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P76458

- ATOD_ECOLI

UniProt

P76458 - ATOD_ECOLI

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Protein

Acetate CoA-transferase subunit alpha

Gene

atoD

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Pathwayi

GO - Molecular functioni

  1. acetate CoA-transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. short-chain fatty acid metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:ATOD-MONOMER.
ECOL316407:JW2215-MONOMER.
MetaCyc:ATOD-MONOMER.
UniPathwayiUPA00656.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate CoA-transferase subunit alpha (EC:2.8.3.8)
Alternative name(s):
Acetyl-CoA:acetoacetate-CoA transferase subunit alpha
Gene namesi
Name:atoD
Ordered Locus Names:b2221, JW2215
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11669. atoD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Acetate CoA-transferase subunit alphaPRO_0000157904Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP76458.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

DIPiDIP-9191N.
IntActiP76458. 3 interactions.
MINTiMINT-1293580.
STRINGi511145.b2221.

Structurei

Secondary structure

1
220
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63
Helixi8 – 114
Helixi12 – 143
Beta strandi20 – 234
Helixi33 – 4210
Beta strandi46 – 505
Helixi62 – 665
Beta strandi70 – 778
Helixi82 – 898
Beta strandi92 – 976
Helixi100 – 11112
Beta strandi116 – 1205
Turni121 – 1244
Beta strandi133 – 1364
Beta strandi139 – 1446
Beta strandi149 – 16012
Helixi169 – 1724
Helixi175 – 1817
Beta strandi182 – 19312
Helixi200 – 2023
Helixi207 – 2093
Beta strandi212 – 2143

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K6DX-ray1.90A/B1-220[»]
ProteinModelPortaliP76458.
SMRiP76458. Positions 1-219.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76458.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 307CoA-bindingSequence Analysis

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1788.
HOGENOMiHOG000221244.
InParanoidiP76458.
KOiK01034.
OMAiNKAGRNF.
OrthoDBiEOG6HMXJG.
PhylomeDBiP76458.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76458-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTKLMTLQD ATGFFRDGMT IMVGGFMGIG TPSRLVEALL ESGVRDLTLI
60 70 80 90 100
ANDTAFVDTG IGPLIVNGRV RKVIASHIGT NPETGRRMIS GEMDVVLVPQ
110 120 130 140 150
GTLIEQIRCG GAGLGGFLTP TGVGTVVEEG KQTLTLDGKT WLLERPLRAD
160 170 180 190 200
LALIRAHRCD TLGNLTYQLS ARNFNPLIAL AADITLVEPD ELVETGELQP
210 220
DHIVTPGAVI DHIIVSQESK
Length:220
Mass (Da):23,526
Last modified:February 1, 1997 - v1
Checksum:iD1DD69ECEBB2676D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC75281.1.
AP009048 Genomic DNA. Translation: BAA16017.1.
PIRiC64992.
RefSeqiNP_416725.1. NC_000913.3.
YP_490462.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75281; AAC75281; b2221.
BAA16017; BAA16017; BAA16017.
GeneIDi12930185.
947525.
KEGGiecj:Y75_p2184.
eco:b2221.
PATRICi32119801. VBIEscCol129921_2310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00096 Genomic DNA. Translation: AAC75281.1 .
AP009048 Genomic DNA. Translation: BAA16017.1 .
PIRi C64992.
RefSeqi NP_416725.1. NC_000913.3.
YP_490462.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K6D X-ray 1.90 A/B 1-220 [» ]
ProteinModelPortali P76458.
SMRi P76458. Positions 1-219.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-9191N.
IntActi P76458. 3 interactions.
MINTi MINT-1293580.
STRINGi 511145.b2221.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75281 ; AAC75281 ; b2221 .
BAA16017 ; BAA16017 ; BAA16017 .
GeneIDi 12930185.
947525.
KEGGi ecj:Y75_p2184.
eco:b2221.
PATRICi 32119801. VBIEscCol129921_2310.

Organism-specific databases

EchoBASEi EB1620.
EcoGenei EG11669. atoD.

Phylogenomic databases

eggNOGi COG1788.
HOGENOMi HOG000221244.
InParanoidi P76458.
KOi K01034.
OMAi NKAGRNF.
OrthoDBi EOG6HMXJG.
PhylomeDBi P76458.

Enzyme and pathway databases

UniPathwayi UPA00656 .
BioCyci EcoCyc:ATOD-MONOMER.
ECOL316407:JW2215-MONOMER.
MetaCyc:ATOD-MONOMER.

Miscellaneous databases

EvolutionaryTracei P76458.
PROi P76458.

Gene expression databases

Genevestigatori P76458.

Family and domain databases

InterProi IPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view ]
PANTHERi PTHR13707. PTHR13707. 1 hit.
Pfami PF01144. CoA_trans. 1 hit.
[Graphical view ]
SMARTi SM00882. CoA_trans. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEi PS01273. COA_TRANSF_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiATOD_ECOLI
AccessioniPrimary (citable) accession number: P76458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3