ECOLI
AccessioniPrimary (citable) accession number: P76458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.