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Protein

Multidrug resistance protein MdtA

Gene

mdtA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:MDTA.
ECOL316407:JW5338-MONOMER.

Protein family/group databases

TCDBi8.A.1.6.2. the membrane fusion protein (mfp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtA
Alternative name(s):
Multidrug transporter MdtA
Gene namesi
Name:mdtA
Synonyms:yegM
Ordered Locus Names:b2074, JW5338
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14056. mdtA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 415394Multidrug resistance protein MdtAPRO_0000018699Add
BLAST

Proteomic databases

PaxDbiP76397.
PRIDEiP76397.

Expressioni

Inductioni

The mdtABC operon is transcriptionally activated by BaeR.2 Publications

Interactioni

Subunit structurei

Part of a tripartite efflux system composed of MdtA, MdtB and MdtC.

Protein-protein interaction databases

BioGridi4260423. 135 interactions.
STRINGi511145.b2074.

Structurei

3D structure databases

ProteinModelPortaliP76397.
SMRiP76397. Positions 61-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105ENT. Bacteria.
ENOG410XSF7. LUCA.
HOGENOMiHOG000158248.
InParanoidiP76397.
KOiK07799.
OMAiQELDTQQ.
PhylomeDBiP76397.

Family and domain databases

HAMAPiMF_01422. MdtA. 1 hit.
InterProiIPR022824. Multidrug-R_MdtA.
IPR006143. RND_pump_MFP.
[Graphical view]
PANTHERiPTHR30469:SF12. PTHR30469:SF12. 2 hits.
TIGRFAMsiTIGR01730. RND_mfp. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P76397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSYKSRWV IVIVVVIAAI AAFWFWQGRN DSRSAAPGAT KQAQQSPAGG
60 70 80 90 100
RRGMRSGPLA PVQAATAVEQ AVPRYLTGLG TITAANTVTV RSRVDGQLIA
110 120 130 140 150
LHFQEGQQVK AGDLLAEIDP SQFKVALAQA QGQLAKDKAT LANARRDLAR
160 170 180 190 200
YQQLAKTNLV SRQELDAQQA LVSETEGTIK ADEASVASAQ LQLDWSRITA
210 220 230 240 250
PVDGRVGLKQ VDVGNQISSG DTTGIVVITQ THPIDLVFTL PESDIATVVQ
260 270 280 290 300
AQKAGKPLVV EAWDRTNSKK LSEGTLLSLD NQIDATTGTI KVKARFNNQD
310 320 330 340 350
DALFPNQFVN ARMLVDTEQN AVVIPTAALQ MGNEGHFVWV LNSENKVSKH
360 370 380 390 400
LVTPGIQDSQ KVVIRAGISA GDRVVTDGID RLTEGAKVEV VEAQSATTPE
410
EKATSREYAK KGARS
Length:415
Mass (Da):44,464
Last modified:July 15, 1998 - v2
Checksum:i26240DBBE0DE1A5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089187 Genomic DNA. Translation: BAC06607.1.
U00096 Genomic DNA. Translation: AAC75135.2.
AP009048 Genomic DNA. Translation: BAA15928.2.
PIRiA64974.
RefSeqiNP_416578.2. NC_000913.3.
WP_000678989.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75135; AAC75135; b2074.
BAA15928; BAA15928; BAA15928.
GeneIDi946604.
KEGGiecj:JW5338.
eco:b2074.
PATRICi32119481. VBIEscCol129921_2151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089187 Genomic DNA. Translation: BAC06607.1.
U00096 Genomic DNA. Translation: AAC75135.2.
AP009048 Genomic DNA. Translation: BAA15928.2.
PIRiA64974.
RefSeqiNP_416578.2. NC_000913.3.
WP_000678989.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP76397.
SMRiP76397. Positions 61-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260423. 135 interactions.
STRINGi511145.b2074.

Protein family/group databases

TCDBi8.A.1.6.2. the membrane fusion protein (mfp) family.

Proteomic databases

PaxDbiP76397.
PRIDEiP76397.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75135; AAC75135; b2074.
BAA15928; BAA15928; BAA15928.
GeneIDi946604.
KEGGiecj:JW5338.
eco:b2074.
PATRICi32119481. VBIEscCol129921_2151.

Organism-specific databases

EchoBASEiEB3809.
EcoGeneiEG14056. mdtA.

Phylogenomic databases

eggNOGiENOG4105ENT. Bacteria.
ENOG410XSF7. LUCA.
HOGENOMiHOG000158248.
InParanoidiP76397.
KOiK07799.
OMAiQELDTQQ.
PhylomeDBiP76397.

Enzyme and pathway databases

BioCyciEcoCyc:MDTA.
ECOL316407:JW5338-MONOMER.

Miscellaneous databases

PROiP76397.

Family and domain databases

HAMAPiMF_01422. MdtA. 1 hit.
InterProiIPR022824. Multidrug-R_MdtA.
IPR006143. RND_pump_MFP.
[Graphical view]
PANTHERiPTHR30469:SF12. PTHR30469:SF12. 2 hits.
TIGRFAMsiTIGR01730. RND_mfp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDTA_ECOLI
AccessioniPrimary (citable) accession number: P76397
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.