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Protein

UDP-glucose 6-dehydrogenase

Gene

ugd

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei253 – 2531By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2 – 1918NADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: EcoCyc

GO - Biological processi

  1. colanic acid biosynthetic process Source: EcoCyc
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  3. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:UGD-MONOMER.
ECOL316407:JW2010-MONOMER.
MetaCyc:UGD-MONOMER.
SABIO-RKP76373.
UniPathwayiUPA00030.
UPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:ugd
Synonyms:pmrE, udg, yefA
Ordered Locus Names:b2028, JW2010
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13407. ugd.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388UDP-glucose 6-dehydrogenasePRO_0000074041Add
BLAST

Post-translational modificationi

Phosphorylated on a tyrosine residue. It results in a significant increase of the dehydrogenase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP76373.
PRIDEiP76373.

Expressioni

Gene expression databases

GenevestigatoriP76373.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
uvrBP0A8F82EBI-1120497,EBI-552176

Protein-protein interaction databases

IntActiP76373. 4 interactions.
STRINGi511145.b2028.

Structurei

3D structure databases

ProteinModelPortaliP76373.
SMRiP76373. Positions 1-388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
HOGENOMiHOG000280378.
InParanoidiP76373.
KOiK00012.
OMAiGTNENIA.
OrthoDBiEOG61CM1K.
PhylomeDBiP76373.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

P76373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITISGTGY VGLSNGLLIA QNHEVVALDI LPSRVAMLND RISPIVDKEI
60 70 80 90 100
QQFLQSDKIH FNATLDKNEA YRDADYVIIA TPTDYDPKTN YFNTSSVESV
110 120 130 140 150
IKDVVEINPY AVMVIKSTVP VGFTAAMHKK YRTENIIFSP EFLREGKALY
160 170 180 190 200
DNLHPSRIVI GERSERAERF AALLQEGAIK QNIPMLFTDS TEAEAIKLFA
210 220 230 240 250
NTYLAMRVAY FNELDSYAES LGLNSRQIIE GVCLDPRIGN HYNNPSFGYG
260 270 280 290 300
GYCLPKDTKQ LLANYQSVPN NLISAIVDAN RTRKDFIADA ILSRKPQVVG
310 320 330 340 350
IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVMK EDSFFNSRLE
360 370 380
RDLATFKQQA DVIISNRMAE ELKDVADKVY TRDLFGSD
Length:388
Mass (Da):43,657
Last modified:February 1, 1997 - v1
Checksum:iDA33CEE3EF944AED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75089.1.
AP009048 Genomic DNA. Translation: BAA15860.1.
PIRiC64968.
RefSeqiNP_416532.1. NC_000913.3.
YP_490271.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75089; AAC75089; b2028.
BAA15860; BAA15860; BAA15860.
GeneIDi12932362.
946571.
KEGGiecj:Y75_p1991.
eco:b2028.
PATRICi32119391. VBIEscCol129921_2105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75089.1.
AP009048 Genomic DNA. Translation: BAA15860.1.
PIRiC64968.
RefSeqiNP_416532.1. NC_000913.3.
YP_490271.1. NC_007779.1.

3D structure databases

ProteinModelPortaliP76373.
SMRiP76373. Positions 1-388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP76373. 4 interactions.
STRINGi511145.b2028.

Proteomic databases

PaxDbiP76373.
PRIDEiP76373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75089; AAC75089; b2028.
BAA15860; BAA15860; BAA15860.
GeneIDi12932362.
946571.
KEGGiecj:Y75_p1991.
eco:b2028.
PATRICi32119391. VBIEscCol129921_2105.

Organism-specific databases

EchoBASEiEB3183.
EcoGeneiEG13407. ugd.

Phylogenomic databases

eggNOGiCOG1004.
HOGENOMiHOG000280378.
InParanoidiP76373.
KOiK00012.
OMAiGTNENIA.
OrthoDBiEOG61CM1K.
PhylomeDBiP76373.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00038; UER00491.
BioCyciEcoCyc:UGD-MONOMER.
ECOL316407:JW2010-MONOMER.
MetaCyc:UGD-MONOMER.
SABIO-RKP76373.

Miscellaneous databases

PROiP76373.

Gene expression databases

GenevestigatoriP76373.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028357. UDPglc_DH_bac.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Autophosphorylation of the Escherichia coli protein kinase Wzc regulates tyrosine phosphorylation of Ugd, a UDP-glucose dehydrogenase."
    Grangeasse C., Obadia B., Mijakovic I., Deutscher J., Cozzone A.J., Doublet P.
    J. Biol. Chem. 278:39323-39329(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT A TYROSINE.

Entry informationi

Entry nameiUDG_ECOLI
AccessioniPrimary (citable) accession number: P76373
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.