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Protein

Acetate CoA-transferase subunit alpha

Gene

atoD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

Pathwayi

GO - Molecular functioni

  1. acetate CoA-transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. short-chain fatty acid metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:ATOD-MONOMER.
ECOL316407:JW2215-MONOMER.
MetaCyc:ATOD-MONOMER.
UniPathwayiUPA00656.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate CoA-transferase subunit alpha (EC:2.8.3.8)
Alternative name(s):
Acetyl-CoA:acetoacetate-CoA transferase subunit alpha
Gene namesi
Name:atoD
Ordered Locus Names:b2221, JW2215
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11669. atoD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Acetate CoA-transferase subunit alphaPRO_0000157904Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP76458.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

DIPiDIP-9191N.
IntActiP76458. 3 interactions.
MINTiMINT-1293580.
STRINGi511145.b2221.

Structurei

Secondary structure

1
220
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Helixi8 – 114Combined sources
Helixi12 – 143Combined sources
Beta strandi20 – 234Combined sources
Helixi33 – 4210Combined sources
Beta strandi46 – 505Combined sources
Helixi62 – 665Combined sources
Beta strandi70 – 778Combined sources
Helixi82 – 898Combined sources
Beta strandi92 – 976Combined sources
Helixi100 – 11112Combined sources
Beta strandi116 – 1205Combined sources
Turni121 – 1244Combined sources
Beta strandi133 – 1364Combined sources
Beta strandi139 – 1446Combined sources
Beta strandi149 – 16012Combined sources
Helixi169 – 1724Combined sources
Helixi175 – 1817Combined sources
Beta strandi182 – 19312Combined sources
Helixi200 – 2023Combined sources
Helixi207 – 2093Combined sources
Beta strandi212 – 2143Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K6DX-ray1.90A/B1-220[»]
ProteinModelPortaliP76458.
SMRiP76458. Positions 1-219.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP76458.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 307CoA-bindingSequence Analysis

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1788.
HOGENOMiHOG000221244.
InParanoidiP76458.
KOiK01034.
OMAiNKAGRNF.
OrthoDBiEOG6HMXJG.
PhylomeDBiP76458.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKLMTLQD ATGFFRDGMT IMVGGFMGIG TPSRLVEALL ESGVRDLTLI
60 70 80 90 100
ANDTAFVDTG IGPLIVNGRV RKVIASHIGT NPETGRRMIS GEMDVVLVPQ
110 120 130 140 150
GTLIEQIRCG GAGLGGFLTP TGVGTVVEEG KQTLTLDGKT WLLERPLRAD
160 170 180 190 200
LALIRAHRCD TLGNLTYQLS ARNFNPLIAL AADITLVEPD ELVETGELQP
210 220
DHIVTPGAVI DHIIVSQESK
Length:220
Mass (Da):23,526
Last modified:February 1, 1997 - v1
Checksum:iD1DD69ECEBB2676D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75281.1.
AP009048 Genomic DNA. Translation: BAA16017.1.
PIRiC64992.
RefSeqiNP_416725.1. NC_000913.3.
YP_490462.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75281; AAC75281; b2221.
BAA16017; BAA16017; BAA16017.
GeneIDi12930185.
947525.
KEGGiecj:Y75_p2184.
eco:b2221.
PATRICi32119801. VBIEscCol129921_2310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75281.1.
AP009048 Genomic DNA. Translation: BAA16017.1.
PIRiC64992.
RefSeqiNP_416725.1. NC_000913.3.
YP_490462.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K6DX-ray1.90A/B1-220[»]
ProteinModelPortaliP76458.
SMRiP76458. Positions 1-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9191N.
IntActiP76458. 3 interactions.
MINTiMINT-1293580.
STRINGi511145.b2221.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75281; AAC75281; b2221.
BAA16017; BAA16017; BAA16017.
GeneIDi12930185.
947525.
KEGGiecj:Y75_p2184.
eco:b2221.
PATRICi32119801. VBIEscCol129921_2310.

Organism-specific databases

EchoBASEiEB1620.
EcoGeneiEG11669. atoD.

Phylogenomic databases

eggNOGiCOG1788.
HOGENOMiHOG000221244.
InParanoidiP76458.
KOiK01034.
OMAiNKAGRNF.
OrthoDBiEOG6HMXJG.
PhylomeDBiP76458.

Enzyme and pathway databases

UniPathwayiUPA00656.
BioCyciEcoCyc:ATOD-MONOMER.
ECOL316407:JW2215-MONOMER.
MetaCyc:ATOD-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP76458.
PROiP76458.

Gene expression databases

GenevestigatoriP76458.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiATOD_ECOLI
AccessioniPrimary (citable) accession number: P76458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.