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P76373

- UDG_ECOLI

UniProt

P76373 - UDG_ECOLI

Protein

UDP-glucose 6-dehydrogenase

Gene

ugd

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei253 – 2531By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi2 – 1918NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. protein binding Source: IntAct
    3. UDP-glucose 6-dehydrogenase activity Source: EcoCyc

    GO - Biological processi

    1. colanic acid biosynthetic process Source: EcoCyc
    2. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    3. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciEcoCyc:UGD-MONOMER.
    ECOL316407:JW2010-MONOMER.
    MetaCyc:UGD-MONOMER.
    SABIO-RKP76373.
    UniPathwayiUPA00030.
    UPA00038; UER00491.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
    Short name:
    UDP-Glc dehydrogenase
    Short name:
    UDP-GlcDH
    Short name:
    UDPGDH
    Gene namesi
    Name:ugd
    Synonyms:pmrE, udg, yefA
    Ordered Locus Names:b2028, JW2010
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG13407. ugd.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388UDP-glucose 6-dehydrogenasePRO_0000074041Add
    BLAST

    Post-translational modificationi

    Phosphorylated on a tyrosine residue. It results in a significant increase of the dehydrogenase activity.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP76373.
    PRIDEiP76373.

    PTM databases

    PhosSiteiP0310109.

    Expressioni

    Gene expression databases

    GenevestigatoriP76373.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    uvrBP0A8F82EBI-1120497,EBI-552176

    Protein-protein interaction databases

    IntActiP76373. 4 interactions.
    STRINGi511145.b2028.

    Structurei

    3D structure databases

    ProteinModelPortaliP76373.
    SMRiP76373. Positions 1-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1004.
    HOGENOMiHOG000280378.
    KOiK00012.
    OMAiSAIQDVM.
    OrthoDBiEOG61CM1K.
    PhylomeDBiP76373.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028357. UDPglc_DH_bac.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500134. UDPglc_DH_bac. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P76373-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKITISGTGY VGLSNGLLIA QNHEVVALDI LPSRVAMLND RISPIVDKEI    50
    QQFLQSDKIH FNATLDKNEA YRDADYVIIA TPTDYDPKTN YFNTSSVESV 100
    IKDVVEINPY AVMVIKSTVP VGFTAAMHKK YRTENIIFSP EFLREGKALY 150
    DNLHPSRIVI GERSERAERF AALLQEGAIK QNIPMLFTDS TEAEAIKLFA 200
    NTYLAMRVAY FNELDSYAES LGLNSRQIIE GVCLDPRIGN HYNNPSFGYG 250
    GYCLPKDTKQ LLANYQSVPN NLISAIVDAN RTRKDFIADA ILSRKPQVVG 300
    IYRLIMKSGS DNFRASSIQG IMKRIKAKGV EVIIYEPVMK EDSFFNSRLE 350
    RDLATFKQQA DVIISNRMAE ELKDVADKVY TRDLFGSD 388
    Length:388
    Mass (Da):43,657
    Last modified:February 1, 1997 - v1
    Checksum:iDA33CEE3EF944AED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC75089.1.
    AP009048 Genomic DNA. Translation: BAA15860.1.
    PIRiC64968.
    RefSeqiNP_416532.1. NC_000913.3.
    YP_490271.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75089; AAC75089; b2028.
    BAA15860; BAA15860; BAA15860.
    GeneIDi12932362.
    946571.
    KEGGiecj:Y75_p1991.
    eco:b2028.
    PATRICi32119391. VBIEscCol129921_2105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAC75089.1 .
    AP009048 Genomic DNA. Translation: BAA15860.1 .
    PIRi C64968.
    RefSeqi NP_416532.1. NC_000913.3.
    YP_490271.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P76373.
    SMRi P76373. Positions 1-388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P76373. 4 interactions.
    STRINGi 511145.b2028.

    PTM databases

    PhosSitei P0310109.

    Proteomic databases

    PaxDbi P76373.
    PRIDEi P76373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75089 ; AAC75089 ; b2028 .
    BAA15860 ; BAA15860 ; BAA15860 .
    GeneIDi 12932362.
    946571.
    KEGGi ecj:Y75_p1991.
    eco:b2028.
    PATRICi 32119391. VBIEscCol129921_2105.

    Organism-specific databases

    EchoBASEi EB3183.
    EcoGenei EG13407. ugd.

    Phylogenomic databases

    eggNOGi COG1004.
    HOGENOMi HOG000280378.
    KOi K00012.
    OMAi SAIQDVM.
    OrthoDBi EOG61CM1K.
    PhylomeDBi P76373.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00038 ; UER00491 .
    BioCyci EcoCyc:UGD-MONOMER.
    ECOL316407:JW2010-MONOMER.
    MetaCyc:UGD-MONOMER.
    SABIO-RK P76373.

    Miscellaneous databases

    PROi P76373.

    Gene expression databases

    Genevestigatori P76373.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028357. UDPglc_DH_bac.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500134. UDPglc_DH_bac. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. "Autophosphorylation of the Escherichia coli protein kinase Wzc regulates tyrosine phosphorylation of Ugd, a UDP-glucose dehydrogenase."
      Grangeasse C., Obadia B., Mijakovic I., Deutscher J., Cozzone A.J., Doublet P.
      J. Biol. Chem. 278:39323-39329(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT A TYROSINE.

    Entry informationi

    Entry nameiUDG_ECOLI
    AccessioniPrimary (citable) accession number: P76373
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3