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Protein

Protein Rtn

Gene

rtn

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in resistance to phages N4 and lambda.

Enzyme and pathway databases

BioCyciEcoCyc:G7148-MONOMER.
ECOL316407:JW2164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Rtn
Gene namesi
Name:rtn
Ordered Locus Names:b2176, JW2164
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14077. rtn.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Protein RtnPRO_0000097517Add
BLAST

Proteomic databases

PaxDbiP76446.
PRIDEiP76446.

Expressioni

Inductioni

Expressed at both 28 and 37 degrees Celsius during exponential growth. Repressed by RpoS.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261095. 10 interactions.
DIPiDIP-10813N.
STRINGi511145.b2176.

Structurei

3D structure databases

ProteinModelPortaliP76446.
SMRiP76446. Positions 268-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini261 – 514254EALPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EAL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CXC. Bacteria.
COG2200. LUCA.
HOGENOMiHOG000273106.
InParanoidiP76446.
OMAiQLYADSW.
OrthoDBiEOG69GZGV.
PhylomeDBiP76446.

Family and domain databases

Gene3Di3.20.20.450. 1 hit.
InterProiIPR024744. CSS-motif_dom.
IPR001633. EAL_dom.
[Graphical view]
PfamiPF12792. CSS-motif. 1 hit.
PF00563. EAL. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P76446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIRAPNFGR KLLLTCIVAG VMIAILVSCL QFLVAWHKHE VKYDTLITDV
60 70 80 90 100
QKYLDTYFAD LKSTTDRLQP LTLDTCQQAN PELTARAAFS MNVRTFVLVK
110 120 130 140 150
DKKTFCSSAT GEMDIPLNEL IPALDINKNV DMAILPGTPM VPNKPAIVIW
160 170 180 190 200
YRNPLLKNSG VFAALNLNLT PSLFYSSRQE DYDGVALIIG NTALSTFSSR
210 220 230 240 250
LMNVNELTDM PVRETKIAGI PLTVRLYADD WTWNDVWYAF LLGGMSGTVV
260 270 280 290 300
GLLCYYLMSV RMRPGREIMT AIKREQFYVA YQPVVDTQAL RVTGLEVLLR
310 320 330 340 350
WRHPVAGEIP PDAFINFAES QKMIVPLTQH LFELIARDAA ELEKVLPVGV
360 370 380 390 400
KFGINIAPDH LHSESFKADI QKLLTSLPAH HFQIVLEITE RDMLKEQEAT
410 420 430 440 450
QLFAWLHSVG VEIAIDDFGT GHSALIYLER FTLDYLKIDR GFINAIGTET
460 470 480 490 500
ITSPVLDAVL TLAKRLNMLT VAEGVETPEQ ARWLSERGVN FMQGYWISRP
510
LPLDDFVRWL KKPYTPQW
Length:518
Mass (Da):58,588
Last modified:February 1, 1997 - v1
Checksum:iBABA5768CBC47C41
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti482 – 51837RWLSE…YTPQW → D no nucleotide entry (Ref. 4) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75237.1.
AP009048 Genomic DNA. Translation: BAA15984.1.
U12780 Genomic DNA. Translation: AAA50754.1.
U83404 Genomic DNA. Translation: AAB51508.1.
PIRiG64986.
RefSeqiNP_416681.1. NC_000913.3.
WP_000470560.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75237; AAC75237; b2176.
BAA15984; BAA15984; BAA15984.
GeneIDi946695.
KEGGiecj:JW2164.
eco:b2176.
PATRICi32119707. VBIEscCol129921_2264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75237.1.
AP009048 Genomic DNA. Translation: BAA15984.1.
U12780 Genomic DNA. Translation: AAA50754.1.
U83404 Genomic DNA. Translation: AAB51508.1.
PIRiG64986.
RefSeqiNP_416681.1. NC_000913.3.
WP_000470560.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76446.
SMRiP76446. Positions 268-512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261095. 10 interactions.
DIPiDIP-10813N.
STRINGi511145.b2176.

Proteomic databases

PaxDbiP76446.
PRIDEiP76446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75237; AAC75237; b2176.
BAA15984; BAA15984; BAA15984.
GeneIDi946695.
KEGGiecj:JW2164.
eco:b2176.
PATRICi32119707. VBIEscCol129921_2264.

Organism-specific databases

EchoBASEiEB3830.
EcoGeneiEG14077. rtn.

Phylogenomic databases

eggNOGiENOG4105CXC. Bacteria.
COG2200. LUCA.
HOGENOMiHOG000273106.
InParanoidiP76446.
OMAiQLYADSW.
OrthoDBiEOG69GZGV.
PhylomeDBiP76446.

Enzyme and pathway databases

BioCyciEcoCyc:G7148-MONOMER.
ECOL316407:JW2164-MONOMER.

Miscellaneous databases

PROiP76446.

Family and domain databases

Gene3Di3.20.20.450. 1 hit.
InterProiIPR024744. CSS-motif_dom.
IPR001633. EAL_dom.
[Graphical view]
PfamiPF12792. CSS-motif. 1 hit.
PF00563. EAL. 1 hit.
[Graphical view]
SMARTiSM00052. EAL. 1 hit.
[Graphical view]
SUPFAMiSSF141868. SSF141868. 1 hit.
PROSITEiPS50883. EAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Structural analysis of an rtn gene isolated from Proteus vulgaris."
    Kim C.S., Lee D.W., Chae K.-S., Hwang U.W.
    Mol. Cells 4:387-391(1994)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The rtn gene of Proteus vulgaris is actually from Escherichia coli."
    Hall B.G.
    J. Bacteriol. 179:2433-2434(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 404-518, SHOWS THAT SEQUENCE DESCRIBED IN KIM ET AL ORIGINATES FROM E.COLI.
    Strain: K12 / MG1063.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.
  7. "Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli."
    Sommerfeldt N., Possling A., Becker G., Pesavento C., Tschowri N., Hengge R.
    Microbiology 155:1318-1331(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, RPOS-REPRESSION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiRTN_ECOLI
AccessioniPrimary (citable) accession number: P76446
Secondary accession number(s): P77139, Q52613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 20, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally (Ref. 4) thought to originate from Proteus vulgaris, but was shown to originate from E.coli.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.